Abstract: A platform structure is provided that is suitable for incorporation into a drawer, a slidable tray, a storage pedestal, or the like. The platform structure comprises a formed thermoplastic sheet member which has desired compartments defined therein, and an underlying frame structure, preferably wood or a wood-containing material. Contacting surfaces are bonded together with an adhesive. Rails can be mounted along opposite side walls for slide purposes, as in a drawer or tray assembly. Alternatively, rear facial portions of the frame structure can be connected to the top of a storage pedestal or the like.
Abstract: An improved method for expressing peptides as fusion proteins, uses a carrier for a heterologous peptide to provide a fusion protein having a high pI. The high isoelectric point facilitates separation of the fusion protein from all other host cell proteins, and separation of the carrier from the peptide after cleavage.
Type:
Grant
Filed:
August 7, 1990
Date of Patent:
April 13, 1993
Assignee:
Scios Nova Inc.
Inventors:
S. Joseph Tarnowski, Sandra Hilliker, W. Scott Willett
Abstract: A method of declawing poultry by applying a form of heat to the claws of a one-day old poult. The preferred form of heat is microwave energy, which is applied for one-half second. After such a bloodless and relatively painless treatment, the claws fall off in one to three weeks. Declawing apparatus including a magnetron supplying microwave energy into a waveguide into which a poult's toes are inserted by conveyer which carries the poult in inverted position by shackles from which the poult is suspended in inverted position.
Abstract: A microsuspension system and method for its preparation is disclosed. The microsuspension contain lipospheres, which are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid substance to be delivered, or a substance to be delivered that is dispersed in an inert solid vehicle, such as a wax.
Abstract: PKC modulating compounds of the formula ##STR1## Also disclosed are pharmaceutical compositions including these compounds which inhibit PKC activity, methods of using these compounds to inhibit PKC activity in mammals, and intermediates useful in preparing the PKC modulating compounds.
Type:
Grant
Filed:
June 4, 1991
Date of Patent:
February 23, 1993
Assignee:
Nova Pharmaceutical Corporation
Inventors:
Ronald M. Burch, Raymond J. Patch, Barry G. Shearer, John J. Perumattam
Abstract: Pharmaceutical compositions containing a 57 amino acid protease inhibitor and uses for those compositions are taught. The protease inhibitor is referred to as A4i which is associated with Alzheimer's disease. In addition to the A4i protease, other analogs are taught as are pharmaceutical compositions containing such analogs and their uses in treating a variety of abnormalities associated with Kunitz-type basic protease inhibitors. For example, it has been found that pharmaceutical compositions containing A4i protease and analogs thereof inhibit plasmin and tryptase, and also inhibit pancreatic trypsin, alpha-chymotrypsin, tissue kallikrein and serum kallikrein. In that certain diseases are associated with a general release of proteases such as trypsin, chymotrypsin and elastase into the circulatory system pharmaceutical compositions containing A4i and analogs thereof can be used in the management of such diseases.
Type:
Grant
Filed:
March 29, 1990
Date of Patent:
February 16, 1993
Assignee:
Scios Nova Inc.
Inventors:
Barbara Cordell, James W. Schilling, Nobuhiko Katunuma
Abstract: A number of data storage cassettes are held in a removeable magazine that forms part of a tape drive by which the magnetic tapes are recorded or played. The magazine holds two parallel vertically-displaced decks of cassettes that are moved under positive driving force along a rectangular pathway formed by the two decks. From a pick-up position in the magazine, a cassette is automatically extracted by a robotic arm and placed in the tape platform for reading or writing by a conventional tape drive mechanism. When the use of the cassette is finished and it is ejected by the tape drive, a sensor activates the robotic arm to return the cassette to the pick-up position. Each deck has one unoccupied cassette space. If during the sequence of operations, the cassettes on the lower deck are moved by the width of one cassette in one direction, the cassettes on the upper deck are moved the same distance in the opposite direction.
Abstract: Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof are described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fatty acid terminated polyanhydrides. The fatty acid terminated polyanhydrides are also more hydrophobic than the corresponding polyanhydrides that are not terminated with a fatty acid, and combine the properties of thermodynamic and hydrolytic stability, and easy storage. The polymers can be produced with a controlled and low molecular weight. The polyanhydrides are useful in a number of applications, including as a matrix in biodegradable drug delivery systems.
Abstract: A double row, angular contact ball bearing comprises of an integral inner race ring and an integral outer race ring, the outer race ring having at least one circumferential depression between the rows of balls and the inner race ring having a circumferentially radially extending end member axially outside each row of balls. The present invention also relates to a method of manufacturing double row, angular contact ball bearings by shaping sheet metal or tubular work pieces to finished inner or outer race rings by rolling, pressing or deep drawing, introducing rows of balls between the race rings, shaping the race rings to final form by rolling or pressing, and rolling the rows of balls constantly about the circumferential periphery of the inner race ring during the rolling or pressing of the race rings.
Abstract: Branched polyanhydrides that have superior properties for use in the controlled delivery of substances, prepared by the polymerization of a dicarboxylic acid monomer and a branching agent. The branching agent is a polycarboxylic acid monomer such as 1,3,5-benzenetricarboxylic acid ("BTC"), or an oligomerized fatty acid trimer. Alternatively, the branching agent is a polycarboxylic acid polymer such as poly(acrylic acid) ("PAA"). These branched polymers have significantly higher molecular weights and lower specific viscosity than linear polymers prepared under similar conditions. A major advantage of branched polyanhydrides is that the degradation and release kinetics can be substantially altered without significantly changing the physical properties of the polymer relative to the corresponding linear polymer. By manipulating both the diacid and the branching agent, a wide variety of biodegradable controlled delivery devices for diverse applications can be prepared.
Abstract: A polyanhydride suitable for use as a matrix material in controlled delivery devices polymerized from monomers of the general formula: ##STR1## wherein R, R', and R" are the same or a different aliphatic chain of C.sub.1 to C.sub.20 or hydrogen; m, n, and p are integers from 0 and 20; y is 0 or 1; and, if y is 0, one of R or R' is not H.
Abstract: Pipelines are maintained in subterranean location by a plurality of weighting devices which include an elongate central raised region enclosing the pipeline and generally planar flanges extending outwardly from the central raised region in a common plane. Backfill overlaying the flanges provides an increased resistance to upward movement of the buried pipeline under the influence of an encompassing fluid medium or other force.
Abstract: A protective gas nozzle (6) and a gas feed channel (10) for the protective gas is arranged concentric around a spray jet nozzle (5). The protective gas nozzle (6) has a core hollow space (26) with a curved closing surface (9) at the rear end (8) of the nozzle (6). With this, the protective gas nozzle (6) with the gas feed channel (10) and the wall (13) lying opposite forms a nozzle channel (14) which at first extends radial and then about parallel between the gas feed channel (10) and the core hollow space (26).
Abstract: The axial forces imposed on a rotor of a fluid machine such as a compressor is controlled by modulating the pressure supplied to a piston and cylinder device acting between the rotor shaft and housing. A parameter indicative of axial force on the rotor during operation is monitored and changes in the magnitude and direction of the axial forces countered by varying the pressure in the cylinder. The net axial forces imposed on the shaft may thus be controlled in a predetermined range.
Abstract: Disclosed are oligonucleotide compounds that inhibit interleukin receptor expression when administered to a human subject. Also disclosed are pharmaceutical compositions and methods for inhibiting human interleukin receptor expression.
Abstract: Piston rings for internal combustion engines and compressors are described. The piston ring comprises a generally "L-shaped" cross section and may be used in place of a conventional oil control piston ring. It may fulfill an exclusively oil scraping function or may act as a combined oil scraper and compression ring.
Abstract: An arrangement of a wheelchair with a movable seat and leg rest and a bed equipped with transfer apparatus including rollers, a movable sheet, a lift member, and a control system for transporting an invalid comfortably across the bed to a sitting position on the wheelchair.