Patents Assigned to Nova
  • Recombinant expression system for human anti-inflammatory phospholipase inhibitor protein
    Patent number: 5342764
    Abstract: Cloning and expression of the gene encoding human phospholipase inhibitory protein (hPIP) permits production of an anti-inflammatory protein in practical quantities using recombinant techniques.
    Type: Grant
    Filed: September 1, 1993
    Date of Patent: August 30, 1994
    Assignee: Scios Nova Inc.
    Inventors: Lorin K. Johnson, John P. Longenecker
  • Liposphere carriers of vaccines
    Patent number: 5340588
    Abstract: Solid, water-insoluble lipospheres including a solid hydrophobic core, having a layer of a phospholipid embedded on the surface of the core, that contain an antigen are disclosed for use in immunizing an animal. The antigen (or "immunogen"), alone or in combination with a carrier, can form the core, be attached to or within the phospholipid, or both. Lipospheres containing antigens are prepared by two general procedures, either melt preparation or solvent preparation. The resulting lipospheres have several advantages over other delivery systems, including emulsions, vesicles and liposomes, including stability, low cost of reagents, ease of manufacture, high dispersibility in an aqueous medium, a release rate for the entrapped substance that is controlled by the phospholipid coating and the carrier.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: August 23, 1994
    Assignee: Nova Pharmaceutical Corporation
    Inventor: Abraham J. Domb
  • Process for purification of basic fibroblast growth factor
    Patent number: 5331095
    Abstract: The invention relates to a method of purifying basic fibroblast growth factor. The method involves the use of strong cation exchange chromatography followed by hydrophobic interaction chromatography and then by weak cation exchange chromatography.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: July 19, 1994
    Assignee: Scios Nova Inc.
    Inventors: Paula J. Shadle, Kate B. Silverness, Robert S. King
  • Speculum protector with smoke tube
    Patent number: 5329937
    Abstract: A speculum cover for a speculum blade has a smoke tube associated therewith. The speculum cover may be removable from the blade.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: July 19, 1994
    Assignee: Nova Healthcare Industries, Inc.
    Inventors: Stephen Krstevich, Fredrick Kamienny, Frederick Erlich, Steve Watkins
  • Double row angular contact ball bearings and a method for the manufacture thereof
    Patent number: 5325586
    Abstract: A double row, angular contact ball bearing comprised of an integral inner race ring and an integral outer race ring, the outer race ring having at least one circumferential depressing between the rows of balls and the inner race ring having a circumferentially radially extending end member axially outside each row of balls. The present invention also relates to a method of manufacturing double row, angular contact ball bearings by shaping sheet metal or tubular work pieces to finished inner or outer race rings by rolling, pressing or deep drawing, introducing rows of balls between the race rings, shaping the race rings to final form by rolling or pressing, and rolling the rows of balls constantly about the circumferential periphery of the inner race ring during the rolling or pressing of the race rings.
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: July 5, 1994
    Assignee: SKF Nova AB
    Inventor: Borje Andersson
  • Expression of recombinant polypeptides with improved purification
    Patent number: 5322930
    Abstract: An improved method for expressing peptides as fusion proteins, uses a carrier for a heterologous peptide to provide a fusion protein having a high pI. The high isoelectric point facilitates separation of the fusion protein from all other host cell proteins, and separation of the carrier from the peptide after cleavage.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: June 21, 1994
    Assignee: Scios Nova Inc.
    Inventors: S. Joseph Tarnowski, Sandra Hilliker, W. Scott Willett
  • Invalid transfer arrangement
    Patent number: 5319813
    Abstract: An arrangement of a wheelchair with a movable seat and leg rest and a bed equipped with transfer apparatus including rollers, a movable sheet, a lift member, and a control system for transporting an invalid comfortably across the bed to a sitting position on the wheelchair.
    Type: Grant
    Filed: July 6, 1992
    Date of Patent: June 14, 1994
    Assignee: Nova Technologies, Inc.
    Inventors: Paul DiMatteo, Charles Chubb
  • Die coating
    Patent number: 5318091
    Abstract: A metal casting die, and a method for its production, are described. By the method the die has provided over at least a part of its internal cavity forming surfaces, indentations of predetermined depth, area and distribution, by employing a technique selected from the group comprising photoetching, electrochemical etching and grit blasting. The die cavity forming surfaces also have thereon, over at least those surfaces with indentations, a coating of a hard, corrosion and erosion resistant material which extends into and between each indentation as a continuous layer.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: June 7, 1994
    Assignee: Borgo-Nova SpA
    Inventors: Mario Pavoni, Luigi Basile
  • Fatty acid terminated polyanhydride
    Patent number: 5317079
    Abstract: Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof are described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fatty acid terminated polyanhydrides. The fatty acid terminated polyanhydrides are also more hydrophobic than the corresponding polyanhydrides that are not terminated with a fatty acid, and combine the properties of thermodynamic and hydrolytic stability, and easy storage. The polymers can be produced with a controlled and low molecular weight. The polyanhydrides are useful in a number of applications, including as a matrix in biodegradable drug delivery systems.
    Type: Grant
    Filed: September 18, 1992
    Date of Patent: May 31, 1994
    Assignee: Nova Pharmaceutical Corporation
    Inventors: Abraham J. Domb, Manoj Maniar
  • Axial inlet beam-type compressor
    Patent number: 5306117
    Abstract: A rotary fluid machine suitable for transferring energy between a fluid and a rotor assembly is disclosed. The rotor assembly contains a shaft carrying one or more impellers which are located between axially spaced radial bearings in a beam-type arrangement. The rotary fluid machine is of the beam type--i.e. it has one end of the shaft extending beyond one end wall of the housing and one end of the shaft terminating within the housing. Two passages are formed in the housing to allow fluid to flow in and out of the machine. One passage is formed in the housing parallel to and coaxial with the rotational axis of the rotor assembly. Fluid moving between the passage parallel to and coaxial with the rotational axis does not have to be redirected thus reducing fluid turbulence and improving machine efficiency.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: April 26, 1994
    Assignee: NOVA Corporation of America
    Inventors: Clayton Bear, Robert A. Peterson
  • Modular desk with adjustable monitor support
    Patent number: 5294193
    Abstract: A desk structure is provided that is adapted for use in a modular work environment. The desk structure has a transparent portion in its top member and incorporates a pair of side walls, a bottom shelf, and a back brace. The desk structure is cooperatively associated with an underdesk adjustable monitor support assembly. The support assembly incorporates a shelf member and a pair of side supports and such are all preferably comprised of formed wire. Each side support is associated with desk components including adjacent portions of one side wall, the top member, the bottom shelf, and the back brace. The shelf member is adjustably associated with the side supports.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: March 15, 1994
    Assignee: Nova Manufacturing & Assembly, Inc.
    Inventors: Thomas Wegman, John N. Lechman
  • Adjustable monitor support
    Patent number: 5290099
    Abstract: A self-upholding, free-standing adjustable monitor support structure that is adopted for association with, and for support of, a top platform member that includes a transparent portion. The monitor support structure includes a shelf member, a pair of side supports which are each equipped with a pair of legs and a plurality of transversely extending, vertically spaced load bearing members, and adjustable connector means for connecting the shelf member with each side support. Optionally but preferably, the side supports also each include a transverse bar which is configured to support a drawer slide in combination with an associated leg member; thus, the monitor support structure can also support a horizontally slidable keyboard tray. The combination of the monitor support structure and the top platform member provides a useful work station.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: March 1, 1994
    Assignee: Nova Manufacturing & Assembly, Inc.
    Inventor: John N. Lechman
  • Puncture resistant insole for safety footwear
    Patent number: 5285583
    Abstract: A protective insole for use in safety footwear comprising a protective layer composed of plastic and including a flexible forepart portion having an insole board bonded to its bottom surface and a fabric liner bonded to its top surface during the process of molding the protective plastic layer. A fabric mesh may be embedded in the plastic layer for reinforcement. A further embodiment provides a steel forepart plate anchored to a plastic shank and heel about the region of greatest flexure.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: February 15, 1994
    Assignee: Terra Nova Shoes Ltd.
    Inventor: Albertus A. W. Aleven
  • Sigma binding site agents
    Patent number: 5278174
    Abstract: Sigma binding site agents having the formula ##STR1## which are useful to inhibit sigma binding site-induced activity, pharmaceutical compositions including these agents, and methods of using these agents to inhibit sigma binding site-induced activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented agents.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: January 11, 1994
    Assignee: Scios Nova, Inc.
    Inventors: Ronald H. Erickson, Kenneth J. Natalie, Jr., Michael J. Pontecorvo, Waclaw J. Rzeszotarski
  • Reusable heat releasing pack
    Patent number: 5275156
    Abstract: A reusable device for delivering a release of heat to an area such as a body portion. The device comprises a flexible, fluid-tight container holding a liquid which releases heat upon crystallization such as sodium acetate tetrahydrate. A trigger located within the container initiates the crystallization of the liquid to release the latent heat. The trigger comprises a plurality of rigid objects held within a receptacle located within the container. The receptacle is in fluid communication with the container so that the plurality of rigid objects are in contact with the liquid. The trigger initiates the crystallization of the liquid when pressure is applied to the plurality of rigid objects such as by squeezing the trigger between one's fingers.
    Type: Grant
    Filed: July 13, 1992
    Date of Patent: January 4, 1994
    Assignee: Nova Design Partners, L.P.
    Inventors: Andrew J. Milligan, Robert A. Lewis
  • Polyanhydrides of oligomerized unsaturated aliphatic acids
    Patent number: 5270419
    Abstract: A polyanhydride suitable for use as a matrix material in controlled delivery devices polymerized from monomers of the general formula: ##STR1## wherein R, R', and R" are the same or a different aliphatic chain of C.sub.1 to C.sub.20 or hydrogen; m, n, and p are integers from 0 and 20; y is 0 or 1; and, if y is 0, one of R or R' is not H.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: December 14, 1993
    Assignee: Nova Pharmaceutical Corporation
    Inventor: Abraham J. Domb
  • Desk
    Patent number: D342396
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: December 21, 1993
    Assignee: Nova Office Furniture, Inc.
    Inventors: John N. Lechman, Thomas Wegman
  • Desk
    Patent number: D346913
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: May 17, 1994
    Assignee: Nova Office Furniture, Inc.
    Inventors: John N. Lechman, Thomas Wegman
  • Office desk
    Patent number: D347949
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: June 21, 1994
    Assignee: Nova-Link Limited
    Inventor: Antonius A. Vander Park
  • Container for segregating waste materials
    Patent number: D348964
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: July 19, 1994
    Assignee: Nova Sylva Inc.
    Inventors: Pierre J. Roy, Denis Houle