Patents Assigned to Research Triangle Institute
  • ELECTRONIC DEVICES UTILIZING CONTACT PADS WITH PROTRUSIONS AND METHODS FOR FABRICATION
    Publication number: 20150235898
    Abstract: An electronic device includes a substrate including a front side, a back side, a thickness between the front side and back side, one or more front-side vias extending from the front side into a part of the thickness, and an interconnect via extending from the back side toward the front side; a contact pad on the front side and including one or more protrusions extending through corresponding front-side vias and into the interconnect via; and an interconnect extending through the interconnect via and into contact with the protrusion(s).
    Type: Application
    Filed: September 4, 2013
    Publication date: August 20, 2015
    Applicant: Research Triangle Institute
    Inventors: Erik Vick, Garry Brian Cunningham, Dorota Temple
  • Photoluminescent nanofiber composites, methods for fabrication, and related lighting devices
    Patent number: 9101036
    Abstract: A photoluminescent nanofiber composite includes a nanofiber substrate, first luminescent particles, and second luminescent particles. The first luminescent particles are supported by the nanofibers and span at least a portion of a substrate surface, as a layer on the substrate surface, or with some particles located in a bulk of the substrate, or both. The second luminescent particles are disposed on the substrate. The second luminescent particles may be disposed directly on the substrate surface or on the first luminescent particles. The second luminescent particles may be deposited in a pattern of deposition units. The first and second luminescent particles are configured for emitting light of different respective wavelengths in response to excitation by a light beam. One or more surface treatment coatings may be provided at different locations.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: August 4, 2015
    Assignee: Research Triangle Institute
    Inventors: Kimberly A. Guzan, Karmann C. Mills, Li Han, James Lynn Davis, Paul G. Hoertz
  • Integrated optical upconversion devices and related methods
    Patent number: 9054262
    Abstract: Integrated upconversion devices capable of upconverting incident visible to short wavelength infrared photons to visible photons are disclosed. The device may include a quantum dot-based photodiode and a light-emitting diode. The device may further include a gain element such as a thin-film transistor.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: June 9, 2015
    Assignee: Research Triangle Institute
    Inventors: John Lewis, Ethan Klem
  • Treatment of disorders associated with G protein-coupled receptor 35 (GPR35)
    Patent number: 9040583
    Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: May 26, 2015
    Assignees: Temple University-Of the Commonwealth System of Higher Education, Duke University, Research Triangle Institute
    Inventors: Mary E. Abood, Pingwei Zhao, Lawrence S. Barak, Herbert H. Seltzman
  • Fluorescence based thermometry
    Patent number: 9022649
    Abstract: A temperature sensor includes a photon source, a fluorescent element and a photodetector. The fluorescent element includes a temperature-insensitive first fluorophore and a temperature-sensitive second fluorophore. The photodetector includes a first photosensor exhibiting a first spectral responsivity and a second photosensor exhibiting a second spectral responsivity. To measure a temperature of a surface, the fluorescent element may be placed adjacent to the surface and irradiated with a photon beam. First photons emitted from the first fluorophore and second photons emitted from the second fluorophore are collected. The first and second photons may be transmitted as a single dichromatic beam to the photodetector. The photosensors generate two different photodetector output signals, the ratio of which may be correlated to temperature.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: May 5, 2015
    Assignee: Research Triangle Institute
    Inventors: John Lewis, Ethan Klem, Jeffrey Robert Piascik, Garry Brian Cunningham
  • Nicotinic receptor compounds
    Patent number: 8981102
    Abstract: Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: March 17, 2015
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Pauline Wanjiku Ondachi
  • Three dimensional interconnect structure and method thereof
    Patent number: 8975753
    Abstract: A three-dimensional interconnect includes a first substrate bonded to a second substrate, the first substrate including a device layer and a bulk semiconductor layer, a metal pad disposed on the second substrate, an electrically insulating layer disposed between the first and second substrates. The structure has a via-hole extending through the device layer, the bulk semiconductor layer and the electrically insulating layer to the metal pad on the second substrate. The structure has a dielectric coating on a sidewall of the via-hole, and a plasma-treated region of the metal pad disposed on the second substrate. The structure includes a via metal monolithically extending from the plasma-treated region of the metal pad through the via-hole and electrically interconnecting the device layer of the first substrate to the metal pad of the second substrate.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: March 10, 2015
    Assignee: Research Triangle Institute
    Inventors: Charles Kenneth Williams, Christopher A. Bower, Dean Michael Malta, Dorota Temple
  • Heat recovery from sorbent-based COcapture
    Patent number: 8975464
    Abstract: The present invention provides a method of increasing the efficiency of exothermic CO2 capture processes. The method relates to withdrawing heat generated during the exothermic capture of CO2 with various sorbents via heat exchange with a working fluid. The working fluid is provided at a temperature and pressure such that it is in the liquid state, and has a vaporization temperature in a range such that the heat arising from the reaction of the CO2 and the sorbent causes a phase change from liquid to vapor state in whole or in part and transfers heat from to the working fluid. The resulting heated working fluid may subsequently be used to generate power.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: March 10, 2015
    Assignee: Research Triangle Institute
    Inventors: Aqil Jamal, Raghubir P. Gupta
  • COMPOSITION AND METHOD FOR NEUROPEPTIDE S RECEPTOR (NPSR) ANTAGONISTS
    Publication number: 20150057268
    Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.
    Type: Application
    Filed: December 6, 2012
    Publication date: February 26, 2015
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott Runyon, Yanan Zhang, Carla Hassler, Brian Gilmour
  • FIBER SAMPLER FOR RECOVERY OF BIOAEROSOLS AND PARTICLES
    Publication number: 20150024379
    Abstract: An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection medium downstream from the moisture exchange device and configured to collect the bioparticles. The method includes delivering bioparticles in a gas stream, humidifying or dehumidifying the bioparticles in the gas stream by transport of water across a partition member and into a vapor phase of the gas stream, and collecting the bioparticles by a collection medium.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 22, 2015
    Applicants: RESEARCH TRIANGLE INSTITUTE, AEROSOL DYNAMICS INC.
    Inventors: David S. Ensor, Howard Jerome Walls, Karin K. Foarde, Susanne Vera Hering, Steven Russel Spielman
  • INTEGRATED OPTICAL UPCONVERSION DEVICES AND RELATED METHODS
    Publication number: 20150008390
    Abstract: Integrated upconversion devices capable of upconverting incident visible to short wavelength infrared photons to visible photons are disclosed. The device may include a quantum dot-based photodiode and a light-emitting diode. The device may further include a gain element such as a thin-film transistor.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 8, 2015
    Applicant: Research Triangle Institute
    Inventors: John Lewis, Ethan Klem
  • 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20150005315
    Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.
    Type: Application
    Filed: December 10, 2012
    Publication date: January 1, 2015
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank I. Carroll, James B. Thomas, Hernan A. Navarro, S. Wayne Mascarella, Scott P. Runyon, Chunyang Jin, Chad M. Kormos
  • Hydroxybupropion analogues for treating drug dependence
    Patent number: 8906908
    Abstract: The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: December 9, 2014
    Assignees: Research Triangle Institute, Dignity Health, Virginia Commonwealth University
    Inventors: F. Ivy Carroll, Bruce E. Blough, Hernan A. Navarro, S. Wayne Mascarella, Ana Zamfira Muresan, M. Imad Damaj, Ronald J. Lukas
  • AEROSOL EXPOSURE MONITORING
    Publication number: 20140347663
    Abstract: A gas processing device such as an aerosol exposure monitor is configured for acquiring chronic data, acute data, or both simultaneously, and may include a pump and a noise dampening device. The noise dampening device may include an elastomeric membrane between an inlet chamber and an outlet chamber. In another aspect, an aerosol exposure monitor may include an impactor, a collection filter, and a nephelometer that includes a sample chamber integrated with an aerosol flow path associated with the impactor and collection filter.
    Type: Application
    Filed: October 26, 2012
    Publication date: November 27, 2014
    Applicant: Research Triangle Institute
    Inventors: Charles E. Rodes, J. Randall Newsome
  • HUMAN CONDUCTING AIRWAY MODEL COMPRISING MULTIPLE FLUIDIC PATHWAYS
    Publication number: 20140335496
    Abstract: A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.
    Type: Application
    Filed: December 4, 2012
    Publication date: November 13, 2014
    Applicants: Research Triangle Institute, The University of North Carolina at Chapel Hill
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, Scott H. Randell
  • Reflective nanofiber lighting devices
    Patent number: 8884507
    Abstract: A fiber-based reflective lighting device and a lighting device. The fiber-based reflective lighting device includes a source configured to generate a primary light, a mat of reflective fibers which diffusely reflects light upon illumination with at least the primary light, and a light exit configured to emanate the reflected light. The lighting device includes a housing, a source configured to generate primary light and direct the primary light into the housing, a reflective mat of fibers disposed inside the housing at a position to reflect the primary light, and a light exit in the housing configured to emanate the reflected light from the housing.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: November 11, 2014
    Assignee: Research Triangle Institute
    Inventors: James Lynn Davis, Howard J. Walls, Karmann Mills, Vijay Gupta, Michael Kasper Lamvik
  • NANOPARTICLE COMPACT MATERIALS FOR THERMOELECTRIC APPLICATION
    Publication number: 20140318593
    Abstract: A thermoelectric composite and a thermoelectric device and a method of making the thermoelectric composite. The thermoelectric composite is a semiconductor material formed from mechanically-alloyed powders of elemental constituents of the semiconductor material to produce nano-particles of the semiconductor material, and compacted to have at least a bifurcated grain structure. The bifurcated grain structure has at least two different grain sizes including small size grains in a range of 2-200 nm and large size grains in a range of 0.5 to 5 microns. The semiconductor material has a figure of merit ZT, defined as a ratio of the product of square of Seebeck coefficient, S2, and electrical conductivity ? divided by the thermal conductivity k, which varies from greater than 1 at 300 K to 2.5 at temperatures of 300 to 500K.
    Type: Application
    Filed: November 21, 2012
    Publication date: October 30, 2014
    Applicants: Research Triangle Institute, North Carolina State University
    Inventors: Rama Venkatasubramanian, Judy Stuart, Ryan Wiitala, Peter Thomas, Carl C. Koch, Tsungta Ethan Chan
  • High density faraday cup array or other open trench structures and method of manufacture thereof
    Patent number: 8866081
    Abstract: A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: October 21, 2014
    Assignee: Research Triangle Institute
    Inventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner
  • Reflective nanofiber lighting devices
    Patent number: 8864341
    Abstract: A fiber-based reflective lighting device. The lighting device includes a source configured to generate a primary light, a substrate including a mat of reflective nanofibers, and a light exit configured to emanate the reflected light. The fibers have an average fiber diameter AFD less than 500 nm which diffusively reflects visible light upon illumination with at least the primary light. The mat has a basis weight less than 40 gram per square meter (gsm) and a reflectance greater than 80%.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: October 21, 2014
    Assignee: Research Triangle Institute
    Inventors: James Lynn Davis, Larry Charles Michael, Karmann C. Mills
  • Faraday cup array integrated with a readout IC and method for manufacture thereof
    Patent number: 8866080
    Abstract: A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: October 21, 2014
    Assignee: Research Triangle Institute
    Inventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner, Dorota Temple