Abstract: In one aspect, the disclosure relates to drug delivery devices for the ionophoretic delivery of a therapeutic agent(s) to the eye. In some aspects, the disclosed ionophoretic ocular delivery device is configured for delivery of a therapeutic agent to the anterior portion of the eye. In various aspects, the present disclosure provides methods for treatment of an ophthalmological disorder, disease, or clinical condition by delivering a therapeutic agent(s) to the eye using a disclosed ionophoretic ocular delivery device. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: The present disclosure relates to a method and apparatus for predicting application service response time in a communication system. Particularly, the present disclosure relates to a method, apparatus and system for predicting response time required to provide an application service to a user in response to the user's request of the application service in a server of a communication system. A method for predicting application service response time according to an embodiment of the present disclosure includes: data collection for collecting network data associated with a user application service, in response to a request for the application service by a user device; and data analysis for performing, by utilizing the collected data, a response time predictive analysis, in order to predict a user's application service response time. The data analysis selects an optimal prediction model by initially applying a response time prediction model and testing the initial prediction model that is applied.

Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and sternness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect the Yap1:Oct4 interaction.

Abstract: A recyclable inclination measuring device includes measuring units arranged in a linear array during installation, and two adjacent measuring units are eccentrically hinged by a joint; during the measurement, measuring units are arranged in a Z shape in the measuring tube, the inner wall of the measuring tube is closely attached to the joint, and measuring units extending out of the measuring tube are folded and arranged. the present invention adopts a recyclable inclination measuring device with the above structure, during the measurement, it is placed in the measuring tube, which can be arranged in a Z shape under the action of gravity, and then it can be measured with the synchronous rotation of the measuring tube, when it is recovered, it only needs to be pulled out, which reduces the difficulty of recovery and improves the recovery efficiency.

Abstract: Vectors having a nucleotide sequence having SEQ ID NO:1 or a nucleotide sequence having at least 85% identity to SEQ ID NO:1, or a portion thereof, that is capable of regulating bocaparvovirus replication, or vectors having the complement of the nucleotide sequence, and methods of using the vectors, are provided.

Abstract: A substrate processing system includes a first chamber including a substrate support. A showerhead is arranged above the first chamber and is configured to filter ions and deliver radicals from a plasma source to the first chamber. The showerhead includes a heat transfer fluid plenum, a secondary gas plenum including an inlet to receive secondary gas and a plurality of secondary gas injectors to inject the secondary gas into the first chamber, and a plurality of through holes passing through the showerhead. The through holes are not in fluid communication with the heat transfer fluid plenum or the secondary gas plenum.

Abstract: A method for calibrating a chest of a vehicle crash dummy, includes: controlling, under each preset test condition, a pressing apparatus to press down a chest of a target crash dummy with a target pressing speed and a target pressing distance corresponding to the preset test condition, obtaining an actual force-displacement curve under each preset test condition, obtaining a standard force-displacement curve of a chest of a standard crash dummy under each preset test condition, and determining, according to the actual force-displacement curve and the standard force-displacement curve under each preset test condition, whether the chest of the target crash dummy satisfies a biological simulation standard. Through collecting information under various preset test conditions, various complicated conditions of impact on the chest can be more effectively simulated in a crash test by using the method, which improves the accuracy of determining the biological simulation standard.

Abstract: A maize pollen composition containing polyether ether ketone and pollen for collecting pollen and storing pollen.

Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Abstract: A flexible tactile sensor includes a conductive target positioned in a first plane, at least three coils forming an array within a second plane, the second plane spaced apart from the first plane, a pliable material coupling the conductive target to the at least three coils, and an electronic device electrically coupled to each of the at least three coils, the electronic device configured to induce an AC signal within each of the at least three coils and measure a change in inductance in the at least three coils in response to movement of the conductive target.

Abstract: A femtosecond pulse laser apparatus includes a pump light source configured to provide a pump light, a gain medium configured to obtain a gain of a laser light using the pump light, a first curved mirror and a second curved mirror, which are provided at both sides of the gain medium, an output mirror configured to transmit a portion of the laser light and reflect the other portion of the laser light to the gain medium, a mode locking portion configured to generate a femtosecond pulse of the laser light, and an acoustic wave generator configured to provide an acoustic wave into the gain medium so as to adjust self-phase modulation of the laser light.

Abstract: A block production method and a block producing node including creating an entangled transaction list by combining a plurality of transactions received through the communication unit and producing a block using the entangled transaction list are provided.

Abstract: Disclosed herein is an intra prediction method including: deriving neighbor prediction mode information from a left neighbor prediction mode and an upper neighbor prediction mode; deriving an intra prediction mode for a decoding target unit by using the derived neighbor prediction mode information; and performing intra prediction on the decoding target unit based on the intra prediction mode. According to exemplary embodiments of the present invention, image encoding/decoding efficiency can be improved.

Abstract: Provided is a thin film including Mo1-xWxTe2 stacked in a plurality of layers. The thin film has a thickness of about 1 nm to about 100 nm in a stacking direction, has a symmetric lattice structure at a temperature higher than a threshold temperature, and has an asymmetric lattice structure at a temperature equal to or lower than the threshold temperature.

Abstract: A method for extracting road data comprises obtaining ground data from first environment detection data of a detected region. A first ground model may be obtained using the ground data. A missing region of the first ground model may be filled to obtain a second ground model. Road attributes of the detected region may be obtained according to the second ground model. Road damage recognition may be performed using second environment detection data of the detected region and the second ground model. The method may include storing the road attributes and the result of the road damage recognition as pieces of road data of the detected region.

Abstract: Disclosed are methods and apparatuses for supporting BWP-based operations in sidelink communication. An operation method of a first terminal in a communication system may include receiving, from a base station, configuration information of a mapping relationship between an uplink (UL) bandwidth part (BWP) and a sidelink (SL) BWP; when a UL switching operation for the UL BWP is performed, performing an SL switching operation for the SL BWP mapped to the UL BWP based on the mapping relationship without separate signaling indicating execution of the SL switching operation; and performing sidelink communication with a second terminal in a switched SL BWP.

Abstract: Various examples are provided for modular prosthetic devices and their use. In one example, a device includes a chassis assembly including a joint portion; and an interchangeable module that can be removably attached to the chassis assembly. The interchangeable modules can be configured for use in a wide variety of applications. The interchangeable modules can be quickly exchanged for different activities.

Abstract: The present invention provides pyrazole derivatives, e.g., a compound of Formula (I), and their uses in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.

Abstract: An ultra-large horizontal seepage test system with intelligent graded loading and variable seepage path is provided, which includes a water storage system, a water pressure system, a horizontal seepage test system and an intelligent loading and control system. The water storage system, the water pressure system and the horizontal seepage test system are connected in sequence, and the water pressure system is used to apply a water pressure and a vertical pressure to a test piece to be tested in the horizontal seepage test system. An outlet valve of the horizontal seepage test system is connected to the water storage system, and the intelligent loading and control system is used to control operations of electrical components of the water pressure system and the horizontal seepage test system. With the test system, a water head pressure can be loaded intelligently, and an infiltration angle of water inflow can be adjusted.

Abstract: A cluster-supporting catalyst including porous carrier particles having acid sites, and catalyst metal clusters supported within the pores of the porous carrier particles. In the cluster-supporting catalyst including porous carrier particles having acid sites, and catalyst metal clusters supported within the pores of the porous carrier particles, the catalyst metal may be rhodium, the catalyst metal may be palladium, the catalyst metal may be platinum, or the catalyst metal may be copper.