Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
Type:
Grant
Filed:
November 22, 2021
Date of Patent:
August 27, 2024
Assignees:
University of Central Florida Research Foundation, Inc., The Regents of the University of California, Memorial Sloan-Kettering Cancer Center, The Broad Institute, Inc.
Inventors:
Derek Shieh Tan, Corinne N. Foley, Gustavo Moura-Letts, James McKerrow, Sivaraman Dandapani, Rahul Edwankar, Alyssa Verano, Debopam Chakrabarti, Bracken Roberts
Abstract: A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
August 27, 2024
Assignee:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
Inventors:
Fei Wang, Leon M. Tolbert, Yiwei Ma, Kevin Louis Tomsovic, Kai Sun, Shuoting Zhang, Jingxin Wang, Bo Liu
Abstract: A substrate processing system includes a hinge assembly configured to allow a substrate support and an RF bias assembly to slide, from a docked position to an undocked position, relative to other components of a processing chamber. A make-break connector is configured to supply fluid to at least one of the substrate support and the RF bias assembly. The make-break connector includes a first portion including a first fluid passage connected to a first conduit. A second portion includes a second fluid passage connected to a second conduit. The first fluid passage in the first portion fluidly communicates with the second fluid passage in the second portion. The first portion is configured to slide with the substrate support and the RF bias assembly relative to the second portion and the other portions of the processing chamber. The first portion is located inwardly relative to the second portion.
Abstract: The present invention relates to a method and apparatus for transmitting and receiving data. A data transmission method from a sender terminal to a receiver terminal in a MIMO system using a variable frequency band according to one embodiment of the present invention comprises: repeatedly generating a signal field depending on a frequency band that is applied to the transmission of a data frame; generating a data field including the data; generating a data frame including the signal field and the data field; and transmitting the data frame to the receiver terminal. The present invention is advantageous in that a signal field which is transmitted together with the data being transmitted from the sender terminal to the receiver terminal in the MIMO system can be sent more efficiently.
Type:
Grant
Filed:
October 19, 2022
Date of Patent:
August 27, 2024
Assignee:
Electronics and Telecommunications Research Institute
Abstract: The present disclosure relates methods and systems for refining grain oil compositions using water, and related compositions produced therefrom. The present disclosure also relates to methods of using grain oil derived from a fermentation product in an anti-foam composition and/or feedstock to make diesel.
Type:
Grant
Filed:
October 5, 2020
Date of Patent:
August 27, 2024
Assignee:
POET RESEARCH, INC.
Inventors:
Shannon S. Urban, Cory J. Sarks, Brett A. Flittie, Jacob A. Milbrandt, Steven T. Bly, Alex T. McCurdy
Abstract: A dehumidifying system and method for reducing humidity in ambient air is disclosed. The system includes a circulation unit, a refrigeration unit, a condensate receptacle for receiving condensate generated by the refrigeration unit, a controller to control both the circulation and refrigeration units, and wherein the controller receives input from one or more ambient sensors configured to sense ambient conditions, and a user interface configured to receive input from a user. The system implements variable speed control within the circulation and/or refrigeration unit to maximize efficiency or capacity under a current threshold, and enables the system to delay the need for defrost cycling during low temperature operation.
Type:
Grant
Filed:
March 24, 2023
Date of Patent:
August 27, 2024
Assignee:
Research Products Corporation
Inventors:
Erick L. Sokn, Stephen Moon, Aditya Rane, Sergey Baranov, Charles Baker
Abstract: A method comprising: accessing a block that is not opaque and defines a plurality of wells that are not in fluid communication with each other; and providing a storage medium storing a set of instructions on how to use the block.
Abstract: A substrate support for a substrate processing chamber includes a baseplate, a ceramic layer bonded to the baseplate, and a seal provided in an outer perimeter of an interface between the ceramic layer and the baseplate. The seal is arranged to seal the interface from the substrate processing chamber and includes an adhesive comprising a first material arranged in the outer perimeter of the interface between the ceramic layer and the baseplate and a ring arranged in the outer perimeter of the interface between the ceramic layer and the baseplate. The ring is removable and comprises a second material having a greater resistance to plasma erosion than the first material.
Abstract: A heat transferring device including a heater, a cooler, and a recoverer may be provided. The heater may be configured to heat a first liquid working fluid and change the first liquid working fluid to a gaseous working fluid. The cooler may be configured to cool the gaseous working fluid supplied from the heater and change the gaseous working fluid supplied from the heater to a second liquid working fluid. The recoverer may be configured to enable the second liquid working fluid from the cooler to move to the heater. Accordingly, the second liquid working fluid of the cooler may be movable in an upward direction and then recoverable using gravity, without a separate power source.
Type:
Grant
Filed:
November 29, 2018
Date of Patent:
August 27, 2024
Assignee:
KOREA ATOMIC ENERGY RESEARCH INSTITUTE
Inventors:
Sung-Jae Yi, Sung Uk Ryu, Hyun Sik Park, Ki Yong Choi
Abstract: An oscillation circuit includes an oscillator, first and second capacitors connected between two terminals of the oscillator, and an amplification circuit having an input terminal connected to a connecting point between the oscillator and the first capacitor and an output terminal connected to a connecting point between the first capacitor and the second capacitor. The amplification circuit includes a first n-type transistor and a first p-type transistor respectively having source terminals, the connecting point of which is connected to the output terminal of the amplification circuit, a second p-type transistor connected to a gate terminal of the first n-type transistor, and a second n-type transistor connected to a gate terminal of the first p-type transistor.
Type:
Grant
Filed:
May 7, 2021
Date of Patent:
August 27, 2024
Assignees:
PIEZO STUDIO INC., INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION HIGH ACCELERATOR RESEARCH ORGANIZATION
Abstract: A display device for a timepiece representing the lunar libration phenomenon thanks to at least one Moon disk, to at least one aperture and to at least one drive organ. The at least one Moon disk includes a set of Moon phase representations including at least three Moon phases with a first surface, a second surface and/or a delimitation configured to delimit this first surface and this second surface. The at least one aperture being configured to reveal this set of Moon phase representations and this at least one drive organ is configured to move this at least one Moon disk so as to represent the lunar libration phenomenon.
Type:
Grant
Filed:
July 19, 2021
Date of Patent:
August 27, 2024
Assignee:
The Swatch Group Research and Development Ltd
Abstract: A method generally includes co-administering to a subject a composition that includes an antigen and a cytokine signaling immunomodulator. The method can be for treating a subject for abuse of a drug, treating a subject for toxicity from drug abuse, treating a subject for infection by a pathogen, treating a subject for a non-communicable disease, or for increasing antibody production against the antigen. The antigen can be component of a vaccine. The cytokine-signaling immunomodulator is effective to improve the subject's immune response to the antigen compared to the subject's immune response to the antigen without the cytokine-signaling immunomodulator.
Abstract: The present technology provides a system for monitoring quorum-sensing in bacteria comprising bacteria that release at least one membrane-lytic toxin when the bacteria are at a quorum-sensing density; synthetic lipid vesicles comprising an environmentally sensitive indicator, wherein the synthetic lipid vesicles release the environmentally sensitive dye in the presence of an effective amount of the membrane-lytic toxins; and a growth medium; wherein the bacteria and synthetic lipid vesicles are in contact with the growth medium. Methods using the system and compounds discovered with the system (e.g., compounds of Formulas I and II) are also disclosed.
Type:
Grant
Filed:
August 26, 2022
Date of Patent:
August 27, 2024
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Helen Elizabeth Blackwell, Thomas John Polaske, David Lynn, Curran Gahan, Kayleigh E. Nyffeler Bucci
Abstract: Transparent, electrically conductive vanadium oxide-based perovskite films and methods of making the vanadium oxide-based perovskite films are provided. Transparent conducting vanadate perovskites are made by forming a layer of amorphous vanadate perovskite precursor around a plurality of nanoscale, crystalline, perovskite oxide seeds and heating the layer of amorphous vanadate perovskite precursor at a temperature that favors lateral vanadate perovskite crystal growth from the perovskite oxide seeds over homogeneous crystal nucleation within the layer of amorphous vanadate perovskite precursor material. The crystallization processes can form the desired vanadate perovskite phase directly or via a transformation in a controlled gas environment from an initial crystallized vanadate perovskite phase that has a higher oxidation state.
Type:
Grant
Filed:
September 9, 2020
Date of Patent:
August 27, 2024
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Paul Gregory Evans, Thomas Francis Kuech, Donald E. Savage, Yajin Chen, Samuel Marks
Abstract: There is provided a method of evaluating risk of severe outcome of an infectious disease and/or an inflammatory disease in a patient, the method comprising: determining/measuring the number of one or more immune cells selected from the group consisting of VD2 T cells, CD8 T cells, and immature neutrophils in a sample obtained from the patient, wherein the patient has an enhanced risk of severe infectious disease and/or inflammatory disease outcome when: (i) the ratio of immature neutrophils to VD2 T cell is at least 2:1, and/or (ii) the ratio of immature neutrophils to CD8 T cell is at least 0.5:1. Also disclosed are method of treating a patient with a severe infectious disease and/or inflammatory disease and kit for use in methods thereof.
Type:
Grant
Filed:
December 10, 2020
Date of Patent:
August 27, 2024
Assignee:
Agency for Science, Technology and Research
Inventors:
Guillaume Robert Carissimo, Immanuel Kwok Weng Han, Weili Xu, Lisa Fong Poh Ng, Laurent Renia, Anis Larbi, Lai Guan Ng
Abstract: The present disclosure provides compositions comprising miR-3132 and one or more pharmaceutical agents that upregulate TNF-related apoptosis-inducing ligand (TRAIL) or activate TRAIL signaling pathway, and methods for treating a cancer comprising administering miR-3132, or a composition comprising miR-3132 and one or more pharmaceutical agents that upregulate TRAIL or activate TRAIL signaling pathway, to a subject.
Abstract: A decrease in performance of an antenna is suppressed while maintaining metallic design by a metal vapor deposition layer in a cover with antenna function. A back cover includes cover member, a pictorial pattern layer, and a metasurface. The pictorial pattern layer is arranged in a layering direction with respect to the cover member and includes a metal vapor deposition layer. The metasurface is arranged side by side in the layering direction with the pictorial pattern layer. The metasurface amplifies an antenna signal.
Type:
Grant
Filed:
November 11, 2020
Date of Patent:
August 27, 2024
Assignees:
NISSHA CO., LTD., INU RESEARCH & BUSINESS FOUNDATION
Abstract: The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R3CONR1R2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R3CO2)3—B—NHR1R2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.
Type:
Grant
Filed:
August 20, 2021
Date of Patent:
August 27, 2024
Assignee:
Purdue Research Foundation
Inventors:
Padinjaremadhom V. Ramachandran, Henry J. Hamann
Abstract: Disclosed is an RFID antenna including: a central inductive circuit; and at least two lobes extending radially from the central inductive circuit.
Type:
Grant
Filed:
January 19, 2023
Date of Patent:
August 27, 2024
Assignees:
INTERNATIONAL IMAGING MATERIALS, INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
Daniel J. Harrison, Ishita Dhopeshwar, Zhangyu Guan
Abstract: The present invention provides a polypropylene cable protective layer and a preparation method thereof. The polypropylene cable protective layer sequentially includes a dielectric layer, a buffer layer and an insulating layer from the inside to the outside, and the thickness of the dielectric layer accounts for 5%˜12% of the thickness of the polypropylene cable protective layer; the thickness of the buffer layer accounts for 17%˜25% of the thickness of the polypropylene cable protective layer; the dielectric layer, the buffer layer and the insulating layer are respectively obtained by the wrapping of a polypropylene film A, a polypropylene film B and a polypropylene film C. The polypropylene cable protective layer of the present invention forms a dielectric gradient, and realizes the improvement of the insulation strength and voltage level of the power cable, and the increase of the transmission capability.
Type:
Grant
Filed:
September 18, 2021
Date of Patent:
August 27, 2024
Assignee:
ELECTRIC POWER RESEARCH INSTITUTE. CHINA SOUTHERN POWER GRID
Inventors:
Yifan Zhang, Mingli Fu, Shuai Hou, Xiaolin Li, Lei Jia, Baojun Hui, Bin Feng, Wenbo Zhu, Yunpeng Zhan, Yongjie Nie