Abstract: The present invention aims to obtain an optical isomer of DCP-LA, which shows more superior activity and is suitable for clinical utilization, and provide an agent having a superior PKC-? activation action, a prophylactic and/or therapeutic agent for neurotransmitter release disorders, and a prophylactic and/or therapeutic agent for neuropsychiatric diseases, which contain the isomer as an active ingredient. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and a selective PKC-? activator containing same as an active ingredient, and is the like.

Abstract: Treprostinil is prepared by a process which involves Pauson-Khan cyclization of an an alkene-substituted, alkyne-substituted benzene corresponding to formula: (I) where PMB represents para-methoxy benzyl protecting group and R1 and R2 are alcohol protecting groups. Following cyclization, the resulting compound can be subjected to several chemical trans-formations followed by alkylation, hydrolysis and salt formation to yield treprostinil sodium. The use of para-methoxybenzyl group as the phenolic protecting group confers several process advantages that result in simplified purification of the final product and improved yields.

Abstract: A highly pure 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil) has been prepared in high yield from 4-hydroxybenzonitrile using eco-friendly brominating reagent comprising of 2:1 mole ratio of bromide to bromate salts in aqueous acidic medium without any catalyst under ambient conditions with no work up procedure. The product 3,5-dibromo-4-hydroxybenzonitrile was obtained in 91-99% yield with melting point 189-191° C. and more than 99% purity by gas chromatographic analysis without any purification.

Abstract: A high affinity molecule is provided. The high affinity molecule comprises a binding domain which binds a type-A plexin receptor, wherein said binding domain inhibits proliferative signals through said type-A plexin receptor but does not interfere with binding of a neuropilin or semaphorin 6A to said type-A plexin receptor.

Abstract: The invention refers to a tube configured as an implant for insertion at least at one location into the exposed Schlemm's canal of an eye and which, for example, has been mechanically dilated. The elongated tube insertable into the Schlemm's canal includes a plurality openings that are arranged at the tube in axial direction distanced from each other by ring parts and that are in communication with the trabecular tissue the interior space of the tube and the aqueous humor veins of the episcleral vein system and further includes openings oriented in axial direction at a circular arc shaped segment corresponding to the cross section profile of the tube. To realize the natural trabecular aqueous humor drainage, the tube are inserted into the Schlemm's canal that either the openings in the segment are in communication with the aqueous humor veins or that segment with the openings are associated with the trabecular tissue.

Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.

Abstract: Disclosed herein is an apparatus and method for graphic offloading based on a virtual machine monitor. A graphic offloading server device includes a virtual machine unit for performing graphics processing of three-dimensional (3D) graphics software, and a virtual machine monitor unit for transmitting graphics processing instructions of the 3D graphics software input from the virtual machine unit to a graphic offloading client device using a pass-through technique, so that the graphic offloading client device actually performs graphics processing of the 3D graphics software.

Abstract: An electrolytic cell comprising, a housing having a channel extending there through and an opening formed in the housing for receiving an electrode cartridge, an inlet allowing water to pass into the channel, an outlet allowing water to pass from the channel, and a removable electrode cartridge comprising, a support member, having a outer side an inner side, the support member being adapted to close off the opening in the housing when the electrode cartridge is received in the opening, and a series of separate spaced electrode plates supported by the support member, each electrode plate having a terminal which extends through the support member from the inner side to project from the outer side.

Abstract: A photonically assisted analog to digital conversion (ADC) system is presented. The system comprises: an optical sampling signal generator configured and operable for generating an optical sampling signal comprising a predetermined sampling pulse sequence in the form of a time separated pulse train of spectral components dispersed in a periodic fashion, where each pulse is distinguishable by a central wavelength thereof different from its neighboring pulses. The generation of the pulse sampling sequence is achieved by combining broadband dispersion and compensation with a periodic dispersion compensator having a free spectral range smaller than the broad bandwidth of the ultrashort pulse. The second innovative element is the introduction of coherent detection with oversampling of the interference terms of the phase modulated pulse sampling sequence and a reference pulse.

Abstract: Compositions useful for preparing pressure sensitive adhesives, coatings, and/or films are provided, along with methods of making and using the same. The compositions are made from renewable, plant-based materials. The compositions comprise plant oil triglycerides that are polymerized and crosslinked to yield polymer matrices. Plant-based carriers and/or tackifiers can be used in the invention, including epoxidized plant oil triglycerides, acrylated epoxidized plant oil triglycerides, and dihydroxylated plant oil triglycerides. Natural tackifiers such as rosin esters and terpenes can also be used in the compositions. Dihydroxylated plant oil triglyceride tackifiers for use in biobased and synthetic adhesives are also provided.

Abstract: Disclosed are 19-nor-vitamin D compounds, and specifically seco-A-2,19-dinor-1,25-dihydroxyvitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high activity in vivo, specifically in intestinal tissues, but relatively low VDR binding activity, cell differentiation activity and gene transcription activity. There is thus potential for these compounds to have strong cell selectivity for use as therapeutic agents against some cancers, such as colon cancer or polyps, as well as hyperplastic intestinal disorders, such as Crohn's disease, ulcerative colitis and celiac disease. These compounds also have relatively high intestinal calcium transport activity evidencing potential in the treatment of bone diseases.

Abstract: A method and apparatus for mobility management, load management, sharing management and configuration update and setup in a mobile network having a first radio access technology node and a second radio access technology node, the first radio access technology node and the second radio access technology node communicating over a backhaul interface. In one aspect the method detects, at the first radio access technology node, that a handover for a user equipment to a new node is required; provides, from the first radio access technology node, handover information to the second radio access technology node over the backhaul interface; and performs the handover of the user equipment from the first radio access technology node to the new node.

Abstract: A carbon black-containing polyamide masterbatch composition is provided. The carbon black-containing polyamide masterbatch composition includes a polyamide compounded with an admixture of carbon black and a water-soluble polyamide. The water-soluble polyamide is a copolymer of caprolactam, ethylene glycol bis(2-aminoethyl)ether or ethylene glycol bis(3-aminopropyl)ether, and 5-sulfoisophthalic acid monosodium salt.

Abstract: A method of managing a memory by a unit of memory chunk is provided. The method includes managing multiple memory chunks according to a chunk tree structure, managing program frequencies of the memory chunks of the memory according to a program of the memory, and allocating the memory chunks based on the program frequencies and the chunk tree structure.

Abstract: Disclosure relates to a method of sharing a session key between wireless communication terminals using a variable-length authentication code. The method includes: generating a public key by using an own private key; generating a message including the public key and a first random number and encoding the message using an own secret key to exchange an encrypted message with the other terminal; decoding the encrypted message of the other terminal by receiving a secret key of the other terminal; generating an authentication code by calculating the first random number and a second random number included in the decoded message; obtaining a medium value from the authenticated code; and generating a session key by using a public key included in the decoded message of the other terminal.

Abstract: A method includes displaying information in a display area of a first display of an electronic device, detecting a low-power condition for the electronic device, in response to detecting the low-power condition, discontinuing displaying information in the display area of the first display, and displaying information on a second display, which information is visible through the non-display area of the first display.

Abstract: Disclosed herein are novel proteins that have reduced binding to the interleukin-7 receptor, compositions containing such proteins, and methods of using the same.

Abstract: The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithelial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.

Abstract: A mechanochemical oxidation process that allows relatively benign oxidizers to be used for the production of at least partially oxidized graphite, and a method of preparing a carbon fiber using oxidized graphite and a fiber component. Partially oxidized graphite is fully dispersible in water and can be used to prepare thin films with conductivities rivaling pure graphite. This offers the potential for improved electronic displays, solar cells, and lithium ion batteries. A carbon nanotube and a method of making the same is also provided.

Abstract: Various embodiments of a pelvic treatment system and method are provided. The present invention can include one or more drug eluting darts or barbs that are lodged into the wall and will elute the drug over a desired time period (weeks, months for example) to treat OAB, BPH, tissue weaknesses, or other disorders or diseases.