Patents Assigned to SANDOZ
  • Pent-2-en-4-on-2-yl 2-(4-(5-trifluoromethyl-2-pyridinyloxy)phenoxy)propanoate useful for increasing recoverable sugar in sugar cane
    Patent number: 4661148
    Abstract: The subject matter of this invention is the new compound, pent-2-en-4-on-2-yl 2-[4-(5-trifluoromethyl-2-pyridinyloxy)phenoxy]propanoate. This compound is useful for increasing the recoverable sugar in sugarcane.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: April 28, 1987
    Assignee: Sandoz Ltd.
    Inventors: Louis G. Nickell, Leonard J. Stach, Takeo Hokama
  • Treatment of leather with resins and lacquers derived from polyaminoacrylates
    Patent number: 4659630
    Abstract: A lacquer composition comprising a water soluble reaction product of(a) a water soluble acrylic polymer or copolymer having pendant amine groups, and(b) a glycidyl ether of a di- or polyhydric alcohol or monomeric phenolic compound having 2-4 aromatic hydroxy groupswith the proviso that per amine equivalent of component (a) 0.5-0.85 epoxide equivalents of component (b) are present, the reaction product being hardened by a mixture of component (b) above and a glycidyl ether of a polymeric phenol-aldehyde condensate or of polyamine derived from ethyleneimine and/or propyleneimine.The composition is useful for coating such substrates as leather.
    Type: Grant
    Filed: May 20, 1985
    Date of Patent: April 21, 1987
    Assignee: Sandoz Ltd.
    Inventor: Werner Walther
  • Binding agent aqueous dispersions having improved coagulation properties
    Patent number: 4657957
    Abstract: A method of regulating the coagulation characteristics of a binding agent aqueous dispersion which comprises adding thereto a compound of the formula ##STR1## in which R is an unsubstituted or hydroxy substituted alkyl or alkenyl radical,A is --O--CH.sub.2 --CH.sub.2 -- or --O--CH.sub.2 --CHOH--CH.sub.2 --,p is zero or 1,X is ##STR2## wherein r is an integer and both R.sub.x 's are hydrogen or one is a methyl or an ethyl radical and the other is a hydrogen atom,Y and Z are, independently, R--(A).sub.p --, as defined above, or a group as represented by but independent of X,m is zero or an integer 1 to 5, andn is an integer 2 to 6, the compound containing at least one group of the type represented by X, and being in free base, acid addition salt or quaternary ammonium salt form.Such modified binder dispersions are advantageous for the production of non-woven fabrics.
    Type: Grant
    Filed: January 15, 1986
    Date of Patent: April 14, 1987
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Baumann, Marcel Grossmann
  • Novel N-(5-pyrimidinyl)-chloroacetamides
    Patent number: 4657579
    Abstract: The invention provides novel pyrimidine compounds substituted in the 5-position by a chloroacetylamino group which are useful as herbicides. Other objects of the invention are herbicidal compositions comprising such novel compounds and methods of combatting weeds with the aid of said novel compounds.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: April 14, 1987
    Assignee: Sandoz Ltd.
    Inventors: Karlheinz Milzner, Fred Kuhnen, Karl Seckinger
  • Naphthoxazines and their use as psychostimulating and antidepressant agents
    Patent number: 4656167
    Abstract: 3,4,4a,5,10,10a-hexahydro-2H-naphth[2,3-b]-1,4-oxazines are useful as psychostimulating and antidepressant agents.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: April 7, 1987
    Assignee: Sandoz Ltd.
    Inventors: Joachim Nozulak, Rudolf K. A. Giger
  • Occular formulation comprising bromocriptine
    Patent number: 4654345
    Abstract: Lyophylisates comprising bromocriptine or an acid addition salt thereof capable of reconstitution in an isotonic vehicle to provide a stable formulation for occular instillation, useful e.g. in the treatment of glaucoma. Typical lyophylisates in accordance with the invention comprise: a lyophylisable acid, e.g. methane sulfonic acid, an acid addition salt of bromocriptine with said acid, e.g. bromocriptine mesylate, benzalkonium chloride and a lyophylisate matrix material.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: March 31, 1987
    Assignee: Sandoz Ltd.
    Inventor: Thomas Cavanak
  • Piperazine derivatives, their production and pharmaceutical compositions containing them
    Patent number: 4652565
    Abstract: Piperazine derivatives or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic, anti-hypertensive or bradycardic agents.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: March 24, 1987
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Preparation of olefinic compounds and intermediates thereof
    Patent number: 4650890
    Abstract: 7-Substituted lower alkyl hept-6-enoates and 4-hydroxy-tetrahydropyran-2-ones bearing 6-olefinic substituents (E), (Z), ethyl erythro-3,5-dihydroxy-7-phenyl-hept-6-enates are prepared by a multi-step process involving lower alkyl 3,5-dihydroxy-hept-6-enates. The final products are useful as anti hypercholesteremic agents.
    Type: Grant
    Filed: July 26, 1985
    Date of Patent: March 17, 1987
    Assignee: Sandoz Corp.
    Inventors: Charles F. Jewell, Jr., James R. Wareing
  • 1:2 metal complexes of a disazo compound having a 5-hydroxy-1-(aminophenyl)pyrazole coupling/diazo component radical and disazo compound having a 1-amino-8-hydroxynaphthalene coupling/diazo component
    Patent number: 4649194
    Abstract: 1:2 Metal complexes of the formula ##STR1## wherein X.sub.1 is --O-- or ##STR2## and X.sub.2 is --O-- or ##STR3## the starred atom being attached A.sub.1 or A.sub.2, respectively, A.sub.1 is a diazo component radical of the benzene series,A.sub.2 is a diazo component radical of the benzene or naphthalene series,W is --CH.sub.3 or --COOH,R is hydrogen or --SO.sub.3 H,each of B.sub.1 and B.sub.2 is independently a coupling component radical or a phenolic hydroxy group-containing coupling component radical at least one phenolic hydroxy group of which is etherified or acylated,M is iron, cobalt or chromium, andn is 1 or 2,which complexes are useful as anionic dyestuffs having olive to brown colors for substrates such as natural and regenerated cellulose, natural and synthetic polyamides, polyurethane and anodized aluminum, especially leather.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: March 10, 1987
    Assignee: Sandoz Ltd.
    Inventor: Heinz Wicki
  • Novel compositions
    Patent number: 4647698
    Abstract: Substituted oximes and hydroxylamine ethers, intermediates therefor, synthesis thereof, and their use for the control of pests.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: March 3, 1987
    Assignee: Sandoz Ltd.
    Inventor: Clive A. Henrick
  • Aftertreatment of dyed or printed textiles with a polymeric polybasic amino compound
    Patent number: 4645511
    Abstract: Aftertreatment of textile fibres which have been optically brightened or dyed or printed with certain direct dyes, or with basic or sulphur dyes, increases wet-fastness properties. The aftertreatment agent is a polymeric, polybasic amino compound, which is applied under alkaline conditions.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: February 24, 1987
    Assignee: Sandoz Ltd.
    Inventors: Jurg Heller, Bruno Kissling, Tibor Robinson, Salvatore Valenti
  • Exhaust dyeing of cellulosic substrates with reactive dyes controlled simultaneous addition of salt and alkali
    Patent number: 4645510
    Abstract: The invention provides a process for the exhaust dyeing with a reactive dyestuff of a textile material comprising cellulosic fibres, which process comprises the step of adding to the dyebath containing the reactive dyestuff, simultaneously the salt and the alkali in specified quantities metered per unit time so as to give a substantially linear exhaustion of the dyebath.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: February 24, 1987
    Assignee: Sandoz Ltd.
    Inventors: Rolf Hasler, Francis Palacin
  • Novel cyclosporins
    Patent number: 4639434
    Abstract: Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-.alpha.Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH--wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.
    Type: Grant
    Filed: March 19, 1985
    Date of Patent: January 27, 1987
    Assignee: Sandoz Ltd.
    Inventors: Roland Wenger, Rene P. Traber, Hans Kobel, Hans Hofmann
  • Process for the production of human mono-clonal antibodies
    Patent number: 4634664
    Abstract: Hybridoma cell line made by fusing a xenogeneic hybridoma cell to a genetically compatible substance producing cell. Such hybridomas can be used i.a. for the production of antibodies.
    Type: Grant
    Filed: January 20, 1983
    Date of Patent: January 6, 1987
    Assignee: Sandoz Ltd.
    Inventor: Lars Oestberg
  • Non-azo and azo compounds containing at least one 4,6-diamino-1-substituted-5-substituted carbamoylpyrid-2-one group
    Patent number: 4634764
    Abstract: Compounds of the formula ##STR1## wherein each R is independently --N(R.sub.1).sub.2, --N.sup..sym. (R.sub.2).sub.3 A.sup..crclbar. or hydroxy, whereineach R.sub.1 is independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl or aryl orboth R.sub.1 's taken together and with the nitrogen atom to which they are attached form a 5- or 6-membered saturated heterocyclic ring,each R.sub.2 is independently alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl or aryl ortwo R.sub.2 's taken together and with the nitrogen atom to which they are attached form a 5- or 6-membered saturated heterocyclic ring orall three R.sub.2 's taken together and with the nitrogen atom to which they are attached form a 5- or 6-membered unsaturated heterocyclic ring, andA.sup..crclbar. is a non-chromophoric anion,each T is independently a bridging radical, andZ is hydrogen or --N.dbd.
    Type: Grant
    Filed: November 10, 1983
    Date of Patent: January 6, 1987
    Assignee: Sandoz Ltd.
    Inventor: Manfred Greve
  • Indolophenanthridines useful as dopaminergic and analgesic agents
    Patent number: 4634708
    Abstract: 4,6,6a,7,8,12b-hexahydro-indolo[4,3-ab]phenanthridines are useful as dopaminergic and analgesic agents.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: January 6, 1987
    Assignee: Sandoz Ltd.
    Inventors: Alexander Hagenbach, Max P. Seiler, Hans J. Wuthrich
  • Certain 1-(N-methylsulfonamido)-prop-2-yl 2-/4-(pyrid-2-yloxy)phenoxy/-propionate derivatives and their use for increasing recoverable sugar contained in sugar cane
    Patent number: 4629497
    Abstract: The subject matter of this invention are the following sulfonamides: ##STR1## wherein X is chlorine or trifluoromethylY is chlorine or hydrogenZ is hydrogen or methyl
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: December 16, 1986
    Assignee: Sandoz Ltd.
    Inventors: Louis G. Nickell, Leonard J. Stach, Takeo Hokama
  • Process for exhaust dyeing a textile fiber material: controlled addition of dye or electrolyte
    Patent number: 4629465
    Abstract: The invention relates to a process for exhaust dyeing a textile fibre substrate to obtain level dyeings, which process comprises the step of adding to the dyebath the effective amount of dyestuff or electrolyte or dyestuff and electrolyte either simultaneously or one after the other in specified quantities per cycle of the dyeing machine, metered according to a mathematical function.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: December 16, 1986
    Assignee: Sandoz Ltd.
    Inventors: Rolf Hasler, Francis Palacin
  • 4-trisubstituted silyl protected hydroxy-6-oxo-tetrahydropyran-2-yl-aldehyde intermediates
    Patent number: 4625039
    Abstract: 6-trans-indol-2-yl-ethenyl)-4-hydroxy-tetrahydro-2H-pyran-2-ones of formula I are obtained by a multi-step reaction involving the procedure: ##STR1## wherein p.sup.1 is trisubstituted silyl protective group, and Z is a 2-indolyl radical which may be bear at the 4, 5, 6 and 7-positions up to two substituents such as alkyl, alkoxy, halo and CF.sub.3, and at either one the 1 or 3-positions a substituted or unsubstituted phenyl; and at the other an assymetric alkyl, cycloalkyl or aralkyl radical. Compounds I, e.g. (E)-trans-6-[1'-methyl-3'-(4"-fluorophenyl)indol-2'-ylethenyl]3,4,5,6 -tetrahydro-4-hydroxy-2H-pyran-2-one(4R,6S); are useful as anti-atheroselerotic agents.
    Type: Grant
    Filed: December 21, 1983
    Date of Patent: November 25, 1986
    Assignee: Sandoz Pharm. Corp.
    Inventors: Charles F. Jewell, Jr., James R. Wareing
  • Cement mixes and admixtures thereof
    Patent number: 4623682
    Abstract: Cement mix, particularly concrete mixes, for high compressive strength including early compressive strength, have extended workability without substantial loss in rate of hardening when containing an admixture combination of a sulfonated naphthalene-formaldehyde condensated and fractionated sulfonated lignin, such as ultrafiltered lignosulfonate.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: November 18, 1986
    Assignee: Sandoz Ltd.
    Inventors: Richard R. Nicholson, Arthur H. Gerber