Abstract: The present invention concerns tropane derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy,R.sub.3 and R.sub.4 are, independently, lower alkyl, n is 0, 1 or 2, and p0 X.sup..crclbar. is the anion of a pharmaceutically acceptable salt-forming acid.
Abstract: The present invention relates to reactive dye-compounds of formula I, ##STR1## in which Y is hydrogen or sulpho,X is a straight chain or branched (C.sub.2-6) alkylene group or ##STR2## in which each of A.sub.1 and A.sub.2, independently, is a direct bond or a (C.sub.1-4) alkylene group, n is 1 or 2 and the ring D is optionally substituted by up to three (C.sub.1-4) alkyl groups,with the proviso that when n is 2, the group ##STR3## is the radical of an unsymmetrical diamine, R.sub.1 is hydrogen; (C.sub.1-4) alkyl; (C.sub.2-4) alkyl substituted in the .beta.,.gamma.-or .delta.-position by hydroxy and/or carboxy; or (C.sub.5-6) cycloalkyl or (C.sub.1-4) alkyl-substituted (C.sub.5-6) cycloalkylZ is the radical of a fibre reactive group which contains a single fibre reactive componentor mixtures thereof, which compounds are in free acid or water-soluble salt form and are useful as dyestuffs for dyeing or printing hydroxy group-containing or nitrogen containing organic textile substrates.
Abstract: This invention provides compounds of formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, alkenyl or alkynyl, the multiple bond of which is not adjacent to the nitrogen atom,R.sub.2 is, for example, hydrogen, alkyl, alkoxy, hydroxy or halogen, andR.sub.3 is hydrogen, halogen, hydroxyl, alkyl or alkoxy,useful, for example, in the treatment of allergic asthma.
Abstract: The compounds of formula I ##STR1## wherein R is a group ##STR2## wherein A is alkylene of 2 to 5 carbon atoms,X is a bond, oxygen or sulfur,R.sub.3 is hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, halogen of atomic member of from 9 to 35, cyano, carbamoyl or a group NHCOR.sub.d, wherein R.sub.d is alkyl of 1 to 4 carbon atoms, andR.sub.4 is hydrogen and, when R.sub.3 is alkoxy of 1 to 4 carbon atoms, R.sub.4 additionally may be alkoxy of 1 to 4 carbon atoms or, when R.sub.3 is halogen of atomic number of from 9 to 35, R.sub.4 additionally may be halogen of atomic number of from 9 to 35 either(i) R.sub.1 is hydrogen or methyl andR.sub.2 is cyano, CONR.sub.a R.sub.b, COOR.sub.c or CH.sub.2 OR.sub.e, wherein R.sub.a, R.sub.b, R.sub.c and R.sub.e independently are hydrogen or alkyl of 1 to 4 carbon atoms,or(ii) either R.sub.1 is methyl and R.sub.2 is halogen of atomic number of from 17 to 35or R.sub.1 is halogen of atomic number of from 17 to 35 and R.sub.
Abstract: The invention provides a process for the production of 4-phenyl-2(1H)-quinazolinones by cyclising a corresponding 2-aminobenzophenone with urea or an alkylcarbamate in the presence of an aromatic acid. The products are known anti-inflammatory agents.
Type:
Grant
Filed:
February 1, 1979
Date of Patent:
November 25, 1980
Assignee:
Sandoz Ltd.
Inventors:
Guido Gamboni, Walter Schmid, Alfred Sutter
Abstract: The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 5 carbon atoms; cycloalkyl of 5 to 7 carbon atoms; alkyl of 1 to 4 carbon atoms mono-substituted by cycloalkyl of 3 to 7 carbon atoms; phenylalkyl of 7 to 11 carbon atoms in the aggregate thereof, wherein the phenyl ring is unsubstituted or mono-substituted by halogen of atomic number from 9 to 35, alkyl of 1 to 4 carbon atoms; or alkoxy of 1 to 4 carbon atoms; alkenyl of 3 to 5 carbon atoms, wherein the multiple bond is other than in the .alpha.,.beta. position; or 2-hydroxyethyl, andR.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,having GABA-like activity.
Type:
Grant
Filed:
July 3, 1978
Date of Patent:
November 25, 1980
Assignee:
Sandoz Ltd.
Inventors:
Roland Achini, Wolfgang Oppolzer, Beat Gahwiler
Abstract: The invention concerns polymeric basic amides produced by reacting a polymer containing carboxyl groups and a polyamine which contains an alkyl or alkenyl radical of 11 to 22 carbon atoms, at least one ethylene or propylene radical and at least two nitrogen atoms, of which at least one forms a primary or secondary amino group, at a temperature over 100.degree. C., which in the form of their acid salts are water-dispersible and useful textile softeners.
Abstract: The invention provides compounds of formula I, ##STR1## wherein R.sub.1 is branched alkyl, cycloalkyl or phenyl,R.sub.2 is hydrogen, methyl or halogen,X--Y is --CHR.sub.3 CH.sub.2 --, --CR.sub.3 .dbd.CH-- or --(CH.sub.2).sub.4, andR.sub.3 is hydrogen or alkyl,useful, for example, in the treatment of oedemas, inflammation and arthritis.
Type:
Grant
Filed:
April 14, 1978
Date of Patent:
November 4, 1980
Assignee:
Sandoz Ltd.
Inventors:
Annemarie Closse, Walter Haefliger, Daniel Hauser
Abstract: Carbonates and urethanes of 2,2'-alkylene or -cycloalkylene-bis-4,6-disubstituted phenols are useful for stabilizing organic materials against the degradative effects of oxygen.
Type:
Grant
Filed:
May 23, 1978
Date of Patent:
October 28, 1980
Assignee:
Sandoz Ltd.
Inventors:
William O. Drake, Hans Hinsken, Horst Mayerhoefer, Wolfgang H. Mueller
Abstract: Mono- or poly-unsaturated fatty acid hydrazides, e.g. cis,-9-octadecenoic acid, 2-(o-methylphenyl)-hydrazide are useful as pharmaceutical agents and are obtainable by reacting a derivative, e.g. mixed anhydride, of a long chain unsaturated carboxylic acid with an appropriate hydrazine compound.
Abstract: Polyester or polyester blend textile material is dyed with a disperse dyestuff in the presence of a benzalketo derivative as a dyeing carrier.
Abstract: This invention provides new compounds of formula I, ##STR1## wherein R is branched chain alkyl of 3 to 6 carbon atoms, useful as venoconstrictors and venotonics.
Abstract: A process for the production of compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms,R.sub.2 is hydrogen, fluorine, chlorine or bromine, andR.sub.3 is bromine, iodine, isobutyl, tert. butyl, cyclohexyl, cyclohexenyl; or phenyl, optionally substituted by fluorine, chlorine, bromine or alkoxy of 1 to 4 carbon atoms; or a radical of formula II, ##STR2## in which either R.sub.4 and R.sub.5 are the same or different and each signifies alkyl of 1 to 3 carbon atoms,orR.sub.4 and R.sub.5 together signify the radical --(CH.sub.2).sub.n --, in which n is 4 or 5, the radical --CH.sub.2 --CH.sub.2 --0--CH.sub.2 --CH.sub.2 --, the radical --CH.sub.2 --CH.dbd.CH--CH.sub.2 --, or the radical --CH.sub.2 --CH.sub.2 --N(R.sub.6)--CH.sub.2 --CH.sub.2 --, in which R.sub.6 is hydrogen or alkyl of 1 to 3 carbon atoms. Hydroxyketone and hydroxy imine intermediates are also disclosed.The compounds of formula I are known to exhibit anti-inflammatory activity.
Abstract: Compounds of the formula ##STR1## wherein R is chlorine or bromine,R.sub.1 is straight or branched chain unsubstituted C.sub.1-4 alkyl,R.sub.2 is --CH.sub.3, C.sub.2 H.sub.5, n--C.sub.3 H.sub.7 or n--C.sub.4 H.sub.9,R.sub.3 and R.sub.4, independently, are hydrogen, chlorine, bromine or methyl,R.sub.5 is methyl or ethyl,n is 2 or 3, andA.sup..crclbar. is an anion,their production and use for dyeing and printing cationic dyeable substrates, e.g., polymers and copolymers of acrylonitrile and asymmetric dicyanoethylene and synthetic polyamides and polyesters modified by the introduction of acidic groups, and for dyeing plastics in the mass, paper and leather.
Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andX represents ##STR2## which are useful as minor tranquilizers and sleep inducers.
Abstract: Ketone derivatives of 4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R.sub.1 is halo having an atomic weight of from 19 to 36, andR.sub.2 is a branched chain lower alkyl having 3 to 4 carbon atomsare useful as central nervous system depressants, in particular, as muscle relaxants.
Abstract: The present invention provides a textile finishing process comprising applying to a substrate containing cellulose fibres an aqueous medium comprisingA. a water-soluble, monomeric, resin-forming precondensate consisting of one or more N-methylol derivates of melamine, urea, substituted ureas, triazones, carbamates and urones, or mixtures thereof, said derivative containing at least 3 N-methylol groups or their lower alkyl ethers,B. one or more compounds having solvent properties for disperse dyes, which also increase their substantivity to cellulose, and at the same time have affinity for polyester fibres.C. One or more reactive softeners which are capable of chemical reaction with the --OH groups of cellulose, thereby reducing their hydrophilic properties, andD. a catalyst system for the simultaneous cross-linking of components A, B and C which causes neglible yellowing of cellulose fibres up to a temperature of 220.degree. C.
Type:
Grant
Filed:
June 29, 1978
Date of Patent:
September 30, 1980
Assignee:
Sandoz Ltd.
Inventors:
Brian Acton, Bruno Kissling, Tibor Robinson, Milica Urosevic
Abstract: Compounds of the formula ##STR1## in which R.sub.1 signifies a substituted thiazole, thiadiazole, isothiazole, oxadiazole or thiophene radical,R.sub.2 signifies hydrogen or an optionally substituted hydrocarbon radical,R.sub.3 signifies hydrogen or an optionally substituted alkyl radical,R.sub.4 signifies hydrogen or an alkyl radical which is unsubstituted or substituted by an aryl radical,K.sup..sym. signifies an ammonium, cycloimmonium, hydrazinium, aminoxide or optionally substituted etherified hydroxyammonium group,A.sup.n.crclbar. signifies an anion,n signifies 1, 2 or 3, and the ring B is unsubstituted or monosubstituted, provided that at least one of R.sub.3 and R.sub.4 is other than hydrogen, and provided that the molecule does not contain a water-solubilizing group.
Abstract: A method for the treatment of congestive heart failure in animals comprises administering a therapeutically effective amount of an ergolene or ergoline having dopaminergic activity to an animal in need of such treatment.