Abstract: A system and method for determining position of a steerable assembly within tissue of an animal body utilizes an elongated body structure with an implement arranged at a distal end thereof, and a premagnetized material proximate to the distal end. A signal indicative of a length of insertion of the elongated body structure into the tissue is used with a signal indicative of (i) force, strain, shape of a sensor associated with the elongated body structure and/or (ii) directionality of magnetic field applied to the premagnetized material, to determine a three-dimensional (3D) trajectory of the steerable assembly. The 3D trajectory is superimposed on a 3D model of the tissue to determine position of the steerable assembly within the tissue.
Type:
Grant
Filed:
June 4, 2024
Date of Patent:
April 29, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.
Type:
Application
Filed:
October 23, 2024
Publication date:
April 24, 2025
Applicants:
University of Florida Research Foundation, Incorporated, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
David C. Bloom, Alfred S. Lewin, Donna M. Neumann, Zachary L. Watson, Sonal Sanjeev Tuli, Gregory Scott Schultz
Abstract: A walking rover system with a rover, a base station, and a tether extending between the rover and the base station. The rover has a rover body, a plurality of mobilizing legs, and a plurality of stabilizing legs. The stabilizing legs have one degree of freedom and the mobilizing legs have three degrees of freedom. The mobilizing legs and the stabilizing legs may alternate around the rover body such that each of the mobilizing legs is separated from adjacent mobilizing legs by a stabilizing leg and each of the stabilizing legs is separated from adjacent stabilizing legs by a mobilizing leg. The tether is configured to transmit electricity from the base station to the rover, transmit data gathered by the rover back to the base station, and support a weight of the rover and act as a mechanical rappel line between the base station and the rover.
Type:
Application
Filed:
October 24, 2024
Publication date:
April 24, 2025
Applicant:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Gowan ROWLAND, Andrew DEROS, Connor NAIL, Tyler SMITH
Abstract: A pressure sensor apparatus is provided. In another aspect, a wireless intraocular pressure sensor includes a deformable or stretchable inductor having a three-dimensionally serpentine or wavy shape. A further aspect of an intraocular pressure sensing system includes a closed loop, deformable and variable inductor of an undulating shape in lateral and depth directions, within a ring-shaped and polymeric carrier layer, sized to contact an eye. A method of making a wireless intraocular pressure sensor, including a three-dimensionally deformable metal layer, is also provided.
Type:
Application
Filed:
November 4, 2024
Publication date:
April 24, 2025
Applicant:
Board of Trustees of Michigan State University
Abstract: Systems and methods for utilizing laboratory equipment in a hybrid reality environment or augmented virtual reality environment, are contemplated herein and include: at least one piece of laboratory equipment having at least one feature, wherein the at least one piece of laboratory equipment is tracked; a tracking module for tracking a position and an orientation of the at least one piece of tracked laboratory equipment; a virtual model, stored in a memory, comprising at least one 3-D virtual representation of the at least one feature of the at least one piece of laboratory equipment; and an experimentation module.
Type:
Application
Filed:
December 22, 2024
Publication date:
April 24, 2025
Applicant:
The Trustees of the California State University
Inventors:
Kambiz Hamadani, Ali Ahmadinia, Xin Ye, Yuanyuan Jiang
Abstract: This document provides multiblock copolymers comprising: at least one block obtained from a polyester having an average MN of from about 2,000 to about 200,000, wherein the polyester contains one or more terephthalate units; and at least one block obtained from a polyolefin having an average MN of from about 2,000 to about 200,000. This document further provides methods of making and using the multiblock copolymers, and multilayer films, polymer blends, and molded articles comprising the multiblock copolymers.
Type:
Grant
Filed:
April 1, 2020
Date of Patent:
April 22, 2025
Assignees:
Regents of the University of Minnesota, Murray State University
Inventors:
Christopher John Ellison, Kevin Michael Miller
Abstract: Octaaminonaphthalene and a method of synthesizing octaaminonaphthalene are described. A two-dimensional coordination polymer and a method of synthesizing the two-dimensional coordination polymer are described. The two-dimensional coordination polymer includes ligands including anchorage sites, and metal linkers, each metal linker including a metal and an organic moiety. Each metal linker is coupled to two ligands via the anchorage sites. Synthesizing the two-dimensional coordination polymer includes contacting a first liquid precursor with a second liquid precursor at an interface, reacting the metal linker and the water-soluble ligand to yield a two-dimensional coordination polymer at the interface, and removing the two-dimensional coordination polymer from the interface.
Type:
Grant
Filed:
June 15, 2022
Date of Patent:
April 22, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Inventors:
Matthew Green, Sefaattin Tongay, Meng Wang, Ying Qin
Abstract: The invention relates to a process for fabricating complex mechanical shapes, and in particular to fabricating complex mechanical shapes using a pressure-assisted sintering technique to address problems relating to variations in specimen thickness and tooling, or densification gradients, by 3-D printing of a polymer model that is surrounded by and filled with sintering powder material, wherein the 3-D polymer model decomposed into a graphite interface layer and facilitates release of the cast, e.g. metal, metal-alloy, ceramic, etc., manufactured item.
Type:
Grant
Filed:
March 12, 2024
Date of Patent:
April 22, 2025
Assignee:
San Diego State University Research Foundation
Abstract: The disclosure provides a cancer vaccine composition comprising inactivated cancer cells and an adjuvant, wherein the inactivated cancer cells are incapable of replication. Also provided is a method for producing a cancer vaccine composition, the method comprising contacting cancer cells with light (e.g., UV light) in the presence of a photosensitizer (e.g., riboflavin).
Type:
Grant
Filed:
March 21, 2019
Date of Patent:
April 22, 2025
Assignee:
Colorado State University Research Foundation
Inventors:
Terry Opgenorth, Amanda Guth, Raymond Goodrich
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
Type:
Grant
Filed:
May 18, 2023
Date of Patent:
April 22, 2025
Assignee:
Wayne State University
Inventors:
Gregory William Auner, Michelle Ann Brusatori, Changhe Huang
Abstract: The present disclosure relates to a method that includes utilizing a microorganism for the converting of a substrate to an acid contained in a mixture that includes the acid and water, maintaining a pH of the mixture to less than 5, and treating the mixture with a first stream comprising an organic.
Type:
Grant
Filed:
May 3, 2021
Date of Patent:
April 22, 2025
Assignees:
Alliance for Sustainable Energy, LLC, Colorado State University Research Foundation
Inventors:
Violeta Sanchez Nogue, Eric M. Karp, Patrick Owen Saboe, Lucas Hans Loetscher, Sybil Sharvelle
Abstract: The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm.
Type:
Grant
Filed:
July 4, 2022
Date of Patent:
April 22, 2025
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: The present invention includes scalable and cost-effective auxetic foam sensors (AFS) created through conformably coating a thin conductive nanomaterial-sensing layer on a porous substrate having a negative Poisson's ratio. In general, the auxetic foam sensors possess multimodal sensing capability, such as large deformation sensing, small pressure sensing, shear/torsion sensing and vibration sensing and excellent robustness in humidity environment.
Type:
Grant
Filed:
October 11, 2023
Date of Patent:
April 22, 2025
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Changchun Zeng, Zhiyong Liang, Yan Li, Sida Luo, Tao Liu
Abstract: A system for measuring real-time seed placement of seeds, such as corn seeds, during planting wherein the sensing and measurement (SAM) system comprises various elements selected from the group consisting of a high-speed camera, light-section sensor, potentiometer, GPS unit, data acquisition system, and a control computer. The SAM system measures seeding depth, seed spacing, and geo-location of the seed. It is mounted on a planter row unit located in between the closing wheels and the gauge wheels with the camera and light section sensor directly facing the furrow.
Type:
Grant
Filed:
July 24, 2020
Date of Patent:
April 22, 2025
Assignee:
Kansas State University Research Foundation
Inventors:
Ajay Sharda, Sylvester Badua, Daniel Flippo
Abstract: Briefly, embodiments of an apparatus including at least one computing device that includes at least one processor and at least one non-transitory storage medium, for example, are described. The at least one non-transitory storage medium, in an embodiment, includes executable instructions stored thereon in which executing the instructions by the at least one processor are to result in processing sensor measurements, including images, from at least one optical sensor array, of at least one object. In an embodiment, for example, sensor measurements are processed with a three-dimensional pose estimation model to produce at least one substantially view-invariant morphometric measurement estimate of the at least one object.
Type:
Application
Filed:
October 2, 2024
Publication date:
April 17, 2025
Applicant:
Oregon State University
Inventors:
Susan Elizabeth Hilber Piacenza, Joseph R. Piacenza, III, Kenneth John Faller, II, Elliott Joseph Chimienti
Abstract: A new and distinct Corylus avellana plant is disclosed, distinguished by its low vigor, globose growth habit, production of nuts with round kernels that fall free of the husk at maturity, resistance to eastern filbert blight and big bud mite, S-alleles, nut size, kernel percentage, frequency of nut defects, time of pollen shed, and length of the husk or involucre.
Abstract: A precise cardiac data reconstruction method is provided, which may also be referred to herein as radar cardiography (RCG). RCG can reconstruct cardiac data, such as heart rate and/or electrocardiogram (ECG)-like heartbeat waveform signals wirelessly by using advanced radar signal processing techniques. For example, heartbeat and related characteristics can be monitored by isolating cardiovascular activity from strong respiratory interference in spatial spaces: azimuth and elevation. This results in significant improvements to pulse signal-to-noise-ratio (SNR) compared to conventional approaches, facilitating heart-rate variability (HRV) analysis.
Type:
Grant
Filed:
March 19, 2020
Date of Patent:
April 15, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: An apparatus, systems, and methods of providing enrichment to poultry during raising or maintaining of the poultry. One or more light sources project beams to generate laser spots at and around the poultry. A control regimen moves the light spots relative the poultry in generally random fashion during timed sessions for each given time period (e.g. each day). The spot movement is designed to promote benefits to poultry and producer in correlation to experimental data related to animal welfare, health, and commercial value.
Type:
Grant
Filed:
August 17, 2023
Date of Patent:
April 15, 2025
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Elizabeth Ann Kraayenbrink, Anna Butters-Johnson, Derek Kraayenbrink
Abstract: Described herein are means for the generation of semantic genesis models through self-supervised learning in the absence of manual labeling, in which the trained semantic genesis models are then utilized for the processing of medical imaging.
Type:
Grant
Filed:
April 30, 2021
Date of Patent:
April 15, 2025
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Abstract: ‘NCCH3’ is a new cultivar of flowering dogwood with a unique combination of traits including large white bracts, large glossy leaves, a fast growth rate, and showy fall color.
Type:
Grant
Filed:
June 28, 2024
Date of Patent:
April 15, 2025
Assignee:
North Carolina State University
Inventors:
Thomas Ranney, Nathan Lynch, Andra Nus, Irene Palmer