Abstract: A skylight for a building includes a solar panel arranged within the skylight, the solar panel comprising one or more photovoltaic cells to collect direct radiation from rays of sunlight for conversion to electrical power, and an optical element to receive the direct radiation and refract it to the solar panel, and to receive the direct radiation and diffuse radiation scattered from the rays of sunlight and refract the direct radiation and the diffuse radiation through the skylight, bypassing the solar panel, to provide daylighting in the building.

Abstract: Disclosed are therapeutic agent delivery vehicle comprising a modified platelet comprising a therapeutic agent cargo and a targeting moiety and methods for treating cancer comprising administering the same to a subject.

Abstract: Compositions and methods for the treatment of malignancy are disclosed.

Abstract: The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to receive radar data including a radar pixel having a radial velocity from a radar; receive camera data including an image frame including camera pixels from a camera; map the radar pixel to the image frame; generate a region of the image frame surrounding the radar pixel; determine association scores for the respective camera pixels in the region; select a first camera pixel of the camera pixels from the region, the first camera pixel having a greatest association score of the association scores; and calculate a full velocity of the radar pixel using the radial velocity of the radar pixel and a first optical flow at the first camera pixel. The association scores indicate a likelihood that the respective camera pixels correspond to a same point in an environment as the radar pixel.

Abstract: The invention provides inhibitors of interferon regulatory factor 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE).

Abstract: A cathode is provided for electrolysis of water wherein the cathode material comprises a multi-principal element, transition metal dichalcogenide material that has four or more chemical elements and that is a single phase, solid solution. The pristine cathode material does not contain platinum as a principal (major) component. However, a cathode comprising a transition metal dichalcogenide having platinum (Pt) nanosized islands or precipitates disposed thereon is also provided.

Abstract: Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.

Abstract: Self-limiting electrospray compositions including a non-charge-dissipative component and/or a charge-dissipative component. Self-limiting electrospray composition including a plurality of charge-dissipative components and excluding a non-charge-dissipative component. Methods for forming layers of self-limiting thickness. Methods for determining a conductivity of a material. Methods for repairing a flaw in a layer on a surface of an object.

Abstract: Methods and systems for image-based guidance in deep-brain stimulation. An endoscope system includes a waveguide tube, a right-angle prism, a light source, and a photoacoustic transducer. Light from the light source propagates along the length of the waveguide tube via internal reflection within the wall. The right-angle prism is positioned to redirect light emitted at a distal end of the waveguide tube in a direction perpendicular to the length of the waveguide tube. Light emitted in the perpendicular direction causes soundwaves to be generated by the surrounding tissue via photoacoustic effect. Those soundwaves are then conducted through the interior channel of the waveguide tube from the distal end of the waveguide tube to a proximal end of the waveguide tube where the soundwaves are detected by the photoacoustic transducer, which is acoustically coupled to the interior channel of the waveguide tube at the proximal end of the waveguide tube.

Abstract: Disclosed is a method of functional genomics determination including transducing a cell population with a set of nucleic acid molecules including a pooled library of genomic perturbagens to integrate multiple perturbagen cassettes into the genome. A phenotype of individual cells is determined and single cells of the population with targeted phenotypes are individually sorted into a set of compartments. Each compartment includes a forward primer with a nucleic acid sequence (NAS) that specifically binds a common nucleic acid sequence on the nucleic acid molecules and a compartment (cell)-specific nucleic acid barcode. Also included is a reverse primer with a NAS that specifically binds a common NAS on the nucleic acid molecules comprising a pooled library of genomic perturbagens. The genome-integrated perturbagen cassettes are create amplicons which are pooled and sequences determined.

Abstract: An Internet-of-Things (IoT) learning framework (IoT learning framework) may train AI models to infer user activities from IoT connected device events using machine learning based algorithms. According to such an example, processing circuitry obtains a training dataset indicating IoT device events and extracts representative user activity patterns from the sequences of IoT device events. In such an example, processing circuitry trains the AI model to learn an optimal subset of the sequences of IoT device events corresponding to a smallest quantity of the sequences of IoT device events to predict user activities with accuracy that satisfies a threshold and outputs the AI model. According to such an example, processing circuitry may obtain new data indicating new sequences of IoT device events and generates output indicating one or more user activities predicted by the AI model to have occurred based on the new sequences of IoT device events.

Abstract: Methods for producing single N-terminal domain functional camelid-derived heavy (H)-chain antibody fragments (VHH) that specifically bind to a receptor binding domain (RBD) of SARS-CoV-2 spike protein include transgenic plants, plant parts, plant cells, plant tissue, and seeds that express the VHH that specifically binds to an RBD of SARS-CoV-2 spike protein.

Abstract: A processing workflow centered on machine-learning algorithms that identifies a number of chemical features that can best distinguish the presence or absence of a chemical source. These chemical features are a chemical fingerprint that is unique to each source. The analysis workflow is rapid (e.g., fingerprints can be generated in minutes). The analysis workflow has wide-ranging applications such as detecting markers of pollution sources in rivers and fish tissues, forest pathogen outbreaks, and hard-to-diagnose diseases.

Abstract: A system and method for determining position of a steerable assembly within tissue of an animal body utilizes an elongated body structure with an implement arranged at a distal end thereof, and a premagnetized material proximate to the distal end. A signal indicative of a length of insertion of the elongated body structure into the tissue is used with a signal indicative of (i) force, strain, shape of a sensor associated with the elongated body structure and/or (ii) directionality of magnetic field applied to the premagnetized material, to determine a three-dimensional (3D) trajectory of the steerable assembly. The 3D trajectory is superimposed on a 3D model of the tissue to determine position of the steerable assembly within the tissue.

Abstract: The elastocaloric effect underpins a promising solid-state heat pumping technology that, when adopted for commercial and residential applications, can revolutionize the cooling and heating industry due to low environmental impact and substantial energy savings. Known operational demonstration devices based on the elastocaloric effect suffer from low endurance of materials and, in most experimental systems, from large footprints due to bulky actuators required to provide sufficient forces and displacements. We demonstrate a new approach which has the potential to enable a more effective exploitation of the elastocaloric effect by reducing the forces required for actuation. Thin strips of NiTi were incorporated into composite structures with base polymer, such that bending the structures results in either exclusively compression or exclusively tension applied to the elastocaloric strips.

Abstract: A device may include a metallic substrate and a plurality of nanorod arrays arranged on the substrate. The nanorod arrays may be made of porous metallic nanostructures and may appear black in color.

Abstract: A multi-modal screw propelled excavation system for small body sample collection includes a craft having screw-shaped wheels to traverse the surface of the target body. When the craft is ready to collect a sample, the craft opens a door to an excavation bin on a bottom face of the craft, and uses the screw-shaped wheels to churn up regolith which is captured by closing the door.

Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).

Abstract: Various arrangements described herein relate to a dual-sided display with improved light scattering. In one embodiment, a display is disclosed. The display includes an inside transparent layer disposed parallel to and spaced apart from an outside transparent layer. The display also includes a liquid crystal (LC) layer disposed between the inside transparent layer and the outside transparent layer and together forming a waveguide that is planar. The display includes ground electrodes disposed between the LC layer and the outside transparent layer and arranged in strips along the transparent layer, the strips being spaced apart and parallel. The display includes inside electrodes and outside electrodes disposed between the inside transparent layer and the LC layer and defining a geometric pattern that is in plane with the waveguide and a light source disposed at an edge surface of the waveguide and providing light along the waveguide.