Patents Assigned to State University
  • Coiled coil helix cristae morphology 1 (CHCM1) tumor marker and cancer therapeutic target
    Patent number: 9945863
    Abstract: Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: April 17, 2018
    Assignee: The Research Foundation of State University of New York
    Inventors: M. Saeed Sheikh, Ying Huang, Jie An
  • High performance microwave dielectric systems and methods
    Patent number: 9947861
    Abstract: Loss tangents in microwave dielectric materials may be modified (increased and/or reduced), particularly at cryogenic temperatures, via application of external magnetic fields. Exemplary electrical devices, such as resonators, filters, amplifiers, mixers, and photonic detectors, configured with dielectric components having applied magnetic fields may achieve improvements in quality factor and/or modifications in loss tangent exceeding two orders of magnitude.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: April 17, 2018
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Nathan Newman, Lingtao Liu
  • Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
    Patent number: 9945051
    Abstract: A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: April 17, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Richard Ebright
  • Platinum complexes and devices
    Patent number: 9947881
    Abstract: Platinum compounds of Formulas I and II useful in a variety of devices, such as, for example organic-light emitting diodes (OLEDs).
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: April 17, 2018
    Assignees: Arizona Board of Regents on behalf of Arizona State University, Universal Display Corporation
    Inventors: Jian Li, Guijie Li, Jason Brooks
  • Photosynthetic production of 3-hydroxybutyrate from carbon dioxide
    Patent number: 9944955
    Abstract: Construction and expression of synthetic pathways to produce (5) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: April 17, 2018
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Bo Wang, Weiwen Zhang, Deirdre Meldrum, David Nielsen
  • HOLD VIOLATION FREE SCAN CHAIN AND SCANNING MECHANISM FOR TESTING OF SYNCHRONOUS DIGITAL VLSI CIRCUITS
    Publication number: 20180102766
    Abstract: A sequential state element (SSE) is disclosed. In one embodiment, an SSE includes a differential sense flip flop (DSFF) and a completion detection circuit (CDC) operably associated with the DSFF. The DSFF is configured to generate a differential logical output. During a normal operational mode, the DSFF is synchronized by a clock signal to provide a differential logical output in a differential output state in accordance with a data input or in a precharge state based on the clock signal. The differential logical output is provided in a differential output state in accordance with a test input during a scan mode. The CDC is configured to generate a test enable input during the scan mode that indicates the scan mode once the differential logical output is in the differential output state. Accordingly, another SSE can be asynchronously triggered to operate in the scan mode without a separate scan clock.
    Type: Application
    Filed: May 23, 2016
    Publication date: April 12, 2018
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sarma Vrudhula, Niranjan Kulkarni
  • METHOD OF PROVIDING AN ELECTRONIC DEVICE AND ELECTRONIC DEVICE THEREOF
    Publication number: 20180102272
    Abstract: Some embodiments include a method. The method can include: providing a carrier substrate; providing a bond promoting layer over the carrier substrate; and depositing a first device substrate over the carrier substrate and the bond promoting layer. The first device substrate can be configured to bond to the carrier substrate with a first device substrate-carrier substrate adhesion strength. Meanwhile, depositing the first device substrate can include: bonding the first device substrate to the bond promoting layer, the first device substrate bonding to the bond promoting layer with a first device substrate-bond promoting layer adhesion strength greater than the first device substrate-carrier substrate adhesion strength; and coupling the first device substrate to the carrier substrate. Other embodiments of related methods and devices are also disclosed.
    Type: Application
    Filed: December 4, 2017
    Publication date: April 12, 2018
    Applicant: Arizona Board of Regents, Acting for and on Behalf of Arizona State University
    Inventors: Emmett Howard, Nick Munizza, Paul Yee, Zachary Hartke
  • GENERATING A SENSOR TASK BASED ON A TARGET DETECTION AND PLATFORM DATA FROM A PUBLISH/SUBSCRIBE RELATIONSHIP
    Publication number: 20180100736
    Abstract: For measuring an area of interest based on a sensor task, a method generates a sensor task comprising a sensor type and an area of interest. The method further routes the sensor task to a sensor of the sensor type and with a sensor motion track that includes the area of interest. The method measures the area of interest with the sensor based on the sensor task.
    Type: Application
    Filed: October 11, 2016
    Publication date: April 12, 2018
    Applicants: Utah State University, The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Scott Allen Anderson, Troy R. Johnson, Jonathan Haws, Brad D. Petersen, Thomas J. Walls
  • HIV-1 antigens with discrete conformational forms in the V1/V2 domain and methods of use thereof
    Patent number: 9938325
    Abstract: The present invention relates to a novel composition of HIV-1 Env proteins that contain structurally and immunologically distinct VI/V2 domains. Methods of isolating such proteins, and methods of using such proteins as immunogens, therapeutic agents, vaccines, and test compounds for use in identifying a HIV antiviral are also provided.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: April 10, 2018
    Assignee: Rutgers, The State University of New York
    Inventor: Abraham Pinter
  • Compositions and methods for high-throughput nucleic acid analysis and quality control
    Patent number: 9938575
    Abstract: Methods for improved quality control of nucleic acid containing biological samples utilized in high-throughput situations such as biorepositories engaged in the collection, processing, storage, distribution and analysis of such samples are disclosed.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: April 10, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Jay A. Tischfield, Andrew I. Brooks
  • Curcumin conjugates for treating and preventing cancers
    Patent number: 9937260
    Abstract: Conjugating LHRH to curcumin (LHRH-Curcumin) substantially enhances the bioavailability of curcumin, targets it to cells expressing LHRH receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin. The conjugate may be used against cancer cells that express the LHRH receptor: pancreas, prostate, breast, testicular, uterine, ovarian, melanoma. LH-Curcumin conjugates may be used against cancer cells that express the LH receptor: prostate, breast, ovary, testis, uterus, pancreas, and melanoma.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 10, 2018
    Assignees: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY, AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: William Hansel, Sita Aggarwal, Robert P. Hammer
  • Process mapping of cooling rates and thermal gradients
    Patent number: 9939394
    Abstract: A method performed by one or more processing devices includes conducting a plurality of tests of a manufacturing process. Each test is conducted at a different combination of at least a first process variable and a second process variable, and each test comprises locally heating a region of a structure, where the local heating results in formation of a thermal field in the structure, and assessing a temperature derivative of the thermal field. Based on results of the plurality of tests, a process map of the temperature derivative of the thermal field is generated, with the temperature derivative based on a function of the first process variable and the second process variable.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: April 10, 2018
    Assignees: Carnegie Mellon University, Wright State University
    Inventors: Jack Lee Beuth, Jr., Nathan W. Klingbeil, Joy Davis Gockel
  • Nano-electrode multi-well high-gain avalanche rushing photoconductor
    Patent number: 9941428
    Abstract: Provided is a detector that includes a scintillator, a common electrode, a pixel electrode, and a plurality of insulating layers, with a plurality of nano-pillars formed in the plurality of insulating layers, a nano-scale well structure between adjacent nano-pillars, with a-Se separating the adjacent nano-pillars, and a method for operation thereof.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: April 10, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Amirhossein Goldan, Wei Zhao, John A. Rowlands
  • Cesium primary ion source for secondary ion mass spectrometer
    Patent number: 9941089
    Abstract: A primary ion source subassembly for use with a secondary ion mass spectrometer may include a unitary graphite ionizer tube and reservoir base. A primary ion source may include a capillary insert defining an ionizer aperture. An ionizer aperture may be centrally arranged in an outwardly protruding conical or frustoconical surface, and may be overlaid with a refractory metal coating or sheath. Parameters including ionizer surface shape, ionizer materials, ionizer temperature, and beam stop plate orifice geometry may be manipulated to eliminate ghost images. A graphite tube gasket with a dual tapered surface may promote sealing of a source material cavity.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: April 10, 2018
    Assignee: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Peter Williams, Karen Amanda Williams, Maitrayee Bose, John Prince
  • Nanoscale process to generate reagents selective for individual protein variants
    Patent number: 9938330
    Abstract: The present invention provides devices and methods to separate and concentrate target protein species at a microliter scale and to generate reagents to those variants with exquisite selectivity for specific protein isoforms using only picograms of target material.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: April 10, 2018
    Assignee: Arizona Board of Regents, a Body Corporate of the State of Arizona, Acting for and on Behalf of Arizona State University
    Inventors: Michael Sierks, Mark Hayes
  • High level platform trapdoor with built in moving slide for railway platform gap bridging
    Patent number: 9937933
    Abstract: A trapdoor assembly for use on railcars is provided. The trapdoor assembly is pivotable between an up position and a down position. In the up position, the trapdoor assembly provides access to stairs on the railcar so that passengers can egress between the railcar and a ground level platform at a rail station. In the down position, the trapdoor assembly covers the stairs and provides a platform so that passengers can egress between the railcar and an elevated platform at a rail station. The trapdoor assembly also includes an extendible platform for bridging the gap between the railcar and the elevated station when the trapdoor is in the down position and the railcar is stopped at the elevated station.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: April 10, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Basily B. Basily, Thomas O. Boucher
  • Tetradentate cyclometalated platinum complexes containing 9,10-dihydroacridine and its analogues
    Patent number: 9941479
    Abstract: Platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structure:
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 10, 2018
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jian Li, Guijie Li, Zhi-Qiang Zhu
  • Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling
    Patent number: 9938523
    Abstract: Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 10, 2018
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventor: Joshua LaBaer
  • VISUALIZING CONVOLUTIONAL NEURAL NETWORKS
    Publication number: 20180096078
    Abstract: Convolutional neural networks can be visualized. For example, a graphical user interface (GUI) can include a matrix of symbols indicating feature-map values that represent a likelihood of a particular feature being present or absent in an input to a convolutional neural network. The GUI can also include a node-link diagram representing a feed forward neural network that forms part of the convolutional neural network. The node-link diagram can include a first row of symbols representing an input layer to the feed forward neural network, a second row of symbols representing a hidden layer of the feed forward neural network, and a third row of symbols representing an output layer of the feed forward neural network. Lines between the rows of symbols can represent connections between nodes in the input layer, the hidden layer, and the output layer of the feed forward neural network.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 5, 2018
    Applicants: SAS Institute Inc., North Carolina State University
    Inventors: Samuel Paul Leeman-Munk, Saratendu Sethi, Christopher Graham Healey, Shaoliang Nie, Kalpesh Padia, Ravinder Devarajan, David James Caira, Jordan Riley Benson, James Allen Cox, Lawrence E. Lewis, Mustafa Onur Kabul
  • tree named ‘NCMX1’
    Patent number: PP29218
    Abstract: ‘NCMX1’ is a new cultivar of magnolia with large, fragrant red-purple flowers, an upright habit and a late flowering time.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 10, 2018
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventor: Thomas G. Ranney