Abstract: A DC-DC converter for generating a DC output voltage includes: a digitally controlled pulse width modulator (DPWM) for controlling a switching power stage to supply a varying voltage to an inductor; and a digital voltage feedback circuit for controlling the DPWM in accordance with a feedback voltage corresponding to the DC output voltage, the digital voltage feedback circuit including: a first voltage controlled oscillator for converting the feedback voltage into a first frequency signal and to supply the first frequency signal to a first frequency discriminator; a second voltage controlled oscillator for converting a reference voltage into a second frequency signal and to supply the second frequency signal to a second frequency discriminator; a digital comparator for comparing digital outputs of the first and second frequency discriminators and for outputting a digital feedback signal; and a controller for controlling the DPWM in accordance with the digital feedback signal.
Type:
Grant
Filed:
December 20, 2011
Date of Patent:
May 5, 2015
Assignees:
California Institute of Technology, Arizona State University, Ira A. Fulton Schools of Engineering
Inventors:
Philippe C. Adell, Bertan Bakkaloglu, Bert Vermeire, Tao Liu
Abstract: The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the proteins. The present invention also provides methods to administer the conjugates to animals, for the purpose of directing toxin to particular cells.
Type:
Grant
Filed:
October 3, 2013
Date of Patent:
May 5, 2015
Assignees:
Colorado State University Research Foundation, Cedus, Inc.
Abstract: Apparatus is disclosed for substantially reducing the momentum, velocity, or both of a first liquid that is flowing into a second liquid. The device allows one to substantially reduce or even eliminate large-scale turbulent eddies that could otherwise be produced by liquid flowing into or within a vessel, for example in a clarifier. Suitably-sized and positioned plates and baffles induce changes of flow direction in a limited volume. By the time the fluid leaves this volume, the fluid velocity is low, and turbulence is nearly or entirely eliminated. Several of the devices may be placed at different inputs within a single clarifier, and thus increase efficiency further.
Type:
Grant
Filed:
September 20, 2010
Date of Patent:
May 5, 2015
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechchanical College
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Grant
Filed:
February 27, 2012
Date of Patent:
May 5, 2015
Assignee:
The Ohio State University
Inventors:
Carlo M. Croce, George A. Calin, Stefano Volinia
Abstract: The present invention relates to compositions and methods of optically imaging tissues or cells using imaging agents have in vivo properties that result in signal-to-background ratios of at least about 1:1. TL is a targeting ligand and n is ?1, 0 or +1.
Type:
Grant
Filed:
February 5, 2010
Date of Patent:
May 5, 2015
Assignees:
Beth Israel Deaconess Medical Center, Georgia State University Research Foundation, Inc.
Abstract: An electron microscope is provided. In another aspect, an electron microscope employs a radio frequency which acts upon electrons used to assist in imaging a specimen. Furthermore, another aspect provides an electron beam microscope with a time resolution of less than 1 picosecond with more than 105 electrons in a single shot or image group. Yet another aspect employs a super-cooled component in an electron microscope.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
May 5, 2015
Assignee:
Board of Trustees of Michigan State University
Inventors:
Chong-Yu Ruan, Martin Berz, Zhensheng Tao
Abstract: The present invention discloses a method of inhibiting an ethylene response in a plant, comprising step of applying to at least one portion of the plant an effective ethylene response-inhibiting amount of a H1-cyclopropene-1-propanoic acid salt (CPAS). A method of prolonging the life of a cut flower, comprising applying to the cut flower an effective life-prolonging amount of CPAS and a method for the production a CPAS, comprising steps of (i) preparing 4-bromo-4-pentenoic acid or derivatives thereof; (ii) producing 1-cyclopropene-1-propanoic acid; and (iii), converting this acid into its water soluble salt, especially its sodium salt are presented. Additionally, a new family of water soluble CPAS inhibitors for ethylene response in a plant is disclosed.
Type:
Grant
Filed:
July 17, 2008
Date of Patent:
May 5, 2015
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., North Carolina State University
Inventors:
Raffi Goren, Akiva Apelbaum, Eliezer Goldschmidt, Moshe Huberman, Joseph Riov, Edward C. Sisler
Abstract: The present invention relates facile method to synthesize magnetic PNCs with highly dispersed and narrow size distributed NPs. The PNCs have highly thermal stability and unique electrical and dielectric properties.
Type:
Grant
Filed:
November 29, 2011
Date of Patent:
May 5, 2015
Assignees:
Lamar University, A Component of the Texas State University System, An Agency of the State of Texas, Texas State University San Marcos, A Component of the Texas State University System, An Agency of the State of Texas
Abstract: Methods involve a combination of polyelectrolyte multilayer (PEM) coating or silane self assembly on a substrate; microcontact printing; and conductive graphite particles, especially size controlled highly conductive exfoliated graphite nanoplatelets. The conductive graphite particles are coated with a charged polymer such as sulfonated polystyrene. The graphite particles are patterned using microcontact printing and intact pattern transfer on a substrate that has an oppositely-charged surface. The method allows for conductive organic patterning on both flat and curved surfaces and can be used in microelectronic device fabrication.
Type:
Grant
Filed:
September 14, 2012
Date of Patent:
May 5, 2015
Assignee:
Board of Trustees of Michigan State University
Inventors:
Ilsoon Lee, Lawrence T. Drzal, Jue Lu, Troy R. Hendricks
Abstract: The present invention relates to conjugated polymers. In various embodiments, the present invention provides a conjugated polymer including a repeating unit including a benzene ring conjugated with the polymer backbone, wherein the benzene ring is fused to two 5-membered rings, wherein each fused 5-membered ring includes N and at least one of O and S. In various embodiments, the present invention provides semiconductor devices including the polymer, and methods of making the polymer.
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
May 5, 2015
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Malika Jeffries-EL, Jeremy J. Intermann, Brian C. Tlach
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Grant
Filed:
February 27, 2012
Date of Patent:
April 28, 2015
Assignee:
The Ohio State University
Inventors:
Carlo M. Croce, George A. Calin, Stefano Volinia
Abstract: The invention provides novel nicotinic acetylcholine receptor agonists, for example, phantasmidine and derivatives thereof, for example a compound of formula (I). Also disclosed are methods of treating disorders responsive to nicotinic acetylcholine receptor agonists such as Alzheimer's disease, schizophrenia, Myasthenia Gravis, Tourette's syndrome, Parkinson's disease, epilepsy, pain, and cognitive dysfunction by treatment with the nicotinic acetylcholine for agonists.
Type:
Grant
Filed:
March 18, 2011
Date of Patent:
April 28, 2015
Assignees:
Indiana State University, The United States of America, as Represented by the Secretary, Department of Health and Human Services
Inventors:
Richard W. Fitch, Thomas F. Spande, H. Martin Garraffo, Herman J. C. Yeh, Kathryn Daly
Abstract: A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely double-stranded RNA. Rather, the method depends on constructs that yield single-stranded RNA transcripts, and exploits endogenous or in vivo-produced miRNAs or siRNAs to initiate production of siRNAs. The miRNAs or siRNAs guide cleavage of the transcript and set the register for production of siRNAs (usually 21 nucleotides in length) encoded adjacent to the initiation cleavage site within the construct. The method results in specific formation of siRNAs of predictable size and register (phase) relative to the initiation cleavage site. The method can be used to produce specific siRNAs in vivo for inactivation or suppression of one or more target genes or other entities, such as pathogens.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
April 28, 2015
Assignee:
State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
Abstract: An acceleration-triggered or shock-triggered, smart, tunable MEMS switch that may function as both a classic accelerometer and an acceleration threshold detector. A parallel element MEMS device has a stationary and a movable element forming a capacitor. Varying acceleration moves the movable member with respect to the stationary member, thereby changing the capacitance of the device. The capacitance varying may be used, in cooperation with appropriate circuitry, to provide a signal representative of instantaneous acceleration. By applying a biasing voltage, the movable element may be positioned in a predetermined fashion such that acceleration of a predetermined magnitude causes the movable element to pull in (snap down). The movable and stationary elements may function as a switch such that when the predetermined acceleration or shock level occurs, electrodes close, a current flows between the elements so that an external device such as an air bag may be activated.
Type:
Grant
Filed:
September 4, 2012
Date of Patent:
April 28, 2015
Assignee:
The Research Foundation for The State University of New York
Abstract: A wind turbine tower system is provided which includes a wind turbine tower with a height of at least 80 meters, said wind turbine tower comprised of ultra-high performance concrete and a wind turbine mounted on the wind turbine tower. The wind turbine tower system may include a vertically extending lattice structure formed of a plurality of modular components, wherein each of said plurality of modular components being pre-stressed. The tower may also be formed using UHPC shells.
Type:
Grant
Filed:
May 23, 2012
Date of Patent:
April 28, 2015
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Sivalingam Sritharan, Thomas James Lewin
Abstract: A method and apparatus includes an optical source for a single order single-sideband suppressed-carrier optical signal with a bandwidth that scales from over 1 gigaHertz to greater than 20 gigaHertz. In an example embodiment, an apparatus includes a stable laser source configured to output an optical carrier signal at a carrier frequency. The apparatus includes a radio frequency electrical source configured to output an electrical radio frequency signal with a radio frequency bandwidth less than one octave. The apparatus also includes an optical modulator configured to output an optical signal with the optical carrier signal modulated by the radio frequency signal in a plurality of orders of optical frequency sidebands. The apparatus further includes an optical filter configured to pass one single order optical frequency sideband of the optical signal.
Type:
Grant
Filed:
June 27, 2011
Date of Patent:
April 28, 2015
Assignees:
Montana State University, S2 Corporation
Inventors:
Colton Richard Stiffler, Scott Henry Bekker, Kristian D. Merkel, Randy R. Reibel, William R. Babbitt, Krishna Mohan Rupavatharam
Abstract: Substrates may be bonded according to a method comprising contacting a first bonding surface of a first substrate with a second bonding surface of a second substrate to form an assembly; and compressing the assembly in the presence of an oxidizing atmosphere under suitable conditions to form a bonding layer between the first and second surfaces, wherein the first bonding surface comprises a polarized surface layer; the second bonding surface comprises a hydrophilic surface layer; the first and second bonding surfaces are different.
Type:
Grant
Filed:
April 30, 2010
Date of Patent:
April 28, 2015
Assignee:
Arizona Board of Regents, A Body Corporate of the State of Arizona, Acting for and on Behalf of Arizona State University
Inventors:
Nicole Herbots, Robert J. Culbertson, James Bradley, Murdock Allen Hart, David Alexander Sell, Shawn David Whaley
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Grant
Filed:
February 29, 2012
Date of Patent:
April 28, 2015
Assignee:
The Ohio State University
Inventors:
Carlo M. Croce, George A. Calin, Stefano Volinia
Abstract: A laser material processing system and method are provided. A further aspect of the present invention employs a laser for micromachining. In another aspect of the present invention, the system uses a hollow waveguide. In another aspect of the present invention, a laser beam pulse is given broad bandwidth for workpiece modification.
Type:
Grant
Filed:
April 9, 2007
Date of Patent:
April 28, 2015
Assignee:
Board of Trustees of Michigan State University