Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation.

Abstract: A testing system for use in measuring thermal properties of material is described herein. The testing system includes a testing apparatus and monitoring system coupled to the testing apparatus. The testing apparatus includes a housing assembly that is configured to receive a material. A heating assembly is coupled to the housing assembly to supply a heat to at least a portion of the material to increase the temperature of the material. A sensing assembly is coupled to the housing assembly and is configured to sense a temperature of the material. The monitoring system comprises a controller having a processor comprising computer-readable instructions for operating the heating assembly to apply a heat to the material volume, receiving signals from the sensing assembly indicative of a temperature of the material, and estimating at least one thermal property of the material utilizing the sensed temperature of the material volume.

Abstract: Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an isolated amino acid sequence wherein at least one pair of amino acids are of an opposite charge and the pair members are separated by a spacer of 1-12 amino acid residues including at least one hydrophobic amino acid, and wherein the length of the amino acid sequence is greater than 5 and less than 20 amino acids. Pharmaceutical compositions for gastro-intestinal delivery and methods for the gastrointestinal delivery of poorly absorbed therapeutic agents are also disclosed.

Abstract: A thermal simulator simulates the thermal behavior of items such as eggs for which the actual internal temperature profile is difficult to measure. A yolk body simulates the egg yolk, an albumen body surrounds the yolk body and simulates the egg albumen, and a shell layer surrounds the albumen body to simulate the shell. The thermal properties of the materials forming the egg body, albumen body and shell layer are tuned to match the thermal properties of the egg yolk, egg albumen and egg shell. Thermometric devices are positioned within the egg body and egg albumen along with communication devices which process signals from the thermometric devices indicative of temperature and communicate these signals to a computer for further processing and display.

Abstract: The present invention discloses a mating ring, a primary ring, and associated mechanical seal having superior heat transfer and wear characteristics. According to an exemplary embodiment of the present invention, one or more dimples are formed onto the cylindrical outer surface of a mating ring sidewall and/or a primary ring sidewall. A stationary mating ring for a mechanical seal assembly is disclosed. Such a mating ring comprises an annular body having a central axis and a sealing face, wherein a plurality of dimples are formed into the outer circumferential surface of the annular body such that the exposed circumferential surface area of the annular body is increased. The texture added to the sidewall of the mating ring yields superior heat transfer and wear characteristics.

Abstract: Some embodiments include an imaging system. The image sensor array includes multiple image sensor sheets configured in an array grid. Each image sensor sheet of the multiple image sensor sheets can include a flexible substrate layer, and the flexible substrate layer can include a first flexible substrate side and a second flexible substrate side opposite the first flexible substrate side. Meanwhile, each image sensor sheet of the multiple sensor sheets can include multiple image sensors over the first flexible substrate side, the multiple image sensors can include multiple flat panel image detectors configured in a sheet grid, and the image sensor array can include an approximately constant pixel pitch. Other embodiments of related systems and methods are also disclosed.

Abstract: Disclosed herein is the identification of a new therapeutic target, an upstream target, the microtubule-organizing center (MTOC), for arresting mitosis and inhibiting cell growth and proliferation. Achieving mitotic arrest involves the interaction of two proteins with the ?TuRC of the MTOC: Kinesin-14 or a Tail peptide of Kinesin-14 having the amino acid sequence of SEQ ID NO: 1 and an antagonist capable of disarming the function of the BimC domain of Kinesin-5. Methods and compositions for screening for Kinesin-5 BimC antagonists are also disclosed.

Abstract: A method for forming a compound on a substrate is provided. The method includes depositing a composition onto a surface of a substrate; illuminating the composition and the substrate with pulsed energy; melting the substrate and decomposing the composition simultaneously; and forming a compound on the substrate. A first component of the compound is derived from the substrate and a second component of the compound is derived from the composition.

Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed.

Abstract: A method and system for analysis of protein interaction kinetics in microarray or whole-cell based formats includes positioning a sensor chip on a prism. The sensor chip is spotted with a plurality of target molecules. A movable printer head deposits a plurality of analyte droplets on predefined regions of the sensor chip surface. A light source transmits light through the prism to excite surface plasmon resonance on the sensor chip surface, whereby the plurality of target molecules bound to the upper surface are changing the SPR resonance angle and therefore the intensity of the reflected beam. A detector receives reflected light transmitted through the prism from the bottom surface. Signals from the detector are received and processed into kinetic data and microarray labeled data to determine molecular interactions and binding kinetic properties for the plurality of analyte droplets.

Abstract: IgA-based Fc-folate conjugates as a treatment for cancer are provided. The conjugates utilize only the Fc portion of IgA to target its receptor on neutrophils (Fc?R1) to elicit antibody-dependent cellular-cytotoxicity (ADCC).

Abstract: The present disclosure provides tobacco inbred plants TN90 SRC, CMS TN90 SRC, KY14 SRC, CMS KY14 SRC, L8 SRC, NC775 SRC, CMS NC775 SRC, NC645 SRC, NC638 SRC, CMS NC638 SRC, TN86 SRC, and CMS TN86 SRC, and hybrids KY14×L8 SRC, NC7 SRC, and NCBH129 SRC. The present disclosure also provides parts of such plants and products made from those parts. The present disclosure also includes progeny of the provided plants including hybrids.

Abstract: Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.

Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.

Abstract: A method and software supporting the method that improves the perceived quality of a vocalist's and/or singer's spoken or sung tone by teaching how to self-lower the larynx and maintain the lower laryngeal position while vocalizing and singing. An exemplary vocal instruction method comprising instructing a vocalist to self-monitor electromyographic data during singing, the data provided from an electromyograph device, the device comprising electrodes attached to a skin surface covering the vocalist's larynx, translating the data to a graphic display indicating to the vocalist the relative tension or flaccidity of the vocalist's laryngeal depressor muscles, instructing the vocalist to perform at least one physiological and/or anatomical function sufficient to result in lowered real-time tension of the laryngeal depressor muscle assessed by the electromyo-graphic device.

Abstract: According to one embodiment, a medical image diagnostic apparatus includes an X-ray tube, X-ray detector, image generation circuitry, display, and correction circuitry. The X-ray tube generates X-rays to an object. The X-ray detector detects the X-rays. The image generation circuitry generate an X-ray image based on the detected X-rays. The display displays an incident dose of the X-rays on the object, on an object image indicating the object. The correction circuitry correct a relative positional relationship between the object image and a display area of the incident dose on the object image based on the X-ray image.

Abstract: A system and method for using the system that permits a severely-ability challenged user to communicate with his or her environment using a brain-controlled interface. In one embodiment, the user's functional capability with the system is assessed to enhance candidate optimization for system benefit.

Abstract: Microcin MccPDI and bacteria harboring the mcpM gene which encodes MccPDI limit growth of and/or kill pathogenic bacteria such as pathogenic Escherichia coli (E. coli) and/or Shigella bacteria via proximity-dependent inhibition (PDI).

Abstract: A system and method for tracking and tracing motions of multiple incoherent sound sources and for visualizing the resultant overall sound pressure distribution in 3D space in real time are developed. This new system needs only four microphones (although more could be used) that can be mounted at any position so long as they are not placed on the same plane. A sample configuration is to mount three microphones on the y, z plane, while the 4th microphone on a plane perpendicular to the y, z plane. A processor receives signals from the microphones based on the signals received from noise sources in unknown locations, and the processor determines the locations of these sources and visualizes the resultant sound field in 3D space in real time. This system works for broadband, narrowband, tonal sound signals under transient and stationary conditions.

Abstract: A new cranberry variety distinguished by mid-season ripening, round to ovate fruit, high productivity, and moderate fruit anthocyanin development, as compared to the currently cultivated commercial varieties.