Abstract: Electronic communications can be normalized using neural networks. For example, an electronic representation of a noncanonical communication can be received. A normalized version of the noncanonical communication can be determined using a normalizer including a neural network. The neural network can receive a single vector at an input layer of the neural network and transform an output of a hidden layer of the neural network into multiple values that sum to a total value of one. Each value of the multiple values can be a number between zero and one and represent a probability of a particular character being in a particular position in the normalized version of the noncanonical communication. The neural network can determine the normalized version of the noncanonical communication based on the multiple values. Whether the normalized version should be output can be determined based on a result from a flagger including another neural network.

Abstract: A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.

Abstract: A micromechanical structure, comprising a substrate having a through hole; a residual portion of a sacrificial oxide layer peripheral to the hole; and a polysilicon layer overlying the hole, patterned to have a planar portion; a supporting portion connecting the planar portion to polysilicon on the residual portion; polysilicon stiffeners formed extending beneath the planar portion overlying the hole; and polysilicon ribs surrounding the supporting portion, attached near a periphery of the planar portion. The polysilicon ribs extend to a depth beyond the stiffeners, and extend laterally beyond an edge of the planar portion. The polysilicon ribs are released from the substrate during manufacturing after the planar region, and reduce stress on the supporting portion.

Abstract: Disclosed are antibody drug conjugates (ADC) that include highly potent toxic agents with specific antibodies to target tumors. Also disclosed are related antibodies, polypeptides, nucleic acids, host cells, compositions, and uses.

Abstract: A checkpointing method for creating a file representing a restorable state of a virtual machine in a computing system, comprising identifying processes executing within the virtual machine that may store confidential data, and marking memory pages and files that potentially contain data stored by the identified processes; or providing an application programming interface for marking memory regions and files within the virtual machine that contain confidential data stored by processes; and creating a checkpoint file, by capturing memory pages and files representing a current state of the computing system, which excludes information from all of the marked memory pages and files.

Abstract: The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to H2; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets H2-oxidizing methanogens.

Abstract: The present application generally relates to the use of metabolites of ginger and analogs thereof for the treatment and prevention of diseases, including but not limited to, cancer.

Abstract: Platinum complexes that exhibit photoabsorption and photoemission, methods of making such complexes, and applications thereof are disclosed, including optical devices comprising the complexes.

Abstract: A solid carrier sprayer apparatus, including a solid carrier container, a liquid container, a solid carrier spreading apparatus, and a liquid application apparatus is provided. The solid carrier spreading apparatus can be coupled to receive solid carrier from the solid carrier container, and is configured to drop the received solid carrier substantially evenly over an area of ground. The liquid application apparatus can be coupled to receive liquid from the liquid container, and is configured to spray received liquid substantially evenly over the received solid carrier, such that the liquid is sprayed substantially evenly over the received solid carrier before the solid carrier is dropped substantially evenly over the area of ground. Methods of using a solid carrier sprayer apparatus are also discussed.

Abstract: An ionizing system includes a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region. A heater is coupled to the channel and configured to heat the channel. A device is configured to introduce an analyte into the channel where the analyte is ionized.

Abstract: The invention relates to novel luminescent compositions of matter containing two fluorophores (sensitizers), synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions and their conjugates in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

Abstract: Synthetic disaccharide hydrocarbons (DSHs) that reactive bacterials swarming motility and inhibit bacterial adhesion and biofilm formation. A library of DSHs were tested in several experiment for the impact on various Pseudomonas aeruginosa populations and compared against existing compounds to determine efficacy and utility. Certain DSHs were also to determine the ability to clear bacteria in a mouse pneumonia model.

Abstract: The embodiments provide for a method and system of automated online control of a power system's voltage stability or even provide quick suggestions for fast decision support to the system operators to ensure a desired voltage stable system when needed. An example embodiment includes estimating data representing system parameters of a power system; non-iteratively determining a voltage stability index for each bus in the power system based on the estimated and received data sets; monitoring the voltage stability index for each bus so as to compare a computed voltage stability index for each bus to a predetermined voltage stability index threshold; and activating a voltage stability control mode resultant from the comparison of the computed voltage stability index for each bus to the predetermined voltage stability index threshold, wherein the voltage stability control mode is selected from: a normal mode of operation and an emergency mode of operation.

Abstract: Methods for distributed storage in accordance with embodiments of the invention enable secret sharing. One embodiment includes encoding source data using an encoding system to produce a plurality of sets of encoded data, where: the source data can be recovered from at least a portion of less than all of the plurality of sets of encoded data; and the source data cannot be recovered using less than a threshold number of the plurality of sets of encoded data; storing each of the plurality of sets of encoded data on a storage device from a set of storage devices on which encoded data is stored; determining a set of storage devices that are available using a decoding system, where the set of storage devices that are available does not include all of the storage devices in the set of storage devices on which encoded data is stored.

Abstract: A profusion system for a mammalian organ comprising a first and a second pump to propel perfusion fluid through one of a closed fluid circuit system and a selectively closeable fluid circuit system that includes an organ artery and an organ vein, a filter cartridge bank consisting of a plurality of filtration cartridges, and a first and a second fluid reservoir.

Abstract: Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (FR) of cancerous tumor cells and inhibit purine synthesis and hence, DNA synthesis.

Abstract: The present disclosure is directed toward membrane biofilm reactors primarily comprising microorganisms that produce chemical fuel products or precursors thereof. Reactors of the present disclosure can primarily comprise acetogens, a methanotrophs, and/or Methanosarcina acetivorans.

Abstract: Recombinant antibodies (including binding fragments thereof) that bind IgE are described, along with compositions and methods of using the same in the treatment of subjects in need thereof, including subjects afflicted with atopic dermatitis, allergic rhinitis, allergic conjunctivitis, urticaria, gastro-intestinal inflammation, or oral-pharyngeal inflammation. In some embodiments, the antibody is a single chain variable fragment (scFv) or a disulfide linked variable fragment (sdFv). In some embodiments, the subject is a dog, cat, or horse.

Abstract: ‘NCPH1’ is a new cultivar of hybrid cherry tree with a strict weeping habit, small stature, and showy pink flowers.

Abstract: A new and distinct cultivar of strawberry plant (Fragaria×ananassa), was developed from seed produced by a hand pollinated cross between ‘NJ96-12-1’ and ‘Camarosa’ (U.S. Plant Pat. No. 8,708). The new strawberry named ‘NJ99-204-1’ is distinguished by its ability to produce large, smooth, long wedge and conical shaped fruit, with attractive red color and excellent flavor. ‘NJ99-204-1’ plants have vigorous growth and an upright form.