Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
Type:
Grant
Filed:
October 14, 2015
Date of Patent:
January 31, 2017
Assignees:
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.
Abstract: Disclosed is a method for performing X-ray Computed Tomography scanning, the method including acquiring a plurality of images of an object, obtaining an initial image from the plurality of images, calculating NonLocal weight of the initial image, utilizing a current image estimation and registered prior image, performing a successive over-relaxation optimization to yield a new image estimation with an intensity of the new image estimation equal or greater than zero, performing a cycle update, generating an image of the object utilizing the new image estimation obtained from the optimization, and outputting a resultant image.
Type:
Grant
Filed:
April 16, 2014
Date of Patent:
January 31, 2017
Assignee:
The Research Foundation for the State University of New York
Inventors:
Jerome Z. Liang, Jianhua Ma, Hao Zhang, William Moore, Hao Han
Abstract: Robotic systems and specialized end-effectors provide for automated harvesting of produce such as fresh market apples. An underactuated design using tendons and flexure joints with passive compliance increases robustness to position error, overcoming a significant limitation of previous fruit harvesting end-effectors. Some devices use open-loop control, provide a shape-adaptive grasp, and produce contact forces similar to those used during optimal hand picking patterns. Other benefits include relatively low weight, low cost, and simplicity.
Type:
Grant
Filed:
September 10, 2015
Date of Patent:
January 31, 2017
Assignee:
Washington State University
Inventors:
Joseph Ryan Davidson, Changki Mo, Qin Zhang, Abhisesh Silwal, Manoj Karkee
Abstract: The present invention is directed to polyisocyanates and polyurethanes derived therefrom. In various embodiments, the present invention provides polyisocyanates, methods of making the polyisocyanates from fused bicyclic alcohols, polyurethanes, and methods of making the polyurethanes from the polyisocyanates.
Type:
Grant
Filed:
October 15, 2013
Date of Patent:
January 31, 2017
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Jason Shih-Hao Chen, Michael Richard Kessler, Michael Dennis Zenner
Abstract: A portable self medication management system and method of provided. For example, the system may include a removable tote and docking station. The removable tote including a plurality of receptacles, communicating section for transferring data to and from a docking station and a power reception station for receiving power from the docking station. The docking station including a scanner, a display screen, a controller, a storage device, communicating sections for transmitting data to the removable tote and other external devices and a power transmitting section for transferring power to the removable tote.
Type:
Grant
Filed:
July 1, 2015
Date of Patent:
January 31, 2017
Assignee:
The Research Foundation for The State University of New York
Inventors:
Craig Lehmann, John Brittelli, Chang Hong Chen, Tim Kehoe, Robert Barnikel
Abstract: The present invention provides an adsorbent catalytic nanoparticle including a mesoporous silica nanoparticle having at least one adsorbent functional group bound thereto. The adsorbent catalytic nanoparticle also includes at least one catalytic material. In various embodiments, the present invention provides methods of using and making the adsorbent catalytic nanoparticles. In some examples, the adsorbent catalytic nanoparticles can be used to selectively remove fatty acids from feedstocks for biodiesel, and to hydrotreat the separated fatty acids.
Type:
Grant
Filed:
November 30, 2012
Date of Patent:
January 31, 2017
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: A system and method allow for extracting target signals from the overall measurement data without knowing how and where these data are collected, the locations and characteristics of target sources as well as those of random background noise sources. In essence, it uses an innovative and advanced signal processing technique to reveal certain critical information from a mixture of data that is hard to obtain otherwise. In particular, it allows for denoising the measured data that have been contaminated by various interfering and background noise, making it possible to extract certain target information that may be otherwise difficult to observe. The only assumption made in this method is that the target signal is incoherent with respect to all interfering signals and background noise. The more information about a target signal is available, the more complete the extracted signal becomes.
Abstract: The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the SEQ ID NO: 4D. The present invention also provides a method for treating a disorder comprising administering peptide 4D to a mammal.
Type:
Grant
Filed:
October 11, 2013
Date of Patent:
January 31, 2017
Assignee:
The Research Foundation for The State University of New York
Inventors:
Elizabeth Kornecki, Anna Babinska, Yigal H. Ehrlich, Moro Salifu
Abstract: This disclosure provides a novel role for microRNA (miR) regulation of lipid metabolism via the MTP pathway, leading to reductions in apoB secretion and blood lipid levels. MiR regulation of the MTP pathway is shown herein to reduce hyperlipidemia and atherosclerosis in vivo. Therefore, inhibition of MTP expression and activity by miR regulation is identified as a new therapeutic target for treatment of cardiovascular disease and conditions or diseases associated with cardiovascular disease such as hyperlipidemia, atherosclerosis, and metabolic syndrome. Treatment of cardiovascular disease and associated conditions or diseases with the novel MTP inhibitors of the invention, such as miR-30c homologs or miR-30c agonists, reduces MTP-associated lipid production without side effects that occur with other methods of MTP inhibition.
Type:
Grant
Filed:
January 9, 2013
Date of Patent:
January 31, 2017
Assignee:
The Research Foundation for The State University of New York
Abstract: A deodorant composition comprising arginine, bicarbonate, zinc and carbonate, preferably arginine bicarbonate and zinc carbonate (ABZC), and one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras—generally to reduce axillary odor, promote the growth of Staphylococcus epidermidis bacteria, inhibit the growth of Corynebacterium striatum bacteria, or any or all of the preceding.
Type:
Grant
Filed:
September 29, 2015
Date of Patent:
January 31, 2017
Assignee:
The Research Foundation for The State University of New York
Abstract: An active noise control system includes a first microphone, a controller operably coupled to the first microphone, and a speaker operably coupled to the controller. The first microphone senses a sound input in an audible spectrum, wherein the sound input includes a disturbance noise portion. The controller includes a selection unit and an output unit. The selection unit determines the disturbance noise portion of the sound input based on a highest frequency level of the sound input. The output unit removes the disturbance noise portion from the sound input to generate a filtered sound input. The speaker generates a speaker output based on the filtered sound input.
Type:
Grant
Filed:
August 12, 2008
Date of Patent:
January 31, 2017
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: A method and apparatus are described including a laser with a plurality of internal or external actuators for affecting an optical frequency of light output by the laser, wherein the plurality of actuators have a corresponding plurality of different frequency response bands for changing optical properties of the laser and a corresponding plurality of actuation ranges of optical frequencies affected. Also included is an optical detector, and a plurality of optical paths configured to direct light output by the laser onto the detector. A laser controller is configured to provide a plurality of inputs to the plurality of actuators based on a detector signal output from the optical detector and the corresponding frequency response bands and actuation ranges.
Type:
Grant
Filed:
November 11, 2014
Date of Patent:
January 31, 2017
Assignees:
Montana State University, Bridger Photonics, Inc.
Inventors:
Peter A. Roos, Randy R. Reibel, Brant Kaylor, Zeb Barber, William Randall Babbitt
Abstract: Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The catalyst comprises an Fe/Fe3O4 nanocatalyst that may be supported on a non-reactive support material such as a zeolite or alumina CO2 and H2 are preferred sources of carbon and hydrogen atoms for the reaction. The aromatic hydrocarbon compounds produced are suitable for direct usage as fuel without need for further refining.
Type:
Grant
Filed:
January 23, 2015
Date of Patent:
January 31, 2017
Assignee:
Kansas State University Research Foundation
Inventors:
Hongwang Wang, Stefan H. Bossmann, Donghai Wang, Deryl L. Troyer, Tej Shrestha
Abstract: One embodiment is a pressure sensitive adhesive construct comprising: (a) a backing substrate; and (b) a pressure sensitive adhesive composition disposed on the backing substrate, wherein the pressure sensitive adhesive composition includes a product made from (i) at least one epoxidized vegetable oil and; (ii) a dimer acid or anhydride thereof, a trimer acid or anhydride thereof, a polymerized fatty acid or anhydride thereof, or a mixture thereof.
Abstract: A method is provided for making a solar cell. The method includes providing a stack including a substrate, a barrier layer disposed on the substrate, and an anti-reflective layer disposed on the barrier layer, where the anti-reflective layer has charge centers. The method also includes generating a corona with a charging tool and contacting the anti-reflective layer with the corona thereby injecting charge into at least some of the charge centers in the anti-reflective layer. Ultra-violet illumination and temperature-based annealing may be used to modify the charge of the anti-reflective layer.
Type:
Grant
Filed:
August 11, 2014
Date of Patent:
January 31, 2017
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Abstract: The disclosure provides a method of oil delivery to a chainsaw chain blade using a gerotor pump in sequence with flow control valves to provide lubrication to the chain blade to reduce friction with the chainsaw bar guide and prevent overheating and damage to the chain blade or guide bar.
Type:
Application
Filed:
July 25, 2016
Publication date:
January 26, 2017
Applicant:
The Research Foundation for The State University of New York
Abstract: Disclosed herein are embodiments of methods for detecting the presence of and amount of drugs in a sample, particularly a particle sample obtained from a subject. In particular disclosed embodiments, the particle samples are skin particle samples, saliva particle samples, and/or mucous samples isolated from a subject and analyzed using thermal desorption methods combined with a selected detection method.
Type:
Application
Filed:
July 22, 2016
Publication date:
January 26, 2017
Applicant:
Washington State University
Inventors:
Herbert H. Hill, JR., Brian Clowers, Nicholas Lovrich
Abstract: The use of the electride form of 12CaO-7Al2O3, or C12A7, as a low work function electron emitter in a hollow cathode discharge apparatus is described. No heater is required to initiate operation of the present cathode, as is necessary for traditional hollow cathode devices. Because C12A7 has a fully oxidized lattice structure, exposure to oxygen does not degrade the electride. The electride was surrounded by a graphite liner since it was found that the C12A7 electride converts to it's eutectic (CA+C3A) form when heated (through natural hollow cathode operation) in a metal tube.
Type:
Grant
Filed:
April 5, 2016
Date of Patent:
January 24, 2017
Assignee:
Colorado State University Research Foundation
Inventors:
Lauren P. Rand, John D. Williams, Rafael A. Martinez
Abstract: A field shaping multi-well avalanche detector and method for fabrication thereof are disclosed. The field shaping multi-well avalanche detector provides stable avalanche multiplication gain in direct conversion amorphous selenium radiation detectors. The detector provides stable avalanche multiplication gain by eliminating field hot-spots using high-density avalanche wells with insulated wells and field-shaping within each well.
Type:
Grant
Filed:
July 19, 2013
Date of Patent:
January 24, 2017
Assignee:
The Research Foundation for The State University of New York
Abstract: Cercis ‘Pink Pom Poms’ is a new and distinct variety of redbud tree that has the following unique combination of desirable features that are outstanding in a new variety including (1) ease of asexual propagation using chip budding, (2) semi-upright growth habit; (3) foliage with glossy green color; (4) bright purple-violet double flowers produced in abundance during the spring; and female structures that are essentially sterile, resulting in no seed pod set.
Type:
Grant
Filed:
December 11, 2014
Date of Patent:
January 31, 2017
Assignee:
North Carolina State University
Inventors:
Dennis James Werner, Edward Alex Neubauer