Abstract: Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, wherein the inner phase comprises the additive and an active agent dissolved therein, wherein the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, wherein the maintenance of the permeation rate is proportional to the amount of active agent in the biphasic layer.

Abstract: An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

Abstract: A device and a method for determining a suitability of an active ingredient to be applied transdermally or transmucosally. In particular, a system that includes: at least one input device for inputting at least one designation of an active ingredient; a database for storing a plurality of data at least relating to the active ingredient; a computing unit for assessing a suitability of the active ingredient to be applied transdermally and/or transmucosally while taking into consideration data entered via the input device and/or data stored in the database; and an output device for displaying the assessed suitability.

Abstract: An exemplary arrangement for securing the shaft of an exhaust-gas turbocharger includes a catch ring with a central opening and a radial projection on the shaft. The catch ring having an inner contour in the region of the central opening. The radial projection on the shaft is provided with an outer contour. The inner contour on the catch ring and the outer contour on the shaft are configured such that, during mounting of the shaft and of the turbine wheel connected thereto and in at least one specified angle position of the shaft with respect to the housing, the radially outwardly protruding projection on the shaft can be passed in an axial direction through the central opening of the housing element. The radially outwardly protruding projection abuts in the axial direction against the housing element in specified angle positions of the shaft with respect to the housing.

Abstract: The present invention relates to a transdermal therapeutic system for applying the active ingredient norelgestromin onto the skin, optionally in combination with estrogens. It further relates to the use of such systems for hormonal contraception, and for hormone replacement therapy.

Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.

Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.

Abstract: The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionery, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material.

Abstract: The spray assembly of a dispensing device is arranged together with a mixing assembly inside a mixing and spray head, the mixing assembly being arranged before the swirl chamber of the spray assembly, and the mixing and spray head, which forms a unit, being removably attached to a multicomponent dispensing appliance. The result is a more homogeneous spray action, on one hand, and an easy replacement of the head, on the other hand.

Abstract: Method for performing announcements in a means of transport that has an announcement device having at least one loudspeaker and an entertainment device, having the following steps: an announcement start signal is sent from the announcement device to the entertainment device at the beginning of an announcement; an interruption to the reproduction of the reproduction appliance is prompted by the entertainment device when the announcement start signal is received; the announcement is reproduced as an audible announcement signal via the announcement loudspeaker; continuation of the reproduction of the reproduction appliance is prompted by the entertainment device when an announcement end signal is received or at the end of reception of the announcement start signal, characterized by detection of an audio signal that is output by the announcement loudspeaker by the entertainment device, wherein the reproduction of the reproduction appliance is automatically interrupted after the audio signal is detected.

Abstract: A childproof packaging for individual doses, in particular for preparations for administration in film form, wherein the packaging constitutes a bag produced by sealing, which has a covering layer which is provided at each side of the packaging with local weak points which do not touch the edge of the packaging, wherein the local weak points form a cohesive pattern which runs around the individual dose in an arc or a curve and overlaps an angular region of at least 90° when considered from the main area of the individual zone. The local weak points have a start area and an end area which have a Y configuration when the local weak points on each side of the packaging are superposed.

Abstract: A carton and carton blank for forming a carton, and comprising first, second, third and fourth substantially four-edged panels, each comprising a side wall part (4,6,8,10), a top closure obturating part (24,26,28,30) and a top sealing fin part, one of the panels being substantially free from any line of weakness extending inwardly from lateral edge zones of the one of the panels from an outermost boundary of the side wall part (8) to an outermost boundary of the top sealing fin part. Alternatively, the one of the panels is substantially free from any line of weakness extending inwardly from lateral edge zones of the one of the panels from an innermost boundary of the top closure obturating part (28) to an outermost boundary of the top sealing fin part.

Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the layer remote from the skin and the skin-contact layer.

Abstract: The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step.

Abstract: Transdermal therapeutic systems are described which have at least one electronic component, as well as methods for producing this type of transdermal therapeutic systems.

Abstract: The invention relates to a gearshifting device (1), which is intended for a transmission and comprises a selector lever (2) that can be moved in such a manner that different shift positions (P, R, N, D, S, M+, M?) can be selected in at least two gearshift gates (3, 4) and that it is possible to shift between one of the gearshift gates (3, 4) and the at least one other gearshift gate (4, 3), and comprises at least one lock (5), which is used to block the traversing path of the selector lever (2) with respect to one of the gearshift gates (3, 4), in order to shift from one of the shift positions (P, R, N, D, S) into another of the shift positions (P, R, N, D, S).

Abstract: A shifting device for a transmission of a motor vehicle has an actuation lever (1) which can be selectively transferred into (a) a first selector gate, more particularly an automatic selector gate, in which the lever is mechanically coupled to a transmitting component (2) for actuating a gearshift cable or a gearshift linkage, or (b) a second selector gate, more particularly a sequential selector gate, in which the lever is decoupled from the transmitting component, the transmitting component being movably mounted, more particularly pivotably mounted. A locking means (11) can immobilize the transmitting component such that no force is exerted on the gearshift cable or the gearshift linkage as long as the actuation lever has been transferred into the second selector gate. The transmitting component may be released by a transfer of the actuation lever into the first selector gate.