Patents Assigned to Systems AG
  • Method for preventing the crystallisation of pharmaceuticals in a polymer film
    Patent number: 8932665
    Abstract: The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: January 13, 2015
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Johannes Josef Leonhard, Walter Mueller
  • Device for opening an ampoule
    Patent number: 8915413
    Abstract: A device for opening an ampoule (3) comprises a hollow cylindrical housing (11) having an interior for accommodating the ampoule (3) and a rotary element (12) having a proximal section (121), to which a break-off section (124) extending in a distal direction is connected to. The break-off section (124) is flexible in a radial direction and is pivotably connected to the proximal section (121) in the radial direction. The rotary element (12) is rotatable relative to the housing (11) about the longitudinal axis. The housing (11) has a first guiding structure (119) for pressing the break-off section (124) inward during a rotation of the rotary element so that the break-off section (124) exerts a radial shear force on an ampoule head (33) of an ampoule (3) to break the ampoule head (33) off of the ampoule body (31).
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: December 23, 2014
    Assignee: Medmix Systems AG
    Inventor: Ralph Egon Kayser
  • Release liner or protective sheet having a slit covered by another layer for use in adhesive laminates
    Patent number: 8911772
    Abstract: The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof. The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: December 16, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Dieter Sahm, Heinrich Thoeing, Wolfgang Laux
  • Mucoadhesive dispersible pharmaceutical preparation for active-agent dosing in veterinary and human medicine
    Patent number: 8906406
    Abstract: The invention relates to a mucoadhesive medicinal preparation for administering active substances in veterinary or humane medicine, containing at least one active substance, which preparation is characterized in that it is a mucoadhesive matrix disintegratable in aqueous media, which matrix contains at least one matrix-forming polymer and wherein at least one active substance is dissolved or dispersed, and in that the said preparation disintegrates or erodes within maximally 15 minutes after introduction in an aqueous medium or in body fluids, or in that the preparation initially gels within maximally 15 min after its introduction in an aqueous medium or in body fluids, and disintegrates or erodes within maximally 30 min after said introduction.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 9, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Tina Rademacher, Frank Seibertz, Petra Brandt, Markus Krumme, Christian Von Falkenhausen
  • Self-destructing transdermal therapeutic system having improved functionality and efficacy
    Patent number: 8894621
    Abstract: The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach the agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: November 25, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Stefan Maier, Margit Wirz
  • Rotor blade and method for producing same
    Patent number: 8888463
    Abstract: The invention relates to a rotor blade for wind energy installation, comprising at least one flange running in a longitudinal direction from a rotor blade root to a rotor blade tip, whereby a width of the flange decreases along the longitudinal direction. The invention also relates to a method for producing a rotor blade in that at least one flange with a width decreasing in the longitudinal direction is applied to a rotor blade inner wall, and to a laying assistance device for positioning strips of the flange.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: November 18, 2014
    Assignee: REpower Systems AG
    Inventor: Matthias Schubert
  • Seat conditioning module and method
    Patent number: 8888573
    Abstract: A seat conditioning module for a seat conditioning assembly including an air mover, an intake port, outtake port, wherein at least one of the intake port, the outtake port, or both are in fluid communication with a seat surface. A valve assembly with at least two apertures movably disposed between the air mover and the at least one intake and at least one outtake ports. An actuation device for moving the valve assembly to control the passage of the fluid through the at least two apertures. An optional conditioning device in fluid communication with the air mover and the seat surface. A control device for at least controlling the position of the at least two apertures of the valve assembly, the activation of the optional conditioning device, the operation of the air mover, or any combination thereof.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: November 18, 2014
    Assignee: W.E.T. Automotive Systems AG
    Inventors: Goran Bajic, Syed Iqbal, Dmitri Axakov, Matthew Zuzga
  • Transdermal therapeutic system having stabilized membrane
    Patent number: 8882729
    Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.
    Type: Grant
    Filed: February 28, 2009
    Date of Patent: November 11, 2014
    Assignee: LTS Lohmann Therapie Systeme AG
    Inventors: Michael Horstmann, Patrick Mohr, Mohammad Sameti
  • Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid
    Patent number: 8883191
    Abstract: A method for producing individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w), of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.
    Type: Grant
    Filed: December 26, 2003
    Date of Patent: November 11, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Wolfgang Laux
  • Transdermal, therapeutic system with activatable oversaturation and controlled permeation promotion
    Patent number: 8883197
    Abstract: A transdermal therapeutic system (TTS) that is essentially composed of two compartments and is provided with activatable oversaturation and controlled permeation promotion. The invention more particularly relates to a TTS wherein an oversaturated active ingredient solution is produced in an active-substance-containing polymer matrix when the system is applied to the skin, caused by the controlled supply of one or several substances promoting the permeation of the pharmaceutical active ingredient; to the two compartments from which the inventive transdermal therapeutic system is assembled; and to the production of the transdermal therapeutic system from the two compartments.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: November 11, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Andreas Koch
  • Transdermal rivastigmine therapeutic system
    Patent number: 8883198
    Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterized in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: November 11, 2014
    Assignee: LTS Lohmann Therapie Systeme AG
    Inventors: Thomas Hille, Lothar Deurer
  • Stackable container assembly with reciprocal locking of the stacked containers
    Patent number: 8875888
    Abstract: It is a matter of a container assembly with at least one stackable container (1) which has a bottom part (7) and a lid (8) mounted on top thereof Several containers (1) may be so stacked that the lid (8) of the lower container (1) is located between two bottom parts (7). The container (1) is equipped with at least one connecting device (3) which has coupling means (26) mounted movably on the lid (8) of the container (1). The coupling means (26) are movable, for the connection of two containers (1) mounted one above the other, into a connected position relative to the lid (8), in which they are simultaneously in connecting engagement with the bottom parts (7) of both stacked containers (1).
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: November 4, 2014
    Assignee: TTS Tooltechnic Systems AG & Co. KG
    Inventors: Andreas Koenig, Raimund Schäffer, Timo Kuhls, Lutz Wolle
  • TRANSDERMAL THERAPEUTIC SYSTEM FOR 5-AMINOLEVULINIC ACID HYDROCHLORIDE
    Publication number: 20140323994
    Abstract: The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.
    Type: Application
    Filed: August 24, 2012
    Publication date: October 30, 2014
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Tobias Jung, Michael Horstmann, Gerd Hoffmann
  • MULTILAYERED TRANSMUCOSAL THERAPEUTIC SYSTEM
    Publication number: 20140316354
    Abstract: A film-shaped therapeutic system comprising at least two layers connected with each other, for transmucosal administration of active substances. The system has a layer which is mucoadhesive in an aqueous environment and a mono-layered or multi-layered backing layer. At least one of these layers contains an active substance. The mucoadhesive layer is capable of swelling in an aqueous media, but is insoluble or only poorly soluble in an aqueous media. A process for treating a patient by medicinal therapy or prophylaxis by the film-shaped therapeutic system is also provided.
    Type: Application
    Filed: July 9, 2014
    Publication date: October 23, 2014
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventor: Markus Krumme
  • Water soluble film for oral administration with instant wettability
    Patent number: 8865202
    Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: October 21, 2014
    Assignee: LTS LOHMANN Therapie-Systeme AG
    Inventors: Horst Georg Zerbe, Jian-Hwa Guo, Anthony Serino
  • Actuator that can be decoupled, in particular having an electromechanical drive
    Patent number: 8864154
    Abstract: An actuator having an electromechanical drive and a housing is provided. The driving torque provided by an electric motor is transmitted by gear train to two actuator outputs connected to two parts of a stabilizer. The gear train is an eccentric gear train, the drive shaft of which is driven by the electric motor. An overall eccentric driven by the drive shaft has on its circumference a drive gear having a first outer profile and a second outer profile different therefrom. In the operating state the drive gear first outer profile is connected to a first inner profile of a first one of the outputs and the drive gear second outer profile is connected to a second inner profile of the second one of the outputs, and the connection can be eliminated by changing the eccentricity of the eccentric such that both outputs can rotate freely relative to each other.
    Type: Grant
    Filed: September 5, 2011
    Date of Patent: October 21, 2014
    Assignee: Asturia Automotive Systems AG
    Inventors: Wolfgang Freund, Andreas Kissler, Tino Schmidt, Matthias Maier, Juergen Schulze
  • Fluid bed apparatus for coating solid particles
    Patent number: 8863686
    Abstract: A fluid bed apparatus for coating solid particles. The apparatus includes a housing having upwardly extending walls surrounding a perforated base plate, a nozzle for atomizing a coating liquid, the nozzle being provided in the upwardly extending walls, and a device for providing fluidisation gas through the perforations of the base plate for the maintenance of a fluidised layer. The coating liquid nozzle is provided in a channel for co-current introduction of a dispersion gas, the channel debouching into the fluid bed through an orifice having a radius of 5 mm or more. The apparatus provides for the production of particles having smooth surfaces, high yield and a low tendency to form agglomerates.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: October 21, 2014
    Assignee: GEA Pharma Systems AG
    Inventor: Jürg Paul Ris
  • Method for producing a multilayer compound on a CIP-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavities
    Patent number: 8864047
    Abstract: Methods for producing a mono- or multilayer composite are provided in which one or several layers are applied onto a carrier material by coating, the coated mono- or multilayer composite is dried and rolled up, and the installation is subsequently cleaned. The air circuit in the drying oven is entirely set to fresh air supply, and the drying oven is configured to be cleaned in a controlled manner. All components of the drying oven that come into contact with the product do not have to be removed during cleaning, but can be cleaned-in-place using technology integrated into the drying oven. The drying oven Outer housing is designed so that it can be lifted upwardly. All assembly parts in the drying oven interior are designed to eliminate disassembling for cleaning purposes. Transport rollers within the drying oven are designed as hollow shafts and provided with spraying nozzles.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: October 21, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Rudi Brathuhn, Peter Schwarz, Wolfgang Schaefer
  • Container
    Patent number: D717644
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: November 18, 2014
    Assignee: Elopak Systems AG
    Inventor: Ivica Franic
  • Computer peripheral device
    Patent number: D720761
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: January 6, 2015
    Assignee: WIBU-Systems AG
    Inventor: Oliver Winzenried