Abstract: The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells.
Abstract: The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the composite is a calcium sulfate-polylactic acid composite or porous composite and the composite can be especially used as an in situ pore forming scaffold.
Abstract: The present invention discloses a method for detecting and examining traumatic brain injury (TBI) in vitro. The method is according to the principle of expression of Etk/Bmx mRNA which is correspondingly increased when TBI occurs, so that the Etk/Bmx mRNA is defined as a quantification reference indicator specific for neurological injury degree of TBI. Thus, the method can be used to detect the expression of the Etk/Bmx mRNA for examining and evaluating the neurological injury degree of TBI occurred due to an external impact.
Abstract: The invention relates to a kit and method for the capture of tumor cells in a body fluid sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be found.
Abstract: A method for manufacturing bioactive glass includes the steps below. A precursor and a polar solvent are mixed to form a mixed solution, in which the precursor includes a silicon precursor, a calcium precursor and a phosphorus precursor. The mixed solution is atomized to form a mixture droplet. The mixture droplet is oxidized in an environment of 500° C. to 900° C. to form the bioactive glass.
Type:
Application
Filed:
November 7, 2013
Publication date:
November 27, 2014
Applicants:
Taipei Medical University (TMU), National Taiwan University of Science and Technology
Inventors:
Shao-Ju SHIH, Yu-Jen CHOU, Chung-Kwei LIN
Abstract: This invention relates to microfluidic chips for and their applications in acquiring sperms with high velocity and/or motility. The microfluidic chip comprises an inlet region, a first flow channel, a divergent channel, an optional block structure with rounded corners and one or more outlet region(s). The invention mimics sperm activation process in body and designs a microfluidic chip mimicking the activation process so that higher amount of populations and/or subpopulations of sperms with high motility can be acquired.
Type:
Application
Filed:
September 14, 2012
Publication date:
October 23, 2014
Applicants:
DCB-USA LLC, TAIPEI MEDICAL UNIVERSITY
Abstract: Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
Type:
Grant
Filed:
March 29, 2011
Date of Patent:
September 30, 2014
Assignees:
Taipei Medical University, Ohio State University, National Taiwan University
Abstract: The invention relates to a novel use of the members of the IL-10 cytokine family in wound healing. Particularly, the invention relates to the use of the member of the IL-10 cytokine family in the promotion of the proliferation and the migration of keratinocyte cells in wound healing.
Type:
Application
Filed:
March 14, 2013
Publication date:
September 18, 2014
Applicants:
CHI MEI MEDICAL CENTER, TAIPEI MEDICAL UNIVERSITY
Abstract: A method of detecting hepatocellular carcinoma includes the steps of: detecting a methylation level of a CpG site of HOXA9 gene in a biological sample taken from a suspected subject; and comparing the methylation level to a reference methylation level of a CpG site of HOXA9 gene in another biological sample taken from a normal subject not suffering from hepatocellular carcinoma, wherein when the methylation level is higher than the reference methylation level, the suspected subject is likely to suffer from hepatocellular carcinoma, and wherein each of the biological samples is selected from the group consisting of a blood sample, a serum sample, and a plasma sample.
Type:
Application
Filed:
December 13, 2013
Publication date:
August 21, 2014
Applicants:
ACADEMIA SINICA, TAIPEI MEDICAL UNIVERSITY
Abstract: The invention relates to a kit and method for the capture of tumor cells in a body fluid sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be found.
Abstract: The invention provides a method for promoting osteogenesis, increasing bone mass or enhancing the rate of bone growth, which comprises administering to a subject an effective amount of Uraria, a part thereof or an extract thereof. Also provided are a method for treating and/or preventing osteoporosis and a method for providing neuroprotection, comprising administering to a subject an effective amount of Uraria, a part thereof or an extract thereof.
Abstract: The invention relates to a composition comprising deer velvet antler blood (DVAB) in combination with velvet antler for use in the treatment and/or prevention of osteoporosis and a method for treating and/or preventing osteoporosis, comprising administering a therapeutically effective amount of a composition comprising DVAB and velvet antler to a subject at risk of developing or afflicted with osteoporosis. The composition of the invention, when administered to a subject with osteoporosis, increases anti-osteoporotic activity, decreases the biomarker of osteoporosis and recovers the biomechanical strength and structure of bone, suggesting that the said composition could significantly prevent and even treat osteoporosis.
Abstract: The invention provides an electrospinning apparatus, which comprises one or more spinneret, a rotating collector disposed from the spinneret and configured to collect the fibers, and a sideway motion device disposed on or connected to the spinneret or the rotating collector and configured to propel or move the spinneret or the rotating collector, wherein the sideway motion device is controlled by a controlling unit for providing an angular speed (?) of the sideway motion with a formula: ?=tan?1 x/H wherein x is a parallel motion speed of the device and H is a vertical height between the spinneret and the rotating collector and wherein the angular speed (?) is in a range of about 1.0×10?4 to about 1.0 (°/sec). Also provided is the 2-D or 3-D membranes produced therefrom and a method of using the apparatus of the invention.
Abstract: A method of surface treatment for zirconium oxide implants and the etching formula for the same are disclosed. The processes are carried out at room temperature. The average surface roughness Ra and the standard deviation of the implant are measured showing significant improvement while comparing with the un-treated sample and the hydrofluoric acid treated samples. The average contact angle is provided showing an almost hydrophilic surface after etched by the formula according to the present invention.
Type:
Application
Filed:
November 28, 2012
Publication date:
May 29, 2014
Applicant:
TAIPEI MEDICAL UNIVERSITY
Inventors:
Sea-Fue Wang, Chung-Kuang Yang, Jen-Chang Yang, Sheng-Yang Lee
Abstract: The invention relates to a kit and method for the capture of tumor cells in a body fluid sample or a serum-containing sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be identified.
Abstract: This invention relates to piperazinedione compounds shown in the specification. These compounds are tyrosine kinase inhibitors and can be used to treat cancer.
Abstract: The present invention discloses a grain germinating system comprising a temperature controlling device, an incubation device, a drying device and a monitoring device. The temperature controlling device comprises a heat pump module, an air conditioning module and a piping module. The heat pump module can output a high or low temperature heat exchanging liquid. The temperature of a culture medium of a grain is adjusted by the incubation device. The incubated grain is dried by the drying device. The air conditioning module is for a plant building. The piping module is connected with the heat pump module, and is provided for the high or low temperature heat exchanging liquid to flow. The incubation device and the drying device are heated by the high temperature heat exchanging liquid. The drying device is cooled by the low temperature heat exchanging liquid provided for the air condition of the plant building to use.
Type:
Grant
Filed:
March 22, 2010
Date of Patent:
April 1, 2014
Assignee:
Taipei Medical University
Inventors:
Chun-Mao Lin, Fu-Der Mai, Chien-Lung Hung, Chwen-Ming Shih
Abstract: The invention provides a method for promoting wound healing or tissue injury treatment in a subject in need thereof, the method comprising administering to the subject an effective amount of one or more fungal immunomodulatory protein (preferably, Ganoderma immunomodulatory protein).
Abstract: This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.
Type:
Grant
Filed:
January 26, 2010
Date of Patent:
January 21, 2014
Assignees:
Taipei Medical University, National Taiwan University, National Tsing Hua University, DCB-USA LLC
Inventors:
Feng-Lin Hsu, Shing-Hwa Liu, Biing-Jiun Uang
Abstract: The invention provides a single surgical procedure by using autologous platelet-rich fibrin (PRF) and cartilage fragments to solve problems of contamination during incubation of chondrocytes and transplant rejection in vivo, which has the benefit of a more efficient and shorter recovery time. The invention also provides a device for easily and rapidly cutting cartilage to cartilage fragments so as to reduce contamination of the implant and infection.