Patents Assigned to Technion Research & Development
  • Exploiting similarity in adjacent slices for compressed sensing MRI
    Patent number: 9619904
    Abstract: A method for reconstructing high signal-to-noise ratio (SNR) magnetic resonance imaging (MRI) slices, including: receiving a thick MRI slice of bodily tissue acquired using a single MRI scan, wherein the thick slice has a high SNR; receiving two thin MRI slices of the bodily tissue acquired using a single MRI scan, wherein each of the two thin MRI slices has a low SNR; and reconstructing multiple high SNR thin slices of the bodily tissue using the thick slice and the two thin slices.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: April 11, 2017
    Assignees: Technion Research & Development Foundation Limited, The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center
    Inventors: Lior Weizman, Yonina Eldar, Dafna Ben Bashat
  • Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
    Patent number: 9616112
    Abstract: A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: April 11, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yoram Reiter, Cyril Cohen
  • Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
    Patent number: 9617347
    Abstract: The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: April 11, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Gera Neufeld
  • Aminoglycosides and uses thereof in treating genetic disorders
    Patent number: 9616079
    Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
    Type: Grant
    Filed: September 27, 2015
    Date of Patent: April 11, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
  • Query networks evaluation system and method
    Patent number: 9607052
    Abstract: A query network is disclosed, comprising sets of nodes and edges connecting pairs of nodes. The nodes of the query network are associated with edge-defining queries. A method is taught for fully evaluating such a query network. A language is further disclosed for constructing queries. The query network may be used to model a social network, a professional network or the like.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: March 28, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Oded Shmueli, Royi Ronen
  • Example-based audio inpainting
    Patent number: 9583111
    Abstract: A method for packet loss concealment, that includes: continuously receiving a digital audio stream; extracting audio features from the digital audio stream while the digital audio stream is unharmed; and upon detecting a gap in the digital audio stream, filling the gap with one or more previous segments of the digital audio stream, wherein the filling is based on a matching of the one or more of the extracted audio features with one or more audio features adjacent to the gap.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: February 28, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Yoav Schechner, Michael Elad, Yuval Bahat
  • ENCAPSULATED MESENCHYMAL STEM CELLS AND USES THEREOF
    Publication number: 20170049821
    Abstract: Provided is a composition-of-matter comprising a microcapsule encapsulating mesenchymal stem cells, wherein at least 97% of cells in said microcapsule are said mesenchymal stem cells. Also provided are methods of generating and using the composition-of-matter.
    Type: Application
    Filed: September 4, 2016
    Publication date: February 23, 2017
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Marcelle MACHLUF, Amit GOREN
  • Example-based cross-modal denoising
    Patent number: 9576587
    Abstract: A method for cross-modal signal denoising, the method comprising using at least one hardware processor for: providing a first multi-modal signal comprising at least two relatively clear modalities; correlating features exhibited simultaneously in the at least two relatively clear modalities of the first multi-modal signal; providing a second multi-modal signal comprising at least one relatively noisy modality and at least one relatively clear modality; and denoising the at least one relatively noisy modality of the second multi-modal signal by associating between (a) features exhibited in the at least one relatively noisy modality of the second multi-modal signal and (b) the features of the first multi-modal signal.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: February 21, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Dana Segev, Yoav Schechner, Michael Elad
  • Manufacturing and applications of adhesive materials
    Patent number: 9572908
    Abstract: A novel method of manufacturing and applications of a composition of matter comprising of a cross-linked form of a polysaccharide, at least one cross-linking agent comprised of divalent ions for effecting said cross-linked form of said polysaccharide, and at least one synthetically prepared phloroglucinol compound selected from the group comprising of phloroglucinol, a derivative of phloroglucinol, and a polymer synthetically prepared from phloroglucinol or a derivative of phloroglucinol, as an adhesive in procedures for reattaching or repairing body parts or components thereof, such as tissue, of (human or animal) subjects, especially under wet conditions, for example, involving adhesion of wet surfaces.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: February 21, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Havazelet Bianco-Peled, Ronit Biton
  • System and method for energy conversion by pressure wave and/or phase-exchange
    Patent number: 9562522
    Abstract: System and method for converting energy; the system comprising: an acoustic resonator; a phase-exchange device configured for forming across a section of said resonator a concentration gradient of a first substance in a gaseous medium contained by said resonator, to thereby generate a pressure wave within said resonator; and a conversion device for converting mechanical energy constituted by said pressure wave to non-mechanical energy.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: February 7, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yehuda Agnon, Guy Ramon, Carlos Dosoretz
  • CONTROL OF INTERACTIONS WITHIN VIRTUAL ENVIRONMENTS
    Publication number: 20170028302
    Abstract: A method for restricting the number of consequential interactions to further virtual objects having a relationship with a first virtual object, resulting from an interaction with said first virtual object. The method comprises: defining a maximum number of consequential interactions, counting consequential interactions, and stopping further interaction when the maximum number of consequential interactions is reached.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Gershon ELBER, Orit SHAKED, Oded SHMUELI
  • Robotic mechanism with two degrees of freedom
    Patent number: 9550299
    Abstract: A robotic link mechanism comprising a pair of base elements connected by a passive flexible joint, such that flexure of the joint changes the mutual orientation of the base elements. A pair of obliquely truncated cylinders are confined between the base elements such that the obliquely formed end surfaces of the cylinders can rotate in sliding contact with each other, and the other end of each cylinder can rotate in sliding contact with its associated base element. Driving motors are attached to the base elements, each one controlled to rotate the cylinder associated with that base element, such that rotation of at least one of the cylinders causes the base elements to undergo change in their mutual orientation. The mechanism thus has a backbone composed of the passive flexible joint, which is supported and actuated by the oblique truncated cylindrical structure that serves as an active exoskeleton.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: January 24, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Alon Wolf, Oded Salomon
  • Volatile organic compounds as diagnostic markers for various types of cancer
    Patent number: 9551712
    Abstract: The present invention provides sets of VOCs for breath analysis. Methods of use thereof in diagnosing, monitoring or prognosing breast cancer, head and neck cancer, prostate cancer or colon cancer are disclosed.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: January 24, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Hossam Haick, Meggie Hakim
  • Method and system for transmitting light
    Patent number: 9544065
    Abstract: A method of transmitting light is disclosed. The method comprises: transmitting a first light pulse into a medium to form in the medium a filamented region that is capable of guiding light, and transmitting a second light into the filamented region, wherein the second light is a pulsed light or continues wave light, and wherein the second light is transmitted at least 10 nanoseconds after the first light pulse.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: January 10, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Mordechai Segev, Oren Cohen, Liad Levi
  • Management and recovery of distributed storage of replicas
    Patent number: 9535802
    Abstract: A method of data replica recovery that is based on separate storage drives connected to a network where each storage drive has a storage space divided to contiguous storage segments and is electronically connected to a memory support component via a connection. Pairs of replicas, each of one of a plurality of data units, are stored in a manner that allows, in response to detection of a storage failure in one storage drive, to create replacement replicas in the memory support components of the other storage drives to assure that two replicas of each data unit can be found in the storage system.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: January 3, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Dan Tsafrir, Eitan Rosenfeld
  • Stent for restenosis prevention
    Patent number: 9510959
    Abstract: A device for use in reducing or preventing the occurrence of restenosis following procedures such as PTCA, in which a stent is used to hold a bodily lumen open. The device comprises a two layered stent, one lying within the other. Both stent layers have an open weave structure, such that they can expand to the correct dimensions after implantation. The outer stent layer is static and grips the inner wall of the lumen in which it is deployed in the usual manner. The inner layer stent is constructed such that it can be vibrated relative to the outer static stent layer. The inner layer stent may be made of a material which can be vibrated from an external source, such as a ferromagnetic material. This vibration prevents restenosis of the treated lumen. Alternatively, a vibrator, such as a piezoelectric device, can be installed on the inner stent layer.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: December 6, 2016
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Moshe Shoham, Amit Reches, Lucy Leshansky, Michael Groskop, Shachar Millis, Yishai Pentanovich
  • Diamond-coated substrates
    Patent number: 9487856
    Abstract: A composite structure, comprising a cemented carbide substrate (e.g., tungsten carbide substrate cemented with cobalt, such as WC—Co), a thin interlayer disposed over the substrate, and a contiguous diamond film disposed over the interlayer, as well as processes of preparing such a composite structure and uses thereof, are provided. The composite structure is characterized by at least one of a substrate binder concentration of at least 2 percents by weight, interlayer thickness less than 20 microns, a homogenous interlayer made substantially of crystalline chromium nitride, a low to null binder concentration in the interlayer, and a high co-adhesion of the diamond film to the interlayer and the interlayer to the substrate.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: November 8, 2016
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Alon Hoffman
  • MEDIA FOR CULTURING STEM CELLS
    Publication number: 20160319241
    Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
    Type: Application
    Filed: July 14, 2016
    Publication date: November 3, 2016
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
  • MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR
    Publication number: 20160312180
    Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
    Type: Application
    Filed: July 4, 2016
    Publication date: October 27, 2016
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
  • NOVEL ANTIMICROBIAL AGENTS
    Publication number: 20160303246
    Abstract: A novel class of antimicrobial polymeric agents, which include a plurality of positively charged amino acid residues and at least one omega-amino-fatty acid residue linking therebetween, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 20, 2016
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Amram MOR, Inna RADZISHEVSKY