Abstract: A theranostic composition and method for determining the cell-specific potency of drugs is provided. Further, compositions and methods useful for studying the therapeutic profile of one or more drugs within a cell microenvironment, including but not limited to a tumor, are provided.
Type:
Grant
Filed:
August 13, 2015
Date of Patent:
October 27, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: A microchannel-membrane device comprises a microchannel extending through at least one electrode, the microchannel having a predetermined depth; an ionic permselective medium, such as a membrane, across the microchannel between the electrodes; and a heater, or array of heaters, embedded below the microchannel on at least one side of the permselective membrane. The heaters can be either prefabricated or dynamically patterned using laser illumination with/without photoconductive coating. The heaters are on the depletion side of the membrane and induce a vortex which limits the growth of the diffusion area. Operation of the heaters allows for controlled positioning of the end of the diffusion area and with it also the position of the preconcentrated molecule plug.
Type:
Application
Filed:
July 2, 2020
Publication date:
October 22, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: Methods for modeling a 3-dimensional (3D) object, comprising operating at least one hardware processor for, receiving a 3D volumetric model of the object, receiving a 3D model of a tile, paving multiple ones of the tiles in the interior domain of the 3D volumetric model, and providing a 3D filled model of the filled inner volume of the 3D volumetric model are provided. Computer program products and systems for doing same are also provided.
Type:
Grant
Filed:
March 13, 2018
Date of Patent:
October 20, 2020
Assignee:
Technion Research & Development Foundation Limited
Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.
Type:
Grant
Filed:
May 19, 2015
Date of Patent:
October 20, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: Low-density thermoplastic expandable microspheres are disclosed. Various low-density structures, in particular, sandwich panels, based on foam prepared from the low-density microspheres, are also disclosed. Process of preparing low-density polymeric microspheres, per se, and the corresponding low-density structures, based on the microsphere foam, are also disclosed.
Type:
Grant
Filed:
November 11, 2015
Date of Patent:
October 20, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION
Abstract: Provided is an electrode including conductive particles, which sediment under gravitational force and a liquid fluidizing medium flowing through the electrode, in which the conductive particles are suspended and optionally further including conductive particles, which do not sediment under gravitational force when the fluidizing medium flows in the electrode. Further provided are electrochemical devices and energy storage systems including the electrode.
Type:
Grant
Filed:
July 10, 2017
Date of Patent:
October 13, 2020
Assignee:
Technion Research and Development Foundation Limited
Inventors:
Hagai Cohen, Ilya Loiferman, Matthew Suss
Abstract: There is provided a method of design and analysis of a geometric object comprising: receiving an initial definition of the geometric object in a coordinate system; generating a volumetric model according to the initial definition, the volumetric model comprises: volumetric cells each represented by one or more multivariate of three variables or more functions, and intra object general border surfaces in general orientation each defines topological adjacency between at least two of said plurality of volumetric cells.
Type:
Application
Filed:
June 18, 2020
Publication date:
October 8, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.
Type:
Application
Filed:
October 24, 2018
Publication date:
October 1, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: Provided is a novel Nanofiltration-DiaNanofiltration (NF-DiaNF) system and method for extracting divalent ions from saline water (e.g., seawater) to produce solutions rich in divalent ions (in particular Mg2+, Ca2+ and SO42?), while minimizing the concentrations of undesirable species (e.g., Cl?, Br?, B and Na+). The solutions may be added to water (e.g., desalinated, soft, drinking or irrigation water) to enrich the water with divalent ions, thereby improving its quality.
Type:
Application
Filed:
March 30, 2017
Publication date:
September 24, 2020
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Ori LAHAV, Liat BIRNHACK, Paz NATIV, Oded NIR
Abstract: Isolated peptides and compositions comprising same are provided. Further, methods for targeting mitochondria in a cell, methods for assessing mitochondrial function in a cell and methods for diagnosing mitochondria associated diseases are provided.
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
September 22, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Arnon Henn, Boris Shneyer, Andreas Reichert
Abstract: A sensing device that may include a substrate; a single-ended SPAD; first electrical components; second electrical components; and capacitors. The SPAD, the first electrical components and the second electrical components are formed on the substrate. The SPAD and the first electrical components belong to a high voltage domain of the sensing device. The high voltage domain is configured to receive a high supply voltage that exceeds a breakdown voltage of the SPAD. The second electrical components belong to a low voltage domain of the sensing device. The capacitors are coupled between the low voltage domain and the high voltage domain. The first electrical components and the second electrical components belong to an electrical circuit that is configured to perform quenching of the SPAD.
Type:
Application
Filed:
February 11, 2020
Publication date:
September 10, 2020
Applicant:
Technion research and development foundation
Abstract: A gas sensing device that includes a (a) gas reactive element that has a gas dependent temperature parameter; and (b) a semiconductor temperature sensing element that is spaced apart from the gas reactive element and is configured to sense radiation emitted from the gas reactive element and generate detection signals that are responsive to a temperature of the gas reactive element; wherein the gas reactive element and the semiconductor temperature sensing element are of microscopic scale.
Type:
Grant
Filed:
August 1, 2016
Date of Patent:
September 8, 2020
Assignees:
TODOS TECHNOLOGIES LTD., TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: The present invention relates to a process for the selective removal of nitrates from ground water using a hybrid nanofiltration (NF)—reverse osmosis (RO) filtration system. The process generates product water that is low in nitrate and can be used for drinking, irrigation and other purposes, as well as waste water that is relatively low in salinity and can be safely discarded to sewage systems and recycled, e.g., for irrigation purposes.
Type:
Grant
Filed:
May 3, 2016
Date of Patent:
September 8, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Michal Green, Ori Lahav, Razi Epsztein, Oded Nir
Abstract: A compositions-of-matter in the form of HIPE-templated hydrogels, comprising a crosslinked polymer of zwitterionic monomers, which exhibit unusual antipolyelectrolyte characteristics, dual pH-, and temperature-responsiveness, as well as processes of obtaining the same and using the same.
Type:
Application
Filed:
October 30, 2018
Publication date:
September 3, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: An analog to digital converter comprises an input for receiving an analog input signal; a plurality of outputs for outputting parallel bits of a digital signal that represents said analog input signal; and a neural network layer providing connections between each of said outputs respectively, each connection having an adjustable weighting. The synapses of the neural networks may be memristors and training may use online gradient descent.
Type:
Application
Filed:
May 14, 2020
Publication date:
August 27, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.
Type:
Application
Filed:
May 11, 2020
Publication date:
August 27, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.
Type:
Application
Filed:
September 6, 2018
Publication date:
August 20, 2020
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Hadas ZISO, David ZARROUK, Moshe SHOHAM, Menashe ZAAROOR
Abstract: The present invention provides a photo-electrochemical (PEC) cell electrode having a surface portion and a bulk portion composed of the same material, wherein at least one of the bulk portion and the surface portion of the electrode is doped with at least one dopant, and wherein said doping is non-uniform along an axis perpendicular to the surface portion. The non-uniform doping can include different concentrations and/or types of the dopants in the bulk portion and in the surface portion of the electrode. There is further provided a PEC cell comprising said electrode and an electrolyte, wherein the surface portion of the electrode faces the electrolyte.
Type:
Grant
Filed:
January 5, 2016
Date of Patent:
August 18, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: A method for treating cancer and/or preventing or reducing metastasis or treating angiogenesis related disorders comprising the step of administering IL-31 or peptide which is at least about 70%, homologous to the IL-31 sequence as set forth in SEQ ID No. 1.
Type:
Grant
Filed:
March 26, 2018
Date of Patent:
August 18, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Ella Fremder, Ami Aronheim, Yuval Shaked