Abstract: The present invention relates to a method for preparing an expression vector encoding a well-tolerated and highly specific tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences within the long terminal repeat (LTR) of proviral DNA of a plurality of retrovirus strains which may be inserted into the genome of a host cell, as well as to the obtained expression vector, cells transfected with these, expressed recombinase and pharmaceutical compositions comprising the expression vector, cells and/or recombinase. Pharmaceutical compositions are useful, e.g., in treatment and/or prevention of retrovirus infection, in particular, HIV infection. In particular, the invention relates to well-tolerated and highly specific tailored recombinases capable of combining asymmetric target sequences in a more than 90% of HIV-strains, thereby excising the HIV-1 sequences, and expression vectors encoding them.

Abstract: The invention relates to a device (100; 200; 300; 400) for analyzing biological substances in a test solution, comprising a test substrate (101; 203; 303; 401) which is transparent at least in part, having a test region (107a, 108a, 109a, 110a; 211; 411) for receiving the test solution, a plurality of electrodes (111, 106; 201, 202; 301, 302; 402, 403) which are arranged on the test substrate (101; 203; 303; 401) and extend into the test region (107a, 108a, 109a, 110a; 211; 411), wherein in each case, at least one portion of the electrodes (111, 106; 201, 202; 301, 302; 402, 403) is made of a transparent material.

Abstract: The invention relates to a method (1) for designing and dimensioning a new part (2) of a motor vehicle (3). All of the motor vehicles (5) of a motor vehicle fleet (6) have a reference part (4) with an identical structure, and the reference parts (4) and the new part (2) are of the same component type. Load spectra and damage levels of the reference parts of all the motor vehicles (5) of the motor vehicle fleet (6) are continuously ascertained on the basis of sensor and vehicle state information available in each motor vehicle (5) using specified algorithms. The load spectra and damage levels are stored in a central database (9). A reference stress on a component of the component type is ascertained regularly on the basis of the load spectra and damage levels provided in the central database (9) at a specific point in time for the reference parts (4) of all of the motor vehicles (5) of the vehicle fleet (6). The new part (2) is designed and dimensioned while taking into consideration the reference stress.

Abstract: The present invention relates to a hydrophobic cement-based material composition comprising a bacterial biofilm, or at least one hydrophobicity-conveying component of a bacterial biofilm, an additive for a cement-based material composition comprising a bacterial biofilm or at least one hydrophobicity-conveying component of a bacterial biofilm and the use of such biofilm or component therefore for decreasing the wettability of a cement-based material.

Abstract: Positioning structures in at least one indentation present on a or in a support, wherein said indentation is an indentation having a diameter in the nanometer range, makes it possible to position the structure in the indentation substantially centrally with defined orientation. A support having at least one indentation, wherein the indentation has a size in the nanometer range, includes a predetermined structure which is arranged substantially centrally within said indentation and which optionally has a functional unit diametrically opposite to the side pointing to the bottom surface. The arrangement is especially suitable for single molecule analysis and, here especially, for single molecule sequencing and other high-throughput methods.

Abstract: The disclosure relates to a manually operable tactile input/output device for a data processing system, in particular a tactile computer mouse, which is configured with a housing and a plurality of actuators in operative connection with the housing and in which the actuators are arranged and jointly controlled in the housing to cause at least temporarily a tactile perception by a user in manual contact with the housing, by which simultaneously at least two and in particular all five tactile perception dimensions of microscopic roughness, macroscopic roughness, friction, hardness and heat are simulated. Furthermore, the disclosure relates to an operating method for a manually operable tactile input/output device and a data processing system.

Abstract: The present invention relates to a new fusion gene, KIAA0368-ROBO2, and the use thereof in methods for diagnosing cancer, in particular a glioblastoma in a subject, wherein the presence and/or expression of said fusion gene in a sample derived from said subject is determined, and wherein the presence or expression of said fusion gene is attributed to the presence of a glioblastoma in said patient. Also methods for the identification of compounds useful in the medical intervention of glioma, in particular glioblastoma, are provided. Accordingly, the present invention also relates to diagnostic means as well as to the medical intervention in cancer, like glioma and in particular glioblastoma. The invention further relates to the use of the fusion gene for diagnosing and/monitoring of tumor progression, preferably of the progression of brain tumors, as well as for the subclassification of brain tumors and other proliferative diseases.

Abstract: A method for manufacturing metal structures for the electrical connection of components comprises the following steps: depositing an auxiliary layer on a substrate; structuring the auxiliary layer in a manner such that the substrate is exposed at least one environment which is envisaged for the metal structures; depositing a galvanic starting layer on the structured auxiliary layer; depositing a lithography layer on the galvanic starting layer and structuring the lithography layer in a manner such that the galvanic starting layer is exposed at least one location envisaged for the metal structure; galvanically depositing the at least one metal structure at the at least one exposed location; removing the structured auxiliary layer. An electronic component is also described.

Abstract: This invention relates to a biogenic substance production process wherein a) at least one starting material has b) at least one enzyme added to it and the product resulting from b) has c) at least one liver cell added to it, and d) at least one biogenic substance is isolated.

Abstract: A method and a device for discharging fertilizer for agricultural cultivated plants are disclosed. According to the invention, the required quantity of fertilizer is determined depending on the current nutrient uptake (nutrient status), optimum nutrient uptake (nutrient requirement) by the fertilizing deadline, and optimum nutrient uptake (nutrient requirement by the next fertilizing deadline, wherein other influencing factors are taken into consideration via a correction factor DIMA.

Abstract: A device (1) for producing a moulding of surface properties comprises a housing (3) having a pressure plunger (4) mounted on or in the housing (3), which can be moved and can be pressed on a surface (2), which pressure plunger has a blank carrier (5) comprising a pressure surface (6) which can be pressed on the surface (2), on which pressure surface a moulding blank (7) comprising a moulding layer (9) made of a curable material can be secured in a detachable manner. The device further comprises a curing device (12) arranged on or in housing (3), with which the curable material of the moulding blank (7) can be cured while being pressed on the surface (2).

Abstract: The invention relates to methods for coating a substrate with at least one monolayer of self-assembling proteins, using stabilized aqueous solutions with self-assembling proteins, and also to substrates obtainable as a result. Methods for stabilizing solutions with self-assembling proteins, and the stabilized solutions obtainable therefrom, are likewise provided by the invention. According to the coating method, at least one monolayer of a self-assembling protein is produced on a substrate by first providing a stabilized aqueous solution which comprises at least one self-assembling protein.

Abstract: Device and method for generating brief strong current pulses in a coil for generating magnetic field pulses which according to the electromagnetic induction principle induce stimulation currents in the body tissue triggering an action potential of the nerve and/or muscle cells, where the coil is positionable close to the body tissue to be stimulated so that its magnetic field passes through the body tissue, and where the device comprises a power generating unit that can generate a freely selectable temporal course of the current through the coil during the current pulse.

Abstract: A static Fourier transform spectrometer is disclosed that includes a beam splitter, a mirror device, and a collection optic. The beam splitter divides an input light beam into a first arm and a second arm, wherein the first arm is reflected by the beam splitter and the second arm passes through the beam splitter, wherein the first arm extends to the converging optical unit without deflection after reflection at the mirror device, wherein the second arm extends to the converging optical unit without deflection after passing through the beam splitter, and wherein the collection optic merges the first arm and the second arm for interference.

Abstract: The invention relates to a system and a method for haptic interaction with virtual objects. The system of the invention is based on the idea that, for the haptic representation of any virtual three-dimensional object—synchronized with the visual representation—only the tangible haptic characteristics of the surface area of the object at the collision point or the area of contact are important. The haptic display system (morphling) of the invention that displays these characteristics comprises in principle three functional groups, which operate in synchronism with one another and with a visual subsystem. The individual subsystems can be operated statically or dynamically. In dynamic operation, users can change the position and/or shape, for example, of the tactile display by touching it. With regard to the real-time representation of the three-dimensional data of the user, at least the body part that is interacting with the object, e.g.

Abstract: The invention relates to methods for producing hydrophobized, doped or non-doped mixed metal oxide nanoparticles or doped metal oxide nanoparticles by flame spray pyrolysis, wherein a combustible precursor solution A, containing at least two metal alkyloates of general formula Me(OOC—R)x with differing metals Me, or a combustible precursor solution B containing at least one metal alkyloate of general formula Me(OOC—R)x and at least one metal salt containing a metal ion Me and at least one metal salt containing a metal ion Me, with Me selected from metal ions of the subgroups of the periodic system of the elements, with R=alkyl or aryl, wherein the alkyl chain is branched or straight, and wherein x corresponds to the oxidation step of the metal ion, is used in stoichiometric excess relative to a quantity of oxygen, and wherein a combustion ratio c of 3.5 bis 0.4 is established, and hydrophobized nanoparticles and the use thereof.

Abstract: The present invention relates to a computer-implemented method and a system for determining co-occurrences in at least one graph with n vertices and E edges, wherein each edge is defined by a pair of vertices, the method comprising: storing a binary adjacency matrix representing a first graph in a memory; performing a calculation step for the first graph, wherein the calculation step comprises: loading a block of at most K consecutive rows of the binary adjacency matrix from the memory and storing each row into one of K caches; streaming each of the subsequent uncached rows of the binary adjacency matrix from the memory; reading pairs of rows comprising a streamed row and each one of the cached rows; computing the logical conjunction between each couple of elements of the rows at the same position in the rows for each read pair of rows; and adding the results of the logical conjunction for all the couples of elements in each read pair by means of one-bit adders to obtain the co-occurrence, wherein the calcula

Abstract: The invention relates to a heavy-wire bond arrangement, having a substrate (2), a heavy wire (1) and a high-voltage heavy-wire bond connection, in which an end bond section (4) of the heavy wire (1), which extends towards the end (7) of the heavy wire (1), is bonded to the substrate (2), such that in the area of the bond section (4) a bond contact (5) between the heavy wire (1) and the substrate (2) is formed, the heavy wire (1) having a tapering section (6) which adjoins the end of the wire (7) and in which the wire cross-section tapers towards the end of the wire (7). The application additionally relates to a method for producing a heavy-wire bond arrangement.

Abstract: The invention relates to the use of sulfonic acid esters of the following Formula 1 and/or Formula 2, individually or as a mixture of more than one thereof, as regulators in polymerization reactions of radically polymerizable, ethylenically unsaturated monomers: wherein A in each case independently is selected from H, CN, linear, branched or cyclic aliphatic or aromatic C1-C30 hydrocarbon residues; X in each case independently is —COO— or —CON(R1)—, wherein the binding to A occurs via O or N, or is absent if A is an aromatic hydrocarbon residue or CN; B in each case independently is selected from linear, branched or cyclic aliphatic or aromatic C1-C30 hydrocarbon residues; R1 in each case independently is selected from hydrogen and linear, branched or cyclic aliphatic or aromatic C1-C10 hydrocarbon residues, which are optionally substituted with one or more OH groups, wherein the aliphatic hydrocarbon residues are optionally interrupted by one or more oxygen atoms; and n in each case independently is an

Abstract: An optoelectronic component including an optical waveguide integrated into a plane of the component. The optical waveguide configured to guide optical radiation in the plane. The component including a coupling element connected to the waveguide and coupling optical radiation into the waveguide along the main coupling path. The degree of coupling efficiency of the coupling element is less than one in respect to the main coupling path. The coupling element outputs optical loss radiation along a secondary coupling path. The optical loss radiation is proportional to the radiation transferred along the main coupling path. The optoelectronic component includes a detector connected to the coupling element that registers the optical loss radiation and produces a detector signal. The optoelectronic component includes a control unit configured to influence at least one operating variable of the optoelectronic component based on the detector signal.