Abstract: An optical diode (1) comprising an optical wave guide for guiding light, preferably of a light mode, with a vacuum wavelength ?0, wherein the optical wave guide has a wave guide core (2, 3, 14) with a first index of refraction (n1), and the wave guide core (2, 3, 14) is surrounded by at least one second optical medium which has at least one second index of refraction (n2), wherein n1>n2 applies, wherein the wave guide core (2, 3, 14) has at least in sections a smallest lateral dimension (7) which is a smallest dimension of a cross section (6) perpendicular to a propagation direction (5) of the light in the wave guide core (2, 3, 14), wherein the smallest lateral dimension (7) is greater than or equal to ?0/(5*n1) and less than or equal to 20*?0/n1, wherein the optical diode (1) additionally comprises at least one absorber element (10, 11, 15, 16) which is arranged in a near field, wherein the near field consists of the electromagnetic field of the light of the vacuum wavelength ?0 in the wave guide core (2

Abstract: The present invention relates to an inhibitor of Hairy and Enhancer of Split 3 (Hes3) or for use in treating a tumor. The invention further relates to an in-vitro method for diagnosing a tumor, comprising determining the amount of Hes3 protein in a cerebrospinal fluid (CSF)-derived sample obtained from a subject, wherein an increased amount of Hes3 protein is indicative of the presence of a tumor.

Abstract: The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target nucleic acid sequence (targetss) into a repetitive cluster of double-stranded target nucleic acid sequences (targetds), and subsequently cloning the construct into a vector (aptagene vector). The aptagene vector is transformed into host cells for replication of the aptagene and isolated in order to optain single-stranded target sequences (targetss). The invention also relates to single-stranded nucleic acids, produced by a method of the invention.

Abstract: An optoelectronic component including an optical waveguide, an integrated optical resonator, in which the waveguide or at least a portion of the waveguide is arranged, and a heat source which can increase the temperature of the resonator during operation. A web region adjoins laterally the waveguide when viewed in the longitudinal direction of the waveguide. The web region forms a jacket portion of the waveguide and has a smaller thickness than the waveguide. The heat source is thermally connected to the waveguide by means of the web region.

Abstract: A method for manufacturing a three-dimensional object comprises making a material avail-able in a material volume and forming a three-dimensional object made of the material by means of selectively irradiating the material with ultrasound.

Abstract: Computer implemented method for rendering an image of a three-dimensional scene on an image plane by encoding at least a luminosity in the image plane by a luminosity function. The value of the luminosity can be computed at substantially each point of the image plane by using a set of stored input data describing the scene. The method includes constructing the luminosity function as equivalent to a first linear combination involving the functions of a first set of functions, and computing at least the value of the coefficients of the first linear combination, by solving a first linear system, obtained by using at least the functions of the first linear combination, at least a subset of the first subset of the image plane, and the luminosity at the points of said subset. The method further includes storing the value of the coefficients of the first linear combination and at least the information needed to associate each coefficient to the function multiplying said coefficient in the first linear combination.

Abstract: A reconfigurable field effect transistor (RFET) includes a nanowire, wherein the nanowire comprises two Schottky contacts, as well as two gate contacts partially enclosing the nanowire in cross section. An integrated circuit can be produced therefrom. The aim of producing CMOS circuits with enhanced functionality and a more compact design is achieved in that the nanowire is divided along the cross section thereof into two nanowire parts, wherein each nanowire part comprises a respective Schottky contact and a respective gate contact, and the two nanowire parts are connected electrically to one another via a common substrate and stand vertically on the substrate. In a nanowire-parts-array, between the nanowire parts, a respective top-gate contact and/or back-gate contact can be formed in a substrate defining a substrate plane.

Abstract: The present disclosure presents a visuo-haptic sensor, which is based on a passive, deformable element whose deformation is observed by a camera. In particular, the improved simplified sensor may determine the force and/or torque applied to a point of the sensor in multiple spatial dimensions.

Abstract: A method a described which includes depositing a first component of a multicomponent system by means of an inkjet process, and depositing a second component of the multicomponent system by means of an inkjet process.

Abstract: The present invention relates to nanocrystalline cellulose, an efficient way of its preparation and to uses of such nanocrystalline cellulose. The present invention also relates to porous metal oxides having a chiral nematic structure which are prepared using nanocrystalline cellulose.

Abstract: A method and a device for processing a light-polymerizable material (5, 55) for building up an object (27) in layers, using a lithography based generative manufacture having a construction platform (12) for building up the object (27), a projecting exposure unit (10, 60) that can be controlled for locally selected exposing of a surface on the construction platform (12, 62) to an intensity pattern having a prescribed shape, and a control unit (11, 61) prepared for polymerizing overlapping layers (28) on the construction platform (12, 62) in successive exposure steps, each having a prescribed geometry, by controlling the projecting exposure unit (10, 60), in order to thus successively build up the object (27) in the desired shape, said shape resulting from the sequence of layer geometries.

Abstract: The application relates to a method for determining a bonding connection (1) in a component arrangement (2), wherein the method has the following steps: producing a bonding connection (1) between a bonding section (3) of a bonding wire (4) and a metallic contact point (5), structuring a top-side surface of the bonding wire (4) in the region of the bonding section (3) and determining the bonding connection (1), wherein in this case a test voltage is applied to the bonding wire (4) and the bonding connection (1) so that the bonding connection (1) heats up owing to the current flow, generating a thermogram for the heated bonding connection (1) and determining whether the bonding connection (1) has been produced correctly by evaluating the thermogram. Furthermore, the application relates to a test apparatus for determining a bonding connection (1) in a component arrangement (2).

Abstract: With respect to ceramic filters and filter systems for continuous metal melt filtration, to be able to counter high throughputs of steel melt and also the limitations of filter capacities during continuous casting, an alternative technological approach involves the use of novel, replaceable, and/or rotatable filter bodies at positions in the distributor channel. In some cases, the replaceable and/or rotatable filter bodies may be inserted into the distributor channel for 10 seconds to 30 minutes before being replaced. The filter bodies may be configured as an open-celled foam ceramic or a honeycomb body or a spaghetti filter and serve as a filter geometry of the replaceable and/or rotatable filter bodies in the distributor channel.

Abstract: A heat storage system using sand as a solid heat storage medium has a fluidized bed heat exchanger (3) arranged between and separated from a storage tank (1) for cold sand and a storage tank (2) for hot sand by weirs (4, 5). The heat exchanger (3) is divided into a plurality of chambers (7) by weirs (6). The weirs (4, 5, 6) are arranged as a combination of overflow and underflow weirs. Fluidized sand is produced in the chambers (7) by a blower (14) positioned underneath the heat exchanger (3). Heat is transferred from a heat source to the sand fluidized and from the fluidized sand to a heat transport medium by transferring mechanisms (8, 9) in the chambers (7). The sand is redirected in a horizontal direction by horizontally acting blowers and/or installations (12) projecting into a respective chamber from a side.

Abstract: Various embodiments may relate to a component arrangement, including a carrier, wherein at least one electronic component is formed in the carrier, a first metallization layer over the carrier, wherein the first metallization layer has a first metallic coupling structure, which is electrically coupled to the at least one electronic component, a second metallization layer over the first metallization layer, wherein the second metallization layer has a second metallic coupling structure, wherein the first metallic coupling structure is coupled to the second metallic coupling structure by means of at least one via, and a plurality of additional vias, which extend at least between the first metallization layer and the second metallization layer and are electrically conductively coupled to one another in such a way that they form a coil, which has a coil region which is at an angle to the main processing surface of the carrier.

Abstract: An optoelectronic oscillator for generating an optical and/or electric pulse comb, comprising a monolithically integrated passively mode-coupled semiconductor laser and an optical feedback loop which guides a part of the optical radiation of the semiconductor laser and feeds said part back into the semiconductor laser as feedback pulses. Without the influence of the feedback pulses, the semiconductor laser would emit comb-like optical pulses, hereafter referred to as primary pulses, and in the event of an influence, emits comb-like output pulses which have been influenced by the feedback pulses, said output pulses having a lower temporal jitter or less phase noise than the primary pulses. The feedback loop is damped between 27.5 and 37.5 dB, and the time lag of the feedback loop is selected such that each feedback pulse is incident within the temporal half-value width of each subsequent primary pulse.

Abstract: The present invention relates to glypican-3-specific T-cell receptors. The present invention further relates to soluble TCR constructs, chimeric TCRs, bi-specific antibodies, nucleic acids, expression constructs and cells comprising said TCRs or TCR constructs. The present invention further relates to the use of the TCR or the soluble TCR constructs or chimeric TCRs or bi-specific antibodies as a medicament, preferably in the detection, diagnosis, prognosis, prevention and/or treatment of liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The present invention further relates to methods of detecting, diagnosing, prognosing, preventing and/or treating liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The present invention further relates to peptides comprising glypican-3 epitope(s) and respective nucleic acids encoding them, antibodies and compositions as well as their use as (peptide) vaccines.

Abstract: A Li—S battery including a cathode and an anode and at least one of a lithium-containing liquid electrolyte, gel electrolyte, and solid electrolyte disposed between the cathode and the anode. The cathode includes at least one of an electrically conductive carbon material, an electrochemically active cathode material that comprises sulphur, and at least partially fibrillar plastic material. The anode includes a conducting substrate which is coated at least in regions with at least one of silicon and tin. A method for operation thereof.

Abstract: The invention relates to a method for the construction of a shaped body from photopolymerizable material by using lithography-based generative production, in which a layer of liquid photopolymerizable material is defined on a production platform, and is polymerized in an exposure region having a predetermined contour, a further layer of photopolymerizable material is defined, the layer defined last is polymerized in an exposure region having a predetermined contour for the layer defined last, and the latter two steps are repeated until a shaped body having a predetermined shape has been formed by the sequence of cured layers with contours predetermined layer by layer, each exposure in an exposure region having a predetermined contour being carried out by controlled activation of individual exposure elements in a two-dimensional array of exposure elements, each exposure element being assigned an image element, wherein the exposure of the exposure region is carried out by a common light source and by a two-dime

Abstract: The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and polynucleotides for use in treating diseases or disorders of energy homeostasis. Said polypeptides, polynucleotides and pharmaceutical compositions may be administered locally, in particular locally into the visceral adipose tissue. Another aspect of the invention relates to a cosmetic product and the use of said cosmetic product for reducing body weight, in particular for reducing abdominal adipose tissue.