Patents Assigned to The Regents of the University of Colorado, a body corporate
  • Hydraulically Amplified Self-Healing Electrostatic (HASEL) Pumps
    Publication number: 20220316466
    Abstract: A pumping system includes a conduit with an inlet region and an outlet region and a first pump coupled with the conduit between the inlet region and the outlet region. The first pump includes a first actuator chamber configured to house at least a first actuator, a first pump chamber aligned along a longitudinal axis of the conduit, wherein the first pump chamber is in fluid communication with the inlet region and the outlet region, and a first flexible diaphragm separating the first actuator chamber from the first pump chamber. Methods for operating the pumping system are also disclosed.
    Type: Application
    Filed: August 14, 2020
    Publication date: October 6, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Shane Karl Mitchell, Eric Lucas Acome, Christoph Matthias Keplinger
  • Quantum plasmon fluctuation devices
    Patent number: 11463026
    Abstract: Described herein are devices incorporating plasmon Casimir cavities, which modify the distribution of allowable plasmon modes within the cavities. The plasmon Casimir cavities can drive charge carriers from or to an electronic device adjoining the plasmon Casimir cavity by modifying the distribution of zero-point energy-driven plasmons on one side of the electronic device to be different from the distribution of zero-point energy-driven plasmons on the other side of the electronic device. The electronic device can exhibit a structure that permits transport or capture of carriers in very short time intervals, such as in 1 picosecond or less.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Garret Moddel
  • SYSTEMS FOR DRIVING THE GENERATION OF PRODUCTS USING QUANTUM VACUUM FLUCTUATIONS
    Publication number: 20220311360
    Abstract: Described herein are systems incorporating a Casimir cavity, such as an optical Casimir cavity or a plasmon Casimir cavity. The Casimir cavity modifies the zero-point energy density therein as compared to outside of the Casimir cavity. The Casimir cavities are paired in the disclosed systems with product generating devices and the difference in zero-point energy densities is used to directly drive the generation of products, such as chemical reaction products or emitted light.
    Type: Application
    Filed: January 31, 2022
    Publication date: September 29, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Garret Moddel
  • Compositions and methods for preventing and treating radiation-induced bystander effects caused by radiation or radiotherapy
    Patent number: 11452709
    Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: September 27, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, TSINGHUA UNIVERSITY, CHANG GUNG UNIVERSITY
    Inventors: Ding Xue, Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jau-Song Yu, Jeng-Ting Chen
  • Optically pumped magnetometers for communication reception
    Patent number: 11454682
    Abstract: Various embodiments of the present technology use low-frequency magnetic signals for communication and location applications. Compared to the case of traditionally used radio-frequency electromagnetic signals, their advantage in the presence of strong signal attenuation is in the extended spatial range. Some embodiments use an optically pumped atomic magnetometer operated as a sensor to achieve high detection sensitivity. The spatial range can be extended to hundreds of meters when noise is suppressed by the use of the available sensor sensitivity. In some embodiments, a one-channel spread-spectrum signal processing technique can be used to eliminate the systematic fluctuations coming from power grid (or another source) harmonics and reduce the ambient noise by averaging uncorrelated fluctuations from the environment.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 27, 2022
    Assignees: The Regents of the University of Colorado, a body corporate, Government of the United States of America, as represented by the Secretary of Commerce
    Inventors: Vladislav Gerginov, Fabio da Silva
  • METHODS AND COMPOSITIONS FOR INHIBITING FREEZE-THAW DAMAGE IN CONCRETE AND CEMENT PASTE
    Publication number: 20220298075
    Abstract: Cement paste compositions, concrete compositions, and methods of forming the cement paste compositions and concrete compositions are disclosed. Exemplary cement paste compositions and concrete compositions include a water-soluble additive that is dissolved and is configured to perform one or more of ice recrystallization inhibition and dynamic ice shaping when the cement composition is exposed to temperatures less than or equal to a freezing temperature of water.
    Type: Application
    Filed: June 17, 2020
    Publication date: September 22, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Wilfred V. Srubar, III, Shane Frazier, Elizabeth A. Delesky, Jaqueline D. Wallat-Pullara
  • Eyeglass Frames For Treatment Of Dry Eye Syndrome And Corresponding 3D Printing Systems And Methods
    Publication number: 20220291527
    Abstract: Various embodiments of the present technology generally relate to treatment for dry eyes. More specifically, some embodiments of the present technology relate to eyeglass frames for treatment of dry eye syndrome and corresponding three-dimensional printing systems and methods. In some embodiments an eyewear apparatus includes a frame with a seal configured to engage with the skin of the wearer around a majority of the perimeter of an interior portion of the front of the frame sufficient to keep the humidity around the eye high enough to provide relief from symptoms of dry eye syndrome.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 15, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Stephen Petty, Cristos Ifantides, Jahmel Jordon, Jonathan Petty, Jeffrey SooHoo
  • Biomarkers for head and neck cancer and methods of their use
    Patent number: 11441193
    Abstract: Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition, this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, suggesting its utility in early detection. This panel is also capable of detecting cancer by using saliva, blood and FNA tissue samples.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: September 13, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Shi-long Lu, John Song
  • Protection from stress, anxiety, neuroinflammation, and cognitive dysfunction
    Patent number: 11433126
    Abstract: Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated Mycobacterium.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: September 6, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Christopher A. Lowry, Matthew G. Frank, Laura Fonken, Steven F. Maier
  • Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide
    Patent number: 11433088
    Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Photocatalyst-free, light-induced carbon-sulfur cross-coupling methods
    Patent number: 11427536
    Abstract: In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 30, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Garret Miyake, Bin Liu, Chern-Hooi Lim
  • Catalyst, structures, reactors, and methods of forming same
    Patent number: 11426717
    Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: August 30, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Staci A. Moulton, Alan W. Weimer
  • Out-of-band compensation of active electronic device
    Patent number: 11424767
    Abstract: Systems and methods for controlling power amplifier (PA) performance metrics such as linearity and stability based on out-of-band feedback are presented. Various embodiments provide for synthesizing negative baseband termination using a feedback network between the drain and gate bias paths of the PA, so that the intermodulation distortion (IMD) is suppressed without an increase in system complexity. Other embodiments include a feedback network topology between the drain and gate bias paths of the PA that provides stability enhancement of the PA without the need for conventional stability networks in the radio frequency (RF) path. The out-of-band feedback nature of the approach means that the continuous wave (CW) RF performance is not perturbed, enabling conventional design techniques to be used for the input and output matching networks while enhancing aspects of the PA performance.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: August 23, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Taylor Wallis Barton, William Sear
  • Fabrication of corrugated gate dielectric structures using atomic layer etching
    Patent number: 11417849
    Abstract: Integrated circuit structures, arrangements, and manufacturing processes are discussed herein. In one example, a method of forming a transistor structure includes forming a dielectric layer onto a gate element and forming a corrugated surface into the dielectric layer using at least an atomic layer etching (ALE) process to remove portions of the dielectric layer. The method also includes forming a semiconductor layer onto the corrugated surface and forming a source element and a drain element onto the semiconductor layer.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: August 16, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Rayshan Visvanathan, Diana Torres Sanchez, Gregory L. Whiting
  • Modular intraocular lens designs and methods
    Patent number: 11406490
    Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: August 9, 2022
    Assignees: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. Kahook, Naresh Mandava, Glenn Sussman, Paul McLean, Robert E. Atkinson
  • Post-operative surgical site wound treatment and method for device removal
    Patent number: 11400203
    Abstract: A device and method for treatment of post-operative surgical site wounds. Device includes an elongated hollow shaft that spans from the wound closure to the deep wound area, the internal end abutting a wound dressing and the external end connecting to a device that can provide negative-pressure suction and irrigation. Device providing one or more of irrigation, suction, and/or local antibiotic delivery to deep infections through a closed-wound. The method for removal includes narrowing a removal element relative to the long axis, collapsing the wound dressing; removing the wound dressing through the elongated shaft; and removing the device through a closed wound, avoiding a second removal surgery.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: August 2, 2022
    Assignees: Cor Medical Ventures, Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Vikas Patel, Christopher Kleck, Brian Bowman, Tina John, Jude Paganelli
  • METHODS AND COMPOSITIONS FOR TREATING A DISEASE OR DISORDER
    Publication number: 20220235136
    Abstract: The present application provides agents that specifically inhibits the IGFBP7/CD93 signaling pathway, such as agents that specifically block the interaction between CD93 and IGFBF7, methods of using said agents and methods of identifying said agents.
    Type: Application
    Filed: March 25, 2022
    Publication date: July 28, 2022
    Applicants: YALE UNIVERSITY, The Regents of the University of Colorado, a body corporate
    Inventors: Yuwen ZHU, Lieping CHEN, Richard SCHULICK, Yi SUN
  • Tongue localization, teeth interaction, and detection system
    Patent number: 11397470
    Abstract: A computer-implemented method for identifying tongue movement comprises detecting an electroencephalography (“EEG”) signal from an EEG sensor. The EEG sensor is configured to sense the EEG signal generated by a brain in association with a tongue movement. The method also comprises detecting the EMG signal from the EMG sensor. The EMG sensor is configured to sense the EMG signal generated by cranial nerve stimulation of muscles associated with the tongue movement. The method also includes identifying the tongue movement based on the EEG signal and the EMG signal. The method then includes correlating the tongue movement with one of a plurality of tongue location areas.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: July 26, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Tam Vu, Phuc Nguyen, Nam Bui, Robin Deterding
  • Compositions for solution processing of perovskites and methods of making the same
    Patent number: 11390533
    Abstract: The present disclosure relates to a composition that includes a perovskite crystal, where the perovskite crystal is in the form of a powder, and the perovskite crystal is semiconducting and photovoltaically active.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: July 19, 2022
    Assignees: Alliance for Sustainable Energy, LLC, The Regents of the University of Colorado, a Body Corporate
    Inventors: Marinus Franciscus Antonius Maria van Hest, David Todd Moore, Benjia Dou
  • Noninvasive predictive and/or estimative blood pressure monitoring
    Patent number: 11382571
    Abstract: Tools and techniques for estimating and/or predicting a patient's current and/or future blood pressure. In some cases, the tools will analyze physiological data captured from the patient against a model of blood pressure values to estimate/predict the patient's blood pressure value. In particular cases, derived parameters, such as a patient's compensatory reserve index (“CRI”) can be analyzed against such models, while in other cases, data captured from sensors can be directly analyzed against such models.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 12, 2022
    Assignees: Flashback Technologies, Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Isobel Jane Mulligan, Gregory Zlatko Grudic, Steven L. Moulton