Abstract: Methods and devices for real-time detection of fouling chemistry are described herein. In one aspect, a method of detecting and characterizing fouling of a membrane used for separation in a fluid-based system can include illuminating the membrane with one or more light sources, collecting Raman spectroscopy data from the membrane, and based on the Raman data, determining at least one selected from the group consisting of: presence or absence of membrane fouling, severity of membrane fouling, and composition of the membrane fouling, where the Raman spectroscopy is selected from the group consisting of Coherent Anti-Stokes Raman Scattering (CARS), Stimulated Raman Scattering (SRS), and spontaneous Raman Scattering.
Type:
Grant
Filed:
September 19, 2019
Date of Patent:
July 20, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Joseph J. Brown, Omkar D. Supekar, Victor M. Bright, Juliet T. Gopinath, Alan R. Greenberg
Abstract: The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.
Type:
Application
Filed:
December 7, 2020
Publication date:
July 15, 2021
Applicant:
The Regents of The University of Colorado, A Body Corporate
Inventors:
V. Michael Holers, Nirmal Banda, Liudmila Kulik
Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.
Type:
Application
Filed:
February 11, 2019
Publication date:
July 15, 2021
Applicant:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Abstract: The invention includes compositions and methods for promoting gas mixtures separations, such as a carbon dioxide and methane mixture. The composition of the invention is based on a curable polymerized room-temperature ionic liquid [poly(RTIL)].
Type:
Application
Filed:
May 29, 2019
Publication date:
July 8, 2021
Applicant:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
DOUGLAS L. GIN, COLLIN ANDREW DUNN, ZOBAN SINGH, RICHARD D. NOBLE
Abstract: This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.
Type:
Application
Filed:
January 5, 2021
Publication date:
July 8, 2021
Applicant:
The Regents of the University of Colorado, a Body Corporate
Inventors:
Jerome Fox, Ankur Sarkar, Akarawin Hongdusit, Edward Kim
Abstract: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.
Type:
Grant
Filed:
March 19, 2019
Date of Patent:
July 6, 2021
Assignees:
The Regents of the University of Colorado, a body corporate, ImmunoMolecular Therapeutics, Inc.
Abstract: Disclosed herein are methods and compositions for treating nonalcoholic fatty liver disease. Specifically exemplified herein is administration of compositions comprising a V1b inhibitor or V1a agonist or V1a stabilizer.
Type:
Grant
Filed:
September 14, 2018
Date of Patent:
June 15, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Richard J. Johnson, Miguel A. Lanaspa Garcia, Thomas Jensen
Abstract: High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.
Type:
Application
Filed:
December 10, 2020
Publication date:
June 10, 2021
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Christoph Matthias Keplinger, Xingrui Wang, Shane Karl Mitchell
Abstract: Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.
Type:
Application
Filed:
December 4, 2020
Publication date:
June 10, 2021
Applicant:
The Regents of the University of Colorado, A Body Corporate
Abstract: This disclosure describes systems, methods, and apparatus for multilayer superconducting structures comprising electroplated Rhenium, where the Rhenium operates in a superconducting regime at or above 4.2 K, or above 1.8 K where specific temperatures and times of annealing have occurred. The structure can include at least a first conductive layer applied to a substrate, where the Rhenium layer is electroplated to the first layer. A third layer formed from the same or a different conductor as the first layer can be formed atop the Rhenium layer.
Type:
Grant
Filed:
July 2, 2020
Date of Patent:
May 25, 2021
Assignees:
The Regents of the University of Colorado, a body corporate, The Government of the United States of America, as represented by the Secretary of Commerce National Institute of Standards and Technology
Abstract: Various systems and methods for generating images are provided. In some embodiments, the techniques can include acquiring a medical image and an associated motion characterization. The motion characterization can then be used to generate a plurality of gated image data sets, sorted by phase in the motion cycle. A new amplitude-based motion characterization curve is derived from the association of phases with amplitude-based characteristics in the phase gated images. This newly derived amplitude-based motion characterization curve can then be used to re-sort data according to amplitude-based gating techniques known in the field or with data driven optimization techniques.
Type:
Grant
Filed:
April 6, 2020
Date of Patent:
May 18, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device and methods of using the device for drug delivery to an eye, sinuses and/or periocular tissues.
Type:
Grant
Filed:
January 14, 2014
Date of Patent:
May 4, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: A grating coupler couples a waveguide to a beam and is formed of patterned shapes in a first and second layer of planar material, the shapes embedded in background material, the layers separated by less than one wavelength. The shapes are organized as a plurality of adjacent unit cells arranged along a direction of propagation of light with each unit cell including a shape of the first material and a shape of the second material, each unit cell having design parameters including a period, a width wb of the shape of first planar material, a width wt of the shape of second planar material, and an offset between the shapes. The coupler has a directivity ratio D is at least 10 dB between “up” and “down” radiation; and unit cells differ in at least one parameter selected from period, wb, wt, and offset to provide a predetermined beam shape.
Type:
Grant
Filed:
March 21, 2017
Date of Patent:
April 20, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: The invention provides novel compounds and methods that are useful in promoting reactions that proceed through an oxidative quenching pathway. In certain embodiments, the reactions comprise atom transfer radical polymerization.
Type:
Grant
Filed:
April 23, 2018
Date of Patent:
April 13, 2021
Assignees:
The Regents of the University of Colorado, a body corporate, Colorado State University Research Foundation
Inventors:
Garret Miyake, Jordan Corinne Theriot, Matthew D. Ryan, Ryan Michael Pearson, Tracy Allen French, Haishen Yang, Andrew Lockwood, Charles Musgrave, Chern-Hooi Lim, Ya Du, Blaine McCarthy
Abstract: A method of increasing a polymerization reaction rate of a base monomer composition that has slow free-radical polymerization kinetics. The method comprises combining an effective amount of a nanogel to the base monomer composition to form a monomer-nanogel mixture having a polymerization reaction rate that is greater than the polymerization reaction rate of the base monomer composition when subjected to an identical free-radical polymerization reaction conducted under identical conditions. The base monomer composition comprises one or more slow-kinetic monomers with slow free radical polymerization kinetics in which <25% of the double bonds are converted within the first 10 mintes of said reaction. The nanogel is soluble in the base monomer composition. The nanogel is derived from a nanogel-forming monomer mixture that comprises: at least one monovinyl monomer; at least one divinyl monomer; a chain transfer agent; and an initiator.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
April 6, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Jeffrey W. Stansbury, Devatha P. Nair, Steven H. Lewis
Abstract: Systems and methods for human-robot communication are proved. More particularly, some embodiments use augmented reality to facilitate communication of robot intention and teleoperation in human-robot cooperative environments. Various embodiments of the present technology provide a middleware that integrates augmented reality (AR) with novel teleoperation interfaces to increase operation effectiveness, support the user in conducting concurrent work, and decrease stress. Various embodiments provide predictive graphical interfaces such that a teleoperator controls a virtual robot surrogate, rather than directly operating the robot itself, providing the user with foresight regarding where the physical robot will end up and how it will get there. In accordance with various embodiments a user may select between two AR interfaces using such a surrogate: one focused on real-time control and one inspired by waypoint delegation.
Type:
Application
Filed:
March 5, 2019
Publication date:
April 1, 2021
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Daniel Szafir, Michael E. Walker, Hooman Hedayati
Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
Type:
Grant
Filed:
August 27, 2019
Date of Patent:
May 18, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan