Patents Assigned to The Regents of the University of Colorado, a body corporate
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Patent number: 11137409Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis.Type: GrantFiled: November 5, 2015Date of Patent: October 5, 2021Assignee: The Regents of the University of Colorado, a body corporateInventors: Michael P. Chapman, Hunter B. Moore, Eduardo Gonzalez Barreda, Ernest E. Moore
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Publication number: 20210301002Abstract: This disclosure provides anti-HSPA5 antibodies. Also featured is a method for delivering an agent into the brain, spinal cord, or other component of the central nervous system. In addition, methods of identifying a human subject at risk of relapse of neuromyelitis optica (NMO) or neuropsychiatric systemic lupus erythematosus (NP-SLE) are disclosed, as are methods of determining the severity of an attack of NMO or NP-SLE, and methods of diagnosing NP-SLE.Type: ApplicationFiled: February 23, 2021Publication date: September 30, 2021Applicants: Biogen MA Inc., The Regents of the University of Colorado, a body corporateInventors: Jeffrey L. Bennett, Richard M. Ransohoff, Fumitaka Shimizu, Kristin L. Schaller
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Publication number: 20210299406Abstract: A vascular access system and device. The vascular access device includes a frame having a handle, a linear actuation assembly, and a needle retainer, according to various embodiments. The linear actuation assembly is mounted to the frame and has a translating portion configured to translate relative to the frame, according to various embodiments. The needle retainer is coupled to the translating portion and is configured to retainer a needle, according to various embodiments. In various embodiments, the needle retainer is one needle retainer of a plurality of needle retainers, the plurality of needle retainers is configured to retain a respective plurality of needles, and the plurality of needle retainers is configured to operably translate as a unit with the translating portion relative to the frame.Type: ApplicationFiled: August 6, 2019Publication date: September 30, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Juan-Pablo Idrovo, Andrew Scallon
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Patent number: 11133758Abstract: Described herein are devices incorporating Casimir cavities, which modify the quantum vacuum mode distribution within the cavities. The Casimir cavities can drive charge carriers from or to an electronic device disposed adjacent to or contiguous with the Casimir cavity by modifying the quantum vacuum mode distribution incident on one side of the electronic device to be different from the quantum vacuum mode distribution incident on the other side of the electronic device. The electronic device can exhibit a structure that permits transport or capture of hot carriers in very short time intervals, such as in 1 picosecond or less.Type: GrantFiled: April 22, 2020Date of Patent: September 28, 2021Assignee: The Regents of the University of Colorado, a body corporateInventor: Garret Moddel
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Publication number: 20210293643Abstract: Various embodiments of the present technology generally relate to robotics and prosthetics. More specifically, some embodiments of the present technology relate to multi-modal fingertip sensors with proximity, contact, and for localization capabilities. Various embodiments of the present technology provide for a novel multi-modal tactile sensor which comprises an infrared proximity sensor and a barometric pressure sensor embedded in an elastomer layer. Signals from both of these sensors can be fused to measure proximity (0-10 mm), contact (0N), force (0-50N) and localize impact at five spatial locations and three angles of incidence. Gaussian processes in a regression setting can be used to obtain calibrated force measurements with an R-squared value of 0.99. Supervised machine learning approaches can be used to localize the position and direction of probing with classification accuracies of 96% and 89% respectively.Type: ApplicationFiled: July 5, 2019Publication date: September 23, 2021Applicant: The Regents of the University of Colorado, a body corporateInventors: Nikolaus Correll, Radhen Patel, Jacob Segil, John Klingner, Richard F. Weir
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Publication number: 20210290374Abstract: Intraocular lenses (IOLs) that improve lens stability by, for example, increasing anterior-posterior stiffness of the IOL, increasing anterior-posterior dimensions of the IOL and/or increasing contact area with the equator of the bag to resist movement of the IOL as the bag collapses over time. These IOLs may be non-modular (single component) or modular (multiple component). In modular embodiments, the IOL system may include intraocular base and optic components, which, when combined, form a modular IOL.Type: ApplicationFiled: June 3, 2021Publication date: September 23, 2021Applicants: Alcon Inc., The Regents of the University of Colorado, a body corporateInventors: Malik Y. KAHOOK, Glenn SUSSMAN, Rudolph F. Zacher, Paul J. McLean, Robert E. ATKINSON
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Publication number: 20210285471Abstract: An electro-hydraulic actuator includes a deformable shell defining an enclosed internal cavity and containing a liquid dielectric, first and second electrodes on first and second sides, respectively, of the enclosed internal cavity. An electrostatic force between the first and second electrodes upon application of a voltage to one of the electrodes draws the electrodes towards each other to displace the liquid dielectric within the enclosed internal cavity. The shell includes active and inactive areas such that the electrostatic forces between the first and second electrodes displaces the liquid dielectric within the enclosed internal cavity from the active area of the shell to the inactive area of the shell. The first and second electrodes, the deformable shell, and the liquid dielectric cooperate to form a self-healing capacitor, and the liquid dielectric is configured for automatically filling breaches in the liquid dielectric resulting from dielectric breakdown.Type: ApplicationFiled: March 11, 2021Publication date: September 16, 2021Applicant: The Regents of the University of Colorado, a body corporateInventors: Christoph Matthias Keplinger, Eric Lucas Acome, Nicholas Alexander Kellaris, Shane Karl Mitchell
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Patent number: 11118613Abstract: A phononic material and a method of using a phononic material for use in interacting with a fluid or solid flow are provided. The phononic material includes an interface surface and a subsurface feature. The interface surface is adapted to move in response to a pressure associated with at least one wave in a flow exerted on the interface surface. The subsurface feature extends from the interface surface. The subsurface feature comprises a phononic crystal or locally resonant metamaterial adapted to receive the at least one wave having the at least one frequency based upon the pressure from the flow via the interface surface and alter the phase of the at least one wave. The interface surface is adapted to vibrate at a frequency, phase and amplitude in response to the manipulated/altered phase of the at least one wave.Type: GrantFiled: July 28, 2015Date of Patent: September 14, 2021Assignee: The Regents of the University of Colorado, a body corporateInventors: Mahmoud I. Hussein, Sedat H. Biringen, Osama R. Bilal, Alec Kucala
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Patent number: 11114760Abstract: In one example embodiment, a magnetic shutter antenna is provided including at least one dipole magnet comprising a first end and a second end and at least one shutter of magnetically soft material comprising at least one opening and disposed proximate the first end of the at least one dipole magnet. The antenna further includes a motor coupled to the shutter and configured to move the shutter between a first closed position comprising the magnetic material being positioned adjacent the first end of the dipole magnet and a second open configuration comprising the opening being positioned adjacent the first end of the dipole magnet. Alternation between the first closed position and the second open position modulates a magnetic flux emitting from the first end of the at least one dipole magnet.Type: GrantFiled: November 20, 2018Date of Patent: September 7, 2021Assignee: The Regents of the University of Colorado, a body corporateInventors: Mark Golkowski, Jae-Do Park, Ronald A. L. Rorrer, Zbigniew Celinski
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Patent number: 11110080Abstract: An empirical Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae (SAFIRE) was developed. Using this methodology, a library of small molecules and identified antimicrobials that are cell permeable and non-host-toxic were screened. Inhibitors of bacterial efflux pumps were identified as being implicated in antibiotic resistance and are attractive therapeutic targets for antimicrobials.Type: GrantFiled: March 27, 2018Date of Patent: September 7, 2021Assignee: The Regents of the University of Colorado, a body corporateInventors: Abigail L. Reens, Amy L. Crooks, Corrella S. Detweiler
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Publication number: 20210267751Abstract: An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.Type: ApplicationFiled: February 24, 2021Publication date: September 2, 2021Applicants: SpyGlass Pharma, Inc., The Regents of the University of Colorado, a body corporateInventors: Glenn Robert Sussman, Craig Alan Cable, II, Malik Y. Kahook
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Patent number: 11096594Abstract: A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.Type: GrantFiled: March 31, 2021Date of Patent: August 24, 2021Assignee: The Regents of the University of Colorado, a Body CorporateInventors: Joel Friedlander, Jeremy Prager, Emily Deboer, Robin Deterding
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Publication number: 20210255488Abstract: Controlling the propagation and interaction of light in complex media has sparked major interest. Unfortunately, spatial light modulation devices suffer from limited speed precluding real-time applications (e.g., imaging in live tissue). To address this problem, various embodiments use a phase-control technique to characterize complex media based on use of fast 1D spatial modulators and 1D-to-2D transformation performed by the same medium being analyzed. Some embodiments use a micro-electro-mechanical grating light valve (GLV) with 1088 degrees of freedom modulated at 350 KHz, enabling unprecedented high-speed wavefront measurements. Some embodiments continuously measure the transmission matrix, calculate the optimal wavefront and project a focus through various dynamic scattering samples in real-time, (e.g., within 2.4 ms per cycle).Type: ApplicationFiled: August 26, 2019Publication date: August 19, 2021Applicant: The Regents of the University of Colorado, a body corporateInventors: Rafael Piestun, Omer Tzang, Eyal Niv
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Publication number: 20210252102Abstract: The invention relates to methods for treating cancers by targeting the elimination of selective activated immune cell populations in combination with checkpoint inhibitors. The cells may be targeted, for instance, using CLIP inhibitors and or MHC class II inducers.Type: ApplicationFiled: April 29, 2021Publication date: August 19, 2021Applicants: The Texas A&M University System, The Regents of the University of Colorado, a Body CorporateInventors: Richard Tobin, Martha Karen Newell-Rogers
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Publication number: 20210248822Abstract: Systems and methods are described for mobile and augmented reality-based depth and thermal fusion scan imaging Some embodiments of the present technology use sophisticated techniques to fuse information from both thermal and depth imaging channels together to achieve synergistic effects for object recognition and personal identification. Hence, the techniques used in various embodiments provide a much better solution for, say, first responders, disaster relief agents, search and rescue, and law enforcement officials to gather more detailed forensic data. Some embodiments provide a series of unique features including small size, wearable devices, and ability to feed fused depth and thermal streams into AR glasses. In addition, some embodiments use a two-layer architecture for performing device local fusion and cloud-based platform for integration of data from multiple devices and cross-scene analysis and reconstruction.Type: ApplicationFiled: April 23, 2019Publication date: August 12, 2021Applicant: The Regents of the University of Colorado, a body corporateInventors: Min-Hyung Choi, Shane Transue
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Publication number: 20210244307Abstract: A process for more sensitive characterization of tissue composition for generating a quantitative MRI (qMRI) map and corresponding delta analysis. Intervertebral disc degeneration (IVDD), resulting in the depletion of hydrophilic glycosaminoglycans (GAGs) located in the nucleus pulposus (NP), can lead to debilitating neck and back pain. Magnetic Resonance Imaging (MRI) is a promising means of IVD assessment due to the correlation between GAG content and MRI relaxation values. T1 and T2 relaxation data were obtained from healthy cervical IVDs, and relaxation data was modeled using both conventional and stretched exponential (SE) decays. Normalized histograms of the resultant quantitative MRI (qMRI) maps were fit with stable distributions. SE models fit relaxation behavior with lower error compared to monoexponential models, indicating anomalous relaxation behavior in healthy IVDs. SE model parameters T1 and T1 increased with IVD segment, while conventional monoexponential measures did not vary.Type: ApplicationFiled: July 8, 2019Publication date: August 12, 2021Applicants: The Regents of the University of Colorado, a body corporate, Emory UniversityInventors: Corey P. Neu, Robert L. Wilson, David Reiter
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Patent number: 11083720Abstract: Disclosed herein are novel indazole-based compounds that inhibit fructokinase (aka ketohexokinase) and the downstream metabolic effects mediated by fructose metabolism. Fructokinase inhibitors specifically block the metabolism of both dietary and endogenous fructose metabolism and have a host of potential metabolic benefits. These benefits including blocking sugar craving and sugar induced metabolic syndrome and diabetes, but also blocking fructose metabolism can benefit the rare orphan disease Hereditary Fructose Intolerance, obesity, insulin resistance, metabolic syndrome, fatty liver, hypertension, cardiac injury from ischemia, certain cancers (including hepatocellular and pancreas), acute kidney injury from ischemia, heat stress, rhabdomyolysis or radiocontrast, and chronic diabetic and nondiabetic renal disease.Type: GrantFiled: March 19, 2018Date of Patent: August 10, 2021Assignees: Regents of the University of Colorado, a body corporate, Colorado Research Partners. LLCInventors: Sundeep Dugar, Miguel Lanaspa-Garcia, MyPhuong Thi Le, William John Greenlee
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Patent number: 11076948Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.Type: GrantFiled: June 25, 2018Date of Patent: August 3, 2021Assignees: Alcon Inc., The Regents of the University of Colorado, a body corporateInventors: Malik Y. Kahook, Glenn Sussman, Rudolph F. Zacher, Paul J. McLean, Harvey Uy, Robert Cionni, Kerry Solomon
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Patent number: 11077175Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.Type: GrantFiled: March 20, 2020Date of Patent: August 3, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
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Patent number: 11078498Abstract: Described herein are method for generating a vector for editing a cell. The method comprises ligating into a vector that encodes a portion of a gRNA a cassette comprising at least one editing cassette, a promoter, and a gene encoding another portion of the gRNA. Upon ligation, the portion of the gRNA from the editing cassette and the other portion of the gRNA are ligated and form a functional gRNA.Type: GrantFiled: July 24, 2020Date of Patent: August 3, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Andrew Garst, Ryan T Gill