Abstract: This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.

Abstract: Methods for light-induced electroplating of aluminum are disclosed herein. Exemplary methods may comprise preparing an ionic liquid comprising aluminum chloride (AlCl3) and an organic halide, placing the silicon substrate into the ionic liquid, illuminating the silicon substrate, the illumination passing through the ionic liquid, and depositing aluminum onto the silicon substrate via a light-induced electroplating process, wherein the light-induced electroplating process utilizes an applied current that does not exceed a photo-generated current generated by the illumination.

Abstract: A method of recovering hydrocarbons from a subterranean formation includes injecting into the subterranean formation a composition including carbon dioxide and at least one carbon-dioxide-soluble compound under conditions favorable to diffusion into and adsorption of the carbon-dioxide-soluble compound on the subterranean formation so that oil-wettability is decreased or water wettability or CO2-philicity is increased in at least a portion the subterranean formation.

Abstract: The present invention relates to a method for treating cancer. This method involves providing a first agent comprising a first targeting component coupled to a first cancer therapeutic component and providing a second agent comprising a second targeting component coupled to a second cancer therapeutic component. The first and second targeting components have different biodistributions and/or pharmacokinetics. The first and second agents are administered to a subject having cancer to treat the cancer. Also disclosed is a combination therapeutic comprising the first and second agents.

Abstract: The present invention provides an optimization method and system for minimizing network energy consumption based on traffic grooming. The method includes: generating a set of service requests in an elastic optical network, and calculating a reachable node set of shortest paths from source to destination nodes for each service request; establishing a virtual reachable path in the reachable node set of shortest paths; and establishing a target function of an integer linear programming model of the minimizing network energy consumption, and sequentially determining whether a bandwidth capacity constraint of a single spectrum slot, a path uniqueness constraint, a spectrum allocation constraint, and an optical regenerator quantity constraint are satisfied, where if all constraints are satisfied, the service request is successfully established, or if any of the constraints is not satisfied, the service request fails to be established. The present invention helps to improve the energy efficiency of service requests.

Abstract: In one embodiment, a sensor unit includes an outer housing including a top plate and a base member that together define an interior space, the top plate being configured to directly receive and support the leg of the piece of furniture, a load cell provided within the interior space configured to measure forces imposed by the leg on the top plate, the load cell including a planar metal plate having a deformable element to which the top plate is mounted and a sensor element mounted to the planar metal plate at a location at which the deformable element extends from the remainder of the planar metal plate, and an internal platform provided within the interior space and associated with the base member that supports the planar metal plate of the load cell in a manner in which the deformable element of the planar metal plate is free to deform when a force is imposed by the leg on the top plate.

Abstract: A system for processing spatial data may be designed to receive neural network outputs corresponding to a first spatial data set, and translate the neural network outputs corresponding to the first spatial data set based on the motion between a second spatial data set and the first spatial data set. The system may perform zero-gap run length encoding on the neural network outputs to store the neural network outputs in memory. The system may also perform on-the-fly skip zero decoding and bilinear interpolation to translate the neural network outputs.

Abstract: The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4?, O-6?, or O-4? and O-6? positions having reduced antimicrobial activity for targeting Connexin Hemichannels.

Abstract: In one example, an active variable reactance rectifier circuit includes an active variable reactance rectifier circuit input port and an output port. A power splitter circuit includes an input port coupled to the active variable reactance rectifier circuit input port and a pair of output ports. A first rectifier circuit includes an input port is coupled to the first power splitter circuit output port. A second rectifier circuit includes an input port coupled to the second power splitter circuit output port. A power combiner circuit includes a first input port, a second input port and an output port. The first power combiner circuit input port is coupled to the first rectifier circuit output port, the second power combiner circuit input port is coupled to the second rectifier circuit output port and the power combiner circuit output port is coupled to the active variable reactance rectifier circuit output port.

Abstract: A motion sensing system uses high-voltage biasing to achieve high resolution with ultra-low power. The motion sensing system consists of a motion sensor, a readout circuit, and a high-voltage bias circuit to generate the optimized bias voltage for the motion sensor. By using the high-voltage bias, the signal from the motion sensor is raised above the readout circuit's noise floor, eliminating the power-hungry amplifier and signal-chopping used in conventional motion sensing systems. The bias circuit, while producing the programmable bias voltages for the motion sensor, also compensates for the process mismatch raised by the high voltage biases.

Abstract: A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel.

Abstract: An automatic generation method for three-dimensional morphology of ruts in asphalt pavements comprises: constructing a standard rut cross-section representation model, classifying ruts, acquiring detection data of a rutted section of an asphalt pavement, selecting different rut cross-sections at equal intervals in a longitudinal direction of the pavement, denoising and smoothening the rut cross-sections, selecting feature points according to geometric fluctuation features of the rut cross-sections, connecting the feature points and fitting a cross-sectional curve based on an evolution law of rut deformation, and fusing multiple reconstructed rut cross-sections to realize automatic generation and visualization of three-dimensional morphology of a rut.

Abstract: Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.

Abstract: A method of hydrogen (H2) generation includes hydrolyzing a borohydride salt in an aqueous solution including a catalyst to form gaseous hydrogen. The catalyst is a bismuth(III) oxide-doped silicon dioxide with an amount of bismuth(III) oxide from 2 wt. % to 12 wt. % based on a total weight of the bismuth(III) oxide-doped silicon dioxide. The bismuth(III) oxide is dispersed in silicon dioxide in the catalyst. The weight ratio of the catalyst to the borohydride salt present in the aqueous solution is from 0.1:2 to 7:1 and a rate of hydrolysis of the borohydride salt in the presence of the catalyst is 2 to 3 times greater than a rate of hydrolysis of the borohydride salt in the absence of the catalyst.

Abstract: A super strong and tough densified wood structure is formed by subjecting a cellulose-based natural wood material to a chemical treatment that partially removes lignin therefrom. The treated wood retains lumina of the natural wood, with cellulose nanofibers of cell walls being aligned. The treated wood is then pressed in a direction crossing the direction in which the lumina extend, such that the lumina collapse and any residual fluid within the wood is removed. As a result, the cell walls become entangled and hydrogen bonds are formed between adjacent cellulose nanofibers, thereby improving the strength and toughness of the wood among other mechanical properties. By further modifying, manipulating, or machining the densified wood, it can be adapted to various applications.

Abstract: A cocrystal having the formula LiX·aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.

Abstract: Methods, apparatus and systems that relate to a portable chromatic light microscope are described. One example chromatic light microscope includes a light source including light producing elements that produce non-monochromatic output light that can be modulated. The chromatic light microscope further includes an illumination subsection to receive light that is output from the light source. The illumination subsection includes one or more lenses to spatially disperse spectral contents of the light that is received by the illumination subsection and to deliver light having chromatic aberration to a target object. The chromatic light microscope also includes an imaging subsection that includes one or more lenses to receive scattered light from the target object and to deliver the same to a sensor, and a linear variable filter to selectively pass a portion of the light having a particular spectral range of wavelengths to the sensor.

Abstract: Methods, computer program products, and systems can include, for example: receiving a plurality of signal instances of a signal emitted by a transmitter, wherein respective signal instances of the plurality of signal instances are collected at different positions. There is also set forth herein receiving by a movable receiver moving within a first location a plurality of signal instances of a signal emitted by a transmitter, wherein signal instances defining the plurality of signal instances are collected by the moveable receiver at different respective receiver positions within the first location. There is also set forth herein discovering a direction of arrival parameter value that specifies a direction of arrival of the signal emitted by the transmitter, wherein the discovering includes using a set of signal instances from the plurality of signal instances.

Abstract: Provided are a self voice training method for a patient with a voice disorder and a user terminal for self voice training. The user terminal for self voice training includes an input device configured to receive a training program selection command of a user, a storage configured to store voice training candidate programs for the user's voice training, a calculator configured to generate first guide content according to a first voice training program selected from among the voice training candidate programs by the user, an output device configured to output the first guide content, and a microphone configured to receive voice output by the user according to the first guide content output through the output device.

Abstract: Knee joint laxity testing apparatus configured to measure knee laxity in three planes of motion includes a foot and ankle stabilization assembly including a foot plate, a heel clamp and a tibial clamp for securing a foot and an ankle of a person, an anterior-posterior (AP) loading assembly configured to apply an anterior/posterior loading on a knee of the person, and a thigh stabilization assembly including a proximal thigh fixation module and a distal thigh fixation module. The proximal thigh fixation module includes a thigh cradle and a pair of clamping arms for securing a thigh positioned on the thigh cradle. Each clamping arm is pivotable about a hinge. The distal thigh fixation module is operable to firmly hold a distal portion of a thigh of the person in place while a leg of the person is manipulated.