Abstract: In one aspect, the invention relates to 4-substituted benzoylpiperazine-1-substituted carbonyls having a structure represented by a formula: derivatives thereof, and related compounds; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g., various tumors and cancers, associated with ?-catenin/BCL9 protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: An object detection system and method in which a machine learning engine is configured with a region-based knowledge distillation stage that generates region embeddings from a training image having bounding boxes. A linear layer learns a region-level vision-language mapping for projecting feature embeddings from the training image to a common feature space shared by text embeddings to obtain the region embeddings. An image-level supervision stage generates pseudo-box labels for a classification training image and region embeddings from the training image having bounding boxes and corresponding class labels and the classification training image having an image-level label as input. Pseudo-box labels are determined on the classification training image as an image-level vision-language mapping. A weight transfer function conditions the image-level vision-language mapping on the learned region-level vision-language mapping.

Abstract: Disclosed are a flexible pH sensor and detection system, belonging to the technical field of sensors. A material that does not react with electrolyte is mixed with metals to print an anode substrate, and one-step synthesis of a metal ions doped polyaniline composite material is realized through an electrochemical method. The doping amount of metal ions in polyaniline is changed by controlling metal content; due to addition of the metals, the conductivity of the anode substrate is improved, which is conducive to the deposition of polyaniline; such one-step method for preparing the polyaniline composite material is simpler, low in cost, and pollution-free; and compared with pure polyaniline, the sensitivity is further improved. According to the solution, this material is applied to the pH sensor for the first time, achieving a wide pH detection range (2-12) and high bending stability.

Abstract: One or more techniques and/or systems are disclosed for a harvester vehicle that includes a crop processing system comprising at least an accumulator and a round module builder. The harvester vehicle has a feedback fusion system that operably provides crop processing data indicative of an estimated accumulator fill level to a crop feed rate control system. The feedback fusion system has a plurality of feedback devices that operably provide feedback signals including data indicative of two or more of: crop mass flow, module builder status, module size, and accumulator fill level. The feedback fusion system has a control module that operably receives the feedback signals and generates an accumulator fill level signal based at least upon two or more of the feedback signals. The accumulator fill level signal is indicative of the estimated fill level in the accumulator.

Abstract: A bassinet includes a base, a column assembly rotatably connected to the base at a first end of the column assembly, an arm rotatably connected to a second end of the column assembly, a tub frame pivotably connected to the arm, an infant tub retained within the tub frame, the infant tub including a front wall, a back wall, and two side walls and having areas of reduced height along the front wall and at least one of the side walls to provide enhanced access to the infant located within the infant tub, and an insert configured to reversibly fit within an interior of the infant tub.

Abstract: Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin.

Abstract: Embodiments relate to a sensor system configured to detect physical rotation, entire or relative, of one or more objects and/or their environment and/or proximity of a magnetic field, by measuring the degree of localization of a medium trapped in a ring-shaped artificial lattice. The lattice structure can be configured to comprise of lattice sites distributed with a lattice period around an azimuth of a closed ring. The site depths of the plurality of lattice sites can be configured to be modulated with a modulation period different from the lattice period to affect the onsite energies of each lattice site and the eigenstates of the system. Physical rotation of the sensor and/or the proximity of magnetic field will alter the localization properties so as to cause the degree of localization of the medium to change (e.g., the medium becomes more confined in space or more spread out in space).

Abstract: A trenchless multi-stage pipe cleaning device and method combining an artificial tornado and dagger-like mechanical sand is provided. The trenchless multi-stage pipe cleaning device includes a primary pipe cleaning device and a secondary pipe cleaning device that are connected. An outer wall of the pipe cleaning device is provided with multiple air inlet joint pipes evenly distributed in a circumferential direction. The air inlet joint pipes are connected to an air compressor. Each of the air outlet joints is connected to a nozzle. The primary pipe cleaning device is connected to a vibrating screen. The trenchless multi-stage pipe cleaning device further includes a back-end sewage discharge device. In the trenchless multi-stage pipe cleaning method, the mechanical sand continuously scrape and collide with the inner wall of the cleaning target, so as to achieve a desired efficient trenchless water-free pipe cleaning effect.

Abstract: A quantum EIT-based optical switch includes a first waveguide, linear or nonlinear, a separate nonlinear waveguide evanescently coupled to the first waveguide, and a pump coupled to the nonlinear waveguide. A quantum STIRAP-based optical transduction device, which includes an auxiliary, intermediate spectral state for the quantum signal that aids efficient transduction of the quantum signal from the input spectral state to the output spectral state in a single device.

Abstract: A method for detecting an analyte comprises the following steps: providing a SERS-active substrate and a Raman spectra database; applying a sample onto the SERS-active substrate; applying an incident light by a Raman spectrometer onto the SERS-active substrate to generate a Raman spectrum of the sample; and comparing the Raman spectrum of the sample with a Raman spectra database to identify an analyte in the sample. The SERS-active substrate comprises: a support; a first dielectric layer disposed on the support, wherein the first dielectric layer is formed by a plurality of first nanofibers; and a plurality of noble metal particles formed on the plurality of first nanofibers.

Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP? construct comprising an antibody recruiting molecule linked to one or more pHLIP? peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.

Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.

Abstract: A method for manufacturing a conductive bridging memory device includes the following steps. First, a bottom electrode is formed on a substrate. Next, a switching layer is formed on the bottom electrode. The switching layer is made of a semiconducting metal oxide and free of gallium. Then, a surface of the switching layer is subjected to an oxygen plasma surface treatment. Afterwards, a blocking layer including a conductive material is formed on the treated surface of the switching layer, and an upper electrode is formed on the blocking layer.

Abstract: The present invention provides antibody compounds that contain a substitution of arginine for the reactive lysine residue (Lys99) in the hydrophobic cleft (38C2_Arg). The invention also provides antibody drug conjugate compounds (ADCs) that contain cargo moieties that are site-specifically conjugated to the engineered arginine residue in the 38C2_Arg variant antibody. Further provided in the invention are therapeutic applications of the compounds.

Abstract: A method of altering fatty acid and/or triacylglycerol production in plants and/or algae is provided. The method includes altering activity levels of alpha-carboxyltransferase (?-CT), a catalytic subunit of acetyl-CoA carboxylase (ACCase) by modulating an expression of at least one carboxyltransferase interaction (CTI) gene encoding at least one CTI protein.

Abstract: An apparatus and method for a machine learning engine for domain generalization which trains a vision transformer neural network using a training dataset including at least two domains for diagnosis of a medical condition. Image patches and class tokens are processed through a sequence of feature extraction transformer blocks to obtain a predicted class token. In parallel, intermediate class tokens are extracted as outputs of each of the feature extraction transformer blocks, where each transformer block is a sub-model. One sub-model is randomly sampled from the sub-models to obtain a sampled intermediate class token. The intermediate class token is used to make a sub-model prediction. The vision transformer neural network is optimized based on a difference between the predicted class token and the sub-model prediction. Inferencing is performed for a target medical image in a target domain that is different from the at least two domains.

Abstract: A system and method for wirelessly and passively powering and/or interrogating an implanted stent using a touch probe assembly through a near-field electrical connection not over an air interface. The stent apparatus includes at least one stent member functioning as an antenna and an electronics module coupled to the at least one stent member. Also, a wirelessly and passively powered power meter for use with implanted stents. The power meter includes an electronics module coupled to a stent member, wherein the electronics module includes a programmable oscillator structured to generate an oscillating signal that is proportional to an amount of AC power received by the implantable stent apparatus power meter through the stent member.

Abstract: Microfluidic sensing devices utilizing microfluidic sensing electrodes are provided. In one embodiment, a method for fabrication of a microfluidic sensing electrode device for detection of analyte(s) in a fluid is provided, the method comprising: generating a chamber comprising: a tube hole configured to receive a tube, wherein the tube hole extends from a first end of the chamber to a second end of the chamber; and a plurality of electrode holes configured to receive a plurality of electrodes, wherein each of the plurality of electrode holes is in contact with the tube hole; inserting the tube into the tube hole; inserting the plurality of electrodes into the plurality of electrode holes; applying a resin to the chamber; removing the tube from the tube hole, wherein removing the tube from the tube hole exposes a sensing zone that allows the plurality of electrodes to be in contact with the fluid.

Abstract: The present invention relates to a processing method for increasing seed production rate of seed fruits of Cucumis sativus L., comprising the following steps: (1) preparing a plant growth regulator according to a formula proportion; (2) selecting seed fruits of Cucumis sativus L. growing naturally in a greenhouse and reaching a pollination stage, and dipping female flowers thereof with the plant growth regulator prepared in step (1) before pollination; (3) picking male flowers for pollination after the female flowers are completely dry; (4) dipping the pollinated female flowers again; (5) conducting field routine cultivation management. The present invention uses a DNA methyltransferase inhibitor “5-azacytidine” (C8H12N4O5) to treat the seed fruits of Cucumis sativus L. by soaking and dipping, wherein 5-azacytidine increases seed production efficiency by reducing fruit length of the seed fruits, reducing fruit weight and reducing nutrient loss for fruit growth.

Abstract: A coal rock interface directional detection device based on elastic waves includes: a probe body including an elastic wave receiving device and an elastic wave excitation device spaced set at the top; a protective tube with one end connected to the adapter. The protective tube includes a collection circuit board inside the protective tube, and the collection circuit board is electrically connected to the elastic wave receiving device and the elastic wave excitation device; a sleeve, installed outside the protective tube, with one end connected to the side of the probe body near the adapter and with the other end connected to the side of the protective tube away from the adapter; and a control host, wirelessly connected with the acquisition circuit board. A coal rock interface directional detection method based on elastic waves applied in the coal rock interface directional detection device is also disclosed.