Abstract: A fault-tolerant computer system includes a plurality of redundant processor cores configured to simultaneously execute identical sets of processor-executable instructions, and a coprocessor component including a data storage component and a configurable logic region, where the plurality of processor cores are configured with processor-executable instructions to perform operations including configuring the configurable logic region of the coprocessor component with a first coprocessing module, and controlling the first coprocessing module to perform first processing operations on data located in the data storage component. In various embodiments, the redundant processor cores and the coprocessor component may be implemented on an FPGA, and the redundant processor cores may be configured to swap out different coprocessing modules using Partial Reconfiguration (PR) to perform data processing algorithms using hardware acceleration.

Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.

Abstract: Some aspects are directed to an all-on-chip, optoelectronic device for sampling arbitrary, low-energy, near-infrared waveforms under ambient conditions. This solid-state integrated detector uses optical-field-driven electron emission from resonant nanoantennas to achieve petahertz-level switching speeds by generating on-chip attosecond electron burst. Also disclosed is a cross-correlation technique based on perturbation of local electron field emission rates that allows for the full characterization of arbitrary electric fields down to 1 femtojoule, and/or on the order of 500 kV/m, using plasmonic nanoantennas.

Abstract: Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.

Abstract: A method includes receiving a trajectory dataset including a plurality of geospatial points forming a point cloud and acquired along a trajectory wherein for each of the plurality of geospatial points there is a defined an x-coordinate, a y-coordinate and a z-coordinate and at least one mapping device orientation attribute, segmenting the trajectory dataset into a plurality of segments, determining at least one relative constraint for each of the plurality of segments and utilizing, for each of the plurality of segments, at least one of the determined relative constraints to determine a relative position of at least two of the plurality of segments.

Abstract: A method of preparing a nanoscaled dye@ZIF-8-based colorimetric sensor is provided, in which a ZIF-8 nanomaterial is first prepared from Zn(CH3COO)2 and the 2-methylimidazole, and then the ZIF-8 nanomaterial is dispersed with ethanol and mixed with a colorimetric solution. The resultant mixed solution is added with polyethylene glycol-300 and applied to a substrate to obtain the nanoscaled dye@ZIF-8-based colorimetric sensor. This application further provides an evaluation method using the nanoscaled dye@ZIF-8-based colorimetric sensor, in which a back propagation neural network is established as the food quality evaluation model to evaluate the food quality.

Abstract: The invention provides a diagnostic kit for metastasis and invasion of breast cancer and a use of an shRNA molecule for silencing expression of human LINC01614. The shRNAs obtained by the invention can interfere with the expression of LINC01614, thereby reducing the migration and invasion ability of tumor cells, inhibiting the expression of EMT proteins, and inhibiting tumor formation and lung metastasis in an animal model in vivo. The invention provides a new solution for targeted therapy of breast cancer. Therefore, the kit for diagnosing metastasis and invasion of breast cancer and the medication for treating metastasis and invasion of breast cancer are developed. The invention provides a new way and strategy for diagnosing and treating metastasis and invasion of breast cancer.

Abstract: Discloses are a method for preparing fluff pulp from bamboos, and the fluff pulp prepared thereby. The method comprises the following steps: treating the bamboos with high-concentration alkali at a relatively mild temperature, after a certain period of treatment, replacing a treatment liquid for separating hemicellulose with a weak black liquor; Kraft cooking the treated bamboos to obtain unbleached bamboo pulp, removing rejects in the unbleached bamboo pulp by using a slotted screen; then removing miscellaneous cells by using a microporous sieve; carrying out two stages of oxygen delignification on the screened pulp; carrying out ECF bleaching treatment of a D0EpD1P process; and finally obtaining the bamboo fluff pulp which has high whiteness, low DCM extract content, low ash content and long fiber length, contains 4.2-4.6 million fibers per gram, and has relatively high bulkiness.

Abstract: An augmented reality (AR) device and a method of predicting a pose in the AR device is provided. In the augmented reality (AR) device inertial measurement unit (IMU) values corresponding to the movement of the AR device are obtained at an IMU rate, intermediate 6-degrees of freedom (6D) poses of the AR device are estimated based on the IMU values and images around the AR device via a visual-inertial simultaneous localization and mapping (VI-SLAM) module, and a pose prediction model for predicting relative 6D poses of the AR device is generated by performing learning by using a deep neural network.

Abstract: A line-following robot in an assembly line. The line-following robot includes a microcontroller, a camera connected to the microcontroller, disposed on a front of the line-following robot, and configured to collect line images, an Infrared (IR) sensor array connected to the microcontroller, disposed on the line-following robot, and oriented in a direction of travel of the line-following robot, a first wheel set and a second wheel set disposed opposite one another on opposing sides of a bottom of the line-following robot, and a battery. The microprocessor controls a motor speed of the line-following robot based on an upcoming assembly line by continuously capturing and processing the lines images using an advance image processing technique and computer vision techniques.

Abstract: A method and device for supporting weak networks in an AC/DC distribution network are provided. The method includes the following steps: constructing a topology of the AC/DC distribution network, where the topology is configured to support the weak networks and isolate faults actively, and the topology is a multi-terminal ring structure; establishing a distributed optimization method for the AC/DC distribution network based on the topology; obtaining power fluctuations of the AC/DC distribution network, where the AC/DC distribution network can switch a droop control mode automatically according to the power fluctuations; and obtaining frequency fluctuations of the AC/DC distribution network, where the AC/DC distribution network performs energy dispatching according to the frequency fluctuations to match the droop control mode of the AC/DC distribution network.

Abstract: The present invention includes a method for identifying a patient response to treatment for Alzheimer's Disease with a non-steroidal anti-inflammatory drug (NSAID) or an acetylcholinesterase (AChE) inhibitor drug comprising: obtaining a blood or serum sample from the patient; determining the presence of a proinflammatory endophenotype in the blood or serum sample of the patient; using the proinflammatory endophenotype to detect treatment response (a responder, a stable, a non-responder or an adverse responder); and treating the patient with the NSAID or the AChE inhibitor if the patient is in the responder or the stable treatment response phenotype group; or preventing a treatment with the NSAID or the AChE inhibitor if the patient is a non-responder or an adverse responder.

Abstract: A double-inverse opal photonic crystal resin film is formed by embedding nanospheres in pores of polyacrylate inverse opal framework material and then filling the pores of the double-inverse opal photonic crystal resin film with an ethanol solution with hydrophilic acrylamide dissolved therein followed by photopolymerization to form a polyacrylamide network, so as to obtain the double-inverse opal photonic crystal resin film using water as ink. A mass fraction of hydrophilic acrylamide in the ethanol solution is 2 to 8 wt. %. The resin film can induce water to penetrate into the pores of the double-inverse opal photonic crystal resin film, making the nanospheres in the pores of the inverse opal framework distribute from random to order under the action of buoyancy force, thereby eliminating scattering interference and producing brilliant structural colors by regulating refractive index contrast.

Abstract: A method for improving uniformity of an electromagnetic field inside a static microwave resonant cavity is provided. The overlap between a nodal point in one mode and an antinodal point in another node inside a microwave resonant cavity is realized by using two different types of anisotropic media, thereby improving distribution uniformity of an electromagnetic field inside a static resonant cavity. The method can reduce the complexity of cavity mechanisms of a microwave oven having a turntable and a flat panel microwave having an electromagnetic stirrer and improve static microwave treatment uniformity, thereby promoting the application of high-temperature and high-power microwave treatment in the fields such as microwave sintering, microwave smelting, and microwave chemical industry.

Abstract: Provided are a new vertical cavity surface emitting laser structure and a manufacturing method thereof. The structure includes a substrate layer, a lower N-type DBR, an active region, an upper N-type DBR and a mixed dielectric DBR sequentially arranged from bottom to top, where a second-class tunnel junction is arranged on one side of the active region close to the upper N-type DBR, where the second-class tunnel junction is embedded in a bottom of the upper N-type DBR and surrounded by the upper N-type DBR, and the substrate layer, the lower N-type DBR, the active region, the upper N-type DBR, the mixed dielectric DBR and the second-class tunnel junction are all coaxial elliptical cylinders; negative electrodes are arranged on the lower N-type DBR, and positive electrodes are arranged on the upper N-type DBRs substrate layer.

Abstract: Disclosed are fast high-temperature sintering systems and methods. A method of fabrication includes positioning a material at a distance of 0-1 centimeters from a first conductive carbon element and at a distance of 0-1 centimeters from a second conductive carbon element, heating the first conductive carbon element and the second conductive carbon element by electrical current to a temperature between 500° C. and 3000° C., inclusive, and fabricating a sintered material by heating the material with the heated first conductive carbon element and the heated second conductive carbon element for a time period between one second and one hour. Other variations of the fast high-temperature sintering systems and methods are also disclosed. The disclosed systems and methods can quickly fabricate unique structures not feasible with conventional sintering processes.

Abstract: A position/force controller performs a first conversion for distributing control energy to at least one of velocity or position energy and force energy, in accordance with a function to be realized, based on velocity (or position) and force information, which correspond to information relating to a position based on an operation of an actuator, and information serving as reference of control. The position/force controller calculates at least one of a velocity or position control amount and a force control amount based on at least one of the energies obtained through the distribution. The position/force controller integrates the calculated control amounts, performs a second conversion, and determines input to the actuator. The position/force controller performs a process, corresponding to increasing or decreasing performed on at least one of the velocity or position energy and the force energy together or independently, with satisfaction of a condition set for the control energy.

Abstract: Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

Abstract: A method for producing an additively manufactured, graded composite transition joint (AM-GCTJ) includes preparing a grating or lattice pattern from a first alloy A; the grating or lattice pattern includes pores in the grating or lattice patterns. The grating pattern is built from a first end to a second end being denser on the first end than on second end, and gradually reduces density by increasing the pore size and/or reducing density of the grating or lattice pattern; adding a second alloy B powder to the second end of grating or lattice pattern. The second alloy B powder is filled towards the first end. A composite is formed of first alloy A and second alloy B powder in the AM-GCTJ. The composite is subjected to hot isostatic pressing (HIP) to densify the composite. The second alloy B is graduated from the first end to the second end O of AM-GCTJ.

Abstract: A method of treating cancer that includes administering a therapeutically effective amount of an organoselenium benzimidazole compound of Formula (I), where R is at least one selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an unsubstituted benzyl group, a para halo-substituted benzyl group, and an allyl group.