Patents Assigned to The University
  • Insulin monitoring and delivery system and method for CGM based fault detection and mitigation via metabolic state tracking
    Patent number: 12285589
    Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.
    Type: Grant
    Filed: March 8, 2024
    Date of Patent: April 29, 2025
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Marc D. Breton, Stephen D. Patek, Boris P. Kovatchev
  • Bis-indolylmethane derivatives and uses thereof
    Patent number: 12285407
    Abstract: A pharmaceutical composition is described herein, including an antimicrobial agent and a compound having Formula A, or Formula B. Methods of using the pharmaceutical compositions to treat microbial infection are also described.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: April 29, 2025
    Assignee: The University of The West Indies
    Inventors: Antonio Ramkissoon, Adash Ramsubhag, Anderson Maxwell, Jayaraj Jayaraman
  • Device and method for spectral imaging
    Patent number: 12287240
    Abstract: A spectral imaging device includes an imager, a scanning stage to establish relative motion between the imager and a sample in a scanning direction and an optical system controlling a light characteristic of a light beam constituting an image of the sample to the imager. The optical system includes a light varying element to receive the light beam and provide an output light beam with spatially varying light characteristic over a cross-section thereof. A set of redirecting optical elements direct light rays from the sample to form the light beam, and to focus the output light beam onto the imager. A controller controls the scanning stage and the imager to capture a plurality of image frames with an overlap including a defined shift that is greater than 1 pixel along the scanning direction between consecutive image frames. A computing device consolidates image data to provide an image of the sample.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: April 29, 2025
    Assignees: Bar-Han University, Tel HaShomes Medical Research Infrastructure and Services Ltd.
    Inventors: Yuval Garini, Irena Bronshtein-Berger, Iris Barshack
  • Composition comprising bornyl acetate or pharmaceutically acceptable salt thereof as active ingredient for prevention or treatment of stress-related disorder
    Patent number: 12285399
    Abstract: When used as an active ingredient, bornyl acetate or a pharmaceutically acceptable salt thereof according to the present invention exhibits the effects of alleviating behavioral scales in an animal model, inhibiting the activation of microglia and the generation of inflammatory factors (COX-2 and iNOS), and lowering nerve excitability for responsiveness to cell-neural stimuli. Thus, bornyl acetate or a pharmaceutically acceptable salt thereof is found to have an excellent stress modulating potential and to be useful for the prevention and treatment of stress-related diseases, especially, depression, thereby finding advantageous applications in related industries.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: April 29, 2025
    Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Ik-Hyun Cho, Jong-Hee Choi
  • Distributed optimization control method for aircraft energy system considering loss
    Patent number: 12288982
    Abstract: A distributed optimization control method for an aircraft energy system considering loss includes the following steps: S1, based on characteristics of the actual near-space aircraft energy system and the near-space environment, the multi-bus DC microgrid system model is established for the near-space aircraft energy system according to Kirchhoff's law; S2, according to the energy scheduling requirement of the near-space aircraft energy system, the system control target is established; S3, according to the system control target, the optimal scheduling problem of the aircraft energy system considering operating loss is established; and S4, based on projection and penalty, the distributed optimization control algorithm is designed. The distributed optimization control method realizes bus voltage regulation and current distribution.
    Type: Grant
    Filed: December 3, 2024
    Date of Patent: April 29, 2025
    Assignee: Tianjin University
    Inventors: Zhicheng Zhang, Peng Li, Haoyu Wang, Zhiqiang Zuo, Yijing Wang, Yunhao Du, Maoxiang Qiu
  • Bacterium capable of inducing TH1 cells
    Patent number: 12285475
    Abstract: The result of orally administering saliva derived from a Crohn's disease patient or an ulcerative colitis patient to germ-free mice has revealed that Th1 cells markedly increased in the colons. Further, from the bacterial microbiota in the intestines of the mice in which such an increase in Th1 cells were observed, bacteria have been successfully isolated which caused strong Th1 cell induction in the colon upon intestinal colonization.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: April 29, 2025
    Assignee: KEIO UNIVERSITY
    Inventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori
  • Three-dimensional imaging method and system for surface comprehensive geophysical prospecting
    Patent number: 12287449
    Abstract: A three-dimensional imaging method and system for surface comprehensive geophysical prospecting, the method includes: acquiring detection data of a plurality of two-dimensional profiles of a surface detection site; forming two-dimensional profile resistivity data by geophysical inversion of the detection data; performing three-dimensional coordinate conversion on the two-dimensional profile resistivity data to obtain resistivity data of a three-dimensional coordinate system; and converting the resistivity data of the three-dimensional coordinate system into a three-dimensional model by using a Kriging interpolation method.
    Type: Grant
    Filed: June 16, 2021
    Date of Patent: April 29, 2025
    Assignee: SHANDONG UNIVERSITY
    Inventors: Shucai Li, Yiguo Xue, Maoxin Su, Chunjin Lin, Li Guan, Daohong Qiu, Zhiqiang Li, Yimin Liu, Peng Wang, Huimin Gong
  • Skin culturing apparatus and method
    Patent number: 12286609
    Abstract: The invention provides a skin culturing apparatus configured for biphasic culturing of mammalian skin and/or a mammalian skin substitute. The apparatus comprises a first chamber that is configured to provide a gaseous environment having a relative humidity below 90% and comprising less than 5% CO2, and a second chamber that is configured to provide tissue culture medium at a temperature of 33.0-37.5° C. and pH of 6.1-7.9. The invention also provides methods for culturing mammalian skin and/or skin substitutes, as well as methods for testing mammalian skin and/or mammalian skin substitutes cultured in the skin culturing apparatus.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: April 29, 2025
    Assignee: QUEEN MARY UNIVERSITY OF LONDON
    Inventors: Rosalind Francesca Hannen, Jose Rafael Castrejón-Pita
  • Method for mass transfer of mini light-emitting diodes (mini-LEDs) using sliding-on-membrane pin ejection
    Patent number: 12289932
    Abstract: An ejector pin sliding on membrane-based device and method for mass transfer of mini light-emitting diodes (Mini-LEDs) are provided. The device includes a gantry transverse beam. The gantry transverse beam is provided with an ejector pin base, and the ejector pin base is configured to move along the gantry transverse beam. The ejector pin base is fixedly provided with a vision camera and an ejector pin. A blue membrane is horizontally provided at a side of the gantry transverse beam close to the ejector pin, and is spaced from the gantry beam. A surface of a side of the blue membrane away from the gantry transverse beam is adhesively provided with a plurality of Mini-LED chips arranged evenly. A transfer substrate is horizontally provided at a side of the blue membrane close to the plurality of Mini-LED chips, and is spaced from the blue membrane.
    Type: Grant
    Filed: July 11, 2024
    Date of Patent: April 29, 2025
    Assignee: Guangdong University of Technology
    Inventors: Yun Chen, Yanhui Chen, Li Ma, Hao Zhang, Jintao Chen, Maoxiang Hou, Xin Chen
  • Systems and methods for protecting machine learning models against adversarial attacks
    Patent number: 12287892
    Abstract: Embodiments pertain to systems configured to and methods for analyzing a scene comprising one or more objects. The system may be configured to perform the following: obtaining a set of optically encrypted image data describing a scene, including applying an optical manipulation to light incoming to an image acquisition device, whereby the image acquisition device outputs the set of optically encrypted image data, and wherein the optical manipulation is based on an encryption key; providing the set of optically encrypted image data to a machine learning model trained in accordance with the encryption key; and receiving from the machine learning model a prediction related to the scene.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: April 29, 2025
    Assignees: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, UNIVERSITY OF CONNECTICUT
    Inventors: Bahram Javidi, Adrian Stern
  • Method and apparatus for transform-based image encoding/decoding
    Patent number: 12289449
    Abstract: The present invention relates to a method and apparatus for encoding and decoding a video image based on transform. The method for decoding a video includes: determining a transform mode of a current block; inverse-transforming residual data of the current block according to the transform mode of the current block; and rearranging the inverse-transformed residual data of the current block according to the transform mode of the current block, wherein the transform mode includes at least one of SDST (Shuffling Discrete Sine Transform), SDCT (Shuffling Discrete cosine Transform), DST (Discrete Sine Transform) or DCT (Discrete Cosine Transform).
    Type: Grant
    Filed: July 26, 2023
    Date of Patent: April 29, 2025
    Assignees: Electronics and Telecommunications Research Institute, Industry Academy Cooperation Foundation of Sejong University
    Inventors: Sung Chang Lim, Jung Won Kang, Hyun Suk Ko, Jin Ho Lee, Ha Hyun Lee, Dong San Jun, Seung Hyun Cho, Hui Yong Kim, Jin Soo Choi, Yung Lyul Lee, Nam Uk Kim, Jun Woo Choi
  • Network and method for servicing a computation request
    Patent number: 12289205
    Abstract: A framework for joint computation, caching, and request forwarding in data-centric computing-based networks comprises a virtual control plane, which operates on request counters for computations and data, and an actual plane, which handles computation requests, data requests, data objects and computation results in the physical network. A throughput optimal policy, implemented in the virtual plane, provides a basis for adaptive and distributed computation, caching, and request forwarding in the actual plane. The framework provides superior performance in terms of request satisfaction delay as compared with several baseline policies over multiple network topologies.
    Type: Grant
    Filed: February 29, 2024
    Date of Patent: April 29, 2025
    Assignee: Northeastern University
    Inventors: Edmund Meng Yeh, Khashayar Kamran
  • Method for fast automatic calibration of phased array based on residual neural network
    Patent number: 12288936
    Abstract: Disclosed is a method for fast automatic calibration of a phased array based on a residual neural network. A phase setting matrix is set and an amplitude and a phase of a array far-field complex signal are measured with a network analyzer to obtain an amplitude and phase vector of the array far-field complex signal. A real part, an imaginary part, and a magnitude of the far-field measured complex signal value are separated and normalized, and mapped to RGB three-channel image data. Datasets are automatically generated according to a preset amplitude-phase error range by a simulation software, the datasets are proportionally divided into a training set and a test set to be input into the residual neural network for training to obtain a calibration model. Measured data is input into the calibration model for automatic estimation of the amplitude-phase error of the phased array.
    Type: Grant
    Filed: December 20, 2024
    Date of Patent: April 29, 2025
    Assignees: ZHEJIANG UNIVERSITY, DONGHAI LABORATORY
    Inventors: Chunyi Song, Haotian Chen, Nayu Li, Zhiwei Xu, Xinhong Xie, Zixian Ma, Bing Lan
  • Catheter-deployable soft robotic sensor arrays and processing of flexible circuits
    Patent number: 12285260
    Abstract: Methods for fabricating flexible/stretchable circuits can include identifying one or more regions of a printed circuit board (PCB) for selectively removing insulation material. The PCB can include one or more electrically conductive structures arranged on an insulation layer. The method can include applying, within each region of the one or more regions, thermal energy via a heat source to a surface of the PCB within the region such that insulation material of the insulation layer is removed from the region while a portion of the insulation layer beneath the one or more electrically conductive structures is maintained. The flexible/stretchable circuit can be laminated on a soft actuator to form a soft robotic device.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 29, 2025
    Assignee: Cornell University
    Inventors: Simon Dunham, Bobak Mosadegh, Varun Umesh Kashyap, Tejas Doshi, Alexandre Caprio
  • Therapeutic vaccine for Hepatitis B virus (HBV) using the HBV PreS1 and/or PreS2, and/or S-HBsAg regions of the HBV envelope protein
    Patent number: 12285482
    Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: April 29, 2025
    Assignees: UNIVERSITY OF WASHINGTON, ABACUS BIOSCIENCE, INC.
    Inventors: Edward A. Clark, Che-Leung Law, Deborah Fuller, Michael Gale
  • Conductive graphene/carbon nanofiber composite scaffold, its use for neural tissue engineering and a method of preparation thereof
    Patent number: 12285544
    Abstract: Porous electrically conductive graphene/carbon nanofiber bio-scaffolds can be fabricated having a Youngs modulus and electrical conductivity that both match typical values for brain tissue. Such scaffolds have been tested and found to provide improved differentiation of stem cells into functional neural cells relative to conventional scaffolds. In preferred embodiments, neural cell differentiation in conductive graphene/carbon nanofiber scaffolds is promoted by an applied electrical stimulus.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: April 29, 2025
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Byeongtaek Oh, Vivek Nath Lam, Paul George
  • Profit-aware offloading framework towards prediction-assisted mec network slicing
    Patent number: 12289207
    Abstract: A profit-aware Offloading Framework towards Prediction-assisted MEC Network Slicing is provided. Towards MEC network slicing, formulate the optimization problem of maximizing long-term ESP profits and decouple it into the sub-problems of Edge network Slicing (EnS) and Computation offloading Access (CoA). For the slicing sub-problem, use a gated recurrent neural network (GRNN) to accurately predict user requests in different regions, and then use the optimal partitioning of network slices with the predicted requests and expected demands; For the offloading sub-problem, incorporating results from slice partitioning, use an improved deep reinforcement learning with twin ritic-networks and delay mechanism, solving the Q-value overestimation and high variance for approximating the optimal offloading and resource allocation.
    Type: Grant
    Filed: December 29, 2023
    Date of Patent: April 29, 2025
    Assignee: FUZHOU UNIVERSITY
    Inventors: Zheyi Chen, Junjie Zhang, Jie Liang, Pengfei Wang
  • Methods and kits for identifying cancer treatment targets
    Patent number: 12286623
    Abstract: In one aspect, the present disclosure provides a method for identifying treatment targets relating to tumors. In another aspect, the present disclosure provides a method for identifying biomarkers and molecular features of normal and cancer cells.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: April 29, 2025
    Assignee: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Chun-Hao Huang, Spencer C. Knight, Nami Saghaei
  • Method for characterizing interaction force between lignin and cellulase
    Patent number: 12287353
    Abstract: A method for characterizing the interaction force between lignin and cellulase is provided. The method includes the following steps: (1) preparing a lignin solution, then dropwise adding the solution onto a silicon wafer, repeatedly spin-coating with a spin coater, and vacuum-drying the prepared lignin film; (2) modifying an AFM probe coated with a gold film on the surface with HS-PEG-COOH and then activating the carboxyl group, immersing the AFM probe after the carboxyl group activation in a PBS solution of cellulase for incubation, and after the modification is completed, placing the washed AFM probe in a PBS buffer solution for storage for later use; (3) testing the lignin-cellulase interaction force by using an AFM instrument in a liquid phase environment.
    Type: Grant
    Filed: August 31, 2023
    Date of Patent: April 29, 2025
    Assignee: NANJING FORESTRY UNIVERSITY
    Inventors: Caoxing Huang, Xiaoxue Zhao, Qiang Yong, Chenhuan Lai, Yongcan Jin
  • Substituted pyrimido[4,5-b]indoles as CK2 inhibitors
    Patent number: 12286436
    Abstract: Pyrimido[4,5-b]indole compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The pyrimido[4,5-b]indole compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases.
    Type: Grant
    Filed: April 4, 2024
    Date of Patent: April 29, 2025
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Michelyne Haroun, Christophe Tratrat