Patents Assigned to The University
  • Chip on ceramics power module with low inductance and compact arrangement
    Patent number: 12289872
    Abstract: Approaches, techniques, and mechanisms are disclosed for packaging electric power components. A power module comprises: a three-dimensional (3D) cooling structure that has a plurality of planar sides; a first set of mountable power components that are mounted on a first planar side in the plurality of planar sides of the 3D cooling structure; a second set of mountable power components that are mounted on a second planar side in the plurality of planar sides of the 3D cooling structure. The second planar side represents an opposing side, of the 3D cooling structure, to the first planar side. The 3D cooling structure includes an interior space containing one or more cooling channels in which cooling fluid is to flow. The interior space of the 3D cooling structure is spatially surrounded by other planar sides in the plurality of planar sides in combination with the first and second planar sides.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: April 29, 2025
    Assignees: VOLKSWAGEN AKTIENGESELLSCHAFT, University of Tennessee Research Foundation
    Inventors: Rüdiger Kusch, Yue Sun, Hua Bai, Hendrik Gerth
  • 3D printing method for an impact-resistance gradient complex part
    Patent number: 12285911
    Abstract: A 3D printing method for an impact-resistant gradient complex part containing a hollow ceramic sphere complex, wherein the method includes the following steps: 1) designing the size and shape of the part as well as an internal layered structure; 2) providing a raw material, wherein the raw material contains a high polymer, a curing agent and hollow ceramic spheres; and 3) providing the raw material with a certain thickness according to a design, then, curing the raw material by using a heat source to form a high polymer layer containing the hollow ceramic spheres, and repeatedly printing the high polymer layer according to the design until the high polymer layer reaches the designed thickness to form the impact-resistant gradient complex part.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: April 29, 2025
    Assignee: XI'AN JIAOTONG UNIVERSITY
    Inventors: ChunMing Niu, MeiPing Li, QiPing He, Jun Li, Fan Jiang, ZhiHui Li, Xin Ji, ZhaoHai Meng, ShunXiang Gong
  • Object tracking
    Patent number: 12287393
    Abstract: In various example embodiments, a system and method for tracking objects in a three-dimensional space is disclosed. One method includes receiving detections representing targets, increasing a classification of a track in response to a detection matching the track, decreasing a classification of a track in response to no detections matching the track, and processing detections according to a classification level of the track.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: April 29, 2025
    Assignee: Utah State University Space Dynamics Laboratory
    Inventors: Morgan Davidson, Jacob Christensen
  • FCMR-binding molecules and uses thereof
    Patent number: 12286476
    Abstract: The invention provides novel anti-FCMR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 29, 2025
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Richard Brokx, Jacqueline M. Mason, Mark R. Bray
  • Inhibitors of complement factor H
    Patent number: 12286471
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Grant
    Filed: January 3, 2024
    Date of Patent: April 29, 2025
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • Estrogen receptor beta ligands for the prevention and treatment of multiple sclerosis (MS) and other demyelinating, inflammatory and neurodegenerative diseases
    Patent number: 12286407
    Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.
    Type: Grant
    Filed: April 12, 2023
    Date of Patent: April 29, 2025
    Assignees: The Board of Trustees of the University of Illinois, The Regents of the University of California
    Inventors: John A. Katzenellenbogen, Seema K. Tiwari-Woodruff, Sung Hoon Kim, Benita Katzenellenbogen
  • Terahertz transistor
    Patent number: 12290009
    Abstract: Superconducting Meissner effect transistors, methods of modulating, and systems are disclosed. In one aspect a disclosed transistor includes a superconducting bridge between a first and a second current probe, the first and second current probe being electrically connected to a source and a drain electrical connection, respectively and a control line configured to emit a magnetic field signal having signal strength Hsig at the superconducting bridge. In one aspect the emitted magnetic field is configured to break Cooper pairs in the superconducting bridge.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: April 29, 2025
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventor: Christopher K. Walker
  • System and method for the prediction of runway configuration and airport acceptance rate (AAR) for multi-airport system
    Patent number: 12288149
    Abstract: Numerical weather prediction data during a time period of interest for a multi-airport system is used to generate a three-dimensional (3-D) tensor data for the time period of interest. The 3-D tensor data is then used to predict hourly runway configurations for each of a plurality of airports of the multi-airport system during the time period of interest using the 3-D tensor data as input to a plurality of runway configuration convolutional neural networks (CNN) branches and to predict an AAR for each of the plurality of airports of the multi-airport system during the time period of interest using the 3-D tensor data as input to an airport acceptance rate (AAR) CNN branch. The predicted hourly runway configuration for each of the plurality of airports and the predicted AAR for each of the plurality of airports are then used to manage flights within the multi-airport system.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: April 29, 2025
    Assignee: University of South Florida
    Inventors: Yu Zhang, Yuan Wang
  • Hydrophilic and hydrophobic composite packing-based rotating packed bed and system
    Patent number: 12285750
    Abstract: The present application provides a hydrophilic and hydrophobic composite packing-based rotating packed bed and a system. A hydrophobic packing and a hydrophilic packing are formed into a composite packing. When said packing cuts liquid, the hydrophobic packing can sufficiently disperse the liquid so as to make the dispersion of the liquid in the packing zone more uniform, and the wettability of the hydrophilic packing allows the liquid to spread sufficiently so as to increase the wetting efficiency of said packing. The phenomenon of droplet aggregation caused to liquid in a single hydrophobic packing zone and the phenomenon of reduction of liquid turbulence caused to liquid in a single hydrophilic packing zone can be avoided. Therefore, applying a hydrophilic and hydrophobic composite packing to a rotating packed bed can further improve the mass transfer and mixing performance thereof.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: April 29, 2025
    Assignee: BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY
    Inventors: Yong Luo, Yanzhen Lu, Yong Cai, Guangwen Chu, Wei Liu, Haikui Zou, Baochang Sun, Jianfeng Chen
  • Identifying desirable T lymphocytes by change in mass responses
    Patent number: 12287325
    Abstract: In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: April 29, 2025
    Assignee: The Regents of the University of California
    Inventors: Michael A. Teitell, Thomas A. Zangle, Owen M. Witte, Daina Burnes Linton
  • Transformant for producing dodecanedioic acid and method for producing dodecanedioic acid
    Patent number: 12286663
    Abstract: A gene editing system of Candida viswanathii includes a Candida viswanathii, a first gene editing fragment and a second gene editing fragment. The first gene editing fragment successively includes a first homology arm and a screening gene. The second gene editing fragment is connected to a C-terminus of the first gene editing fragment and includes a second homology arm, a Cas9 expression cassette and a sgRNA cassette. The Cas9 expression cassette successively includes a Cas9 promoter, a Cas9 gene and three nuclear localization sequences. The sgRNA cassette successively includes a sgRNA promoter, a first ribozyme, a targeting sequence, a scaffold and a second ribozyme. The first gene editing fragment and the second gene editing fragment are constructed as a linear fragment for gene editing of a chromosome of the Candida viswanathii.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: April 29, 2025
    Assignees: NATIONAL TSING HUA UNIVERSITY, Chang Chun Plastics Co., Ltd., Chang Chun Petrochemical Co., LTD., DAIREN CHEMICAL CORP.
    Inventors: Yu-Chen Hu, Nam Ngoc Pham, June-Yen Chou, Hsing-Yun Wang, Vincent Jianan Liu
  • Fermented milk for improving autonomic nervous function
    Patent number: 12285449
    Abstract: A fermented milk for improving autonomic nervous function containing at least one lactic acid bacterial species of the genus Lactobacillus and its metabolite. The lactic acid bacterial species of the genus Lactobacillus is selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus rhamnosus and Lactobacillus acidophilus. The lactic acid bacterial strain of the genus Lactobacillus is preferably Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1(FERM BP-10741).
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: April 29, 2025
    Assignees: MEIJI CO., LTD, UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Yasuyoshi Watanabe, Kei Mizuno, Jun Henmi, Seiya Makino, Hiroshi Kano
  • Combination serotonin specific reuptake inhibitor and serotonin 1A receptor partial agonist for reducing L-DOPA-induced dyskinesia
    Patent number: 12285426
    Abstract: A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: April 29, 2025
    Assignees: The Research Foundation for The State University of New York, Rosalind Franklin University of Medicine and Science, Board of Trustees of Michigan State University
    Inventors: Christopher Roy Bishop, Anthony West, Fredric Manfredsson
  • Pore measurement device
    Patent number: 12287287
    Abstract: In one aspect, there is provided a system including at least one processor, and at least one memory including program code which when executed by the at least one processor causes operations including capturing an image of at least a portion of a surface of an object; generating, from the captured image, pixel intensity data; in response to generating the pixel intensity data, determining, based on a height error model, height error data, wherein the height error data indicates an uncertainty of at least one height measurement of the object; and determining, based on the height error data, whether the object satisfies a threshold criteria for acceptance of the object. Related system, methods, and articles of manufacture are also disclosed.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: April 29, 2025
    Assignee: The Regents Of the University of California
    Inventors: Niall O'Dowd, Michael Todd
  • Polypeptide set to be used in light dependent gene recombination
    Patent number: 12286650
    Abstract: The purpose of the present invention is to provide a set of two polypeptides for use in light-dependent genetic recombination in which the N-terminal side fragment and the C-terminal side fragment of a Cre protein having an amino acid sequence of SEQ ID NO: 1 respectively bind to two proteins light-dependently forming a dimer.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: April 29, 2025
    Assignee: The University of Tokyo
    Inventor: Moritoshi Sato
  • Anti-bacterial stilbene derivatives and methods of use
    Patent number: 12286398
    Abstract: Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: April 29, 2025
    Assignee: Yale University
    Inventors: Jason Crawford, Tyler Goddard, Hyun Bong Park, Jaymin Patel
  • Cancer risk based on tumour clonality
    Patent number: 12286678
    Abstract: In an aspect, there is provided a method for diagnosing or prognosing a subject with cancer, the method comprising: providing cancer DNA sequencing data from a cancer sample comprising cancer DNA from the subject; comparing the cancer DNA sequencing data with control DNA sequencing data to determine genetic aberrations; determining, from the genetic aberrations, the clonal and subclonal populations present in the sample; constructing a phylogenetic map of the clonal and subclonal populations; assigning to the subject a risk level associated with a better or worse patient outcome or response to therapy; wherein a relatively higher risk level is associated with a higher level of evolution and number of subclonal populations and a relatively lower risk level is associated with a lower level of evolution and number of subclonal populations.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: April 29, 2025
    Assignees: Ontario Institute for Cancer Research (OICR), University Health Network
    Inventors: Shadrielle Melijah G. Espiritu, Yiyang Liu, Paul C. Boutros, Robert G. Bristow
  • Semiconductor system
    Patent number: 12287743
    Abstract: A semiconductor system including a transmitter configured to output a plurality of data as a plurality of data input/output signals through a plurality of channels based on a matrix E, and a receiver configured to generate the plurality of data by differentially amplifying the plurality of data input/output signals received through the plurality of channels based on a matrix D, in which all components of the matrix E and the matrix D are integers, a product matrix of the matrix D and the matrix E is a diagonal matrix, a sum of the components of each row of the matrix D is 0, and a sum of absolute values of the components of each column of the matrix D is less than or equal to a threshold value.
    Type: Grant
    Filed: June 27, 2023
    Date of Patent: April 29, 2025
    Assignees: SAMSUNG ELECTRONICS CO., LTD., UIF (University Industry Foundation), Yonsei University
    Inventors: Hyun Jun Park, Woo-Seok Choi
  • Cloud-edge collaboration forecasting system and method for aluminum oxide production indexes
    Patent number: 12288176
    Abstract: Provided is a cloud-edge collaboration forecasting system and method for aluminum oxide production indexes. The forecasting system performs forecasting algorithm selection, parameter configuration and model training on indexes and variables of the aluminum oxide production process at a cloud model training server, performs evaluation and parameter correction on the trained model to obtain an optimal training model, and pre-processes the data in the aluminum oxide production process at an aluminum oxide production index forecasting computer at an edge end. The trained model parameters are imported from the cloud, and further the trained forecasting model is used for forecasting aluminum oxide production indexes for different production processes.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: April 29, 2025
    Assignee: NORTHEASTERN UNIVERSITY
    Inventors: Changxin Liu, Ning Yuan, Jinliang Ding, Tianyou Chai
  • Method of adhering a microelectromechanical (MEMS) device to a flexible fabric substrate
    Patent number: 12285083
    Abstract: Radial-armed thin-film bilayers are designed and fabricated from a metal and an oxide to produce grippers that interact with the yarns or fibers of the fabric and form a mechanical tangle attachment to the fabric. MEMs devices attached to the grippers enable the MEMs devices to be adhered to a flexible and/or extensible fabric. Fabrics comprise conventional textile, smart textiles, functional fibers or other smart materials. The fabrics thus incorporate wearable sensors, medical devices, and other functional MEMs for commercial, biomedical, industrial and scientific applications.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: April 29, 2025
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Cindy K. Harnett, Jasmin Beharic, Canisha Barbara Ternival, Sushmita Challa, Mohammad Shafquatul Islam