Abstract: The present invention provides an ?-type titanium alloy, the fracture toughness and thermal creep resistance of the prepared ?-type titanium alloy are improved by controlling the content of Al, Zr, and Sn. The room temperature strength is improved by adding a certain amount of Si, and the thermal creep resistance is further improved. The addition of a certain amount of C and Cr improves the high-temperature tensile properties of the prepared ?-type titanium alloy. The method provided by the invention has a simple process and low cost and can achieve good matching of low cost, high performance, and less processing capacity. The prepared ?-type titanium alloy in example 1˜4 of the invention has an elastic modulus of 124˜132 GPa, a tensile strength of 867˜881 MPa, a yield strength of 743˜762 MPa, an elongation of 22%˜24.0%, and a section shrinkage of 47%˜51% at 600° C.

Abstract: Aspects of the present disclosure are directed to borealin-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such borealin-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using borealin-targeting polypeptides.

Abstract: System for effecting a reversible sensory block includes a hybrid neuromodulator and hybrid lead for delivering electrical and pharmacological stimulation. An implantable modulator provides electrical pulse generation and pharmacological fluid infusion. Method for effecting a reversible sensory block delivers low-frequency stimulation based on the conduction velocity of a target afferent. Afferents with different conduction velocities may be blocked by stimulation with different frequencies. Temporally synchronized pulse stimuli from multiple stimulating electrodes may interfere with each other to stimulate a specific afferent. Spatial summation of synchronized low-frequency pulse stimulation may be delivered at multi-sites. Temporal interference of two kilohertz sinusoidal stimuli with slight frequency difference deliver a low-frequency sinusoidal stimulus at a focal region of interference. Spatial summation translates to evoked action potentials that converge at T-junction of a targeted afferent.

Abstract: The present disclosure relates to a highly thermally conductive composite material in which PITCH-based carbon fiber is stitched into a prepreg laminate in which a prepreg including carbon fiber and a thermosetting resin is laminated, and a method for manufacturing the same, and the highly thermally conductive composite material may have excellent through-thickness thermal conductivity, in-plane thermal conductivity and strength.

Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Abstract: Provided herein are nanoengineered biomaterial inks used to 3D print a biocompatible, flexible electronic device, for example, a hydrogel constructs a biocompatible, flexible electronic device or 3D printed wearable electronic devices. The biocompatible, flexible electronic device may be a crosslinked gelatin-SH-2D-MoS2 nanoassembly. Also provided are methods for nanoengineering a biomaterial ink and for determining a treatment for a subject in need thereof utilizing the biocompatible, flexible electronic device.

Abstract: A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to invasively or noninvasively assess whether vaccines and other aqueous-based pharmaceutical products have been frozen during transport and/or storage.

Abstract: A method for manufacturing a Group III nitride crystal, the method including: bringing a surface of a Group III nitride seed crystal into contact with a melt including at least one Group III element selected from among gallium, aluminum, and indium and an alkali metal in an atmosphere containing nitrogen to cause the Group III element and the nitrogen to react with each other in the melt to grow a Group III nitride crystal on the Group III nitride seed crystal, the method includes: growing a plurality of island-like Group III nitride crystal nuclei on the surface of the Group III nitride seed crystal; growing a first Group III nitride crystal having an inverted triangular shape or a trapezoidal shape in section from each of the plurality of island-like Group III nitride crystal nuclei; and growing a second Group III nitride crystal such that the second Group III nitride crystal fills a depression of the first Group III nitride crystal to form the second Group III nitride crystal having a flat surface, wherein

Abstract: A program that defines and assesses the dynamic risk of software vulnerabilities and considers the dynamic risks into patch scheduling to reduce security risks posed by vulnerabilities and provide formal guidance to security operations at various organizations.

Abstract: An application of Bone Marrow Mesenchyml Stem Cell Exosomes (BMSC-Exos) in treating Parkinson's disease (PD) is provided, wherein the BMSC-Exos are generated by stimulating BMSCs with a culture solution and extracted from the culture solution after passage; and the culture solution of the BMSCs is an ?-MEM culture solution containing FBS and PS. The BMSC-Exos can greatly improve a motor function of a model mouse with PD, protect dopaminergic neurons of the model mouse with PD, improve an olfactory function of the model mouse with PD, and also inhibit the activation of olfactory astrocytes of the model mouse with PD.

Abstract: Systems and methods are described herein that create discrete volumes associated with solid-phase particles (e.g., drop-carrier particles) suspended in an immiscible phase (e.g., dropicles). One embodiment of the system includes a plurality of hydrogel-based drop-carrier particles containing a microscale voids or cavities that hold an aqueous phase droplet of fluid within each drop-carrier particle. The plurality of hydrogel drop-carrier particles associated with aqueous drops are suspended as individual elements in an immiscible oil phase. The microscale hydrogel drop-carrier particles containing the voids or cavities may be manufactured using microfluidic droplet generators. The dropicles may be used to analyze single-entities (e.g., single-molecules and single-cells) and analytes.

Abstract: A method of screening new psychoactive substance is provided, including providing a sample; placing the sample on chromatographic paper; ionizing the sample on the chromatographic paper by a direct analysis in real time (DART); performing a mass spectrometry analysis on the ionized sample to obtain a sample mass spectrum; and comparing a known standard mass spectrum with the sample mass spectrum, in which when a profile of the known standard mass spectrum is the same as a profile of the sample mass spectrum and the known standard mass spectrum is not exactly the same as the sample mass spectrum, the sample is determined to be the new psychoactive substance. A platform for screening new psychoactive substance is also provided to quickly screen out the new psychoactive substance.

Abstract: The disclosure provides a construction method including steps of: constructing a detailed model and a simplified model of the rail vehicle using finite element method based on the three-dimensional structure of the rail vehicle; initially setting the simplified model in accordance with the detailed model, including specifying materials, mechanical properties parameters, and mass point; setting different simplification thickness ratio to obtain a plurality of sets of the simplified models, designing longitudinal and lateral collision conditions, and in each type of the collision conditions, performing collision simulations on the detailed model and each set of the simplified models under each thickness ratio to obtain respective collision response curves; calculating a total CORA value corresponding to the plurality of sets of the simplified models; selecting an optimal simplified model from n sets of the simplified models with the highest total CORA values.

Abstract: The present invention relates to a medium composition for culture of extraembryonic endoderm stem cells, and more specifically, to a medium composition for in vitro culture of extraembryonic endoderm stem cells.

Abstract: Materials are disclosed that superconduct at high temperatures and low pressures. Methods of making and measuring the materials are also disclosed. In a particular embodiment, a nitrogen-doped (or other lightweight-atom doped) rare earth metal hydride is disclosed. Also disclosed are thermodynamic pathways to recovering materials that superconduct at room temperature and room pressure and/or at other desirable operating temperatures and pressures to enable superconductivity at conditions that make a wider range of superconductive applications practical. These and other aspects of various embodiments are disclosed herein.

Abstract: Orally-deliverable programmable bacteria cells that colonize colorectal tumors and produce diagnostic and therapeutic molecules, as well as related compositions and methods.

Abstract: The present disclosure relates to a novel Bacillus velezensis strain and a method for preventing, treating, or improving tuberculosis comprising the same. More specifically, the present disclosure relates to a Bacillus velezensis PMC 206 strain extracted from vinegar and a use thereof, for example, an antibacterial composition having antibacterial activity against bacteria belonging to the genus Mycobacterium, a pharmaceutical composition or food composition for improving, treating, or preventing tuberculosis having antibacterial activity against bacteria belonging to the genus Mycobacterium.

Abstract: A walking rover system with a rover, a base station, and a tether extending between the rover and the base station. The rover has a rover body, a plurality of mobilizing legs, and a plurality of stabilizing legs. The stabilizing legs have one degree of freedom and the mobilizing legs have three degrees of freedom. The mobilizing legs and the stabilizing legs may alternate around the rover body such that each of the mobilizing legs is separated from adjacent mobilizing legs by a stabilizing leg and each of the stabilizing legs is separated from adjacent stabilizing legs by a mobilizing leg. The tether is configured to transmit electricity from the base station to the rover, transmit data gathered by the rover back to the base station, and support a weight of the rover and act as a mechanical rappel line between the base station and the rover.

Abstract: An image encoding/decoding method and apparatus and a method for transmitting a bitstream generated by the image encoding method are provided. The image encoding method according to the present disclosure may include: encoding an image in sub-regions with different sizes and generating one or more bitstreams for the sub-regions; obtaining a user viewport for the image; allocating sub-regions corresponding to the user viewport among the sub-regions to the image, wherein the image includes an inner region located inside the user viewport, a boundary region adjacent to a boundary of the user viewport, and an outer region located outside the user viewport; and generating at least one bitstream corresponding to the allocated sub-regions from bitstreams for the sub-regions, and a sub-region with a relatively large size may be allocated within the inner region, and a sub-region with a relatively small size may be allocated within the boundary region.

Abstract: Described herein is a generalizable strategy to rapidly and irreversibly activate protein function with full spatiotemporal control. Through development of an exogenously triggerable self-assembling protein construct, bioactive proteins can be stably reassembled from non-functional split fragment pairs following exposure to a stimulus (e.g., light).