Abstract: A genomic prescribing system and methods utilizes pharmacogenomic information to enhance patient-centered care by delivering preemptively-obtained, patient-specific pharmacogenomic results with accompanying prescribing recommendations.

Abstract: Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers.

Abstract: Methods, systems, and devices are disclosed for controlling the magnetic and electrical properties of materials. In one aspect, a multi-layer structure includes a first layer comprising a ferromagnetic or ferrimagnetic material, and a second layer positioned within the multi-layer structure such that a first surface of the first layer is in direct physical contact with a second surface of the second layer. The second layer includes a material that undergoes structural phase transitions and metal-insulator transitions upon experiencing a change in temperature. One or both of the first and second layers are structured to allow a structural phase change associated with the second layer cause a change magnetic properties of the first layer.

Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

Abstract: An inkjet-based process for programmable deposition of thin films of a user-defined profile. Drops of a pre-cursor liquid organic material are dispensed at various locations on a substrate by a multi-jet. A superstrate that has been bowed due to a backside pressure is brought down such that a first contact of the drops is made by a front side of the superstrate thereby initiating a liquid front that spreads outward merging with the drops to form a contiguous film captured between the substrate and the superstrate. A non-equilibrium transient state of the superstrate, the contiguous film and the substrate then occurs after a duration of time. The contiguous film is then cured to crosslink it into a polymer. The superstrate is then separated from the polymer thereby leaving a polymer film on the substrate. In such a manner, non-uniform films can be formed without significant material wastage in an inexpensive manner.

Abstract: An innovative software-defined backchannel communication scheme is provided for use in ultra-low power devices. The technique enables interconnecting heterogeneous devices through a WiFi backchannel that can be realized with existing infrastructure without any hardware modifications. The backchannel communication scheme can also be extended to other OFDM based communication systems, such as cellular 4G LTE.

Abstract: A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

Abstract: An RF switch is provided with a direct heating method. The RF switch is comprised of two RF electrodes disposed on opposing sides of a phase change element. Depending on the state of the phase change material, the RF electrodes form a conductive path through the phase change material for an RF signal. To control the state of the phase change material, the RF switch further includes a heater formed from two heater electrodes. The two heater electrodes are configured to draw a current through the phase change element in a direction transverse to the conductive path.

Abstract: Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds are useful for treating alcoholism and drug abuse and for treating obesity.

Abstract: An apparatus, system, and method for spectrally dense comb-like filters fashioned with thick-guided-mode resonant gratings. A guided-mode resonance (GMR) filter has a film having a thickness many times larger than a wavelength of operation and the film has a first surface and a second surface opposite to the first surface. The GMR filter further has a periodic pattern on the first surface of the film and an antireflection layer on the second surface of the film.

Abstract: A searchable encryption resistant to frequency analysis. A conversion rule management device generates a conversion rule table associating a search keyword with a conversion keyword group. Based on the conversion rule table, a data registration device generates registration data associating encrypted data with an encrypted keyword, and registers the registration data in a server device. An information processing device obtains from the conversion rule table a conversion keyword group associated with a specified search keyword, generates an encrypted keyword group, and requests a data search by specifying the encrypted keyword group. Using as a search key an encrypted keyword included in the encrypted keyword group, the server device searches for encrypted data associated with the search key, and returns searched encrypted data. The information processing device decrypts the searched encrypted data, and outputs as a search result search data obtained by decryption.

Abstract: A second query execution part is added to a database management system comprising a first query execution part configured to execute a query based on a query execution plan of a query to a database and to return a query execution result to the query issuance source and a buffer management part configured to read a data of a read request from the database to store the data into the buffer and to provide the data to an issuance source of the read request if data of a read request has not been stored in a buffer in the case where the read request of data is received and configured to read data of a read request from the buffer and to provide the data to a issuance source of the read request if data of a read request has been stored in the buffer.

Abstract: A mine management system (1) is used to mine ore from a vein in a mine including mining areas provided at the downside of the vein, a first mine shaft provided at the downside of the vein, and second mine shafts connecting the mining areas to the first mine shaft and includes: a transporting machine which loads the ore mined in the mining area and transports the ore to a soil discharge area while traveling in the first mine shaft; a loading machine which stays in the second mine shaft while a space used for the transporting machine to travel therein is left inside the first mine shaft, excavates the ore in the mining area, conveys the mined ore from the mining area in the opposite direction, and loads the ore on the transporting machine; and a management device which determines the mining area toward which the transporting machine is directed so that the operability of the loading machine becomes maximal or the operability of the transporting machine becomes maximal.

Abstract: In some aspects, the present disclosure relates to a method of hydrolyzing a polysaccharide to obtain the corresponding saccharides using an amino acid solution. In some embodiments, the present disclosure provides a method of using an amino acid salt such as hydrogen glycine in a solution to obtain a monosaccharide such as glucose, xylose, or fructose.

Abstract: An image analyzing apparatus, a non-transitory computer readable medium storing a program, and a method are provided for extracting voids from a three-dimensional image of a fiber-reinforced composite material. The image analyzing apparatus includes a processor which executes image processing to the three-dimensional image. The processor binarizes the three-dimensional image and creates a binary image, transforms the binary image into a distance and creates a distance image, executes closing processing to the binary image by using the distance image, extracts voids from differences between images before and after the closing processing, among the extracted voids, classifies voids that are adjacent to a background voxel as open voids, and classifies voids that are not adjacent to a background voxel as closed voids, and executes opening processing to the open voids in order to eliminate fake voids.

Abstract: The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.

Abstract: The present invention provides systems and methods for creating interlayer mechanical or electrical attachments or connections using filaments within a three-dimensional structure, structural component, or structural electronic, electromagnetic or electromechanical component/device.

Abstract: A low power radio is provided with automatic interference rejection. The radio is comprised generally of: an antenna, a rectifier, a comparator, and a correlator. The comparator receives an input signal from the rectifier, compares the input signal to a reference signal and outputs a digital signal. The correlator in turn receives the digital signal from the comparator, correlates the digital signal to a wake-up code and outputs a wake-up signal having a high value when the digital signal is highly correlated with the wake-up code. The radio further includes an automatic threshold controller which adjusts sensitivity of the comparator. Of note, the rectifier, the comparator, the correlator and the automatic threshold controller are comprised in part by circuits having transistors operating only in subthreshold region.

Abstract: A focusing microprobe system, comprising: one of a single-mode laser radiation source and a few-mode laser radiation source; a coupler coupled to the laser radiation source; one of a single-mode flexible laser radiation delivery system and a few-mode flexible laser radiation delivery system coupled to the coupler; and one or more focusing microlenses coupled to the flexible laser radiation delivery system and arranged in a focusing tip. The coupler comprises a focusing lens. The flexible laser radiation delivery system comprises one of a hollow-core fiber and a flexible waveguide. Optionally, the one or more focusing microlenses are bonded to seal a hollow internal cavity of the flexible laser radiation delivery system. The one or more focusing microlenses comprise one or more conventional lenses or one or more focusing spheres, hemispheres, or cylinders.

Abstract: Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.