Abstract: The devices, systems, and methods can improve magnetic resonance imaging (MRI), MR spectroscopy (MRS), MR spectroscopic imaging (MRSI) measurement(s), thereby providing more reliable quantification. The method may include a method for correcting MR image(s)/spectrum. The method may include providing an inhomogeneity field/response map of a region of interest; and providing MR image(s)/spectrum of the region of interest. The method may include determining an intravoxel/voxel inhomogeneity correction coefficient for each voxel of at least one subregion of the region of the interest using the inhomogeneity field/response map. The method may include correcting each voxel of the MR image(s)/spectrum of the region of interest using the intravoxel/voxel inhomogeneity correction coefficient.
Abstract: Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.
Type:
Grant
Filed:
April 19, 2023
Date of Patent:
January 7, 2025
Assignee:
The University of Chicago
Inventors:
Jeffrey A. Hubbell, Ruyi Wang, D. Scott Wilson, Cathryn R. Nagler, Catherine Plunkett
Abstract: The present disclosure provides, in part, modulators of prostate-specific G-protein receptor (OR51E2/PSGR) and methods of treating, preventing, and diagnosing prostate cancer using the same.
Abstract: Provided is a simple and low-cost method for efficiently fixing a sufficient amount of carbon dioxide contained in a carbon dioxide-containing gas (e.g. a plant exhaust gas). The method of fixing carbon dioxide comprises a contact step of bringing a carbon dioxide-containing gas having a temperature of 350° C. or more into contact with a cementitious hardened body to fix carbon dioxide in the carbon dioxide-containing gas to the cementitious hardened body. The carbon dioxide-containing gas may be a gas that is free from being supplied with moisture before the contact step and during the contact step. One of examples of the carbon dioxide-containing gas is a plant exhaust gas.
Type:
Grant
Filed:
December 2, 2019
Date of Patent:
January 7, 2025
Assignees:
TAIHEIYO CEMENT CORPORATION, THE UNIVERSITY OF TOKYO
Abstract: A body area network (BAN) architecture including a plurality of ultra-wideband (UWB) BAN node devices, a control node device, and a remote node device is described. The plurality of UWB BAN node devices measures real-time physiological data of a patient and transmits the physiological data to the control node device using UWB signals. The control node device encodes the UWB signals using an spectral amplitude coding-optical code division multiple access (SAC-OCDMA) encoder, modulates the encoded UWB signals using an on-off keying (OOK) scheme, combines the modulated UWB signals into an optical signal using an optical coupler, and transmits the combined optical signal through a free space optical (FSO) link to the remote node device. The remote node device decodes the combined optical signal using an SAC-OCDMA decoder, converts the decoded optical signal into an electrical signal, and analyzes the physiological data based on the electrical signal.
Type:
Grant
Filed:
August 13, 2024
Date of Patent:
January 7, 2025
Assignee:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Abstract: Disclosed are synthetic 71 base pair, partially-double stranded DNA oligonucleotides and methods for their use in the amplification and identification or integrated proviral DNA.
Type:
Grant
Filed:
December 12, 2019
Date of Patent:
January 7, 2025
Assignee:
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Abstract: Disclosed is an encryption method and apparatus. The encryption method using homomorphic encryption may include generating a ciphertext by encrypting data, and bootstrapping the ciphertext by performing a modular reduction based on a selection of one or more target points for a modulus corresponding to the ciphertext.
Abstract: Disclosed is a scanning interference photolithography system, comprising a heterodyne optical path, a first interference optical path, a second interference optical path, a motion platform and a control subsystem, wherein a substrate is carried on the motion platform, a displacement measurement interferometer is used to measure the displacement of the motion platform, a first light beam and a second light beam are focused on the substrate for interference exposure; the control subsystem generates instructions according to various measurement information, adjusts angles of corresponding devices or the phase of a light beam, and locks the phase shift of interference exposure fringes of the first light beam and the second light beam. The system has a high precision of fringe pattern locking and a high laser utilization rate, and can be used for producing a large-area high-precision dense grating line gradient periodic grating.
Abstract: The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention.
Type:
Grant
Filed:
November 15, 2022
Date of Patent:
January 7, 2025
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Christopher N. Bowman, Brady T. Worrell, Gayla Berg Lyon, Matthew K. McBride, Chen Wang
Abstract: A method of treating Alzheimer's associated pathology includes a step of identifying subject having a pathology that is associated with Alzheimer's disease. A fasting mimicking diet (FMD) is then administered to the subject for a first time period. Methods for treating amyloid plaque formation and/or elevated levels of tau protein as well as neuroinflammation are also provided.
Abstract: The present disclosure provides a soluble P-selectin (sP-sel) interfering the interaction between stem cells and niches to mobilize stem cells from bone marrow. The mobilization of stem cells with sP-sel can treat a subject in need of preservation, repair, or regeneration of a tissue, or revascularization.
Abstract: The disclosure discloses a method for enhancing denitrification of sewage with a low carbon-to-nitrogen ratio by using an electrode biocarrier, and relates to the field of sewage treatment. The disclosure uses a conductive material as a microbial carrier and a potentiostat to induce a micro-electric field for directional acclimation and enrichment of electroactive denitrification microorganisms, and realizes a high-efficiency denitrification of the sewage with a low carbon-to-nitrogen ratio. The disclosure aims to provide a technical method for solving the problem of deep denitrification of municipal sewage with a low carbon-to-nitrogen ratio.
Abstract: A dampening device that can be coupled to a medical implant to eliminate harmful electrical oscillations. The device includes circuity that detects harmful electrical oscillations in the implant. The device also includes circuity that generates cancelling electrical signals that counter the detected electrical oscillations. Alternatively, in a medical implant having a taper junction such as a standard hip implant, resistance welding of the taper junction just prior to surgical implanting may be performed after the appropriately dimensioned components are selected to eliminate a metal on metal interface where corrosion is most likely to occur.
Abstract: Disclosed herein is a methodology for refining novel-class features in a few-shot learning scenario by fine-tuning the feature extractor by reducing both class-agnostic biases and class-specific biases. A distribution calibration module is used to reduce the class-agnostic bias by normalizing the overall feature distribution for novel classes and further reshaping the feature manifold for fast adaptation during fine-tuning. Selected sampling is used to reduce class-specific bias by augmenting more data for better estimation.
Abstract: A multi-posture bedside writing pen includes a pen shell, a pen tip holder, a fiber rod and a fiber ink storage tube. The fiber ink storage tube is connected with the pen shell and located in the pen shell. The pen tip holder is connected with one end of the pen shell. The pen tip holder is axially provided with a through hole. The fiber rod is inserted into the through hole, one end of the fiber rod is exposed outside the pen tip holder, and an other end of the fiber rod is inserted into the fiber ink storage tube. A first gap is provided between the pen tip holder and the fiber ink storage tube.
Type:
Grant
Filed:
September 11, 2023
Date of Patent:
January 7, 2025
Assignee:
Ningbo Institute of Northwestern Polytechnical University
Abstract: A trauma gurney includes a base connected to a frame by a vertical adjustment mechanism. The base is configured that it can be maneuvered over a receiving table. The frame holds a detachable platform suitable for the positioning of a patient thereon. Actuation of the adjustment mechanism allows the frame to be lowered and the patient platform to be detached. The patient platform is configured to be non-interfering with various procedures such as MRI procedures so the patient platform can remain with the patient after the patient has been transferred without adverse effects to the procedures. The patient platform can also be reattached to the frame after it has been removed. The trauma gurney beneficially allows a patient to be transferred from the gurney to another surface, such as for imaging, without requiring a conventional lateral transfer. Similarly, the trauma gurney allows a patient to be transferred back to the gurney.
Type:
Grant
Filed:
January 18, 2022
Date of Patent:
January 7, 2025
Assignee:
University of Utah Research Foundation
Inventors:
Brandon Bruce Johnson, Charles Craig Logan
Abstract: The invention enables an optical voltage sensor, comprising a piezoelectric actuator mechanically coupled to an optical strain sensor (such as a fibre Bragg grating), to withstand lightning impulses, the effects of which would otherwise be harmful or destructive to the piezoelectric actuator and/or other sensitive components. As such, the optical voltage sensor, comprised within a photonic voltage transducer which also comprises a lightning impulse attenuator, is able to comply with relevant standards and be used for applications in power networks and exposed to the highest voltages for equipment.
Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens.
Type:
Grant
Filed:
May 11, 2022
Date of Patent:
January 7, 2025
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Theodore W. Randolph, Robert Garcea, Alan W. Weimer
Abstract: The present invention provides an inpatient unit of modular design, built of recycled materials and environmentally friendly materials, allowing reconfiguration, redeployment and quick assembly, preventing indoor air from leaking, applicable to epidemic prevention and treating special patients, with high structural strength, lower cost and good environmental benefit.
Type:
Grant
Filed:
April 22, 2021
Date of Patent:
January 7, 2025
Assignee:
FU JEN CATHOLIC UNIVERSITY HOSPITAL, FU JEN CATHOLIC UNIVERSITY
Abstract: The present invention provides an isolated binding reagent that specifically binds to a recombinant Cocoa Swollen Shoot Virus (CSSV) coat protein antigen having at least 80% sequence identity to the amino acid sequence of SEQ ID NO: 2 or 4 and/or at least 80% sequence identity to the nucleotide sequence of SEQ ID NO: 1 or 3. A porous membrane based sensor for detecting CSSV comprising a recombinant CSSV coat protein antigen and a method for detecting CSSV using the sensor are also provided. A competitive ELISA for detecting viral infections in plants is also provided.
Type:
Grant
Filed:
October 29, 2019
Date of Patent:
January 7, 2025
Assignee:
University of the West of England, Bristol
Inventors:
Richard Luxton, Janice Kiely, Joel Allainguillaume, Jacqueline Mary Barnett