Abstract: Embodiments of a system for dynamic reconfiguration of cache are disclosed. Accordingly, the system includes a plurality of processors and a plurality of memory modules executed by the plurality of processors. The system also includes a dynamic reconfigurable cache comprising of a multi-level cache implementing a combination of an L1 cache, an L2 cache, and an L3 cache. The one or more of the L1 cache, the L2 cache, and the L3 cache are dynamically reconfigurable to one or more sizes based at least in part on an application data size associated with an application being executed by the plurality of processors. In an embodiment, the system includes a reconfiguration control and distribution module configured to perform dynamic reconfiguration of the dynamic reconfigurable cache based on the application data size.

Abstract: The current invention features a rod screw for medical application that can be configured and used to fixate fracture of bones varying in shape and dimension, and treating maladies such as scoliosis, and securing an implanted device, to tissue such as bone. This is achieved by designing a flexible rod screw with a mechanism to lock the configuration in a rigid state. In an embodiment, a bone-fracture fixation device, such as a rod screw, includes a flexible body, a plurality of flexible members, and first and second interfaces. The flexible members are disposed longitudinally within the flexible body, such that the flexible body is rigid when the flexible members are fixed into position. And the first and second interfaces are respectively coupled to the flexible body, each of at least one of the first and second interfaces including a respective at least one hole each configured to receive a respective attachment member configured to engage a bone.

Abstract: Systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: The purpose of the present invention is to provide a novel method for making it possible to efficiently induce/produce endocrine cells from pluripotent stem cells. Insulin-producing cells including cells that are insulin-positive and NKX6.1-positive cells in a ratio of at least 30% and cells that are insulin-positive and NKX6.1-negative in a ratio of more than 15%.

Abstract: A vertical ground heat exchanger for reducing the temperature in the carbonaceous shale rock mass and preventing roadbed frost heave includes a heating mechanism, a heat releasing component respectively connected to both ends of the heating mechanism and a refrigeration heat exchange mechanism. The refrigeration heat exchange mechanism is connected to the lower end of the heating mechanism through a heat transfer pipeline and communicates with the heat releasing component. The heat releasing component includes a double-layer heat exchange tube component, a gas-liquid separator and a branch tube, wherein the double-layer heat exchange tube component is respectively connected to the both ends of the heating mechanism, the gas-liquid separator is connected to the double-layer heat exchange tube component, and the branch tube is connected between the gas-liquid separator and the refrigeration heat exchange mechanism. The double-layer heat exchange tube component includes an upper bellows and a lower bellows.

Abstract: According to the application, by measuring mass spectra of urine samples and/or serum samples in a healthy group, a negative control group, a positive control group and a treatment group of a drug to be evaluated, the mass spectra of the samples of the treatment group of the drug to be evaluated and the mass spectra of the samples of the negative control group are compared to calculate a difference between peak areas of characteristic fragment particle peaks of metabolic markers in the samples of the treatment group of the drug to be evaluated and in the samples of the negative control group, and a difference value is used to evaluate multidrug resistance of the drug to be evaluated. The larger the difference value is, the larger a callback value is, and the better an effect of reversing the tumor multidrug resistance is.

Abstract: A method of rapid treatment of heavy metal sludge and preparation of ferrite magnets comprises following steps of: providing a sludge, the sludge at least having zinc metal and ferrous metal; adding an iron-containing substance to the sludge; pickling the sludge and the iron-containing substance with sulfuric acid to obtain a pickling solution with zinc ions and iron ions; neutralizing the pickling solution with sodium hydroxide to form hydroxide precipitates; and airing and heating the neutralized pickling solution by an ultrasonic-microwave method so that the hydroxide precipitates undergoing a ferrite magnet reaction, thereby obtaining ferrite magnets with a spathic structure.

Abstract: The present disclosure provides an adeno-associated virus having a variant capsid protein, and use thereof. The variant adeno-associated virus AAV-ie refers to insert an amino acid sequence DGTLAVPFK between N589 and R590 of the capsid protein VP1 of the wild-type AAV-DJ. The variant adeno-associated virus AAV-ie can efficiently infect hair cells and supporting cells, which is greatly improved compared with the parents, therefore provides better technical support for scientific research.

Abstract: A machine-learning tool learns from sensors' data of a nuclear reactor at steady state and maps them to controls of the nuclear reactor. The tool learns all given ranges of normal operation and responses for corrective measures. The tool may train another learning tool (or the same tool) that forecasts the behavior of the reactor based on real-time changes (e.g., every 10 seconds). The tool implements an optimization technique for differing half-life materials to be placed in the reactor. The tool maximizes isotope production based on optimal controls of the reactor.

Abstract: The present disclosure provides recombinant Pichia pastoris, a construction method thereof, and use thereof in the efficient preparation of 15?-D-ethylgonendione, and belongs to the technical field of fermentation engineering. In the present disclosure, with Pichia pastoris as a host, 15?-steroid hydroxylase and glucose-6-phosphate dehydrogenase (G6PD) are simultaneously induced in a manner of intracellular enzyme production for the first time, and the Pichia pastoris whole-cell induction and catalysis mode is used to achieve the conversion of D-ethylgonendione with high substrate loading and high conversion rate.

Abstract: Controlled release of VIP from PLGA microparticles was accomplished and varied through use of different polymer molecular sizes, addition of solutes to the inner aqueous phase, and use of our computer model. Released VIP from microparticles appeared to be bioactive and caused DCs to produce more CCL22 than DCs treated with blank particles at 7 and 24 hours. Additionally, DCs treated with VIP microparticle releasates recruited higher percentages of FoxP3+ T-cells in in vitro chemotaxis studies. Testing in a mouse model in vivo indicated that VIP microparticles have significant therapeutic potential to treat periodontal disease by reducing the bone loss in infected mice relative to the blank group.

Abstract: One mode is a method for the structural analysis of an organic compound by MALDI mass spectrometry, including: a sample preparation process (S1) which includes preparing a sample by mixing a specimen containing an organic compound to be analyzed with a predetermined matrix at a mixture ratio within a range from 1:5 to 1:5000 in molar ratio; a mass spectrometry process (S3) which includes irradiating the prepared sample with a laser beam having a spot size equal to or smaller than 15 ?m to generate ions originating from a component of the specimen in the sample, and performing a mass spectrometric analysis of the generated ions; and an analyzing process (S4) which includes detecting, from a mass spectrum acquired in the mass spectrometry process, ions including product ions resulting from in-source decay, and estimating the structure of the organic compound to be analyzed based on information concerning the ions.

Abstract: A ring cavity laser source, a tunable ring cavity laser source and a method of fabricating a ring cavity laser source.

Abstract: A method for positioning key features of a lens based on ocular B-mode ultrasound images includes: acquiring and preprocessing the ocular B-mode ultrasound images to obtain a preprocessed B-mode ultrasound image, eyeball coordinates and lens coordinates; sending the preprocessed B-mode ultrasound image, the eyeball coordinates and the lens coordinates into a trained target detection network YOLOv3 to obtain eyeball position images and lens position images; substituting the eyeball position images and the lens position images into a trained feature extraction network group to obtain image features and feature coordinates corresponding to the eyeball position images and the lens position images, respectively; substituting the image features into a trained collaborative learning network to screen key image features; and marking a feature coordinate corresponding to the key image features on the ocular B-mode ultrasound images to complete positioning the key features of the lens.

Abstract: Provided herein are methods for the production of tissue resident memory-like T cells by the combination of hypoxia and TGF?. Further provided herein are methods of using the tissue resident memory T cells as adoptive cell therapy.

Abstract: The present disclosure is directed to methods of treating Zika virus infections using selective estrogen receptor modulators (SERMs), such as Tamoxifen, or a compound selected from CALP-1, A7, PMA, Chelerythrine, PHTPP, Tariquidar or S-Equol.

Abstract: Disclosed is a method of producing an olefin using a circulating fluidized bed process, including: (a) supplying a hydrocarbon mixture including propane and a dehydrogenation catalyst to a riser which is in a state of a fast fluidization regime, and thus inducing a dehydrogenation reaction; (b) separating an effluent from the dehydrogenation reaction into the catalyst and a propylene mixture; (c) stripping, in which a residual hydrocarbon compound is removed from the catalyst separated in step (b); (d) mixing the catalyst stripped in step (c) with a gas containing oxygen and thus continuously regenerating the catalyst; (e) circulating the catalyst regenerated in step (d) to step (a) and thus resupplying the catalyst to the riser; and (f) cooling, compressing, and separating the propylene mixture, which is a reaction product separated in step (b), and thus producing a propylene product.

Abstract: The invention relates to surface modified extracellular vesicles, wherein the extracellular vesicles comprise an exogenous polypeptide tag that is covalently linked to a membrane protein of the extracellular vesicles. In a particular embodiment, the tag is covalently linked to the membrane protein of microvesicles by sortase-mediated ligation. Methods of preparing said extracellular vesicles and methods of using said extracellular vesicles loaded with therapeutic molecules for treating a disease are also disclosed herein.

Abstract: The present application relates to a combination therapy for treatment of inflammatory diseases comprising an immunomodulator compound and a GABA-receptor agonist in an amount effective to reduce inflammation and ameliorate disease. In certain embodiments, the present application relates to treatment of T1D by administering an immunomodulator compound and a GABA-receptor agonist in an amount effective to prevent, reduce, and/or treat hyperglycemia in the human or animal subject. In certain embodiments, the immunomodulator compound and GABA-receptor agonist are administered in an amount effective to control autoimmune responses and safely increase ?-cell mass and function in the context of established ?-cell autoimmunity.

Abstract: A warp-knitted capacitive touch sensor system includes conductive and non-conductive yarns using interlooped stitches that are interlaced, intertwined, and/or spliced into a single conductive pathway having only two connection points to the electronic interface device, across a desired width or length of the textile material.