Patents Assigned to The University
  • Three-dimensional tissue body, method for producing same, and formation agent for three-dimensional tissue body
    Patent number: 11179495
    Abstract: Disclosed is a three-dimensional tissue comprising cells and collagen including endogenous collagen, wherein at least a portion of the cells is adhered to the collagen, and the content of the collagen is from 10 wt % to 90 wt % based on the three-dimensional tissue.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: November 23, 2021
    Assignees: TOPPAN PRINTING CO., LTD., OSAKA UNIVERSITY
    Inventors: Michiya Matsusaki, Shinji Irie, Shiro Kitano
  • Targeted carriers for tacrolimus for ocular inflammation
    Patent number: 11179334
    Abstract: A formulation and method for treating or reducing ocular surface inflammation and associated diseases and disorders. The formulation includes targeted micelles that encapsulate tacrolimus within a pharmaceutically acceptable carrier, wherein the formulation is coated in arginine-glycine-aspartic acid peptide.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: November 23, 2021
    Assignee: Florida A&M University
    Inventors: Mandip Sachdeva, Imran Vhora, Shallu Kutlehria
  • Variant RNA-guided polypeptides and methods of use
    Patent number: 11180778
    Abstract: The present disclosure provides (i) RNA-guided polypeptides (e.g., circular permuted Cas9 proteins) in which the N-terminal end of an N-terminal fragment of a parent RNA-guided polypeptide (e.g., a parent Cas9 protein) is fused (e.g., via linker) to the C-terminal end of the C-terminal fragment (thereby generating new N- and C-termini), (ii) conditionally active RNA-guided polypeptides (e.g., conditionally active circular permuted Cas9 proteins), and (iiii) Cas9 fusion polypeptides that include an internal insertion of a heterologous polypeptide; as well as methods that employ the above polypeptides.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: November 23, 2021
    Assignee: The Regents of the University of California
    Inventors: David Frank Savage, Jennifer A. Doudna, Benjamin L. Oakes, Rayka Yokoo
  • Organic light emitting diode with split emissive layer
    Patent number: 11183670
    Abstract: An organic light emitting diode (OLED) device includes an emissive layer having a first sublayer with a first emitter as a dopant, a second sublayer with a second emitter as a dopant, and a third sublayer with a third emitter as a dopant. The second sublayer is between the first sublayer and the third sublayer. A concentration of the first emitter in the first sublayer exceeds a concentration of the third emitter in the third sublayer, and the concentration of the third emitter in the third sublayer exceeds a concentration of the second emitter in the second sublayer.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: November 23, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jian Li, Kody George Klimes
  • Electric field switchable magnetic devices
    Patent number: 11183227
    Abstract: A magnetic device may include a layer stack. The layer stack may include a first ferromagnetic layer; a spacer layer on the first ferromagnetic layer; a second ferromagnetic layer on the spacer layer; and a dielectric barrier layer on the second ferromagnetic layer. In some examples, the layer stack may also include an additional ferromagnetic layer and an additional spacer layer. The magnetic device also may include a voltage source configured to apply a bias voltage across the layer stack to cause switching of a magnetic orientation of the second ferromagnetic layer without application of an external magnetic field.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: November 23, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Jian-Ping Wang, Delin Zhang, Protyush Sahu
  • Method for preparing 1,3-dicarbonyl compound based on metal hydride/palladium compound system
    Patent number: 11180437
    Abstract: Disclosed is a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method includes the following steps: suspending a palladium compound and a metal hydride in a solvent under the protection of nitrogen, then adding an electron-deficient olefin compound, reacting same at 0° C.-100° C. for 0.3 to 10 hours, then adding a saturated ammonium chloride aqueous solution to stop the reaction, and then subjecting same to extraction, evaporation until dryness, and column chromatography purification to obtain the 1,3-dicarbonyl compound. The hydride and palladium compound catalysts used by the present invention are reagents easily obtained in a laboratory. Compared to a common hydrogen hydrogenation method, the method is easier to operate, and has a higher safety, mild conditions, and a high reaction yield.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: November 23, 2021
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Shilei Zhang, Yujian Mao
  • Dialog method, dialog system, dialog apparatus and program that gives impression that dialog system understands content of dialog
    Patent number: 11183187
    Abstract: The present invention provides a dialog system comprising a speech receiving step in which the dialog system receives input of a speech of a human, a first speech determination step in which the dialog system determines a first speech which is a speech in response to the speech of the human, a first speech presentation step in which the first speech is presented by a first agent, a reaction acquisition step in which the dialog system acquires a reaction of the human to the first speech, a second speech determination step in which the dialog system determines, when the reaction of the human is a reaction indicating that the first speech is not a speech in response to the speech of the human, a second speech which is different from the first speech, and a second speech presentation step in which the second speech is presented by the second agent.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: November 23, 2021
    Assignees: NIPPON TELEGRAPH AND TELEPHONE CORPORATION, OSAKA UNIVERSITY
    Inventors: Hiroaki Sugiyama, Toyomi Meguro, Junji Yamato, Yuichiro Yoshikawa, Hiroshi Ishiguro
  • Univariant extrinsic initiator control system for microbes and an in vitro assembly of large recombinant DNA molecules from multiple components
    Patent number: 11180764
    Abstract: The invention provides, inter alia, a nucleic acid (e.g. expression vector) that comprises at least a first coding sequence and a second coding sequence. Each conding sequence is under the control of an inducible promoter of defined strength. Different promoters can have different strengths. Each promoter is responsive to the same inducer. The invention also provides: methods of expressing coding regions, methods of making a product of a multi-enzyme pathway, and methods of optimizing the yield of a product of a multi-enzyme metabolic pathway using the nucleic acids provided by the invention. Also disclosed is a method of non-enzymatic gene cloning useful for practicing the invention.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 23, 2021
    Assignees: National University of Singapore, Massachusetts Institute of Technology
    Inventors: Heng Phon Too, Ruiyang Zou, Gregory N. Stephanopoulos
  • System and method for a six-primary wide gamut color system
    Patent number: 11183097
    Abstract: Systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: November 23, 2021
    Assignee: BAYLOR UNIVERSITY
    Inventor: Gary B. Mandle
  • Loaded-to-frame detection equipment and method for backfill grouting of shield tunnel
    Patent number: 11181633
    Abstract: The present invention relates to a loaded-to-frame detection equipment for backfill grouting of a shield tunnel, including an automatic loaded-to-frame transmission apparatus, a ground penetrating radar, and an intelligent backfill grouting processing and analysis software. The equipment is integrated by using software and hardware, and can implement real-time visual detection of a backfill grouting layer in a shield construction process. The loaded-to-frame automatic transmission apparatus mainly includes a track, a synchronous belt, a transmission mechanism, a servo machine, and a drive and reducer; and a new air-coupled radar detection apparatus is carried on the loaded-to-frame automatic transmission apparatus and is installed on a shield frame. With the shield performs tunneling, circular detection on a grouting body of the shield and visual layered display of the grouting body are implemented.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: November 23, 2021
    Assignee: Tongji University
    Inventors: Xiongyao Xie, Biao Zhou, Yunxiang Zhou, Hui Qin, Yifan Chen
  • Resiquimod topical and injectable compositions for the treatment of neoplastic skin conditions
    Patent number: 11179385
    Abstract: Compositions and methods for treatment of viral skin disease, precancerous and cancerous skin disease, and other neoplasms are disclosed.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: November 23, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Xiaowei Xu, Shujing Liu, Alain Rook, Pankaj Karande
  • Method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample
    Patent number: 11181501
    Abstract: A method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample, the method including: applying the sample on an electrochemical detector having a substance selection structure, wherein the substance selection structure is sensitive to the polyamine or its derivative; applying at least one voltage bias to the electrochemical detector; and detecting a change of electrical characteristics of the electrochemical detector so as to determine the presence or the amount of the polyamine or its derivative in the sample.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: November 23, 2021
    Assignee: City University of Hong Kong
    Inventors: A. L. Roy Vellaisamy, Chi-Chung Yeung, Shishir Venkatesh, Hon-Wah Lam
  • Wood heating system and method
    Patent number: 11181318
    Abstract: A wood heating system comprises an electric power source, a first electrode assembly, a second electrode assembly, and a control system. The first electrode assembly is connected to the electric power source and is adapted to make electrical contact with a first end of a wood length to apply electric power to the wood length. The first electrode assembly comprises at least two electrode segments. The second electrode assembly is adapted to make electrical contact with a second end of the wood length. The control system is adapted to selectively connect/disconnect electric power flow between the electric power source and at least one electrode segment of the first electrode assembly.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: November 23, 2021
    Assignee: The University of Canterbury of Ilam Road
    Inventors: William John Baxter Heffernan, Nurzhan Nursultanov, Marinus Johannes Wilhelmus Maria Ryan Van Herel
  • Methods and compositions for selectively inhibiting pathogenic microbes
    Patent number: 11180452
    Abstract: A method of selectively inhibiting pathogenic microbes includes: providing a compound that is functional as a selective antimicrobial having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a pathogenic microbe with the compound such that the pathogenic microbe is selectively inhibited; wherein: ring A is a cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or polycycle combination thereof; X is S, SO, or SO2; Y is a linker or bond; Z is CH, CR2, or N; Z1 is C or N to form an imidazopyridine; each Z2, Z3, or Z4 is independently CH, CR2, or N; each Z5 or Z6 is C or CH; each R1, R2, R3 and/or R4 is independently a substituent; m is 0, 1, 2, 3, or 4; and n is zero or a positive integer.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: November 23, 2021
    Assignees: CFD Research Corporation, The Board of Regents of the University of Oklahoma
    Inventors: Anuj Singhal, Robert H. Cichewicz, Lin Du, JianLan You, Hanumantha Rao Paritala, Abigail Grace Edwards
  • Surface-emmiting laser comprising surface gratings
    Patent number: 11183814
    Abstract: A surface-emitting laser, which is a ridge waveguide structure, including: a substrate, a first cladding layer, an active layer, a conductive layer, a second cladding layer; the Bragg gratings is etched on the surface of the ridge waveguide; the two upper electrodes are disposed on both sides of the ridge waveguide; two grooves are formed between the ridge waveguide and each of the two upper electrodes; the first waveguide cladding layer includes one or more current confinement regions; or a buried tunnel junction is formed in the second cladding layer for limiting current. The Bragg gratings comprise two first-order gratings and one second-order grating placed between two first-order gratings.
    Type: Grant
    Filed: December 28, 2019
    Date of Patent: November 23, 2021
    Assignees: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Weihua Guo, Can Liu, Pengfei Zhang, Qiaoyin Lu
  • LIFE-CYCLE PERFORMANCE INTELLIGENT-SENSING AND DEGRADATION WARNING SYSTEM AND METHOD FOR CONCRETE STRUCTURES
    Publication number: 20210356451
    Abstract: A life-cycle performance intelligent-sensing and degradation warning system and method for concrete structures are disclosed. The warning system comprises a main control module, a multifunctional sensor module, an anti-theft module and a critical warning module. Environmental parameters in concrete are monitored by the multifunctional sensor module, and the remaining service life of a concrete structure is accurately predicted through a life prediction model according to the temperature, humidity, chloride ion concentration and pH at different depths, and a critical chloride ion concentration and a structure stress status that are dynamically obtained.
    Type: Application
    Filed: June 11, 2020
    Publication date: November 18, 2021
    Applicant: QINGDAO UNIVERSITY OF TECHNOLOGY
    Inventors: Penggang WANG, Zuquan JIN, Tiejun ZHAO, Dongshuai HOU, Li TIAN, Peng ZHANG, Xiaomei WAN, Siyao GUO, Yupeng TIAN
  • METHODS RELATED TO CARBON DIOXIDE
    Publication number: 20210355064
    Abstract: Some embodiments of the invention include methods of using a compound (e.g., Formula (I)) for the reduction of carbon dioxide to formate by contacting the carbon dioxide with a composition comprising a compound. In certain embodiments, the source of the carbon dioxide is air or is flue gas. Additional embodiments of the invention are also discussed herein.
    Type: Application
    Filed: July 31, 2021
    Publication date: November 18, 2021
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Steve P. CRONIN, Craig A. GRAPPERHAUS, Robert M. BUCHANAN, Jacob M. STRAIN, Joshua M. SPURGEON
  • HETEROCYCLIC COMPOUNDS EXHIBITING THERMALLY ACTIVATED DELAYED FLUORESCENCE (TADF) AND THEIR USE IN ELECTROLUMINESCENT DEVICES
    Publication number: 20210355378
    Abstract: An organic thermally activated delayed fluorescence (TADF) compound selected from the group consisting of compounds according to formula (Ia) and formula (Ib): wherein: Het is a heteroaryl group containing at least one heteroatom; n(D) denotes n donor groups D bonding to the heteroaryl group Het; n is at least 1; and -a and -b denotes bonding to another group.
    Type: Application
    Filed: April 23, 2019
    Publication date: November 18, 2021
    Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
    Inventors: Eli ZYSMAN-COLMAN, Dongyang CHEN, Rajamalli PACHAI GOUNDER
  • METHOD FOR RECTIFICATION OF 2D MULTI-VIEW IMAGES AND APPARATUS FOR THE SAME
    Publication number: 20210360218
    Abstract: Disclosed herein is a method for rectifying a 2D multi-view image. The method for rectifying a 2D multi-view image according to an embodiment of the present disclosure may include: detecting uniformly the at least one feature point in each region unit distinguished by considering a distribution of feature points of a plurality of input images: removing an error of the least one feature point; determining a corresponding pair for a vertical or horizontal direction of the at least one feature point; by considering an arrangement relationship of the plurality of input images, projecting the at least one feature point onto a projection plane; determining a disparity error for a corresponding pair for the at least one feature point that is projected onto the projection plane; and, by considering the disparity error, performing image rectification based on the at least one feature point.
    Type: Application
    Filed: May 14, 2021
    Publication date: November 18, 2021
    Applicants: Electronics and Telecommunications Research Institute, SOGANG UNIVERSITY RESEARCH & BUSINESS DEVELOPMENT FOUNDATION
    Inventors: Joon Soo KIM, Kug Jin YUN, Jun Young JEONG, Suk Ju KANG, Jung Hee KIM, Yeo Hun YUN
  • PHOTOACOUSTIC ION INDICATORS
    Publication number: 20210353782
    Abstract: A system for measuring the membrane potential of a neuron is disclosed. The system comprises one or more photoacoustic ion indicators, each comprising a metal chelating agent linked to a chromophore molecule. The metal chelating agent is configured to selectively bind to one of sodium ions, calcium ions, and potassium ions. The system further comprises a photoacoustic probe including a laser configured to emit a light signal to the chromophore and an ultrasound transducer configured to receive a photoacoustic signal in response to the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer, determine a quantity of photoacoustic ion indicators exhibiting the shift, and calculate a membrane potential of the neuron based on quantity of photoacoustic ion indicators exhibiting the shift.
    Type: Application
    Filed: May 17, 2021
    Publication date: November 18, 2021
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Barbara SMITH, Christopher MIRANDA, Madeleine HOWELL, Joel LUSK