Abstract: Systems and methods are provided for fault detection in a component of a machine during operation. Vibration data is acquired based on a vibration signal output from a sensor associated with the component. The vibration data is analyzed with at least two machine learning models to predict a condition of the component.

Abstract: Tissue scaffolds for neural tissue growth have a plurality of microchannels disposed within a sheath. Each microchannel comprises a porous wall having a thickness of ?about 100 ?m that is formed from a biocompatible and biodegradable material comprising a polyester polymer. The polyester polymer may be polycaprolactone, poly(lactic-co-glycolic acid) polymer, and combinations thereof. The tissue scaffolds have high open volume % enabling superior (linear and high fidelity) neural tissue growth, while minimizing inflammation near the site of implantation in vivo. In other aspects, methods of making such tissue scaffolds are provided. Such a method may include mixing a reduced particle size porogen with a polymeric precursor solution. The material is cast onto a template and then can be processed, including assembly in a sheath and removal of the porogen, to form a tissue scaffold having a plurality of porous microchannels.

Abstract: This disclosure relates to reagents and their use for elemental imaging mass spectrometry of biological samples.

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

Abstract: The present invention discloses a dynamic straightening method for a left/right tilt. The method includes: drawing an unevenness curve according to a distance from a shapemeter to a surface of a plate, where there are a plurality of unevenness curves; using a barycentric formula to obtain a first barycentric coordinate of each unevenness curve; calculating a tilt value of a straightening roll corresponding to each unevenness curve according to the first barycentric coordinate of each unevenness curve; determining an unevenness curve of a current straightening roll; adjusting the straightening roll according to the tilt value of the straightening roll corresponding to the unevenness curve, to straighten the plate; and going back to the step of determining an unevenness curve of a current straightening roll until the plate is totally straightened. The present invention improves plate straightening accuracy by dynamically adjusting parameters of the straightening roll.

Abstract: A magnetic tag sensor includes a cylinder and threaded pipe embedded therein and simulates a magnetic dipole; two threaded pipe wiring interfaces being connected to first and second cables, running through a cylinder upper cross-section outer wall and extending out of the cylinder; the cylinder is sleeved on a guide rail and at a junction between a riverbed and water; an guide rail end inserts into the riverbed, a water sealing box is mounted on a top of the guide rail, a power supply module, a relay and a load arranged inside the water sealing box, the first cable connected to a positive pole of the power supply module, and the second cable connected to a negative pole through the relay and load connected in series; and the threaded pipe in the wall of the cylinder moves up and down with the riverbed to generate a magnetic field signal.

Abstract: A system for predicting an effluent parameter associated with a wastewater treatment process including a predictor module configured to receive a first input dataset comprising a plurality of wastewater inflow parameters to predict a biodegradable type of effluent wastewater; a mechanistic simulator configured to receive the biodegradable type of effluent wastewater and the plurality of wastewater inflow parameters as a second input dataset to predict the effluent parameter.

Abstract: This invention discloses a multimode interconnection interface controller for a converged network, which comprises a SERDES element responsible for serial/parallel conversion, a LANE_TXCLK element responsible for generating a transmit clock, a SERDES initialization element responsible for link training and rate negotiation, and a PCS_EB coding element and an PCS_AF coding element responsible for physical layer coding of messages. The link training and rate negotiation are completed automatically via the shared SERDES initialization element. More universality and flexibility are provided for interconnection chip design by the PCS_EB coding element. The PCS_AF coding element is provided to reduce message penetration delay. The multimode interconnection interface controller is integrated in a single chip. Through flexible configuration, the single chip can meet transmission requirements of dedicated high speed networks and Ethernet networks.

Abstract: The present invention discloses a region-growing motion tracking method based on Bayesian inference and polynomial fitting, including: determining a target region; selecting candidate points; calculating a posterior probability; determining a seed point by judging the seed point according to the maximum posterior probability threshold and the maximum absolute displacement difference; dividing a known-displacement point set (including an interior point (IP) set and a boundary point (BP) set) and an unknown-displacement point set of the target region; selecting an active growing point, with the maximum posterior probability value in the boundary point set; conducting guided search; updating the displacement value; conducting local polynomial fitting; updating the IP set and the BP set; calculating strain elastogram.

Abstract: An apparatus for micromachining a semiconductor material from opposing sides through synchronous coordination of laser and electrochemistry includes an optical path system, a stable low-pressure jet generation system, and an electrolytic machining system. The optical path system includes a laser generator, a beam expander, a reflector, a galvanometer, and a lens. The electrolytic machining system includes a direct-current pulsed power supply, an adjustable cathode fixture, an electrolyte tank, a current probe, and an oscilloscope. The stable low-pressure jet generation system provides an electrolyte flow into a metal needle. The electrolyte flow forms an electrolyte layer between a semiconductor material and a cathode copper plate, such that the cathode and the anode are in electrical contact with each other. In a method employing the apparatus, a laser beam is irradiated onto the semiconductor material to form a local high-temperature region, which leads to a localized increase in electrical conductivity.

Abstract: Described herein are methods and compositions useful to reduce (partially/inhibit or completely—prevent) skin cancer development in an individual in need thereof.

Abstract: The present invention relates to computing-implemented method and system that improves matrix multiplication efficiency, especially to method and system optimizing matrix multiplication using sparse basis approach. Matrices to be multiplied are organized into specially ordered vectors with zero values, facilitates speed up during linear combination computation or synthesis process.

Abstract: The present invention relates to compositions for preventing or treating a muscle disease or improving muscle functions including a ganglioside. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a muscle disease, a food composition for preventing or ameliorating a muscle disease, and a cosmetic composition for preventing or ameliorating a muscle disease. Each of the compositions includes a ganglioside that increases the expression of proteins associated with muscle protein synthesis in muscle cells and an increase in muscle mass and inhibits the expression of enzymes involved in muscle protein degradation at the mRNA level.

Abstract: The present disclosure relates to a method of treating arthritis by targeting Tankyrase. The methods according to the present disclosure can be advantageously used for regeneration of cartilage tissue and for treating osteoarthritis by maximizing the matrix synthesis in cartilage by inhibition of Tankyrase and regulation of other proteins related therewith.

Abstract: Methods, systems, and computer readable media to detect and model a brain tumor in an electronic image and to predict features of the brain tumor based on the model. The method can include classifying one or more magnetic resonance imaging (MRI) images of a brain into one or more of one or more tumorous images containing an image of a tumor or one or more non-tumorous images, wherein the classification is performed using a deep learning CNN system. The method can also include segmenting a tumor region from one of the one or more tumorous images. The segmenting can include a neighboring Fuzzy C-Means (FCM) process. The method can further include classifying the segmented tumor region into one of four classes of brain tumor types. The segmented tumor region is classified as a particular brain tumor type using the deep learning CNN system. The method can also include reconstructing a 3D model of the tumor region and measuring one or more of a location of the tumor, a shape of the tumor, or a volume of the tumor.

Abstract: Systems and methods for active transfer learning in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a deep featurizer, wherein the method comprises training a master model and a set of one or more secondary models, wherein the master model includes a set of one or more layers, freezing weights of the master model, generating a set of one or more outputs from the master model, and training a set of one or more orthogonal models on the generated set of outputs.

Abstract: Methods and systems for automated protein purification are disclosed. The disclosed methods and systems utilize a plurality of magnetic bead chemistries and an automated extraction system for the purification of one or more proteins within a short time frame.

Abstract: A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.

Abstract: A display system includes an optical device configured according to constructive interference for a plurality of wavelengths at a focal length. The display system includes a fiber. The display system includes a controller configured to scan the fiber using a Lissajous scanning method to generate a display. The display can be disposed within a focal plane of the optical device. The controller is configured to modulate light intensity from the fiber. The controller can be configured to form a display image that passes through the optical device. The display system can include an optical combiner configured to reflect the display image from the optical device and form a virtual image. The optical device can be configured to magnify a display image from the display and form a virtual image.

Abstract: Disclosed are a system and method for quantifying changes in animal posture from video recordings of multiple interacting animals. Also disclosed are a system and method for training a posture identification algorithm efficiently with minimal human effort and evaluating the posture of millions of animal images. The disclosed process employs video recordings of behaving animals to produce a full set of geometrical coordinates for each body part over time. Inter alia, the disclosed system should be useful for organizations interested in doing large small-molecule screens to find drugs that affect the behavior of animals, and for those investigating new behavioral diagnostics for human patients. The disclosed system allows one to record video of animals and then automatically calculate the position of each body part over time. The output of this calculation can be used for simple analysis of the amount of movement for specific body parts, or part of a more complex scheme for measuring behaviors.