Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.

Abstract: An all-solution electrode fabrication process is provided. The process comprises the steps of: i) preparing and activating a shrinkable polymer substrate for deposition of a a) conductive film; ii) modifying the substrate to incorporate a linker; iii) immobilizing particles of a conductive material on the linkers of the substrate to form a conductive film on the substrate; and vi) heating the modified substrate to a temperature sufficient to cause contraction of the polymer substrate and to result in micro- and/or nano-texturing in the conductive film. The process advantageously yields a novel multi-scale electrode device comprising a polymer substrate; and a textured electro-conductive film linked to the substrate.

Abstract: Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels, depending on the solvents in the gels.

Abstract: Methods of treating cancer, such as breast cancer or colorectal cancer, in a subject are provided. The methods include administering to the subject a therapeutically effective amount of a chicken cathelicidin, such as cathelicidin-1, cathelicidin-2, or cathelicidin-3. Methods of inhibiting the growth of cancer cells are also provided.

Abstract: A method of treating a patient having an elevated inflammatory response, such as an elevated Type I interferon response, is provided. The method can be used to treat sepsis. The method comprises administering to a patient having an elevated inflammatory response, an inhibitor of anaplastic lymphoma kinase (ALK inhibitors) or expression of ALK, in an amount effective to treat the elevated inflammatory response.

Abstract: Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.

Abstract: Disclosed are a capacitance-type touch panel device and an operation method for the same. In order that the effect of disturbance noise comprised in a receiving signal is minimized, a calculation for a digital code which has been converted into a digital signal type is performed. Information about the noise level of the digital code is compared to a reference value, and, when the frequency of the noise is determined to be similar to the frequency of the receiving signal, the frequency of an operation signal, which is supplied from a signal generation unit, is changed.

Abstract: This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.

Abstract: A long-chain peptide antigen includes a plurality of epitopes. An interepitope sequence located between two of the plurality of epitopes contains four to ten consecutive tyrosines. The long-chain peptide antigen may be administered to a patient together with a hydrophobized polysaccharide, such as cholesterol-modified pullulan, and/or an adjuvant, such as CpG oligo DNA.

Abstract: A phase imaging method and apparatus are provided, the phase imaging method including causing a quantum beam from a radiation source to be incident on a detector through a test object and at least one phase grating and obtaining a phase image of the test object, based on intensity distribution of a beam in a pixel constituting the detector. The intensity distribution of the beam at least includes information of absorption (a0), visibility (V), and phase (?). At least three adjacent pixels are assumed to have a substantially identical value for each of the absorption (a0), the visibility (V), and the phase (?) through variable approximation of an image. The absorption, the visibility, and the phase are obtained, based on at least one measurement image.

Abstract: Methods and devices for tissue remodeling and repair of collagenous tissues, including tendons, ligaments, and bone, as well as scalable connective tissue manufacturing, are provided. Collagen fibers are assembled by extensional strain-induced flow crystallization of collagen monomers. Extensional strain also drives the fusion of already formed short collagen fibrils to produce long-range, continuous fibers. Wearable devices for controlled tissue remodeling and wound healing deliver a tissue remodeling solution to a tissue repair site. The remodeling solution, together with appropriate application of strain to the tissue remodeling site, accelerate healing, prevent injury, and reduce scar formation.

Abstract: A method of detecting whether or not a body chamber has an abnormal structure or function including: (a) providing a stack of images as input to a system comprising one or more hardware processors configured to obtain a stack of medical images comprising at least a representation of the body chamber inside the patient; to obtain a region of interest using a convolutional network trained to locate the body chamber, wherein the region of interest corresponds to the body chamber from each of the medical images; and to infer a shape of the body chamber using a stacked auto-encoder (AE) network trained to delineate the body chamber, wherein the AE network segments the body chamber; (b) operating the system to detect the body chamber in the images using deep convolutional networks trained to locate the body chamber, to infer a shape of the body chamber using a stacked auto-encoder trained to delineate the body chamber, and to incorporate the inferred shape into a deformable model for segmentation; and (c) detecting

Abstract: Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.

Abstract: The present invention is directed to methods of diagnosing, prognosing, and monitoring cancer in a subject. These methods involves selecting a subject having cancer, and obtaining, from the selected subject, a sample containing exosomal DNA. The presence or absence of one or more mutations in BRAF and/or EGFR is detected in the exosomal DNA sample from the subject, and a diagnosis and/or prognosis of the cancer is given based on the detection of the one or more mutations in BRAF and/or EGFR. The present invention further relates to methods of treating a subject having cancer and/or monitoring a subject response to therapy based on the detection of one or more mutations in BRAF and/or EGFR in the exosomal DNA sample.

Abstract: According to one embodiment is a flexible circuit comprising a flexible base, a conductive polymer supported by the base, and an integrated circuit component having an elongated electrical contact, wherein the elongated electrical contact penetrates into the conductive polymer, thereby providing a robust electrical connection. According to methods of certain embodiments, the flexible circuit is manufactured using a molding process, where a conductive polymer is deposited into recesses in a mold, integrated circuit components are placed in contact with the conductive polymer, and a flexible polymer base is poured over the mold prior to curing. In an alternative embodiment, a multiple-layer flexible circuit is manufacturing using a plurality of molds.

Abstract: It is an object to provide a novel wet wiper in which a sterilization effect and a wiping/cleaning effect are maintained even when the wet wiper is stored for a long period of time. A wet wiper is provided which includes: a fabric; and a chlorine-based treatment agent included in the fabric, wherein the chlorine-based treatment agent includes at least one of chlorous acid (HClO2), chlorite ion (ClO2?), and chlorine dioxide (ClO2) as an effective chlorine component.

Abstract: Stimulating cell activity within a tissue is performed by an ultrasound array transducer having a plurality of transducer elements and a controller that actuates a plurality of transducer elements to emit focused acoustic energy to a plurality of focal zone locations in a scan direction at a focal zone scan rate. The actuation of the plurality of transducer elements to emit focused acoustic energy to the plurality of focal zone locations in the scan direction at the focal zone scan rate is repeated for a plurality of sweep cycles at a sweep rate which stimulates cells for optimal tissue growth.

Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Abstract: Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acintobacter lysin polypeptides.

Abstract: A system for frequency conversion, comprises a laser source and a harmonic generation crystal. The laser source is configured to produce optical pulse energy of less than 100 ?J. The harmonic generation crystal comprises a structure characterized by a nonlinear susceptibility, and a crystal grating period which adiabatically varies along the longitudinal direction in a manner that the crystal grating period is inversely proportional to a crystal grating function of a coordinate z measured along the longitudinal direction.