Patents Assigned to The University
  • Methods of treating an IGFBP-3R expressing cancer using anti-IGFBP-3R antibodies
    Patent number: 11179451
    Abstract: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: November 23, 2021
    Assignee: Virginia Commonwealth University
    Inventors: Youngman Oh, Qing Cai
  • Method and apparatus for cuff-less blood pressure measurement in a mobile device
    Patent number: 11179047
    Abstract: A system and method is presented for cuff-less blood pressure measurement in a mobile device. A key aspect of this disclosure is the discovery of a new location for blood pressure measurement at the fingertip of a subject and that reflectance-mode photoplethysmography can be used to help make this measurement. Through experiments in human subjects, it was discovered that it is indeed possible to measure systemic blood pressure by having a subject press the fingertip against a reflectance-mode photo-plethysmography-force sensor unit under visual guidance and then compute blood pressure from the resulting variable-amplitude blood volume oscillations and applied pressure via an oscillometric algorithm.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: November 23, 2021
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramakrishna Mukkamala, Anand Chandrasekhar, Jin-Oh Hahn
  • Aircraft with super high aspect ratio based on self-unfolding folding wing technology
    Patent number: 11180239
    Abstract: Disclosed is an aircraft with a super high aspect ratio based on self-unfolding folding wing technology, the aircraft including: an aircraft body; a fixed wing; and a movable wing assembly including a first movable wing and a second movable wing. When the aircraft takes off, the first movable wing and the second movable wing are in a folded position. The first movable wing and the second movable wing are deflected and moved to an unfolded position or a folded position by the aerodynamic force and moment generated by the deflection of aerodynamic control surfaces and the differential thrust and moment generated by a distributed propulsion system.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: November 23, 2021
    Assignee: TSINGHUA UNIVERSITY
    Inventors: Haixin Chen, Xiaopeng Zhou
  • Structure evaluation system and structure evaluation method
    Patent number: 11181439
    Abstract: According to one embodiment, a structure evaluation system according to an embodiment includes a plurality of sensors, a position locator, and an evaluator. The plurality of sensors detect elastic waves. The position locator locates positions of elastic wave sources by using the elastic waves among the plurality of elastic waves respectively detected by the plurality of sensors having an amplitude exceeding a threshold value determined according to positions of the sources of the plurality of elastic waves and the positions of the plurality of disposed sensors. The evaluator evaluates a deteriorated state of the structure on the basis of results of the position locating of the elastic wave sources which is performed by the position locator.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: November 23, 2021
    Assignees: Kabushiki Kaisha Toshiba, Kyoto University
    Inventors: Tomoki Shiotani, Katsufumi Hashimoto, Hidefumi Takamine, Kazuo Watabe
  • Method for making blackbody radiation source
    Patent number: 11181425
    Abstract: A method for making blackbody radiation source is provided. A blackbody radiation cavity and a carbon nanotube array located on a substrate are provided. A black lacquer layer is coated on an inner surface of the blackbody radiation cavity. A pressure is applied to the carbon nanotube array to form a carbon nanotube paper. The carbon nanotube paper is placed on the black lacquer layer. The substrate is peeled off to make the carbon nanotube paper bond to the black lacquer layer. An adhesive tape is placed on the carbon nanotube paper. And then the adhesive tape peeling off to separate carbon nanotubes in the carbon nanotube paper from the adhesive tape and bond to the black lacquer layer, the carbon nanotubes vertically aligned and forms the carbon nanotube array.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: November 23, 2021
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Guang Wang, Yang Wei, Shou-Shan Fan
  • Foundation substrate for producing diamond film and method for producing diamond substrate using same
    Patent number: 11180865
    Abstract: It is an object to provide a method for producing a diamond substrate effective for reducing various defects including dislocation defects and a foundation substrate used for the same. This object is achieved by a foundation substrate for forming a diamond film by a chemical vapor deposition method, wherein an off angle is provided to the surface of the foundation substrate with respect to a predetermined crystal plane orientation.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: November 23, 2021
    Assignees: SHIN-ETSU CHEMICAL CO., LTD., NATIONAL INSTITUTE OF ADVANCED, INDUSTRIAL SCIENCE AND TECHNOLOGY, NATIONAL UNIVERSITY CORPORATION, KANAZAWA UNIVERSITY
    Inventors: Hitoshi Noguchi, Toshiharu Makino, Masahiko Ogura, Hiromitsu Kato, Hiroyuki Kawashima, Satoshi Yamasaki, Norio Tokuda
  • Compositions and methods for hemoglobin production
    Patent number: 11179379
    Abstract: Methods and compositions for producing fetal hemoglobin and treating a hemoglobinopathy or thalassemia are disclosed.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: November 23, 2021
    Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, COLD SPRING HARBOR LABORATORY
    Inventors: Gerd Blobel, Jeremy Grevet, Junwei Shi, Christopher Vakoc
  • Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(l,3-thiazol-5-yl) benzene which are useful for the treatment of proliferative, autoimmune or inflammatory diseases
    Patent number: 11179373
    Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 23, 2021
    Assignee: University of Dundee
    Inventors: Alessio Ciulli, Michael Zengerle, Kwok-Ho Chan
  • System and method for a six-primary wide gamut color system
    Patent number: 11183098
    Abstract: Systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: November 23, 2021
    Assignee: BAYLOR UNIVERSITY
    Inventor: Gary B. Mandle
  • CRISPR enzymes and systems
    Patent number: 11180751
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: November 23, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, Rutgers, the State University of New Jersey, The United States of America, as represented by the Secretary, Department of Health and Human Services, Skolkovo Institute of Science and Technology
    Inventors: Eugene Koonin, Feng Zhang, Yuri I. Wolf, Sergey Shmakov, Konstantin Severinov, Ekaterina Semenova, Leonid Minakhin, Kira S. Makarova, Silvana Konermann, Julia Joung, Jonathan S. Gootenberg, Omar O. Abudayyeh
  • Automated assessment of cognitive, fine-motor, and memory skills
    Patent number: 11183075
    Abstract: An automated assessment of various capabilities, such as cognitive, fine-motor, and memory skills, includes the use of Tangible Geometric Games (TAG-Games), which are a play-based assessment tools. TAG-Games are based on Sensor-Integrated Geometric Blocks (SIG-Blocks) and an interactive graphical user interface (GUI), which provide a means for real-time and remote monitoring of a user through operative communication between blocks and a remote computer. The data made available by employing TAG-Games includes: 1) block accelerations, 2) time at stages of assembly completion, 3) total completion time for quizzes, and 4) correctness of assembly steps. In addition, a GUI can display the real-time assembly configuration of the blocks.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: November 23, 2021
    Assignee: Case Western Reserve University
    Inventor: Kiju Lee
  • Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals
    Patent number: 11180498
    Abstract: The present technology provides compounds according to Formula I expected to be useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 23, 2021
    Assignee: The Regents of the University of California
    Inventors: Paul Krogstad, Michael E. Jung, Jun Zuo, Yanpeng Xing
  • Method for an acoustic resonance inspection and diagnosing of defects in solid materials and a diagnostic device
    Patent number: 11181507
    Abstract: A method includes exciting a vibration of a solid material preferably in cylindrical shape, detecting the vibration by a pair of transducers attached at opposing positions on the solid material and preferably orthogonally aligned to the excitation force, adding the pair of sensor signals to mostly cancel bending mode signal components, and processing the added output signal to obtain a frequency spectrum. A method may also include identifying a resonance peak of an extensional mode diametrically symmetric, measuring a characteristic of the resonance peak, comparing the characteristic with a series of measured values for standard samples, and determining a defect status such as decay in a wooden pole solid material.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: November 23, 2021
    Assignee: King Fahd University of Petroleum and Minerals
    Inventor: Djamel Ouis
  • Production system and method for improving yield of bayberry juice
    Patent number: 11178888
    Abstract: A production system for improving yield of bayberry juice includes a steam generator, a main body, a feed hopper, an extraction device, a cooling liquid tank and a collection container. A method for improving yield of bayberry juice includes the following steps. Bayberries are selected, soaked, cleaned, squeezed, distilled and condensed. The bayberries are distilled and condensed after ordinary squeezing, which improves the yield of bayberry juice and avoiding the waste of nutrients in the bayberry.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: November 23, 2021
    Assignee: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Jianhui Wang, Zhimin Cheng, Dongmin Liu, Yan Wang, Shouyao Xiong, Jingheng Ning, Wen Li, Yongsheng Zhang, Zhiqiang Hu, Yaru Sun
  • Mobile colorimetric assay device
    Patent number: 11181482
    Abstract: A mobile phone-based system for ELISA (MELISA). The MELISA system can perform all steps of ELISA procedure and output hormone concentration values. The system includes a heater that keeps the temperature required for sample incubation, illumination system for sample image capturing, and a digital camera system. All components are enclosed in a dark box to create optimal light conditions for image capturing. After sample images are captured, they are digitally processed, and hormone concentration values are reported based on colorimetric data from the samples. The system can be used to complete all steps of the assay, including incubation and reading. It is lightweight, can be fabricated at low cost, is portable, and can transfer test results via mobile phone. MELISA can be calibrated for accurate measurements of progesterone and has demonstrated successful measurements with the calibrated system.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: November 23, 2021
    Assignee: University of South Florida
    Inventors: Anna Pyayt, Arsenii Zhdanov, Jordan Keefe, Luis Franco-Waite
  • Identification of molecular pathways and methods of use thereof for treating retinal neurodegeneration and other neurodegenerative disorders
    Patent number: 11180760
    Abstract: Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: November 23, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Donald J. Zack, Derek S. Welsbie
  • Disposable pipette tip and methods of use
    Patent number: 11179717
    Abstract: A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid. The kit may also include a vibratory device in communication with the acoustic channel and configured for imparting a vibratory force thereto. The impartation of the vibratory force may create standing acoustic waves, thereby separating any negative acoustic contrast particles (NACPs) from the remaining contents of the liquid sample. The NACPs may capable of biospecific recognition of the analyte of interest, thereby separating the analytes of interest, which can then be collected or analyzed accordingly.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: November 23, 2021
    Assignee: Duke University
    Inventor: Gabriel P. Lopez
  • Immunogenicity of an optimized synthetic consensus DNA vaccine for porcine epidemic diarrhea virus
    Patent number: 11179458
    Abstract: Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need thereof, by administering the vaccine to the porcine.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 23, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Weiner, Emma L. Reuschel, Karuppiah Muthumani
  • Systems and methods for monitoring updrafts in clouds
    Patent number: 11181665
    Abstract: A weather forecasting system may receive satellite image samples and identify an updraft and components of the updraft within a cloud. These satellite image samples are collected over time (e.g., at 30 second to 1 minute time intervals). The system may identify an area of rotation and/or divergence at cloud top in a cumulus cloud or mature convective storm over time by comparing the samples and determine a parameter indicative of the updraft based on the area of rotation and divergence. The system may estimate aspects of the environment related to storm development and predict the occurrence of a weather event in the future based on the parameter and generate an output indicative of the occurrence.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: November 23, 2021
    Assignee: Board of Trustees of the University of Alabama
    Inventor: John R. Mecikalski
  • Voltage cooperative control method for AC/DC distribution system and an AC/DC distribution system
    Patent number: 11183848
    Abstract: Disclosed herewith is a voltage coordinated control method for an AC/DC distribution system, including steps of: acquiring an actual voltage and an actual current at a DC-side of a converter of the system to obtain a first DC voltage and a first DC current; generating a present reference current signal for the converter according to a voltage-current droop control model, and generating a first control signal to control an output state of the converter; and acquiring an actual voltage at a DC-side of an energy storage adapter in the system to obtain a second DC voltage, generating a present reference power signal for the adapter according to a voltage-power droop control model, and generating a second control signal to control an output state of the adapter.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: November 23, 2021
    Assignee: SHANDONG UNIVERSITY OF TECHNOLOGY
    Inventors: Ke Peng, Xinhui Zhang, Xueshen Zhao, Jiajia Chen, Bingyin Xu