Patents Assigned to The University
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Publication number: 20160182155Abstract: A coherent optical receiver that receives an optical PSK-modulated signal includes optical elements that combine the optical PSK-modulated signal and an optical local-oscillating (LO) signal and splits the combined optical signals into multiple parts that have a predefined phase offset relative to one another. The receiver further includes at least one thyristor and control circuitry operably coupled to terminals of the at least one thyristor. The control circuitry is configured to receive the multiple parts of the combined optical signals and controls switching operation of the at least one thyristor according to phase offset of optical PSK-modulated signal relative to the optical LO signal.Type: ApplicationFiled: December 22, 2014Publication date: June 23, 2016Applicants: The University of Connecticut, Opel Solar, Inc.Inventors: Geoff W. Taylor, Yan Zhang
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Publication number: 20160182219Abstract: An optical phase detector circuit is provided that is suitable for use in an optical phase lock loop. The optical phase detector includes a first optical flip-flop circuit configured to produce a first digital output based on ON/OFF state of a first digital optical input and a digital electrical control signal. A second optical flip-flop circuit is configured to produce a second digital output based on ON/OFF state of a second digital optical input and the digital electrical control signal. An AND gate is operably coupled to both the first and second optical flip-flops. The AND gate produces the digital electrical control signal for supply to the first and second optical flip-flop circuits according to an AND function of the first and second digital outputs produced by the first and second optical flip-flop circuits.Type: ApplicationFiled: December 22, 2014Publication date: June 23, 2016Applicants: The University of Connecticut, Opel Solar, Inc.Inventor: Geoff W. Taylor
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Publication number: 20160176712Abstract: Disclosed are a method for producing a carbon nanotube (CNT) whereby, in the local synthesis of CNTs, a high resolution, a low cost, easiness in production and mass production capability can be established at the same time; and a two-dimensionally patterned CNT obtained thereby.Type: ApplicationFiled: February 16, 2016Publication date: June 23, 2016Applicant: The University of TokyoInventors: Shigeo Maruyama, Rong Xiang
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Patent number: 9370514Abstract: Processes for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase which can serve as the continuous phase of an emulsion. The superheated aqueous phase can be used to melt poorly water soluble bioactive agents and/or matrix materials which them form molten droplets dispersed within the superheated aqueous phase. The size and size distribution of the molten droplets can be controlled using a variety of suitable methods. The molten droplets can then be cooled to form micronized particles comprising the poorly water soluble bioactive agent. If desired, the cooling rate can be selected to control the crystalline morphology of the resulting micronized particles.Type: GrantFiled: August 13, 2014Date of Patent: June 21, 2016Assignee: Board of Regents, The University of Texas SystemInventors: Hugh D. C. Smyth, Matt Herpin
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Patent number: 9370557Abstract: The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.Type: GrantFiled: June 15, 2007Date of Patent: June 21, 2016Assignee: The University Court of the University of GlasgowInventors: Timothy John Mitchell, Lea-Ann Kirkham, Graeme James Cowan, Gillian Douce
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Patent number: 9372111Abstract: A method of designing and manufacturing an acoustic sensor having a high degree of directivity is disclosed. The sensor includes a rotatable plate that is attached to a substrate with mounts. In one aspect the mounts are freely rotatable and the torque on the plate is measured using detectors disposed on springs that provide a resistance to rotation of the plate. In another aspect the plate is mounted to the substrate with mounts that torsionally deform during rotation of the plate. These detectors measure the torque on the plate according to the torsional deformation of the mounts. Methods of improving the signal to noise ratio of acoustic sensors having multiple detectors are also disclosed.Type: GrantFiled: August 12, 2013Date of Patent: June 21, 2016Assignee: Board of Regents, The University of Texas SystemInventors: Neal A. Hall, Michael L. Kuntzman, Donghwan Kim, Nishshanka Hewa-Kasakarage
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Patent number: 9370672Abstract: This is a new technique in IMRT and 3D conformal gamma radiation dose delivery using a linear accelerator with no flattening filter. The technique improves patient radiation therapy by reducing radiation scattered to surrounding normal tissue and reducing electron contamination. It increases dose rate to shorten treatment time. Linear accelerators have for decades come with a photon flattening filter to make the photon profile of planar fluence to make the dose distribution more uniform. These filters, however, resulted in fluence attenuation and contamination of the beam. Now in the age of techniques such as intensity modulated radiation therapy (IMRT) the function of the flattening filter becomes redundant. The flattening filter now merely reduces the efficiency of the beam by reducing the fluence and increasing scattered radiation. Our technique involves removal of the flattening filter for complex treatments. It uses inverse planning along with multi-leaf collimators to shape the dose distribution.Type: GrantFiled: February 20, 2007Date of Patent: June 21, 2016Assignee: The University of ToledoInventors: E. Ishmael Parsai, John J. Feldmeier
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Patent number: 9373492Abstract: Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm2 to about 25 cm2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.Type: GrantFiled: March 14, 2013Date of Patent: June 21, 2016Assignee: The University of North Carolina at Chapel HillInventor: John Michael Ramsey
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Patent number: 9372267Abstract: Apparatus and methods comprising a positron emission tomography detector having a first rectangular cross-section crystal block positioned between a first pentagonal cross-section crystal block and a second pentagonal cross-section crystal block.Type: GrantFiled: November 20, 2013Date of Patent: June 21, 2016Assignee: Board of Regents, The University of Texas SystemInventors: Hongdi Li, Wai-Hoi Wong, Yuxuan Zhang
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Patent number: 9370527Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.Type: GrantFiled: December 19, 2013Date of Patent: June 21, 2016Assignee: The Regents Of The University Of MichiganInventors: Robert U. Simpson, Peter D. R. Higgins, Laura A. Johnson
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Patent number: 9370497Abstract: The present invention relates generally to the field of inflammatory diseases of the peripheral nervous system. More particularly, it concerns methods for treating inflammatory diseases of the peripheral nervous system by modulating sphingosine-1-phosphate receptor activity. In one embodiment, the present invention provides a method of treating a subject with chronic inflammatory demyelinating polyneuropathy (CIDP) or other autoimmune neuropathies comprising administering to the subject an effective amount of FTY720.Type: GrantFiled: August 5, 2015Date of Patent: June 21, 2016Assignee: The University of ChicagoInventor: Betty C. Soliven
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Patent number: 9372245Abstract: An endogenous source of magnetic resonance image contrast of biological tissues is provided by modeling a conventional magnetization transfer (CMT) spectrum using z-spectral data and generating magnetization transfer ratio maps from the magnetization transfer spectrum at a frequency of interest. A contribution by the CMT spectrum from the z-spectral data is removed and a direct water saturation component is modeled using the z-spectral data with removed CMT spectrum (z-spectral). When this modeled direct water saturation component contribution is removed from the z-spectral, then the remaining z-spectra reflects new contrast due to chemical exchange saturation transfer (CEST) and magnetization transfer/exchange effect from aliphatic protons probably associated with labile proteins, peptides and lipids, named as novel magnetization transfer (NMT).Type: GrantFiled: November 21, 2012Date of Patent: June 21, 2016Assignee: The Trustees Of The University Of PennsylvaniaInventors: Anup Singh, Kejia Cai, Mohammad Haris, Hari Hariharan, Ravinder Reddy
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Patent number: 9373742Abstract: Plasma-assisted techniques are provided for fabricating semiconductor devices. In one aspect, a plasma is applied to a substrate before exfoliating layers of a multi-layer structure of atomically thin two-dimensional sheets onto the substrate. The exfoliated layers serve as the basis for constructing a semiconductor device. In another aspect, a p-n junction is formed by applying a plasma to top layers of a multi-layer structure of atomically thin two-dimensional sheets and then exfoliating a portion of the multi-layer structure onto a bottom electrode.Type: GrantFiled: March 6, 2015Date of Patent: June 21, 2016Assignee: The Regents Of The University Of MichiganInventors: Xiaogan Liang, Hongsuk Nam, Sungjin Wi, Mikai Chen
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Publication number: 20160166291Abstract: A fusion device includes a screw having a head and a shaft. A hollow bone dowel is disposed about the shaft of the screw. The bone dowel is formed from a bone-like, biocompatible, or allograft material.Type: ApplicationFiled: June 24, 2014Publication date: June 16, 2016Applicant: The University Of ToledoInventors: Vijay K. Goel, Anand K. Agarwal, David Dick
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Publication number: 20160171293Abstract: A method of tracking the position of a body part, such as a hand, in captured images, the method comprising capturing (10) colour images of a region to form a set of captured images; identifying contiguous skin-colour regions (12) within an initial image of the set of captured images; defining regions of interest (16) containing the skin-coloured regions; extracting (18) image features in the regions of interest, each image feature relating to a point in a region of interest; and then, for successive pairs of images comprising a first image and a second image, the first pair of images having as the first image the initial image and a later image, following pairs of images each including as the first image the second image from the preceding pair and a later image as the second image: extracting (22) image features, each image feature relating to a point in the second image; determining matches (24) between image features relating to the second image and image features relating to in each region of interest inType: ApplicationFiled: March 28, 2014Publication date: June 16, 2016Applicant: The University of WarwickInventors: Chang-Tsun Li, Yi Yao
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Publication number: 20160172080Abstract: A REBCO superconductor tape that can achieve a lift factor greater than or equal to approximately 3.0 or 4.0 in an approximately 3 T magnetic field applied perpendicular to a REBCO tape at approximately 30 K. In an embodiment, the REBCO superconductor tape can include a critical current density less than or equal to approximately 4.2 MA/cm2 at 77 K in the absence of an external magnetic field. In another embodiment, the REBCO superconductor tape can include a critical current density greater than or equal to approximately 12 MA/cm2 at approximately 30 K in a magnetic field of approximately 3 T having an orientation parallel to a c-axis.Type: ApplicationFiled: April 1, 2014Publication date: June 16, 2016Applicant: The University of Houston SystemInventor: Venkat Selvamanickam
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Publication number: 20160170097Abstract: A liquid crystal device (100) for focusing visible light, the liquid crystal device (100) comprising a plurality of curved substrates (101,102) arranged to form one or more curved cavities (104) therebetween, each substrate being configured to provide a focal power, wherein the one or more curved cavities contain liquid crystal and form one or more liquid crystal elements. Each of the one or more liquid crystal elements are configured to provide a focal power, the focal power of each of the liquid crystal elements being dependent on the curvature of the respective cavity and a voltage applied across the liquid crystal contained within the respective cavity. The substrates (101,102) in combination with the one or more liquid crystal elements are arranged to provide a first focal power in a substantial absence of an applied voltage and a second focal power in response to an applied voltage.Type: ApplicationFiled: July 30, 2014Publication date: June 16, 2016Applicant: The University of ManchesterInventors: Harry Edward Milton, Sarabjot Kaur, John Clifford Jones, Helen Frances Gleeson, Philip Bruce Morgan, John Clamp
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Publication number: 20160166736Abstract: Provided is an osteoinductive material comprising a substrate; and a layer of a hydrocarbyl group comprising 10 to 12 carbon atoms, the hydrocarbyl group having one end attached to the substrate and a presenting amine (—NH2) group at the unattached end. The hydrocarbyl group may be 11 carbons long, and may be provided in the form of 11-aminoundecyltriethoxysilane. The substrate may be a glass; metal; polymer; ceramic; plastic; or hydroxyapatite. The substrate may, for example, be a metal selected from the group consisting of: titanium; titanium alloys; cobalt chrome; and steel. An osteoinductive material may be provided in the form of a medical implant, or part thereof, such as an orthopaedic implant or a dental implant or part thereof. Alternatively the substrate may be in the form of a cell culture vessel. Also provided is a method of producing such osteoinductive materials, the medical use of such materials, and a method of producing bone or a bone precursor utilising the disclosed materials.Type: ApplicationFiled: July 29, 2014Publication date: June 16, 2016Applicant: The University Of LiverpoolInventors: Judith Curran, John Hunt
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Publication number: 20160165860Abstract: The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD163 in vivo.Type: ApplicationFiled: July 24, 2014Publication date: June 16, 2016Applicant: The University Court of the University of Edinburg hInventors: Tahar Ait-Ali, Simon Lillico, Alan Archibald, Christopher Bruce Alexander Whitelaw
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Patent number: 9365510Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, R3, R4, M1, M2, X, L1, L2, J1, J2, a1, a2, b1 and b2 are as defined herein, and wherein at least one of M2 or L2 is a moiety comprising an aziridine, acrylamide or sulfonate functional group, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.Type: GrantFiled: April 16, 2013Date of Patent: June 14, 2016Assignees: British Columbia Cancer Agency Branch, The University of British ColumbiaInventors: Raymond John Andersen, Marianne Dorothy Sadar