Abstract: The present disclosure describes compositions and methods for regenerating tissue and/or preventing tissue loss by stimulating stem cells. A method includes providing a treatment composition including one or more CSA compounds and a carrier, applying the treatment composition to a targeted tissue region of a subject, and the treatment composition stimulating tissue regeneration and/or preventing tissue degradation at the targeted region of the subject.
Type:
Grant
Filed:
May 21, 2020
Date of Patent:
January 7, 2025
Assignee:
Brigham Young University
Inventors:
Paul B. Savage, Michael C. Moore, Chad S. Beus
Abstract: The present disclosure provides a method for in-situ monitoring of a full cycle of spatter formation, ejection, and falling in laser additive manufacturing. In a spatter formation stage, a paraxial multiocular high-speed photographing apparatus is used to provide a high temporal-spatial resolution, accurately collect spatial positions of spatters at each sampling time, and reconstruct a motion trajectory of the spatters in three-dimensional (3D) space. In an ejection stage, a coaxial monocular high-speed photographing apparatus is used to provide a long-term high temporal-spatial resolution and accurately collect and count an ejection velocity and angle and a motion trajectory of the spatters, and a photodiode monitors a radiation intensity and changes of the spatters. In a falling stage, a multiocular photographing apparatus is used to provide a high spatial resolution covering an entire powder bed and collect a distribution state of falling spatters.
Abstract: To provide a high emissivity coating composition capable of exhibiting a higher emissivity at a low elevated temperature and substantially reduced formation micro craze when coated upon a substrate, and enabling a simplified application process, a high emissivity coating composition, comprising a powder mixture for providing emissivity; a binder for providing adhesion; and a co-binder for promoting adhesion and film-forming, characterized in that the powder mixture comprises at least three metal compounds of formula A(y?3)By/2Oy, wherein y is 4; A is selectable from a group of Ni and Co; B is selectable from a group of Fe and Cr; and O is oxygen; and the co-binder is an aqueous solution comprising silica in a compound of Formula (1), wherein R1 is H—Si—(CH3)2; and a compound of Formula (2), wherein R2 is CH3, is disclosed herein.
Type:
Grant
Filed:
December 6, 2019
Date of Patent:
January 7, 2025
Assignees:
THAI OIL PUBLIC COMPANY LIMITED, CHULALONGKORN UNIVERSITY
Abstract: To solve problems of frequent occurrence and great harm of membrane fouling during MBR wastewater treatment process, the invention proposes a membrane fouling intelligent early warning method to realize online and accurate early warning of membrane fouling. This early warning method achieves accurate prediction of water permeability by constructing soft-computing model based on recurrent fuzzy neural network. The intelligent early warning of membrane fouling is achieved by the comprehensive evaluation method, which solves the problem that membrane fouling is difficult to be early warning in the MBR wastewater treatment process, improves the pretreatment ability of membrane fouling, reduces the damage caused by membrane fouling, ensures the safe operation of MBR wastewater treatment process, and promotes efficient and stable operation of MBR wastewater treatment plant.
Type:
Grant
Filed:
August 26, 2019
Date of Patent:
January 7, 2025
Assignee:
BEIJING UNIVERSITY OF TECHNOLOGY
Inventors:
Hong-Gui Han, Ying-Xu Wang, Shu-Jun Wu, Min Guo
Abstract: The present invention relates in part to compositions and methods for treating a wound, or location of interest, in mammal by administering a decellularized extracellular matrix (ECM) lacking thrombospondin-2 (TSP-2-null ECM). In certain embodiments, the invention provides an acellular composition comprising a decellularized TSP-2-null ECM. In certain embodiments, the invention provides a tunable hydrogel comprising a decellularized TSP-2-null ECM. The invention also provides, in certain embodiments, methods for accelerating cellular migration, methods for enhancing cellular invasion, methods for enhancing vascular growth and maturation of a region to be treated, and/or methods for enhancing a wound repair in a mammal in need thereof.
Abstract: An integrated triaxial shear and seepage experimental method for hydrate-bearing sediments and device thereof is provided, relating to the field of geotechnical experiments technologies. The method includes the following steps: generating hydrate; preparing a shear and seepage coupling experiment; and performing the shear and seepage coupling experiment. According to a special integrated experimental device, that coupling analysis of seepage and stress in a triaxial shear breakage process of the hydrate can be realized, and different experiments that are liquid seepage experiment and the gas-liquid seepage experiment can be realized.
Abstract: Patient specific medical balloons, assemblies, and systems for forming the same, and devices and methods for treating patients in need of a percutaneous coronary intervention (PCI) are disclosed. The assembly for forming the medical balloon comprises a form for receiving a parison where the form is configured to prepare a patient specific medical balloon matched in geometry to a blood vessel or a lesion for a patient in need of a PCI.
Type:
Grant
Filed:
April 14, 2022
Date of Patent:
January 7, 2025
Assignees:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, BIOVENTURES, LLC
Inventors:
Maxwell Bean, Morten Jensen, Barry Uretsky, Kaitlyn Elmer
Abstract: A method of manufacturing a photonic chip. The method comprises providing a wafer comprising a silicon substrate, and a low refractive index layer above the silicon substrate, forming a first trench having a first height and a second trench having a second height by etching the low refractive index layer. The second height is greater than the first height and the second trench has a bottom surface that is closer to the substrate than a bottom surface of the first trench.
Type:
Grant
Filed:
November 27, 2020
Date of Patent:
January 7, 2025
Assignee:
University of Southampton
Inventors:
David Thomson, Graham Reed, Weiwei Zhang, Martin Ebert
Abstract: According to the present invention, blood pressure surges is detected from time-series data on blood pressure of a subject that varies with pulsation based on predetermined determination criteria. A feature amount indicating a characteristic of each blood pressure surge thus detected is obtained. Statistical processing is performed on an occurrence number of the blood pressure surges thus detected and/or the feature amount to obtain a statistical amount for each of time slots. A required attention degree indicating a level of attention being required to the blood pressure surge is obtained for each of the time slots based on the statistical amount of the occurrence number of the blood pressure surges and/or the feature amount. The required attention degree thus obtained and/or the statistical amount are displayed side by side for each of the time slots on a display screen.
Type:
Grant
Filed:
September 22, 2021
Date of Patent:
January 7, 2025
Assignees:
OMRON HEALTHCARE CO., LTD., JICHI MEDICAL UNIVERSITY
Abstract: An interactive image marking method is introduced. The interactive image marking method includes the following steps, displaying a target image and at least one marked region in the target image; receiving an interactive signal, where the interactive signal corresponds to a first pixel of the target image; calculating a correlation between the first pixel and pixels of the target image, and determining a correlation range in the target image according to the correlation; editing the marked region according to the correlate range; and displaying the edited marked region. In addition, an electronic device and a recording medium using the method are also introduced.
Abstract: Described herein is a method for mixing unequal amounts of two reagents to produce a detectable reaction in a microfluidic chip. In one example, there is a fluorescent microfluidic urinary albumin chip (UAL-Chip) that exploits the nonimmunological fluorescent assay. In this chip, we constructed a passive and continuous mixing module, in which the loading process requires only an inexpensive dropper, and the signal is stable over time, as discussed below. We applied a pressure-balancing strategy based on the immiscible oil coverage which highly improves the precision in controlling the mixing ratio of sample and dye. The UAL-Chip has achieved an estimated limit of detection (LOD) of 8.4 ?g/ml using albumin standards, which is below the 30 ?g albumin per ml urine level considered to be indicative of kidney damage.
Type:
Grant
Filed:
September 24, 2019
Date of Patent:
January 7, 2025
Assignee:
University of Manitoba
Inventors:
Francis Lin, Jiandong Wu, Claudio Rigatto, Paul Komenda, Navdeep Tangri, Gong Zhang
Abstract: A method and apparatus of managing information are configured to replace parts of an Internet of Things (IoT) device in a machine-to-machine (M2M) system. A method for operating a first device may include receiving a first message for requesting registration of at least one resource related to a second device including a plurality of parts, generating at least one resource comprising information on the plurality of parts, and transmitting, to the second device, a second message for recommending replacement of a part corresponding to a condition for replacing at least one of the plurality of parts when the condition is satisfied.
Type:
Grant
Filed:
November 23, 2021
Date of Patent:
January 7, 2025
Assignees:
Hyundai Motor Company, Kia Corporation, Industry Academy Cooperation Foundation of Sejong University
Abstract: A heat pump system having a common refrigerant flow path split coupled to heating mode first and second refrigerant streams. In the common refrigerant flow path, a compressor is coupled to receive refrigerant from the heating mode first refrigerant stream and the heating mode second refrigerant stream. A refrigerant-to-refrigerant heat exchanger couples heat between the heating mode first refrigerant stream and the heating mode second refrigerant stream. A first refrigerant-air heat exchanger and a second refrigerant-air heat exchanger in a second air flow conduit is coupled to receive a first air flow from a first refrigerant-air heat exchanger in a first air flow conduit.
Type:
Grant
Filed:
November 16, 2020
Date of Patent:
January 7, 2025
Assignee:
UNIVERSITY OF HULL
Inventors:
Xudong Zhao, Jing Li, Yi Fan, Ali Badiei, Min Yu, Steve Myers
Abstract: A method for removing hydrogen sulfide (H2S) from a H2S-containing gas composition, including charging an aqueous media to a reactor under continuous agitation, dispersing particles of a composite in the aqueous media to form a composite mixture, continuously agitating the composite mixture, introducing the H2S-containing gas composition to the reactor containing the composite mixture under continuous agitation and passing the H2S-containing gas composition through the composite mixture, and adsorbing and removing H2S from the gas composition by the composite mixture to form a purified gas composition. The composite contains a CuMnAl layered triple oxide (LTO) and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. The ZIF-67 nanoparticles are dispersed between layers of the CuMnAl LTO.
Type:
Grant
Filed:
June 17, 2024
Date of Patent:
January 7, 2025
Assignee:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.
Type:
Grant
Filed:
September 10, 2019
Date of Patent:
January 7, 2025
Assignees:
The Regents of the University of California, University College Dublin
Inventors:
Stefan Oscarson, John Vincent Fahy, Irina Gitlin, Wilfred Raymond
Abstract: The current disclosure provides alternating current based systems and methods to develop chemical compounds, such as drug molecules using electrochemistry in organic synthesis.
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SURF1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a SURF1 polypeptide.
Type:
Grant
Filed:
November 7, 2020
Date of Patent:
January 7, 2025
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Abstract: Improved acoustic neurostimulation is provided by having two or more acoustic transducers generate an acoustic interference pattern in a region of a patient being treated. The apparatus has at least two operating modes it can switch between. A first operating mode has the transducers driven at the same frequency. A second operating mode has the transducers driven at different frequencies. Full control of the acoustic transducers allows the acoustic interference pattern to be varied electronically at will.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
January 7, 2025
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Michael D. Menz, Butrus T. Khuri-Yakub, Stephen A. Baccus, Patrick Ye, Kim Pauly, Kamyar Firouzi, Morten F. Rasmussen, Omer Oralkan, Amin Nikoozadeh
Abstract: To provide an artificial bone having a porous structure with an improved affinity to osteogenic cells, an artificial bone (1) includes: a base material (2) containing porous ceramics provided with mutually interconnected multiple pores (6); a carbonaceous thin film (10) formed on an outer surface of the base material and wall surfaces (7) of the pores; and functional groups (13) including amino groups (12) provided on a surface and in an interior of the carbonaceous thin film.