Patents Assigned to The University
  • Fluorinated aromatic materials and their use in optoelectronics
    Patent number: 9246105
    Abstract: Fluorinated aromatic materials, their synthesis and their use in optoelectronics. In some cases, the fluorinated aromatic materials are perfluoroalkylated aromatic materials that may include perfluoropolyether substituents.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: January 26, 2016
    Assignee: The University of South Dakota
    Inventor: Haoran Sun
  • Nanocomposites for neural prosthetics devices
    Patent number: 9242087
    Abstract: Implantable electrically conductive devices are provided having a nanocomposite material coating comprising gold nanoparticles or carbon nanotubes. Such an implantable device may be a neural or other implantable prosthesis, including microelectrodes for use in vivo. The devices may have dimensions on a cellular scale. Further, the devices may be highly flexible and electrically conductive, while also having low impedance and high storage charge capacity. Layer-by-layer methods for fabricating such nanocomposite materials for implantable devices are also provided. Methods for direct-write lithography patterning of such nanocomposite material coatings are also provided.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: January 26, 2016
    Assignee: The Regents Of The University Of Michigan
    Inventors: Nicholas A. Kotov, Huanan Zhang
  • Patient modeling from multispectral input image volumes
    Patent number: 9245208
    Abstract: A computer-implemented method is provided for generating patient models from multiple imaging contrast sources which may be, for example from magnetic resonance imaging without computed tomography. The method includes: acquiring multiple sets of image data representing a volume of a patient using magnetic resonance imaging, wherein each set of image data is acquired in a different manner so as to create contrast amongst tissue types of the patient; classifying tissue in each voxel in the volume using the multiple sets of image data as input to a classification algorithm; and generating a patient model for the volume from probability distributions of the classes of tissue as derived from the classification algorithm.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: January 26, 2016
    Assignee: The Regents of The University of Michigan
    Inventors: James Balter, Yue Cao
  • Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same
    Publication number: 20160016920
    Abstract: Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul Erhardt, Brian Kress
  • GOLD COMPLEXES
    Publication number: 20160016976
    Abstract: Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(?OH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3? rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
    Type: Application
    Filed: March 2, 2011
    Publication date: January 21, 2016
    Applicant: University Court of The University of St Andrews
    Inventor: Steven P. Nolan
  • Prevention of infarct expansion
    Patent number: 9238046
    Abstract: Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 19, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Robert C. Gorman, Joseph H. Gorman, III, Liam P. Ryan
  • Chimeric factor VII molecules
    Patent number: 9238060
    Abstract: The present invention relates to chimeric Factor VII polypeptides and methods of using the same.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: January 19, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Darrel W. Stafford, Dengmin Feng
  • Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
    Patent number: 9238038
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: January 19, 2016
    Assignees: The University of North Carolina at Chapel Hill, Novan, Inc.
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Methods and systems for using actuated surface-attached posts for assessing biofluid rheology
    Patent number: 9238869
    Abstract: Methods, systems, and computer readable media for using actuated surface-attached posts for assessing biofluid rheology are disclosed. According to one aspect, a method for testing properties of a biofluid specimen includes placing the specimen onto a micropost array having a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end, and generating an actuation force in proximity to the micropost array to actuate the microposts, thereby compelling at least some of the microposts to exhibit motion. The method further includes measuring the motion of at least one of the microposts in response to the actuation force and determining a property of the specimen based on the measured motion of the at least one micropost.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: January 19, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard Superfine, Richard Chasen Spero, Adam Richard Shields, Benjamin Aaron Evans, Briana Lee Fiser
  • Dynamic laser beam shaping methods and systems
    Patent number: 9238577
    Abstract: Dynamic radiation beam shaping methods and systems, comprising: providing a radiation source for delivering an input radiation beam; disposing a first optical element substantially adjacent to the radiation source; disposing a second optical element substantially adjacent to the first optical element; and moving one or more of the first optical element and the second optical element relative to one another such that either an output radiation beam has a variable predetermined shape or the output radiation beam maintains a predetermined shape when the input radiation beam is varied. Optionally, the first optical element and the second optical element each comprise a freeform shape and predetermined diffractive characteristics, refractive characteristics, reflective characteristics, hybrid characteristics, gradient index materials, metamaterials, metasurfaces, subwavelength structures, and/or plasmonics.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: January 19, 2016
    Assignee: The University of North Carolina at Charlotte
    Inventors: Thomas J. Suleski, Paul J. Smilie, Jason A. Shultz
  • SPECIFIC DETECTION TOOL FOR MESENCHYMAL AND EPITHELIAL-MESENCHYMAL TRANSFORMED CIRCULATING TUMOR CELLS
    Publication number: 20160009812
    Abstract: The present invention includes the discovery of cell-surface vimentin as a novel biomarker to detect and isolate mesenchymal and epithelial-mesenchymal transformed circulating tumor cells from blood of cancer patients. In addition, an antibody specific for the detection of cell-surface vimentin on circulating tumor cells and the use the antibody to detect, enumerate, and isolate CTC are provided.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 14, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Arun SATELLI, Shulin LI
  • GLS1 INHIBITORS FOR TREATING DISEASE
    Publication number: 20160009704
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
    Type: Application
    Filed: July 2, 2015
    Publication date: January 14, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Timothy Heffernan, Matthew M. Hamilton, Zhijun Kang, Michael J. Soth, Jason P. Burke, Kang Le, Christopher Lawrence Carroll, Wylie S. Palmer, Richard Lewis, Timothy McAfoos, Barbara Czako, Gang Liu, Jay Theroff, Zachary Herrera, Anne Yau
  • Covalent Attachment of Bacteriophages (Phages) to Polymeric Surfaces
    Publication number: 20160010077
    Abstract: We disclose a method of covalently attaching bacteriophages to a surface, including polymers, to create a resulting antibacterial surface device. Because the bacteriophages are specific for bacteria, other organisms for which the phages are not specific are not damaged by the phage-modified surfaces.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 14, 2016
    Applicant: The University of Southern Mississippi
    Inventors: Marek W. Urban, Mohamed o Elasri
  • Ultrastable Silver Nanoparticles
    Publication number: 20160009736
    Abstract: Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 14, 2016
    Applicant: The University of toledo
    Inventors: Terry BIGIONI, Anil DESIREDDY, Brian CONN
  • Reconfigurable antennas for performance enhancement of interference networks employing interference alignment
    Patent number: 9236955
    Abstract: By using reconfigurable antenna based pattern diversity, an optimal channel can be realized in order to maximize the distance between two subspaces, thereby increasing sum-rate. The inventors show the benefits of pattern reconfigurability using real-world channels, measured in a MIMO-OFDM interference network. The results are quantified with two different reconfigurable antenna architectures. An additional 47% gain in choral distance and 45% gain in sum capacity were achieved by exploiting pattern diversity with IA. Due to optimal channel selection, the performance of IA can also be improved in a low SNR regime.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: January 12, 2016
    Assignees: Drexel University, The Trustees Of The University Of Pennsylvania
    Inventors: Rohit Bahl, Nikhil Gulati, Kapil R. Dandekar, Dwight L. Jaggard
  • Pharmaceutical compositions which inhibit FKBP52-mediated regulation of androgen receptor function and methods of using same
    Patent number: 9233973
    Abstract: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: January 12, 2016
    Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services, The Regents of the University of California, a California Corporation, Board of Regents, The University of Texas System
    Inventors: Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Kugelman-Tonos, Heather A. Balsiger, Robert Fletterick
  • Moisture-activated self-heating analysis device
    Patent number: 9233368
    Abstract: Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: January 12, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, Changchun Liu, Michael G. Mauk, Robert W. Hart, Xianbo Qiu
  • Optical source
    Patent number: 9235101
    Abstract: An integrated optical device and method for generating photons by manipulating path entanglement is provided. An integrated optical splitter splits pump light between two interferometer arms wherein each arm comprises a substantially identical photon pair source configured to be able to convert at least one pump light photon into a signal and idler photon pair. An integrated optical combiner device in optical communication with a first and a second optical output path interferes light from the first and second arms and outputs the signal and idler photons by bunching the signal and idler photons together in one of the optical output paths, or anti-bunching the signal photon in one output path and the corresponding idler photon in the other optical output path.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: January 12, 2016
    Assignee: The University of Bristol
    Inventors: Joshua Wimbridge Silverstone, Damien Bonneau, Mark Gerard Thompson, Jeremy Lloyd O'Brien
  • Non-volatile resistance-switching thin film devices
    Patent number: 9236118
    Abstract: Disclosed herein is a resistive switching device having an amorphous layer comprised of an insulating silicon-containing material and a conducting material. The amorphous layer may be disposed between two or more electrodes and be capable of switching between at least two resistance states. Circuits and memory devices including resistive switching devices are also disclosed, and a composition of matter involving an insulating silicon-containing material and a conducting material comprising between 5 and 40 percent by molar percentage of the composition is disclosed herein as well. Also disclosed herein are methods for switching the resistance of an amorphous material.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: January 12, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: I-Wei Chen, Soo Gil Kim, Albert Chen, Yudi Wang
  • Catalysis by metal nanoparticles dispersed within a hierarchically porous carbon material
    Patent number: 9233366
    Abstract: Disclosed are hierarchically porous carbon materials with a plurality of discreet nanoparticles dispersed on their carbon phase. The materials possess a continuous network of pores that spans the porous material, permitting the flow of fluids into and through the material. The porous materials can be used as heterogeneous catalysts.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: January 12, 2016
    Assignee: Board of Trustees of The University of Alabama
    Inventors: Martin G. Bakker, Franchessa Maddox Sayler, Kevin Shaughnessy