Abstract: Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
Type:
Grant
Filed:
May 11, 2015
Date of Patent:
February 9, 2016
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
John Scott Mellors, Erin Anne Redman, John Michael Ramsey
Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
Type:
Grant
Filed:
March 11, 2014
Date of Patent:
February 9, 2016
Assignee:
The University of North Carolina at Chapel Hill
Abstract: A pixel array includes pixels arranged in columns. A pair of column lines is provided for each column of pixels. A current source circuit is coupled to each pair of column lines. The current source circuit provides current to the pair of column lines in a first mode of operation such that when one column line in a pair of column lines is being provided with a first current the other column line in the pair of column lines is being provided with a second current which is less than the first current.
Type:
Application
Filed:
June 5, 2015
Publication date:
February 4, 2016
Applicants:
STMicroelectronics (Research & Development) Limited, The University Court of the University of Edinburgh
Abstract: The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme.
Type:
Application
Filed:
June 29, 2015
Publication date:
February 4, 2016
Applicants:
Seneb Biosciences, Inc., The University of British Columbia
Inventors:
Karl F. JOHNSON, Shawn DEFREES, Stephen WITHERS, Mark VAUGHAN
Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
Type:
Application
Filed:
July 22, 2015
Publication date:
February 4, 2016
Applicant:
The University of Vermont and State Agricultural College
Abstract: A gas sensor that can enhance gas detection sensitivity more than the conventional sensors with a simple configuration is proposed. An electric double layer including a gate insulating layer is formed in an ionic liquid (IL), a change of a state of the gate insulating layer in the ionic liquid (IL) that occurs by absorbing a gas is directly reflected in a source-drain current (Isd) that flows in a carbon nanotube (8). Therefore, the gas detection sensitivity can be enhanced more than in the conventional sensors. Further, since the ionic liquid (IL) can be simply provided on a substrate (2) to be in contact with the carbon nanotube (8) and a gate electrode (7), the configuration that chemically modifies a surface of the carbon nanotube with a plurality of polymers as in the conventional gas sensors is not needed, and the configuration can be simplified correspondingly.
Type:
Grant
Filed:
December 27, 2012
Date of Patent:
February 2, 2016
Assignees:
The University of Tokyo, Omron Corporation
Abstract: A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure.
Type:
Grant
Filed:
November 19, 2010
Date of Patent:
February 2, 2016
Assignee:
The Regents of The University of Michigan
Abstract: Nanorod and nanowire compositions are disclosed comprising copper indium selenide, copper indium gallium selenide, copper indium sulfide, or a combination thereof. Also disclosed are photovoltaic devices comprising the nanorod and/or nanowire compositions. Also disclosed are methods for producing the nanorod and nanowire compositions, and photovoltaic devices described herein.
Type:
Grant
Filed:
July 8, 2011
Date of Patent:
February 2, 2016
Assignee:
Board of Regents, The University of Texas System
Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.
Type:
Grant
Filed:
August 11, 2014
Date of Patent:
February 2, 2016
Assignee:
The University of North Carolina at Chapel Hill
Abstract: An improvement in a method of making a semiconducting device having a hole-collecting electrode includes coating the hole-collecting electrode with a p-type transition metal oxide through a sol-gel process.
Abstract: Apparatus for inspecting an article comprising: a controller configured to generate a drive signal having a periodic amplitude variation; a source, the source being operable by the controller to emit a source beam thereby to irradiate an article, the source beam comprising a beam of electromagnetic radiation having a periodic amplitude variation corresponding to that of the drive signal; and a detector, the detector being configured to detect a portion of the source beam that has been transmitted through at least a portion of the article, and to generate a detector signal having an amplitude variation corresponding to the amplitude variation of said portion of the source beam, the controller being further configured to generate a difference value corresponding to a difference between the amplitude of the detector signal and the amplitude of a reference signal.
Type:
Grant
Filed:
June 28, 2007
Date of Patent:
February 2, 2016
Assignee:
The University of Warwick
Inventors:
Tat Hean Gan, David Arthur Hutchins, Geoffrey Graham Diamond
Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
Type:
Grant
Filed:
September 11, 2015
Date of Patent:
February 2, 2016
Assignee:
The University of Western Australia
Inventors:
Stephen Donald Wilton, Sue Fletcher, Graham McClorey
Abstract: Novel measurement techniques based on moiré techniques and optical frequency conversion. For example, in the IR realm, the configuration can be any moiré configuration, the detector is an IR detector, and the light source can be at any wavelength. The optical configuration, the detector, and the type of light source depend on the physical properties of object/scene and the parameter(s) to be measured.
Type:
Grant
Filed:
March 18, 2014
Date of Patent:
February 2, 2016
Assignee:
The University of North Carolina at Charlotte
Abstract: A system-wide service can simultaneously harden multiple running JITs, for example by hooking into the memory protections of a target operating system and randomizing newly generated code on the fly when marked as executable. Some embodiments preserve the contents of the calling stack, presenting each JIT with the illusion that it is executing its own generated code.
Type:
Grant
Filed:
November 6, 2014
Date of Patent:
February 2, 2016
Assignee:
The Regents Of The University Of California
Inventors:
Michael Franz, Andrei Homescu, Stefan Brunthaler, Per Larsen
Abstract: The present invention provides a method for providing information and an apparatus for providing information with which information can be secretly displayed, and further, a display technique with a lot of sense of fun can attract keen interest from people around a display such as digital signage. A method for providing information using an apparatus for providing information that displays information using a light array includes: switching and displaying an information array and a concealment array in a display cycle in which a person cannot sense an information display array of the information array using the apparatus for providing information. The information array includes the information display array concerning information to be provided, and the concealment array is generated so that the information display array becomes invisible when the concealment array overlaps with the information array.
Abstract: A WDM transmitter and/or receiver optoelectronic integrated circuit includes a plurality of microresonators and corresponding waveguides and couplers that are integrally formed on a substrate. For the WDM transmitter, the microresonators and waveguides are configured to generate a plurality of optical signals at different wavelengths. Each coupler includes a resonant cavity waveguide that is configured to transmit one optical signal from one waveguide to the output waveguide such that the plurality of optical signals are multiplexed on the output waveguide. For the WDM receiver, an input waveguide is configured to provide for propagation of a plurality of optical signals at different wavelengths. Each coupler includes a resonant cavity waveguide that is configured to transmit at least one optical signal from the input waveguide to one waveguide.
Type:
Application
Filed:
July 28, 2014
Publication date:
January 28, 2016
Applicants:
The University of Connecticut, Opel Solar, Inc.
Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 28, 2016
Applicants:
Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
Abstract: In some aspects, miRNA for the treatment of cancer are provided. In some embodiments, a miRNA (e.g., miR-124, miR-142, and/or miR-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject. In other aspects, the miRNA may be used in, or in combination with, an adoptive immunotherapy.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 28, 2016
Applicant:
Board of Regents, The University of Texas System
Abstract: The present disclosure provides a method of detecting and diagnosing metastatic spread of cancer to the brain by analyzing the product of a gene signature. Gene signatures detailed herein are specific to the brain metastasis and not dependent upon the genetic signature of the primary tumor. Accordingly, disclosed method can be used to guide therapeutic intervention and further diagnostic analysis.
Type:
Application
Filed:
March 13, 2014
Publication date:
January 28, 2016
Applicant:
Board of Regents, The University of Texas System