Patents Assigned to The University
  • Patent number: 9255905
    Abstract: Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: February 9, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, Erin Anne Redman, John Michael Ramsey
  • Patent number: 9255288
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 9, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Publication number: 20160037105
    Abstract: A pixel array includes pixels arranged in columns. A pair of column lines is provided for each column of pixels. A current source circuit is coupled to each pair of column lines. The current source circuit provides current to the pair of column lines in a first mode of operation such that when one column line in a pair of column lines is being provided with a first current the other column line in the pair of column lines is being provided with a second current which is less than the first current.
    Type: Application
    Filed: June 5, 2015
    Publication date: February 4, 2016
    Applicants: STMicroelectronics (Research & Development) Limited, The University Court of the University of Edinburgh
    Inventors: Shatabda Saha, John Kevin Moore
  • Publication number: 20160032342
    Abstract: The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme.
    Type: Application
    Filed: June 29, 2015
    Publication date: February 4, 2016
    Applicants: Seneb Biosciences, Inc., The University of British Columbia
    Inventors: Karl F. JOHNSON, Shawn DEFREES, Stephen WITHERS, Mark VAUGHAN
  • Publication number: 20160030538
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Application
    Filed: July 22, 2015
    Publication date: February 4, 2016
    Applicant: The University of Vermont and State Agricultural College
    Inventor: Ralph C. Budd
  • Patent number: 9250210
    Abstract: A gas sensor that can enhance gas detection sensitivity more than the conventional sensors with a simple configuration is proposed. An electric double layer including a gate insulating layer is formed in an ionic liquid (IL), a change of a state of the gate insulating layer in the ionic liquid (IL) that occurs by absorbing a gas is directly reflected in a source-drain current (Isd) that flows in a carbon nanotube (8). Therefore, the gas detection sensitivity can be enhanced more than in the conventional sensors. Further, since the ionic liquid (IL) can be simply provided on a substrate (2) to be in contact with the carbon nanotube (8) and a gate electrode (7), the configuration that chemically modifies a surface of the carbon nanotube with a plurality of polymers as in the conventional gas sensors is not needed, and the configuration can be simplified correspondingly.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: February 2, 2016
    Assignees: The University of Tokyo, Omron Corporation
    Inventors: Isao Shimoyama, Kiyoshi Matsumoto, Yusuke Takei, Hidetoshi Takahashi, Noboru Kiga, Masahito Honda
  • Patent number: 9247889
    Abstract: A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: February 2, 2016
    Assignee: The Regents of The University of Michigan
    Inventors: Euisik Yoon, Il-Joo Cho
  • Patent number: 9249017
    Abstract: Nanorod and nanowire compositions are disclosed comprising copper indium selenide, copper indium gallium selenide, copper indium sulfide, or a combination thereof. Also disclosed are photovoltaic devices comprising the nanorod and/or nanowire compositions. Also disclosed are methods for producing the nanorod and nanowire compositions, and photovoltaic devices described herein.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: February 2, 2016
    Assignee: Board of Regents, The University of Texas System
    Inventors: Brian A. Korgel, Chet Steinhagen
  • Patent number: 9252005
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: February 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: J. Michael Ramsey, Kevin Schultze
  • Patent number: 9252365
    Abstract: An improvement in a method of making a semiconducting device having a hole-collecting electrode includes coating the hole-collecting electrode with a p-type transition metal oxide through a sol-gel process.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: February 2, 2016
    Assignee: The University of Akron
    Inventors: Xiong Gong, Tingbin Yang
  • Patent number: 9249261
    Abstract: Polymeric ionic liquids, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: February 2, 2016
    Assignee: The University of Toledo
    Inventors: Jared L. Anderson, Fei Zhao, Yunjing Meng, Qichao Zhao
  • Patent number: 9250182
    Abstract: Apparatus for inspecting an article comprising: a controller configured to generate a drive signal having a periodic amplitude variation; a source, the source being operable by the controller to emit a source beam thereby to irradiate an article, the source beam comprising a beam of electromagnetic radiation having a periodic amplitude variation corresponding to that of the drive signal; and a detector, the detector being configured to detect a portion of the source beam that has been transmitted through at least a portion of the article, and to generate a detector signal having an amplitude variation corresponding to the amplitude variation of said portion of the source beam, the controller being further configured to generate a difference value corresponding to a difference between the amplitude of the detector signal and the amplitude of a reference signal.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: February 2, 2016
    Assignee: The University of Warwick
    Inventors: Tat Hean Gan, David Arthur Hutchins, Geoffrey Graham Diamond
  • Patent number: 9249416
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: February 2, 2016
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Patent number: 9250186
    Abstract: Novel measurement techniques based on moiré techniques and optical frequency conversion. For example, in the IR realm, the configuration can be any moiré configuration, the detector is an IR detector, and the light source can be at any wavelength. The optical configuration, the detector, and the type of light source depend on the physical properties of object/scene and the parameter(s) to be measured.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: February 2, 2016
    Assignee: The University of North Carolina at Charlotte
    Inventors: Faramarz Farahi, Mehrdad Abolbashari, Gelareh Babaie
  • Patent number: 9250937
    Abstract: A system-wide service can simultaneously harden multiple running JITs, for example by hooking into the memory protections of a target operating system and randomizing newly generated code on the fly when marked as executable. Some embodiments preserve the contents of the calling stack, presenting each JIT with the illusion that it is executing its own generated code.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: February 2, 2016
    Assignee: The Regents Of The University Of California
    Inventors: Michael Franz, Andrei Homescu, Stefan Brunthaler, Per Larsen
  • Patent number: 9251577
    Abstract: The present invention provides a method for providing information and an apparatus for providing information with which information can be secretly displayed, and further, a display technique with a lot of sense of fun can attract keen interest from people around a display such as digital signage. A method for providing information using an apparatus for providing information that displays information using a light array includes: switching and displaying an information array and a concealment array in a display cycle in which a person cannot sense an information display array of the information array using the apparatus for providing information. The information array includes the information display array concerning information to be provided, and the concealment array is generated so that the information display array becomes invisible when the concealment array overlaps with the information array.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 2, 2016
    Assignee: The University of Tokushima
    Inventors: Hirotsugu Yamamoto, Shiro Suyama
  • Publication number: 20160025926
    Abstract: A WDM transmitter and/or receiver optoelectronic integrated circuit includes a plurality of microresonators and corresponding waveguides and couplers that are integrally formed on a substrate. For the WDM transmitter, the microresonators and waveguides are configured to generate a plurality of optical signals at different wavelengths. Each coupler includes a resonant cavity waveguide that is configured to transmit one optical signal from one waveguide to the output waveguide such that the plurality of optical signals are multiplexed on the output waveguide. For the WDM receiver, an input waveguide is configured to provide for propagation of a plurality of optical signals at different wavelengths. Each coupler includes a resonant cavity waveguide that is configured to transmit at least one optical signal from the input waveguide to one waveguide.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 28, 2016
    Applicants: The University of Connecticut, Opel Solar, Inc.
    Inventor: Geoff W. Taylor
  • Publication number: 20160024503
    Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicants: Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Raghu KALLURI, Sónia MELO
  • Publication number: 20160022728
    Abstract: In some aspects, miRNA for the treatment of cancer are provided. In some embodiments, a miRNA (e.g., miR-124, miR-142, and/or miR-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject. In other aspects, the miRNA may be used in, or in combination with, an adoptive immunotherapy.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Amy HEIMBERGER, Jun WEI
  • Publication number: 20160025728
    Abstract: The present disclosure provides a method of detecting and diagnosing metastatic spread of cancer to the brain by analyzing the product of a gene signature. Gene signatures detailed herein are specific to the brain metastasis and not dependent upon the genetic signature of the primary tumor. Accordingly, disclosed method can be used to guide therapeutic intervention and further diagnostic analysis.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Isaiah J. FIDLER, Sun Jin KIM