Abstract: The invention is directed to a computer-implemented method for obtaining a physical model having physical model parameters wherein solutions to one or more partial-differential-equations (PDE's) are calculated and wherein (i) an appropriate initial model is selected, (ii) setup a system of equations referred to as the data-augmented PDE for the field, comprising of the discretized PDE, the sampling operator, the source function and the observed data, and solve the data-augmented PDE in a suitable manner to obtain a field that both satisfies the PDE and fits the data to some degree, (iii) setup a system of equations by using the PDE, the source function and the field obtained in step (ii) and solve this system of equations in a suitable manner to obtain an update of the physical model parameters and repeat steps (ii)-(iii) until a predetermined stopping criterion is met.

Abstract: A semiconductor memory device including an array of memory cells (MC) formed on a substrate each realized from a load element and thyristor that define a switchable current path whose state represents a volatile bit value stored by the MC. At least one word line corresponding to a respective row of the array is formed on the substrate and coupled to MC current paths for the corresponding row. Bit lines corresponding to respective columns of the array are formed on the substrate and can be coupled to a modulation doped QW interface of the MC thyristors for the corresponding column. Circuitry is configured to apply an electrical signal to the word line(s) in order to generate current that programs phase change material of the MC load elements into one of a high or low resistive state according to state of the current path of the MCs for non-volatile backup purposes.

Abstract: A photovoltaic-thermal (PV-T) system and a method of cooling photovoltaic (PV) cells in the system is described herein. Energy from an excitation source such as the sun hits the PV cells in the PV-T system causing heating that reduces PV efficiency. The PV cells are cooled by fluid in an intact heat-transfer system making a heated water byproduct while the PV cells release a form of energy. In addition, the PV-T system can be implemented in a desalination plant to harvest energy and heat for desalination processes. The present invention also includes methods for transferring heat from PV cells to the earth to improve PV performance and reduce thermal shock to the PV cells.

Abstract: Singly and multiply charged imidazolium cations (ICs) have been identified as a class of chemical compositions that possess potent antineoplastic, antibacterial and antimicrobial properties. The imidazolium cations disclosed demonstrate greater or equivalent potency towards cancerous cells as the current clinical standard, cisplatin. These imidazolium cations, however, achieve this efficacy without any of the known toxic side effects caused by heavy metal-based antineoplastic drugs such as cisplatin.

Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protection from neuron cell death.

Abstract: MRSA CC398 is a clone of S. aureus that has recently emerged in pigs and other domestic animals worldwide. As any other MRSA, the clone displays high levels of antibiotic resistance and poses a serious threat to human health because of the risk of antibiotic treatment failure in human patients. We developed a new diagnostic test for identification of MRSA CC398 using a single one-step PCR that is very easily performed within a few hours. The test is based on the principle that clonal differences within S. aureus are reflected in the sequence of a gene (sau1hsdS1) located on the chromosome of this bacterial species. Accordingly, such a gene represents an optimal target for S. aureus and MRSA identification at the clone level. The test includes detection of the gene conferring methicillin resistance (mecA), therefore allowing rapid discrimination between methicillin-susceptible and methicillin-resistant variants of the clone.

Abstract: An interactive camera calibration tool is presented that provides live feedback on the state of the calibration and produces tightly-distributed calibration parameters even when used by novices. Target positions are suggested by the calibration tool. Once the target has been aligned with the target positions, image data of the target is captured and used to compute calibration parameters. This process is repeated until the computed parameters meet the accuracy requirements specified by the user. A novel calibration quality metric is also leveraged to automatically determine whether a calibration is sufficiently accurate.

Abstract: A charging control system includes a flattened charging speed calculation unit that calculates a flattened charge speed for fully charging EVs at a constant speed according to permitted charging time for the EVs and the amount of charging required by the EVs; a charging speed calculation unit that calculates a charging speed for the EVs by multiplying the flattened charging speed by a request demand ratio function based on change over time in electric power demand requested from the electric power supply side; and a control unit that controls the charging of the EVs on the basis of the charging speed calculated by the charging speed calculation unit.

Abstract: Provided is a photodetector including: an organic semiconductor (20) having protrusions; a metal layer (30) added onto the organic semiconductor (20), for promoting at least one of localized plasmon resonance and surface plasmon resonance in which electrons are excited through irradiation of detection light; and a semiconductor (40) forming a junction with the metal layer (30), for allowing electrons excited through the plasmon resonance to pass through the junction (40a) with the metal layer (30).

Abstract: A spinal fixation device includes a device body configured for implantation in a human body and a clamp that is formed from shape memory material and attached to the device body.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.

Abstract: A circuit and method for generating a signal is disclosed. The circuit includes a set of wide tuning LC tanks, a set of core transistors cross coupled to the set of wide tuning LC tanks, and a combining network coupled to the set of wide tuning LC tanks and the set of core transistors. The combining network further includes a set of inputs connected to the set of wide tuning LC tanks and the set of core transistors, a set of coupling transistors connected to the set of inputs, a set of source inductors connected to the set of coupling transistors, a coupling capacitor connected to the set of source inductors, a load resistor connected to the coupling capacitor. The combining network combines the set of inputs and the signal is delivered to the load resistor as a fourth order harmonic.

Abstract: The present invention provides novel topically-applied skin and face coating and paint compositions comprising near infrared reflecting pigments and hydrogels swollen with aqueous solution and/or with simulated sweat. The invention further provides methods of making and using the compositions. The novel compositions protect the skin of the wearer from damage due to intense external heat or thermal flux and simultaneously divert thermal energy to a complementary evaporative cooling mechanism. The compositions protect skin from external thermal fluxes, conform to skin chemistry, and are easy to apply and remove.

Abstract: A method, system and computer program product for improving the perceptual quality and naturalness of an image captured by an image acquisition device (e.g., digital camera). Statistical features of a scene being imaged by the image acquisition device are derived from models of natural images. These statistical features are measured and mapped onto the control parameters (e.g., exposure, ISO) of the digital acquisition device. By mapping these statistical features onto the control parameters, the perceptual quality and naturalness of the scene being imaged may be based on the values of these control parameters. As a result, these control parameters are modified to maximize the perceptual quality and naturalness of the scene being imaged. After modification of these control parameters, the image is captured by the image acquisition device. In this manner, the perceptual quality and naturalness of the image captured by the image acquisition device is improved.

Abstract: A method of creating an image mosaic is provided. A plurality of image files is read at a computing device. The plurality of image files contains image data defining a plurality of overlapping images. A dual adjacency mesh for an image mosaic is defined based on an arrangement of the plurality of overlapping images. The dual adjacency mesh is defined as a plurality of nodes and edges that connect a pair of the plurality of nodes. A node is defined for each image of the plurality of overlapping images, and an edge is defined when an overlap exists between a pair of images of the plurality of overlapping images. The image mosaic is presented in a display of the computing device. The image mosaic is created from the plurality of overlapping images based on the defined dual adjacency mesh.

Abstract: A semiconductor device suitable for power applications includes a thyristor epitaxial layer structure defining an anode region offset vertically from a cathode region with a plurality of intermediate regions therebetween. An anode electrode is electrically coupled to the anode region. A cathode electrode is electrically coupled to the cathode region. A switchable current path that extends vertically between the anode region and the cathode region has a conducting state and a non-conducting state. An epitaxial resistive region is electrically coupled to and extends laterally from one of the plurality of intermediate regions. An FET is provided having a channel that is electrically coupled to the epitaxial resistive region. The FET can be configured to inject (or remove) electrical carriers into (or from) the one intermediate region via the epitaxial resistive region in order to switch the switchable current path between its non-conducting state and its conducting state.

Abstract: The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an “active compound” herein) of Formula I, IA, or IB.

Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.

Abstract: The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.

Abstract: Provided are effective and highly safe agents, medicaments and the like for ameliorating various disorders caused by brain hypofunction. Also provided is a preventing or ameliorating agent for brain hypofunction containing N-acetyl-D-mannosamine, a pharmaceutical composition for preventing, ameliorating or treating disorders due to brain hypofunction, containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier, and a food comprising N-acetyl-D-mannosamine added thereto.