Abstract: Methods for treating a peripheral neuropathy are disclosed herein. Methods are also disclosed for improving nerve function in a subject with a peripheral neuropathy. These methods use a PNPase inhibitor or a PNPase purine nucleoside substrate. These methods include selecting the subject with the peripheral neuropathy; and administering to the subject a therapeutically effective amount of a purine nucleoside phosphorylase (PNPase) inhibitor and/or a PNPase purine nucleoside substrate.

Abstract: Embodiments described herein provide for a healthcare ecosystem of computing devices participating as nodes of a distributed ledger (e.g., blockchain). The distributed ledger includes NFTs representing corresponding patients, where the initial NET behaves logically as a token scaffold that represents a “digital twin” of the particular patient. The initial patient token represents personal profile data of patient personal data for the patient. The nodes may generate new data and/or new sub-tokens (or other blockchain entry type) representing new data, which the nodes associate with the token scaffold. The sub-tokens contain data for representing physical or digital specimens, health data, and data derived from the health data (e.g., cell lines, organoids, other model systems).

Abstract: Patches configured to hold an oncogenic cargo and deliver the cargo in a controlled manner to a predetermined location of a specified tissue are disclosed. As one example, a patch can comprise a base layer configured to adhere to a predetermined location of a tissue and a hydrogel layer. The hydrogel layer can comprise a plurality of microchannels that are configured to store and release a gene-modifying vector over a time period and in a quantity sufficient to produce a somatic cell tumor through manipulation of the genome of somatic cells at the predetermined location.

Abstract: To control plant diseases caused by Xanthomonas spp., a novel bacteriophage exhibiting bacteriolysis activity specifically on Xanthomonas spp. was isolated. Thus, developed and provided is a plant disease control composition containing the bacteriophage as an active ingredient. Provided are a bacteriolytic agent containing a bacteriophage that has a novel genomic DNA sequence and exhibits bacteriolysis activity specifically on Xanthomonas spp., and a plant disease control composition containing the same as an active ingredient.

Abstract: The present disclosure relates to ionizable lipidoid compounds comprising an anisamide moiety, and lipid nanoparticles (LNPs) comprising the same. In certain embodiments, the LNP selectively binds to at least one sigma receptor. In certain embodiments, the LNP specifically targets a cell of interest (e.g., a cell expressing a sigma receptor, fibroblast, cancer cell, stromal cell, and epithelial cell, inter alia). In another aspect, the present disclosure provides methods for in vivo delivery of therapeutic agents to treat, prevent, and/or ameliorate diseases and/or disorders, including but not limited to fibrosis and cancer.

Abstract: The invention relates to a mixed-anion solid electrolyte, having the following chemical formula: LidAl1?cYcCl3?aXb, wherein Y is selected from at least one of Si4+, Ge4+, Sn4+, Sb5+, Nb5+, Ta5+, Mo6+, and W6+, and X is selected from at least one of O2?, S2?, F?, Br?, I?, and BH4?; and wherein 0<d?2, 0<b?2, 0<a?2, 0<c<0.75 and charge balance is reached.

Abstract: The method comprises separating the outer green rind the room aloe vera leaf thereby cleaning and drying in sunlight for two days followed by oven drying at 80° C. for about 24 hours; pyrolyzing the dried outer green rind in an inert environment of N2 gas at 400° C. for about 1 hour to obtain a pre-carbonized carbon (AV-C); mixing the AV-C with K2CO3 in a 2:1 impregnation ratio to obtain a mixture;; pyrolyzing the mixture of the AV-C and K2CO3 at 900° C.; removing resulting black charred residue and cleaning the resulting charred residue with double-distilled water and isopropyl alcohol; homogenizing the cleaned black material of reduced graphene oxide using an ultrasonic homogenizer at 30% power for 1 hour with 10 pulse rates thereby drying and filtering the reduced graphene oxide to obtain 3D-HPN-rGO; h) preparing an electrode using the obtained 3D-HPN-rGO; and i) constructing a supercapacitor device using the electrodes.

Abstract: The present disclosure provides methods for sorting retinal cells for use in cellular component transfer therapy, sorted populations of retinal cells generated by such methods, and compositions comprising such sorted populations of retinal cells. The present disclosure also provides uses of sorted populations of retinal s and compositions comprising thereof for preventing and/or treating inherited retinal degenerative diseases.

Abstract: An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.

Abstract: The present disclosure provides a pyrolysis process for converting an additive-containing plastic comprising a polyolefin polymer to an alkene, an alkane, or a mixture thereof. The process comprises contacting the plastic with a catalyst in a one-pot pyrolysis system at a temperature between about 350° C. and about 500° C.; wherein the catalyst comprises a solid acid selected from the group consisting of HY, HZSM-5, and Al-SBA-15. The present disclosure further provides a one-pot pyrolysis system and uses of a solid acid in the pyrolysis process for converting plastic comprising a polyolefin polymer to an alkene.

Abstract: A wheel action-based active suspension damping adjustment apparatus recognizes wheel actions through a steering apparatus, distance measuring apparatuses and force sensors and calculates an action damping magnitude according to damping parameters determined by different wheel actions, thereby achieving optimal adjustment under different actions. The changes in an inclination angle of a vehicle cabin floor and a vertical acceleration are monitored by using an inclination angle sensor and acceleration sensors, and meanwhile, an inclination angle damping and an acceleration damping are determined according to exceeding amplitudes, and a total damping of active suspensions is fed back and corrected, thereby further enhancing an adjustment and control effect of the active suspensions.

Abstract: Compositions and methods for treating and/or diagnosing a subject having COVID-19. The treatment composition includes an inhibitor of at least one of doublecortin-like kinase 1 (DCLK1, including DCLK1 isoforms 1-4), and doublecortin-like kinase 2 (DCLK2, including DCLK2 isoforms 1-3). The treatment composition may optionally include an inhibitor of SI 00 calcium binding protein A9 (S100A9), calprotectin (S100A8/S100A9 complex), S100A4, Granulocyte-macrophage colony-stimulating factor (GM-CSF), Vascular endothelial growth factor (VEGF), Interleukin-6 (IL-6), or combinations thereof. The subject may also have a chronic liver disease, disorder, or condition. A method of determining if a patient having COVID-19 should be administered a treatment protocol for severe or critical COVID-19.

Abstract: Disclosed is a nano pulverizing device for processing reconstituted rice flour which includes a bottom plate, support legs are fixedly connected to corners of a lower surface of the bottom plate, a housing is arranged on an upper surface of the bottom plate, and a rotating motor is arranged on the lower surface of the bottom plate. The rotating motor penetrates through the lower surface of the bottom plate and extends to the upper surface of the bottom plate, and a crushing device is rotationally connected to one end, extending to the upper surface of the bottom plate, of the rotating motor. A support frame is fixedly connected to an inner wall of the housing, a support plate is fixedly connected to a lower surface of the support frame, and a flexible plate is fixedly connected to a lower surface of the support plate.

Abstract: Certain examples of the disclosure concern an implantable sensor. The implantable sensor includes a sensor assembly configured to connect to a suture. The sensor assembly also includes a substrate and a resonant circuit coupled to the substrate. The resonant circuit is configured to electrically resonate at a resonant frequency when exposed to a first electromagnetic field and to emit a second remotely detectable electromagnetic field. The substrate is configured to deform in response to a tensile force applied by the suture and to change a resonant parameter of the resonant circuit in response to the deformation.

Abstract: The disclosure belongs to the field of advanced manufacturing technology and discloses a multi-field-assisted laser melting deposition composite additive manufacturing system. The system includes a vacuum chamber atmosphere protection module, a laser melting deposition module, an ultrasonic shock peening module, a workpiece transfer module, an auxiliary thermal field induction heating module, a laser shock peening module, and an integrated control module. The vacuum chamber atmosphere protection module, the laser melting deposition module, the ultrasonic shock peening module, the workpiece transfer module, the auxiliary thermal field induction heating module, and the laser shock peening module are electrically connected to the integrated control module individually and are collaboratively controlled by the integrated control module.

Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.

Abstract: Among the various aspects of the present disclosure are the provision of a bioelectronic device, additive manufacturing methods of bioactive encapsulated conducting polymer hydrogel electrodes, and related methods of use. As described herein, a 3D-printed bioelectronic electrode device, methods to fabricate a bioelectronic device, a method to perform a bioelectronics experiment, and a method to treat a subject with a bioelectronic-related disorder are described.

Abstract: The provided is a method and system for trajectory prediction based on Cro-IntentFormer. The method starts by preprocessing vehicle trajectory data collected by sensors to produce raw data suitable for model input. Vehicles are treated as nodes, and the distance between vehicles serves as the basis for determining whether there is an edge between two vehicle nodes. A physical relationship graph is constructed and, along with the raw data, input into a spatio-temporal feature extraction module to obtain the spatio-temporal features of the trajectory. The spatio-temporal feature matrix is then input into an intent prediction module to determine the predicted intentions of the vehicles. Based on the intent information output by the intent prediction module, a semantic relationship graph is reconstructed and input, along with the raw data, into the spatio-temporal feature extraction module to derive the semantic features of the trajectory.

Abstract: The present invention provides methods of treating cancer with certain co-activator of activator protein-1 and estrogen receptor (CAPER)-based polypeptides. In certain embodiments, the methods of the invention target only cancerous cells without adversely affecting non-cancerous cells.

Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.