Abstract: Provided are peptoid-peptide macrocycles. The peptoid-peptide macrocycles may have inhibitory activity towards the Wnt signaling pathway. The Wnt signaling pathway is associated with cancer and other diseases and conditions. Such diseases include, for example, pulmonary fibrosis. Also described are methods of making the peptoid-peptide macrocycles, compositions containing the peptoid-peptide macrocycles, and methods of using the peptoid-peptide macrocycles.

Abstract: A device for continuously applying a transverse tension in an annealing process of an ultra-thin strip, including an unfolding and receiving mechanism for unwinding and winding the strip and an orthopedic mechanism for correcting the strip including an annealing furnace, and two orthopedic assemblies fixedly arranged inside the annealing furnace; the two orthopedic assemblies are symmetrically arranged on both sides of the strip, are parallel to an advancing direction of the strip and correspond to side edges of the strip, and include annular guide rails; each annular guide rail is fixedly connected with the annealing furnace and is slidably connected with an orthopedic part; the orthopedic part corresponds to each side edge of the strip, and each annular guide rail is internally provided with a driving part; the driving part is in transmission connection with the orthopedic part, and the orthopedic part is communicated with an air source part.

Abstract: A method of forming an optical interconnect between first and second photonic chips located on an optical printed circuit board (OPCB) includes applying a coupling agent to a bonding surface of a flexible, freestanding polymer waveguide array film having at least one polymer waveguide disposed therein. The waveguide array film is placed onto the first and second photonic chips so that the waveguide array film extends over a gap and/or a step between the first and second photonic chips to thereby form a bonding interface between the bonding surface of the waveguide array film and the first and second photonic chips. The coupling agent is selected such that optical coupling between the first and second photonic chips arises simultaneously with formation of the bonding interface.

Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.

Abstract: In one aspect, the invention provides a composition comprising at least one monocyte comprising an agent that increases monocyte homing to a site of injury, and an effective amount of a drug. In another aspect, the invention provides a method of using the composition to deliver a drug to a site of injury.

Abstract: Wellbore treatment fluids are provided that include an aqueous component and an amphiphilic hyperbranched copolymer comprising the polymerized reaction product of at least a first monomer and a second monomer, where the first monomer comprises at least one surface reactive end group chosen from the group consisting of carboxylates, phosphonates, sulfonates, and zwitterions. Also provided are methods of modifying subsurface energy of a carbonate formation using the wellbore treatment fluids.

Abstract: The devices and systems can allow for safe and cost-effective administration intravenous medication, for example, in psychiatric settings by mitigating ligature, disassembly, and weaponization risks associated with intravenous administration. The system may include a fluid connection device. The fluid connection device may include an internal conduit configured to deliver a medical fluid and a housing disposed in which the internal conduit is disposed. The housing may include a first rigid segment and a second rigid segment spaced from the first rigid segment. The housing may also include a first joint segment disposed between the first rigid segment and the second rigid segment and configured to bend to the predetermined bending angle with respect to the first rigid segment.

Abstract: A method, system, and drilling fluid for treating a wellbore for filter cake removal, including providing the drilling fluid having thermochemical reagents that are encapsulated and acid-generating material that is encapsulated into a wellbore in a subterranean formation to attack filter cake in the wellbore, and attacking the filter cake via the drilling fluid.

Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.

Abstract: Disclosed is a method and system for predicting a touch interaction position on a large display based on a binocular camera. The method includes: separately acquiring arm movement video frames of a user and facial and eye movement video frames of the user by a binocular camera; extracting a video clip of each tapping action from the arm movement video frames and the facial and eye movement video frames and obtaining a key frame by screening; marking the key frame of each tapping action with coordinates to indicate coordinates of a finger in a display screen; inputting the marked key frame to an efficient convolutional network for online video understanding (ECO)-Lite neural network for training to obtain a predictive network model; and inputting a video frame of a current operation to be predicted to the predictive network model and outputting a touch interaction position predicted for the current operation.

Abstract: A method and system for generating a logarithmic non-uniform pseudo-random electromagnetic exploration signal including: constructing two or more basic unit signals, according to an exploration requirement, that are stairstep signals obtained by superposing in-phase periodic square wave signals, a frequency ratio between adjacent periodic square wave signals is 2, and the two or more basic unit signals meet the following requirement: if a lowest dominant frequency in a first basic unit signal is a fundamental frequency, lowest frequencies of the remaining basic unit signal are l×2m times the fundamental frequency, where l is an odd number except 1, and m is a natural number; and superposing the two or more basic unit signals to obtain a logarithmic non-uniform 2n sequence pseudo-random signal. A logarithmic non-uniform 2n sequence stairstep signal is constructed within a limited frequency interval, and requirements of prospectors for a higher frequency density within a specific frequency interval are met.

Abstract: A monitoring apparatus for a human body includes a node network with at least one motion sensor and at least one acoustic sensor. A processor is coupled to the node network, and receives motion information and acoustic information from the node network. The processor determines from the motion information and the acoustic information a source of acoustic emissions within the human body by analyzing the acoustic information in the time domain to identify an event envelope representing an acoustic event, determining a feature vector related to the event envelope, calculating a distance between the feature vector and each of a set of predetermined event silhouettes, and identifying one of the predetermined event silhouettes for which the distance is a minimum.

Abstract: Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a metabolic disorder of the liver that results m abnormal nitrogen metabolism. To illustrate the ability of gene therapy to treat CPS1 deficiency, two adeno-associated viruses encoding portions of a codon optimized CPS1 were generated and tested in a conditional CPS1 knock out mouse model. When administered to mice having knocked out endogenous CPS1 expression, mice from this model demonstrate homologous recombination and reconstitution of the codon optimized CPS1 gene, expression of the CPS1 protein and the associated control of plasma ammonia following the administered AAVs comprising the CPS1 gene sequences. While all control mice perish, the mice in this model live and have normal behavior. As there is no effective therapy for human patients with the CPS1 disorder, this invention can address this unmet need for these patients.

Abstract: Systems and methods for spatial graph convolutions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting characteristics for molecules, wherein the method includes performing a first set of graph convolutions with a spatial graph representation of a set of molecules, wherein the first set of graph convolutions are based on bonds between the set of molecules, performing a second set of graph convolutions with the spatial graph representation, wherein the second set of graph convolutions are based on at least a distance between each atom and other atoms of the set of molecules, performing a graph gather with the spatial graph representation to produce a feature vector, and predicting a set of one or more characteristics for the set of molecules based on the feature vector.

Abstract: A method for publicly verifiable symmetric cryptography is disclosed. The method includes: obtaining an initial encrypted key and a homomorphic public key; obtaining a first message and an initial signature; calculating an initial hashed value of the first message; setting a cryptographic function of the initial hashed value of the first message and an initial private key; generating an evaluated value based on the cryptographic function, the homomorphic public key, the initial encrypted key, and the initial hashed value of the first message; and transmitting, at the verifier, a verification result based on a hashed value of the initial signature and the evaluated value. Other aspects, embodiments, and features are also claimed and described.

Abstract: The present disclosure provides a talking glove to aid communication between a medical practitioner and a patient while the patient is undergoing a dental/medical treatment. The talking glove may be a dental glove worn by the patient and/or a dental practitioner and includes a plurality of contact sensors, where each contact sensor is located on a different finger position of the talking dental glove; a suction button; a pulse rate sensor configured to generate pulse rate signals; an LCD screen; a speaker; a power source; and a microcontroller connected to the power source, the plurality of contact sensors, the pulse rate sensor, the LCD screen, and the speaker. Each of these components is disposed on an outer surface of the talking dental glove.

Abstract: The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g., cathodes, for use in electrochemical cells, such as rechargeable batteries. The Chevrel-phase materials have a general formula of Mo6Z8 (Z=sulfur) or Mo6Z18-yZ2y (Z1=sulfur; Z2=selenium), and partially cuprated Cu1Mo6S8 as well as partially de-cuprated Cu1-xMgxMo6S8 and the precursors have a general formula of MxMo6Z8 or MxMo6Z18-yZ2y, M=Cu. The cathode containing the Chevrel-phase material in accordance with the invention can be combined with a magnesium-containing anode and an electrolyte.

Abstract: A system for measuring real-time seed placement of seeds, such as corn seeds, during planting wherein the sensing and measurement (SAM) system comprises various elements selected from the group consisting of a high-speed camera, light-section sensor, potentiometer, GPS unit, data acquisition system, and a control computer. The SAM system measures seeding depth, seed spacing, and geo-location of the seed. It is mounted on a planter row unit located in between the closing wheels and the gauge wheels with the camera and light section sensor directly facing the furrow.

Abstract: Task assignment for multi-robot systems (MRSs) in a smart factory (Industry 4.0) is described. Aspects are directed to a hypergraph based MRS and production model facilitating the cooperation among robots and serving frequent reconfiguration desired in Industry 4.0. Aspects are directed to a time complexity friendly search algorithm for real-time application using a hypergraph model to get task assignment(s). Parameters are provided for a tradeoff between solution optimality and time complexity. In an implementation, an example system can include a MRS including robots, wherein the MRS is configured to perform a manufacturing task, and a computing device configure to perform a multi-robot task allocation (MRTA) for the MRS. In an implementation, an example method can include generating task assignments, using MRTA, for robots of a MRS including the robots, wherein the MRS is configured to perform a manufacturing task, and providing the task assignments to the MRS.

Abstract: A three terminal neuromorphic synaptic device and a method for manufacturing the same are provided. The three terminal neuromorphic synaptic device includes a substrate, source/drain electrodes provided on the substrate, a channel region electrically connected between the source electrode and the drain electrode, an ion transfer layer provided on the channel region, a gate electrode provided on the ion transfer layer, and a voltage application unit to apply a gate voltage to the gate electrode. The ion transfer layer includes an electrolyte material to transfer an active ion of the gate electrode between the gate electrode and the channel region, in response to the gate voltage applied to the gate electrode. The voltage application unit adjusts a resistance and a conductance of the channel region by changing an amount of active ions accumulated in the channel region, depending on the number of times that the gate voltage is applied.