Patents Assigned to Trustee
  • Engineered promiscuous biotin ligases for efficient proximity labeling
    Patent number: 12110522
    Abstract: Engineered promiscuous biotin ligases and methods of using them in proximity labeling are described. In particular, the invention provides novel biotin ligase variants having increased promiscuous biotinylation activity capable of proximity labeling of proteins in live cells in as little as 10 minutes.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 8, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tess Branon, Alice Y. Ting
  • POROUS STRUCTURE WITH MICROCHANNELS
    Publication number: 20240332124
    Abstract: Porous structures and processes for generating porous structures are disclosed. In one embodiment, a porous structure includes a target surface, a photoresist material deposited onto the target surface, and a metal electrodeposited onto the target surface and the photoresist material. An electrodeposition of metal generates a metal porous structure and the photoresist material is removed through reactive ion etching, generating at least one microchannel through the metal porous structure.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 3, 2024
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
    Inventors: Sujan Dewanjee, Gaurav Singhal, Nenad Milijkovic, Paul V. Braun, Danny Lohan, Shailesh Joshi
  • A MOUNTING SYSTEM
    Publication number: 20240325222
    Abstract: The invention provides a backrest mounting system to mount a backrest to a wheelchair post. The mounting system comprises a locking peg that is receivable within a peg receiver. The peg receiver comprises a lock assembly comprising a locking member adapted to engage with the locking peg in a locked position. The locking peg comprises a latch pin housing extending along at least a portion of a length of the peg and also comprises a latch pin within the latch pin housing. The latch pin is slidable between a retracted position and an extended position in which the latch pin engages with and holds the locking member in an unlocked position to allow the locking peg to be readily retracted from the peg receiver.
    Type: Application
    Filed: October 28, 2021
    Publication date: October 3, 2024
    Applicant: Roger Thomas Mascull and Elizabeth Jocely Mascull as Trustees of the RT and EJ Mascull Family Trust
    Inventors: Benjamin EAGLE, Paul EASTWOOD, Anil Raman PATEL
  • SYSTEM FOR GENERATING SOUND WAVES FOR AT LEAST TWO SEPARATE ZONES OF A SINGLE SPACE AND ASSOCIATED METHOD
    Publication number: 20240334152
    Abstract: The invention relates to a system for generating sound waves for at least two separate zones of a single space. The system includes, for each zone of said space: at least one array of high-frequency loudspeakers forming a directional sound wave; and at least one low-frequency loudspeaker. The system also comprises means for audio processing of the signals transmitted to the loudspeakers, which means control at least one loudspeaker to generate destructive sound waves in at least one zone of said space and to obtain distinct sound contents in said at least two distinct zones of said space. To do this, the audio-processing means control each low-frequency loudspeaker individually and each array of high-frequency loudspeaker mutually in order to generate the destructive sound waves.
    Type: Application
    Filed: October 4, 2022
    Publication date: October 3, 2024
    Applicants: The Trustees of Princeton University, Focal jmlab
    Inventors: Edgar Choueiri, Rahulram Sridhar, Joseph G Tylka, Léo Guadagnin
  • SYNTHETIC BIOLOGY APPROACHES TO TARGET RNA-CAPPING ENZYMES FROM VIRUSES
    Publication number: 20240327780
    Abstract: The emergence of zoonotic pathogenic viruses has accentuated the need to develop broad-spectrum antivirals and vaccines. Highly modular yeast-based phenotypic platforms for characterization and targeting of RNA capping enzymes from emerging pathogens including coronaviruses, MPV, ASFV, and WNV, are disclosed herein. This platform can identify key amino acid residues and protein domains. Inactivation and attenuation mutations in viral enzymes are also disclosed herein. This platform is applied to vertebrate RNA capping enzymes, demonstrating use for high-throughput phenotypic screening. The disclosed platforms are highly modular and can be adapted for RNA capping enzymes from viruses and variants that emerge in the future.
    Type: Application
    Filed: March 29, 2024
    Publication date: October 3, 2024
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Angad P. Mehta, Marya Y. Ornelas, Angela Y. Thomas
  • NEUROMODULATION TECHNIQUES AND DEVICES RELATING THERETO
    Publication number: 20240325776
    Abstract: Techniques and devices for improving rhythmic motion of a subject are described herein. In particular, the disclosed techniques and devices utilize stimuli (acoustic, visual, tactile, and/or vibrational stimuli) delivered at beta frequencies and/or gamma frequencies to enhance neural activity and movement at delta frequencies in the subject. The disclosed techniques and devices may be used to improve motor symptoms in subjects with neurodegenerative conditions and/or to promote athletic training in healthy individuals.
    Type: Application
    Filed: March 29, 2024
    Publication date: October 3, 2024
    Applicant: Trustees of Boston University
    Inventors: Xue Han, Sudiksha Sridhar, Sanaya Ness Shroff, Eric Lowet, Howard Gritton, Jennifer Freire
  • DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)
    Publication number: 20240327478
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Application
    Filed: October 19, 2023
    Publication date: October 3, 2024
    Applicants: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • CXC CHEMOKINE AGONISTS AND ANTAGONISTS IN COVID-19 DISEASE AND DIAGNOSTIC ASSAYS
    Publication number: 20240325496
    Abstract: Methods of treating a disease, disorder or syndrome associated with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (such as COVID-19) in a subject by administering one or more C-X-C chemokine receptor 3 (CXCR3) antagonist peptides are described. Diagnostic methods for enhancing replication of SARS-CoV-2 in cultured cells and/or detecting the presence of SARS-CoV-2 in cultured cells by contacting the cells with a CXCR3 agonist peptide are also described.
    Type: Application
    Filed: June 28, 2022
    Publication date: October 3, 2024
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Trustees of Indiana University
    Inventors: Cecelia C. Yates, Monte S. Willis
  • METHODS, PROTOCOLS, AND APPARATUSES OF QUANTUM PHYSICAL UNCLONABLE FUNCTIONS
    Publication number: 20240333536
    Abstract: A method for authentication between multiple communication parties is disclosed. Authentication can be carried out by the means of each communication party having a device having a physical unclonable function. To make this possible, the devices have a known quantum correlation that can be used in conjunction with entangled photons to verify the identities of the devices.
    Type: Application
    Filed: July 22, 2022
    Publication date: October 3, 2024
    Applicant: The Trustees of the Stevens Institute of Technology
    Inventors: Yuping Huang, Lac Thi Thanh Nguyen
  • DURABLE POROUS STRUCTURES AND ELECTRONICS DEVICES INCORPORATING THE SAME
    Publication number: 20240328024
    Abstract: In one embodiment, a method of fabricating a porous structure includes applying a first electroplating current at first current density for a first period of time, wherein the first electroplating current is a constant current, and applying a second electroplating current at a second current density for a second period of time following the first period of time, wherein the second electroplating current is a pulsed current and the first electroplating current and the second electroplating current grows the porous structure on a surface of the substrate.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 3, 2024
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
    Inventors: Sujan Dewanjee, Gaurav Singhal, Nenad Milijkovic, Paul Braun, Danny Lohan, Shailesh Joshi
  • CONFIGURABLE IN MEMORY COMPUTING ENGINE, PLATFORM, BIT CELLS AND LAYOUTS THEREFORE
    Publication number: 20240330178
    Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
    Type: Application
    Filed: June 10, 2024
    Publication date: October 3, 2024
    Applicant: The Trustees of Princeton University
    Inventors: Naveen VERMA, Hossein VALAVI, Hongyang JIA
  • AMNIOTIC FLUID STABILIZED COMPOSITIONS AND METHODS FOR IN UTERO DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20240325308
    Abstract: The present disclosure relates, in part, to lipid nanoparticles (LNPs), and compositions comprising the same, which have increased stability in amniotic fluid, and methods of use thereof for in utero delivery of therapeutic agents, to treat and/or prevent diseases and/or disorders in a fetal subject. The present disclosure further relates to an ex vivo assay for screening LNP stability in a test fluid.
    Type: Application
    Filed: August 3, 2022
    Publication date: October 3, 2024
    Applicants: The Trustees of the University of Pennsylvania, The Children's Hospital of Philadelphia
    Inventors: Michael Mitchell, Kelsey L. Swingle, Margaret M. Billingsley, William Peranteau
  • Scalable bio-element analysis
    Patent number: 12105108
    Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: October 1, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ivan K. Dimov, Thomas M. Baer
  • Methods of isolating allergen-specific antibodies from humans and uses thereof
    Patent number: 12103964
    Abstract: In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: October 1, 2024
    Assignees: CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior
    Inventors: Derek Croote, Stephen R. Quake, Kari Nadeau, Spyros Darmanis, David N. Cornfield
  • Ransomware-aware solid-state drive
    Patent number: 12105861
    Abstract: An example embodiment may involve a storage device comprising one or more processors, memory, a host interface connectable to a host device, a network interface connectable to a backup device, and program instructions, stored in the memory, that upon execution by the one or more processors cause the storage device to perform operations comprising: causing data received, by way of the host interface, to be stored in a page of the memory; after storing the data, marking the page as invalid due to input/output operations of the memory; determining a predicted idle time period within which the memory is not expected to be engaged in further input/output operations; determining that a duration of the predicted idle time period exceeds a threshold length; and during the predicted idle time period, transmitting, by way of the network interface, the data to the backup device.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: October 1, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Jian Huang
  • Coating for anti-fouling and anti-corrosion on metals
    Patent number: 12104076
    Abstract: A coated substrate that may exhibit anti-scaling properties includes a substrate comprising a metal or alloy, an intermediary layer formed on the substrate, and a non-crosslinked omniphobic coating formed on the intermediary layer. A method of forming an anti-scaling coating on a substrate includes forming an intermediary layer on a substrate comprising a metal or alloy, and forming a non-crosslinked omniphobic coating on the intermediary layer.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: October 1, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Hanyang Zhao, Nenad Miljkovic
  • Materials for stabilizing semiconductors and methods of making the same
    Patent number: 12106908
    Abstract: The present disclosure relates to a device that includes a first layer having an active material and a stabilizing material, where the active material includes a semiconductor, the stabilizing material includes at least one of an oligomer, an elastomer, a polymer, and/or a resin, and the stabilizing material provides to the device an improved performance metric compared to a device constructed of the first layer but constructed of only the active material (i.e., in the absence of the stabilizing material).
    Type: Grant
    Filed: April 25, 2023
    Date of Patent: October 1, 2024
    Assignees: Alliance for Sustainable Energy, LLC, Board of Trustees of Northern Illinois University
    Inventors: Kai Zhu, Fei Zhang, Tao Xu
  • Solution-processable superatomic thin-films
    Patent number: 12104114
    Abstract: Ionic superatomic materials that can be solution-processed into completely amorphous and homogeneous thin films are disclosed herein. The amorphous materials disclosed herein have tunable compositions and have electrical conductivities of up to 300 siemens per meter, thermal conductivities of 0.05 watt per meter per degree Kelvin, and optical transparencies of up to 92%. Application of these thin-films are also provided herein.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: October 1, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Colin Nuckolls, Jingjing Yang, Alexander D. Christodoulides, Boyuan Zhang, Qizhi Xu, Amirali Zangiabadi, Christine McGinn, Samuel Peurifoy, Lingyun Dai, Elena Meirzadeh, Michael Steigerwald, Xavier Roy, Ioannis Kymissis, Jonathan A. Malen
  • Boron nitride nanotube aluminum composites and methods of manufacturing the same
    Patent number: 12103071
    Abstract: Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process.
    Type: Grant
    Filed: April 6, 2023
    Date of Patent: October 1, 2024
    Assignee: The Florida International University Board of Trustees
    Inventors: Arvind Agarwal, Cheng Zhang, Tanaji Paul, Sohail Mazher Ali Khan Mohammed, Denny John
  • 2?F-ANA-LET7 mediated utrophin upregulation for DMD therapy
    Patent number: 12104152
    Abstract: The invention relates to compositions and methods for enhancing or upregulating utrophin protein production and methods for treating myopathies, such as Duchenne Muscular Dystrophy (DMD). Specifically, the invention relates to compositions, such as oligonucleotides, and methods for enhancing or upregulating utrophin in a subject by blocking binding of let-7c miRNA to the utrophin mRNA 3 untranslated region (UTR).
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: October 1, 2024
    Assignees: The Trustees of the University of Pennsylvania, AUM LifeTech, Inc
    Inventors: Tejvir S. Khurana, Manoj Kumar Mishra, Veenu Aishwarya