Patents Assigned to Trustee
  • Soluble Epoxide Hydrolase Inhibitors and Use Thereof
    Publication number: 20240293362
    Abstract: Compounds and methods to treat or prevent CNS diseases, such as Alzheimer's disease and brain injury inflammation, are disclosed herein. The compounds are soluble epoxide hydrolase (sEH) inhibitors and have improved physical properties, blood-brain-barrier (BBB) penetration and long drug-target residence time. Pharmaceutical compositions and kits comprising the compounds are also disclosed herein.
    Type: Application
    Filed: April 12, 2024
    Publication date: September 5, 2024
    Applicant: Board of Trustees of Michigan State University
    Inventors: Edmund L. ELLSWORTH, Kin Sing Stephen LEE
  • sBCMA Variants and FC Fusion Proteins Thereof
    Publication number: 20240294604
    Abstract: The invention is directed to novel sBCMA variants and sBCMA variant—Fc fusion proteins, polynucleotides encoding the sBCMA variants and/or sBCMA variant—Fc fusion proteins, methods of making the sBCMA variants and/or sBCMA variant—Fc fusion proteins, and methods of using compositions comprising the sBCMA variants and/or sBCMA variant—Fc fusion proteins, for example, in treating diseases such as tumors/cancers, immunoregulatory disorders, etc.
    Type: Application
    Filed: August 11, 2021
    Publication date: September 5, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Amato J. Giaccia, Yu Miao, Kaushik Thakkar, Kazue Mizuno
  • COMPOSITIONS AND METHODS FOR ACHIEVING HIGH LEVELS OF TRANSDUCTION IN HUMAN LIVER CELLS
    Publication number: 20240294941
    Abstract: Use of a rAAV3B vector to deliver gene products to human hepatocytes is described. The rAAV3B vectors achieve high levels of transduction even in the presence of pre-existing immunity to AAV8 or AAVrh10. Compositions and treatment regimens are described. Also provided are rAAV engineered to facilitate purification and methods of purifying the AAV.
    Type: Application
    Filed: October 27, 2023
    Publication date: September 5, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Lili Wang, Qiang Wang
  • Artificial selection approach for improving secondary microbial functions using a partner organism
    Publication number: 20240296906
    Abstract: A partner-assisted artificial selection (PAAS) approach, in which an assisting population acts as an intermediate to create feedback from the function of interest to the fitness of the producer. The selection for improved growth in this approach successfully leads to improved degradation performance, even in the presence of other sources of stochasticity. Successful implementation of PAAS evolves improved functions of interest such as detoxification of harmful compounds.
    Type: Application
    Filed: May 3, 2023
    Publication date: September 5, 2024
    Applicant: The Trustees of Boston College
    Inventors: Babak Momeni, Marco Zaccaria, Natalie Sandlin
  • Programmable Nanoencapsulation for Delivery of Probiotics in Vivo
    Publication number: 20240293474
    Abstract: Programmable bacterial cells that comprise a gene that regulates capsular polysaccharide nanoencapsulation of the bacterium linked to an exogenous promoter, wherein expression of the gene and the nanoencapsulation can be programmed or controlled by an external modulator of the exogenous promoter and related compositions and methods.
    Type: Application
    Filed: October 31, 2023
    Publication date: September 5, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Tal DANINO, Kam LEONG, Tetsuhiro HARIMOTO, Jaeseung HAHN
  • Systems, devices, and methods for harmonization of imaging datasets including biomarkers
    Patent number: 12079960
    Abstract: An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: September 3, 2024
    Assignees: Terran Biosciences Inc., The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc.
    Inventors: Samuel Clark, Kenneth Wengler, Guillermo Horga Hernandez
  • Polymer excipients for biopharmaceutical formulations
    Patent number: 12077621
    Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.
    Type: Grant
    Filed: October 17, 2023
    Date of Patent: September 3, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior Univeristy
    Inventors: Eric A. Appel, Caitlin Maikawa, Joseph L. Mann
  • Methods, systems, and media for testing insider threat detection systems
    Patent number: 12079345
    Abstract: Methods, systems, and media for testing insider threat detection systems are provided.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: September 3, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Salvatore J. Stolfo, Preetam Kumar Dutta
  • Systems, methods, and media for proving the correctness of software on relaxed memory hardware
    Patent number: 12079102
    Abstract: Mechanisms for proving the correctness of software on relaxed memory hardware are provided, the mechanisms comprising: receiving a specification, a hardware model, and an implementation for the software to be executed on the relaxed memory hardware; evaluating the software using a sequentially consistent hardware model; evaluating the software using a relaxed memory hardware model and at least one of the following conditions: a data-race-free (DRF)-kernel condition; a no-barrier-misuse condition; a memory-isolation condition; a transactional-page-table condition; a write-once-kernel-mapping condition; and a weak-memory-isolation condition; and outputting an indication of whether the software is correct based on the evaluating the software using the sequentially consistent hardware model and the evaluating the software using the relaxed memory hardware model.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: September 3, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Ronghui Gu, Jason Nieh, Runzhou Tao
  • Systems and methods for GPS/GNSS based real time global asset tracking
    Patent number: 12078736
    Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.
    Type: Grant
    Filed: May 22, 2023
    Date of Patent: September 3, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barbara Ann Block, Sherman C. Lo, David S. De Lorenzo, Yu-Hsuan Chen, Per K. Enge
  • Microplasma-based heaterless, insertless cathode
    Patent number: 12078154
    Abstract: The present disclosure generally pertains to devices and methods for generating thrust in vehicles, for instance in space applications. A heaterless, insertless hollow cathode utilizes AC and pulsed DC electric fields to ionize the propellant gas and generate a plasma plume. The cathode uses an argon microplasma generated in a quartz tube with a tungsten filament and brass ion collector. Free electrons are then drawn from the plasma plume and supplied to a thruster engine.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: September 3, 2024
    Assignee: The Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
    Inventors: Kunning Gabriel Xu, Ryan Patrick Gott
  • Integrated system for ultrasound imaging and therapy
    Patent number: 12076193
    Abstract: Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.
    Type: Grant
    Filed: June 19, 2023
    Date of Patent: September 3, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anshuman Bhuyan, Jung Woo Choe, Amin Nikoozadeh, Butrus T. Khuri-Yakub
  • Compositions and methods for inhibiting ACSS2
    Patent number: 12077527
    Abstract: The present invention provides compositions and methods for inhibiting ACSS2 for modulating histone acetylation or for treating or preventing a neurological disease or disorder.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: September 3, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Philipp Mews, Shelley L Berger, Jeffrey D. Winkler, Andrew Glass, Simon David Peter Baugh
  • Tantalum oxide nanoparticle contrast agents
    Patent number: 12077450
    Abstract: A nanoparticle composition is provided. The nanoparticle composition includes a plurality of nanoparticles, each nanoparticle of the plurality having a core including tantalum oxide, and a covalent coating covalently bound to the core. The covalent coating includes a surface modifier selected from the group consisting of (3-aminopropyl)trimethoxy silane (APTMS), (3-aminopropyl)triethoxy silane (APTES), APTMS-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTMS-m-PEG-glutarate), APTES-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTES-m-PEG-glutarate), 2-[methoxy (polyethyleneoxy)-9-12-propyl] trimethoxysilane (PEG-Silane), hexadecyltriethoxy silane, and combinations thereof. Methods of synthesizing and using the nanoparticle composition are also provided.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: September 3, 2024
    Assignee: Board of Trustees of Michigan State University
    Inventors: Shatadru Chakravarty, Erik M. Shapiro
  • Engineered microorganisms for production of 2?fucosyllactose and l-fucose
    Patent number: 12077792
    Abstract: Compositions and methods are provided for producing 2?fucosyliaciose and L-fucose from recombinant microorganisms.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: September 3, 2024
    Assignees: The Board of Trustees of the University of Illinois, Korea University Research and Business Foundation
    Inventors: Yong-Su Jin, Jingjing Liu, Sora Yu, Eun Ju Yun, Suryang Kwak, Kyoung Heon Kim, Jaewon Lee
  • System and method for determining a physiological condition of biological tissue
    Patent number: 12078578
    Abstract: Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.
    Type: Grant
    Filed: June 16, 2023
    Date of Patent: September 3, 2024
    Assignees: Trustees of Boston University, Boston (MA), Beth Israel Deaconess Medical Center, Inc.
    Inventors: Bela Suki, Jae Hun Kim, Joseph Hall, Ramaswamy Krishnan, Niccole Schaible
  • Compositions and methods useful in detecting and diagnosing multiple sclerosis
    Patent number: 12077812
    Abstract: Disclosed herein, are methods of detecting multiple sclerosis in a subject by measuring relative abundances of multiple oral microbiota in sample. Also, disclosed herein are methods of treatment and prophylaxis of MS.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: September 3, 2024
    Assignees: The United States Government As Represented By The Department Of Veterans Affairs, The Board Of Trustees Of The University Of Illinois
    Inventors: Douglas Feinstein, Anne Boullerne
  • VHH polypeptides that bind to toxin b and methods of use thereof
    Patent number: 12077576
    Abstract: Polypeptide products, methods, pharmaceutical compositions, and kits are provided for treating a subject exposed to, or at risk for exposure to, C. difficile microbial pathogens and toxin B produced by C. difficile (TcdB) pathogens. The methods, compositions and kits include a single domain, anti-TedB VHH polypeptide (antibody), or toxin B binding portion thereof, that specifically binds to and/or neutralizes TedB and treats or prevents illness and disease associated with C. difficile infection and TedB intoxication. The anti-TcdB VHHs, or toxin B binding portion thereof, may be recombinantly produced.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: September 3, 2024
    Assignee: Trustees of Tufts College
    Inventor: Charles B. Shoemaker
  • 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
    Publication number: 20240287092
    Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 29, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
  • POLYMER GLASS TRANSITION TEMPERATURE MANIPULATION VIA Z/E HYDRAZONE PHOTOSWITCHING
    Publication number: 20240287218
    Abstract: In an embodiment, the present disclosure pertains to a method of changing the glass transition temperature of a polymer. In some embodiments, the polymer includes at least one hydrazone-containing compound. In general, the methods of the present disclosure include one or more of the following steps of: (1) applying light to the polymer; and (2) thereby changing the glass transition temperature of the polymer. In another embodiment, the present disclosure pertains to a polymer having a light-adjustable glass transition temperature. In some embodiments, the polymer includes at least one hydrazone-containing compound.
    Type: Application
    Filed: April 18, 2024
    Publication date: August 29, 2024
    Applicant: Trustees of Dartmouth College
    Inventors: Ivan Abrahamian, Sirun Yang, Laura L. Jeliazkov, Jared D. Harris