Abstract: In an embodiment, the present disclosure pertains to a method of changing the glass transition temperature of a polymer. In some embodiments, the polymer includes at least one hydrazone-containing compound. In general, the methods of the present disclosure include one or more of the following steps of: (1) applying light to the polymer; and (2) thereby changing the glass transition temperature of the polymer. In another embodiment, the present disclosure pertains to a polymer having a light-adjustable glass transition temperature. In some embodiments, the polymer includes at least one hydrazone-containing compound.

Abstract: Systems and methods for sensory entrained TMS in accordance with embodiments of the invention are illustrated. One embodiment includes a method for transcranial magnetic stimulation, including identifying a beat offset in a music track that when played for a patient is associated with desynchronization of alpha waves and synchronization of beta waves of the patient, playing back the music track for the patient, and providing transcranial magnetic stimulation pulses using a transcranial magnetic stimulation device to the patient, where the pulses are delivered a time equal to the beat offset with respect to beats in the music track.

Abstract: Systems and methods for wireless simultaneous transmit and receive (STAR) using multi-input multi-output (MIMO) radiofrequency (RF) front-ends are provided. A MIMO front-end can be based on the use of a symmetrical pair of arrays, in which one is used for communication while the other is used inside an RF-shielded chamber to act as a reference for subtracting self-interference between transmitters and receivers. In addition to the two arrays, the symmetry of the system can include two identical passive microwave multi-beam beamforming networks. The beamformer networks can be, for example, Butler Matrix based, true-time delay microwave networks, or Rotman lens based.

Abstract: Systems and methods for privacy-preserving optics are described. An embodiments includes a method of preserving-privacy on captured images while performing a computer vision task that includes generating an optimal set of parameters to parameterize an encoding optical element to produce optical distortions such that acquired images by the camera are distorted, where the optimal set of parameters is learned via end-to-end learning that jointly optimizes from a camera optics model to a computational process that performs a computer vision task on the distorted images acquired by the camera, where the distorted images visually obscure a privacy attribute of people to protect their privacy but still preserve features to perform the computer vision task, acquiring several distorted images, and performing a computer vision task directly on the distorted images where the distortions generated by the camera are optimal and allow obtaining high performance on the computer vision task.

Abstract: In various aspects and embodiments the invention provides compositions and methods useful in the treatment of acute lung injury (ALI).

Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.

Abstract: An exemplary catheter can be provided, which can include, for example a source fiber(s) configured to (i) receive a near infrared spectroscopic (NIRS) radiation, and (ii) provide the NIRS radiation to a portion(s) of a sample(s), a detection fiber(s) configured to receive a return radiation from the sample(s) that can be based on the NIRS radiation that was provided to the portion(s) of the sample(s), and an ablation electrode(s) configured to ablate the sample(s) based on the return radiation. The source fiber(s), the detection fiber(s), and the ablation electrode(s) can be integrated into the single sheath. The ablation electrode(s) can be a radiofrequency ablation electrode.

Abstract: In certain embodiments, this application discloses methods for the diagnosis and prognosis of prostate cancer. In some embodiments, the invention takes advantage of the combinatorial utility of certain biomarkers to prognose and diagnose prostate cancer at an early stage. In certain embodiments, the methods described herein do not require the selection of cells from a particular tissue compartment, and are therefore suitable for analysis of cancer tissue in which compartmentalization is lost.

Abstract: The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.

Abstract: Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn.

Abstract: A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.

Abstract: Systems and methods for performing bioremediation using the Geobacillus sp. bacterial strain are provided which are capable of effectively degrading 1,4-dioxane and/or per- and polyfluoroalkyl substances (PFAS) and/or BaP and efficiently degrading other ring-based organic contaminants. The exemplary bioremediation methods include steps for administering an effective, degrading amount of the bacteria to soil containing excess amounts of 1,4-dioxane and/or PFAS and/or BaP and incubating the bacteria administered to the soil at a given temperature and for a duration that are suitable for promoting incubation and reducing and the concentration of 1,4-dioxane and/or PFAS and/or BaP below a maximum concentration, as might be specified by a regulatory body.

Abstract: Translational activators are disclosed along with uses thereof and methods to discover translational activators. Many embodiments provide methods to treat diseases and disorders caused by global downregulation of protein synthesis, including (but not limited to) ribosomopathies and neurodegenerative disorders. Certain embodiments are directed to uses of translational activators for the manufacture of medicaments to treat diseases and disorders caused by global downregulation of protein synthesis, and further embodiments are directed to methods of discovering translational activators.

Abstract: Provided herein are compositions and methods that rapidly detect a target nucleic acid molecule using a CRISPR or a CRISPR Cascade mechanism where binding of a target nucleic acid molecule initiates an amplification cascade by converting high KD guide RNA molecules to low KD guide RNA molecules.

Abstract: Methods for controlled synthesis and chemical recycling of stereoregular polysaccharides via polymerization of biomass-derived anhydrosugars are provided. The anhydrosugars react with an initiator in the presence of a synergy of a catalyst and the initiator providing the polysaccharides with high chain end fidelity and an excellent molecular weight distribution in a controlled manner, which allows for the preparation of polymeric systems with well-defined architectures. The polysaccharides obtained by such methods can be substantially converted to the start monomers in the present of a catalyst and can be used for biomedicine.

Abstract: Discontinuity modeling techniques of computing functions of a program are described. In one example, a program has a computing function that includes a discontinuity. An input is received by the data modeling system that identifies an axis. A plurality of samples is then generated by the data modeling system along the axis based on an output of the program. The samples are then used as a basis by the data modeling system to generate a data model that models the discontinuity. The data model includes, in one example, one or more gradients and models the discontinuity using a 1D box kernel.

Abstract: A system generates a context mask based on quantitative image data. The system obtains the quantitative image data which was captured via a quantitative imaging of a sample. The quantitative image data is compared to previous quantitative image data through application of the quantitative image data to a neural network trained using the previous quantitative image data and corresponding constructed context masks. The comparison generates the context mask for the quantitative image data. The context mask provides context for the quantitative parameter values that facilities characterization of the sample.

Abstract: A method for optical super-multiplexing using polyynes to provide enhanced images from stimulated Raman microscopy is disclosed. In some exemplary embodiments, the polyynes are organelle-targeted or spectral barcoded. Imaging can be enhanced by using the polyynes to image whole live cells or specific organelles within live cells. The polyynes can also be used in optical data storage (i.e., encoding) and identification (i.e., decoding) applications.

Abstract: Systems and methods for event-based gaze in accordance with embodiments of the invention are illustrated. One embodiment includes an event-based gaze tracking system, including a camera positioned to observe an eye, where the camera is configured to asynchronously sample a plurality of pixels to obtain event data indicating changes in local contrast at each pixel in the plurality of pixels, and a processor communicatively coupled to the camera, and a memory communicatively coupled to processor, where the memory contains a gaze tracking application, where the gaze tracking application directs the processor to, receive the event data from the camera, fit an eye model to the eye using the event data, map eye model parameters from the eye model to a gaze vector, and provide the gaze vector.

Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a Botulinum toxin or an Anthrax toxin.