Abstract: This invention provides a generalized electronic computer architecture with multiple cores, memory distributed amongst the cores (a core-local memory). This arrangement provides predictable, low-latency memory response time, as well as a flexible, code-supplied flow of memory from one specific operation to another (using an operation graph). In one instantiation, the operation graph consists of a set of math operations, each accompanied by an ordered list of one or more input addresses. Input addresses may be specific addresses in memory, references to other math operations in the graph, or references to the next item in a particular data stream, where data streams are iterators through a continuous block of memory. The arrangement can also be packaged as a PCIe daughter card, which can be selectively plugged into a host server/PC constructed/organized according to traditional von Neumann architecture.

Abstract: A three-dimensional stereo vision camera communicates the location of a targeted fruit (preferably an apple) to a controller. The controller directs a vacuum selection tube to the location of the targeted apple. The selection tube has a gripping orifice that has a smaller diameter than the apple so that the vacuum suction from the selection tube grips the apple. The selected fruit is then rotated and pulled away from the tree canopy by the selection tube until the apple detaches from the canopy. The detached apple is then gently placed in a collection bin for later sorting and processing.

Abstract: Systems and methods for data-compressive sensing in accordance with embodiments of the invention are illustrated. In one embodiment, a sensor array includes an array of sensor circuitries including a sensor and a comparator. Sensor circuitries in the array are connected via wires which form a series of wired-OR circuits. Readouts can be used to measure the signal on the wires and a decoder in communication with the readouts can be used to resolve signals sensed by particular sensors in the array and their locations.

Abstract: The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.

Abstract: A robotic assistant provides active support for disabled users and may take the approximate form of a cane or a walker.

Abstract: A method for treating type 2 diabetes (T2D) is provided. The method comprises diagnosing a subject as suffering from T2D or as being pre-diabetic; monitoring the response to glucose stimulation of at least one islet in the pancreas of the subject by quantitatively imaging glucose metabolism in vivo; establishing a target range for the response to glucose stimulation of the at least one islet; and upregulating cathelicidin gene expression in the subject until the monitored response to glucose stimulation is within the target range.

Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.

Abstract: A rAAV for treatment of a disorder associated with a deficiency in hypoxanthine-guanine phosphoribosyltransferase (HPRT) enzyme levels via gene delivery is provided herein. Also provided herein is a method for treating disorder associated with a deficiency in hypoxanthine-guanine phosphoribosyltransferase (HPRT) enzyme levels by direct delivery to dopaminergic neurons. Correction of Lesch-Nyhan disease may be monitored by assessing dopamine metabolism levels and/or imaging for the presence of dopaminergic cell bodies.

Abstract: Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.

Abstract: Disclosed is a method for experimentally optimizing information quality and engagement in crowd sourced evaluation systems. It allows estimating efficiencies of different strategies to provide the greatest opportunity for social learning. It can be used for continuous tuning of social feedback. Also disclosed is a system that allows experimentation with crowd sourced evaluations of virtual services. The experimental system supports large scale online recruitment of participants into web-browser 3D virtual world. The virtual world can be designed to approximate several types of real-world, distributed information systems. Social influences can be experimentally introduced into the feedback system in order to empirically optimize its utility.

Abstract: A method of treating a Down syndrome (DS) subject with functional or at risk of decline of organ systems associated with accelerated aging due to over-production of H2S is disclosed. That method contemplates administering a pharmaceutical composition containing a H2S-reducing effective amount of hydrophilic polymer-substituted oxidized carbon nanoparticles (OCNPs) and an optional potentiating amount of lipoic acid or dihydrolipoic acid dissolved or dispersed in a physiologically acceptable diluent to the subject. The pharmaceutical composition can be administered parenterally as a liquid or per os as a solid or liquid.

Abstract: Provided are fusion proteins and modified proteins comprising a neutralizing polypeptide and an antibody (e.g., a non-neutralizing antibody) that specifically binds to an epitope in a conserved region of one or more coronavirus spike proteins. The fusion proteins and modified proteins are able to specifically bind to and neutralize a broad spectrum of coronaviruses, including SARS-CoV-2 and all known SARS-COV-2 variants of concern (e.g., the Delta and Omicron variants). Also provided are various compositions of such proteins, methods of their use, nucleic acids encoding such proteins or domains thereof, constructs, expression cassettes, and vectors containing such nucleic acids, and host cells capable of expressing these proteins or domains thereof. Additionally provided are prophylactic and therapeutic methods employing the fusion proteins and/or modified proteins of the disclosure.

Abstract: A mobile robot can be caused to move according to a planned trajectory. The mobile robot can be a vehicle. Information about agents in an environment of the mobile robot can be received from sensors. At a first time, a spatiotemporal graph can be produced. The spatiotemporal graph can represent relationships among the agents in the environment. The mobile robot can be one of the agents in the environment. Information from the spatiotemporal graph can be input to neural networks to produce information for a mixture of affine time-varying systems. The mixture of affine time-varying systems can represent an evolution of agent states of the agents. Using the mixture of affine time-varying systems and information associated with the first time, a prediction of the agent states at a second time can be calculated. The mobile robot can be caused to move according to the planned trajectory determined from the prediction.

Abstract: An apparatus for fabricating non-planar coils includes a rotating table driven by a first motor; a wire approach height adjustment arm driven by a second motor; and a synchronization module configured such that a wire traversing from the height adjustment arm to a bobbin on the rotating table passes into a non-planar groove cut in the bobbin without damaging the wire. Performing magnetic resonance (MR) measurements includes a plurality of coil units configured for generating a gradient or shim magnetic field. The coil unit includes a plurality of coil windings, and each coil winding is separated longitudinally from an adjacent coil winding. A single pair of electrically conducting leads is configured to cause current to flow through all of the plurality of coil windings in the coil unit. Techniques include methods to fabricate and operate the apparatus.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to receive radar data from a radar, the radar data including radar pixels having respective measured depths; receive camera data from a camera, the camera data including an image frame including camera pixels; map the radar pixels to the image frame; generate respective regions of the image frame surrounding the respective radar pixels; for each region, determine confidence scores for the respective camera pixels in that region; output a depth map of projected depths for the respective camera pixels based on the confidence scores; and operate a vehicle including the radar and the camera based on the depth map. The confidence scores indicate confidence in applying the measured depth of the radar pixel for that region to the respective camera pixels.

Abstract: Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

Abstract: The disclosure is directed to methods and compositions for screening a library of aptamers for aptamers having a binding affinity to a target molecule. Specifically, non-natural nucleotides can be introduced onto aptamers immobilized on the surface of beads. The non-natural nucleotides can then be subsequently chemically modified to include additional binding agents. For example, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions can be used to introduce a wide range of binding agents onto non-natural nucleotides on beads.

Abstract: The disclosure is directed to substituted dibenzo[b,f]azepines of the formula (II): wherein the variables n, X3, R1, R2, R4, and R5 are defined herein, and uses of such compounds to treat conditions including neurodegenerative diseases and cancers.

Abstract: Apparatus and methods calculate and deliver doses of insulin and optionally glucagon into a subject. Online operation controls delivery of correction doses of insulin automatically in response to regular glucose measurements from a sensor, and offline operation calculates and delivers correction doses based on isolated glucose measurements and information gathered autonomously during preceding online operation. In another aspect, offline operation includes automatically calculating and administering meal doses based on information gathered autonomously during preceding periods of online operation. Both methods include generating relevant control parameters tailored to the individual and continually converged upon and potentially modulated during online operation. The control parameters are employed in real time during periods of offline operation to regulate glucose level without the need for user-provided control parameters such as correction factors and insulin-to-carbohydrate ratios.

Abstract: Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient's needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides adaptation of priming dose size at mealtimes for overall better glycemic control and also adapting to longer-term changes in a patient's needs. Adaptation calculations use a receding-horizon window of recent values of the adapted parameter. Doses of a counter-regulatory agent (e.g., glucagon) may also be delivered in response to information about estimated accumulation of exogenously infused insulin (subcutaneously, intramuscularly, intraperitoneally, or intravenously) and/or the effect insulin might have on glucose levels (blood glucose concentration or interstitial fluid glucose concentration).