Abstract: This patent document provides novel compounds as warheads for therapeutic or diagnostic agents. Advantages of the agents modified with the warheads include low off-target conjugation and minimized immunogenicity due to the reversible covalent bonding between the warheads and the targets.

Abstract: The present disclosure provides a compound having the structure:

Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.

Abstract: The embodiments provide a thermionic emission device and a method for tuning a work function in a thermionic emission device is provided. The method includes illuminating an N type semiconductor material of a first member of a thermionic emission device, wherein a work function of the N type semiconductor material is lowered by the illuminating. The method includes collecting, on one of the first member or a second member of the thermionic emission device, electrons emitted from one of the first member or the second member.

Abstract: The current invention is a method of treating, preventing, reducing and/or abolishing edema and/or intracranial pressure in a subject by the administration of hyaluronidase. The edema in the brain and intracranial pressure can be the result of a traumatic event, disease or condition including but not limited to a traumatic brain injury, a stroke, a brain tumor, and post-operative swelling.

Abstract: In certain examples, methods and semiconductor structures are directed to operation of a piezoelectric-based device (e.g., a DC-DC converter) and such operation may involve selectively switching inputs of the piezoelectric-based device at a modulation frequency and, in response, decoupling of the modulation frequency from output power delivered by the piezoelectric-based device. In some examples, the inputs of the piezoelectric-based device are selectively switched to cause decoupling the modulation frequency from output power delivered by the piezoelectric-based device and/or cause operation of the piezoelectric-based device without spurious mode operation.

Abstract: Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.

Abstract: The present disclosure is directed to methods for preparing nanoparticle monolayers on a sub-phase by controlling the spreading rate of the nanoparticles. The nanoparticles are first prepared in a nanoparticle solution at a predetermined concentration with a solvent. The sub-phase solution is prepared to have a density and viscosity compatible with the desired spreading rate. Additives, such as glycerol, are used to alter the density of the sub-phase solution. A volume of nanoparticle solution is deposited on the surface of the sub-phase solution and allowed to spread in a controlled manner on the unconstrained surface, forming a uniform nanoparticle monolayer. A substrate is then placed in contact with the nanoparticle monolayer to form a uniform nanoparticle coating on the surface of the substrate.

Abstract: Limited physical access to target organs of patients inside an MRI scanner is a major obstruction to real-time MRI-guided interventions. Traditional teleoperation technologies are incompatible with the MRI environment and although several solutions have been explored, a versatile system that provides high-fidelity haptic feedback and access deep inside the bore remains a challenge. A passive and nearly frictionless MRI-compatible hydraulic teleoperator is provided designed for in-bore biopsies. A needle driver translates a needle in insertion and retraction directions via a clutch mechanism. A needle holder grips the needle via a retraction lock when the clutch mechanism of the needle driver releases the needle to hold a position of the needle during reposition of the needle driver.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Aspects of the present disclosure relate to genetically altered plants with increased activity of one or more of a PPDK regulatory protein (PDRP), a Rubisco activase (Rea) protein, or a Rubisco protein that have increased photosynthetic efficiency under fluctuating light conditions. Further, aspects of the present disclosure relate to methods of producing and cultivating the genetically altered plants of the present disclosure.

Abstract: Compositions and methods for the prevention and treatment of stress-induced fear, depressive-like and anxiety-like behavior using selective VPAC2 agonist Bay 55-9837.

Abstract: A polymer is the reaction product of a substituted or unsubstituted 2,3-dihydrofuran, a substituted or unsubstituted 2,3-dihydropyran, or a mixture of any two or more thereof with a substituted or unsubstituted cycloalkenyl monomer, or a mixture of any two or more thereof, in the presence of a ring-opening metathesis catalyst. In some embodiments, the substituted or unsubstituted cycloalkenyl monomer is a substituted or unsubstituted norbornene monomer.

Abstract: Methods and apparatus for improved imaging of internal tissue structures, such as lesions in the peritoneum, are disclosed employing Differentially Polarized Light (DPL) imaging. The optical system can include a laparoscope having at least one optical illumination waveguide for directing illuminating radiation and an optical collection waveguide having an aperture for collecting and transmitting radiation backscattered from a tissue region to a detector. The system further can include a polarizer for polarizing the illuminating radiation and a second analyzing polarizer disposed in the optical return path, whereby backscattered radiation of differing polarizations can be passed to the detector. End cap assemblies are also disclosed that that can be fitted to conventional laparoscopes, e.g., by a threaded connection or the like, to facilitate DPL imaging by polarizing the illuminating light of the laparoscope. For example, the end cap can include a polarizing film within a stainless steel housing.

Abstract: Described herein are methods of making and using and apparatus for wirelessly communicating data and providing power, particularly from a location exterior to a body and to an implantable device disposed within a body with tissue. The described embodiments provide apparatus and methods for efficiently transfer data and power between an external transceiver and an (implanted) biomedical device. The method is to modulate power carrier, which wirelessly powers the device, using an asynchronous modulation scheme, such as amplitude shift keying (ASK) modulation, with minimal modulation depth in order to not disrupt the power flow. The digital data is encoded in the pulse width, eliminating the need for synchronization to the power carrier signal and further minimizing the power consumption necessary for data transfer. Additionally, a reverse backscatter method for obtaining data from the implant is described that has flexible, low power operation.

Abstract: Systems and methods are provided for employing informational models trained using the Autoprogressive Algorithm to learn the mechanical behavior and internal structure of biological materials using a sparse sampling of force and displacement measurements. Forces are applied to the biological material and the force and displacement are measured and applied to the AutoP algorithm. Additionally, a coordinate based scaling factor is applied to the measured displacement.

Abstract: Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.

Abstract: A system for charging a battery includes three sub-modules, each receiving a respective phase of a three-phase alternating current (AC) signal. The three sub-modules cooperate to transform the respective phases of the three-phase AC signal to a direct current (DC) signal by passing the respective phases of the three-phase AC signal through a respective semiconductor device configured to discontinuously modulate the respective phase of the three-phase AC signal to convert it to a DC signal provided to the battery to charge the battery.

Abstract: An improved nanocomposite cathode material for lithium-ion batteries comprising vanadium pentoxide substrates with a conductive matrix of graphene sheets and a network former such as silicon dioxide and a method of making the same.

Abstract: Methods are provided for targeting cells for depletion, including, without limitation, cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS and BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.